Click here to switch to the map view.

The map label for this gene is arg

Identifier: 15602673

GI number: 15602673

Start: 956260

End: 957264

Strand: Direct

Name: arg

Synonym: PM0808

Alternate gene names: 15602673

Gene position: 956260-957264 (Clockwise)

Preceding gene: 15602672

Following gene: 15602681

Centisome position: 42.36

GC content: 41.89

Gene sequence:

>1005_bases
ATGCCACTCAATTTACGTCATCGTCATTTCTTGCGTTTAATGGATTTCACGCCAACCGAAATTCAATTCCTACTCGACCT
CTCTGCCAACTTAAAAAAAGCAAAATATACCGGAACAGAACAACCTCGTTTGAAAGGGAAAAATATTGCCTTAATTTTTG
AGAAAACGTCAACACGCACGCGCTGTTCATTTGAAGTGGCGGCGTATGATCAAGGGGCAAATGTCACTTATATCGGTCCA
AGTGGTTCACAAATTGGTCATAAAGAATCGATGAAAGACACGGCTCGAGTTTTAGGCCGTATGTATGACGGAATTCAATA
TCGTGGTTATGGACAGGAATTAGTCGAGATTCTCGCACAGTACTCAGGCGTTCCTGTTTGGAATGGGTTAACTGATGATT
TTCATCCAACACAAATTCTTGCTGATTTTCTGACAATGTTAGAACACGGTGAAGGCAAACGTCTTAATCAAATGAAAATG
GCCTATTTGGGTGATGCCAGAAATAACATGGGAAATTCTTTTGTTGAAGGTGCGGCATTAATGGGCATGGATCTCCGTTT
AGTCGCGCCTAAAGCCTATTGGCCAGAACAAAAACTGCTTGATGAAGTCGCAGAAATGGCGAAGAAAACTGGCGCAAAAA
TTACCTGTACAGAAAACGTAGAGGAAGGGGTGAAAGGTGTTGATTTCCTTTACACCGATATTTGGGTCTCCATGGGCGAG
CCTGAAGAAGCTTGGGAACAGCGCATTAACTTAATGAAACCATACCAAGTCAACAAGGCGTTACTTGAAAAAACAGGTAA
TCCAAAAGTGAAATTCATGCACTGTTTGCCTGCTTTCCACGATGAAAATACAACGGTCGGTAAAGAAATGGCGCAAAAAT
ATGGTATGAACGGTCTTGAAGTCACCGATGAGGTATTTGAATCAGATGCCTCCATCGTGTTTGATGAAGCAGAAAACCGT
ATGCATACAATTAAAGCAGTGATGGTGGCAACGTTAGGTCAGTAA

Upstream 100 bases:

>100_bases
TTTCTCCTAGCCTTTTAATATAATTAAGGTATAATTTTCGATCGCGTAAACGTTTGCTCAAAATCCTACTATAAATTATC
AATTCAAATGAGGAGAATAT

Downstream 100 bases:

>100_bases
GACGTTGTTCTTCTCATAAAAAATCCCCAAAAATGCACCGCACTTTTGGGGTTTTACTTTTAGTATCGGCTATGAAAGCT
GTGTTATGATTTGTTCCAAC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MPLNLRHRHFLRLMDFTPTEIQFLLDLSANLKKAKYTGTEQPRLKGKNIALIFEKTSTRTRCSFEVAAYDQGANVTYIGP
SGSQIGHKESMKDTARVLGRMYDGIQYRGYGQELVEILAQYSGVPVWNGLTDDFHPTQILADFLTMLEHGEGKRLNQMKM
AYLGDARNNMGNSFVEGAALMGMDLRLVAPKAYWPEQKLLDEVAEMAKKTGAKITCTENVEEGVKGVDFLYTDIWVSMGE
PEEAWEQRINLMKPYQVNKALLEKTGNPKVKFMHCLPAFHDENTTVGKEMAQKYGMNGLEVTDEVFESDASIVFDEAENR
MHTIKAVMVATLGQ

Sequences:

>Translated_334_residues
MPLNLRHRHFLRLMDFTPTEIQFLLDLSANLKKAKYTGTEQPRLKGKNIALIFEKTSTRTRCSFEVAAYDQGANVTYIGP
SGSQIGHKESMKDTARVLGRMYDGIQYRGYGQELVEILAQYSGVPVWNGLTDDFHPTQILADFLTMLEHGEGKRLNQMKM
AYLGDARNNMGNSFVEGAALMGMDLRLVAPKAYWPEQKLLDEVAEMAKKTGAKITCTENVEEGVKGVDFLYTDIWVSMGE
PEEAWEQRINLMKPYQVNKALLEKTGNPKVKFMHCLPAFHDENTTVGKEMAQKYGMNGLEVTDEVFESDASIVFDEAENR
MHTIKAVMVATLGQ
>Mature_333_residues
PLNLRHRHFLRLMDFTPTEIQFLLDLSANLKKAKYTGTEQPRLKGKNIALIFEKTSTRTRCSFEVAAYDQGANVTYIGPS
GSQIGHKESMKDTARVLGRMYDGIQYRGYGQELVEILAQYSGVPVWNGLTDDFHPTQILADFLTMLEHGEGKRLNQMKMA
YLGDARNNMGNSFVEGAALMGMDLRLVAPKAYWPEQKLLDEVAEMAKKTGAKITCTENVEEGVKGVDFLYTDIWVSMGEP
EEAWEQRINLMKPYQVNKALLEKTGNPKVKFMHCLPAFHDENTTVGKEMAQKYGMNGLEVTDEVFESDASIVFDEAENRM
HTIKAVMVATLGQ

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=331, Percent_Identity=38.368580060423, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI18105007, Length=340, Percent_Identity=25.8823529411765, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=68.9969604863222, Blast_Score=496, Evalue=1e-141,
Organism=Escherichia coli, GI1786469, Length=332, Percent_Identity=68.0722891566265, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI2367364, Length=292, Percent_Identity=29.4520547945205, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI48994908, Length=376, Percent_Identity=25.2659574468085, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322373, Length=328, Percent_Identity=34.1463414634146, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322331, Length=278, Percent_Identity=27.3381294964029, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24642586, Length=190, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTC_PASMU (P57876)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245745.1
- ProteinModelPortal:   P57876
- SMR:   P57876
- GeneID:   1244155
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0808
- NMPDR:   fig|272843.1.peg.808
- HOGENOM:   HBG579429
- OMA:   DFRIFAP
- ProtClustDB:   PRK02102
- BioCyc:   PMUL272843:PM0808-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 37654; Mature: 37522

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 108-108 BINDING 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNLRHRHFLRLMDFTPTEIQFLLDLSANLKKAKYTGTEQPRLKGKNIALIFEKTSTRT
CCCCCCHHHHHHHHCCCCHHHHHEECCCCCCCHHCCCCCCCCCCCCCCEEEEEECCCCCC
RCSFEVAAYDQGANVTYIGPSGSQIGHKESMKDTARVLGRMYDGIQYRGYGQELVEILAQ
EEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHH
YSGVPVWNGLTDDFHPTQILADFLTMLEHGEGKRLNQMKMAYLGDARNNMGNSFVEGAAL
HCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHCCCHHHCCHHH
MGMDLRLVAPKAYWPEQKLLDEVAEMAKKTGAKITCTENVEEGVKGVDFLYTDIWVSMGE
HCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHCCHHHHHHHHHHHCCCC
PEEAWEQRINLMKPYQVNKALLEKTGNPKVKFMHCLPAFHDENTTVGKEMAQKYGMNGLE
CHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCH
VTDEVFESDASIVFDEAENRMHTIKAVMVATLGQ
HHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PLNLRHRHFLRLMDFTPTEIQFLLDLSANLKKAKYTGTEQPRLKGKNIALIFEKTSTRT
CCCCCHHHHHHHHCCCCHHHHHEECCCCCCCHHCCCCCCCCCCCCCCEEEEEECCCCCC
RCSFEVAAYDQGANVTYIGPSGSQIGHKESMKDTARVLGRMYDGIQYRGYGQELVEILAQ
EEEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHH
YSGVPVWNGLTDDFHPTQILADFLTMLEHGEGKRLNQMKMAYLGDARNNMGNSFVEGAAL
HCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHCCCHHHCCHHH
MGMDLRLVAPKAYWPEQKLLDEVAEMAKKTGAKITCTENVEEGVKGVDFLYTDIWVSMGE
HCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHCCHHHHHHHHHHHCCCC
PEEAWEQRINLMKPYQVNKALLEKTGNPKVKFMHCLPAFHDENTTVGKEMAQKYGMNGLE
CHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCH
VTDEVFESDASIVFDEAENRMHTIKAVMVATLGQ
HHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100