Click here to switch to the map view.

The map label for this gene is tsaA [C]

Identifier: 15602660

GI number: 15602660

Start: 940188

End: 940790

Strand: Direct

Name: tsaA [C]

Synonym: PM0795

Alternate gene names: 15602660

Gene position: 940188-940790 (Clockwise)

Preceding gene: 15602658

Following gene: 15602668

Centisome position: 41.65

GC content: 41.96

Gene sequence:

>603_bases
ATGGTATTAGTAACTCGTCAAGCCCCTGATTTTACAGCGGCTGCCGTTTTAGGTAATGGTGAAATCGTTGATAATTTCAA
TTTTAAACAACATATCGCAGGTAAAGCGGCTGTTGTTTTCTTCTATCCACTCGACTTTACTTTCGTATGCCCATCTGAAC
TTATCGCGTTTGATCATCGCTATGAAGAGTTCCAAAAACGTGGTGTTGAAGTAGTGGGTATTTCCATTGACTCAGAATTC
AGCCACAACGCTTGGCGTAAAACCCCAGTCGAAAATGGCGGTATCGGTGAAGTGAAATATGCTTTAGTTGCCGATATCAA
ACATGAAATCGCACAAGCCTTTGGTATTGAACATCCAGAAGCTGGCGTGGCGTTACGTGCCTCTTTCTTAATTGATAAAG
ATGGCGTAGTACGTCACCAAGTTGTGAATGATTTACCATTAGGTCGTAATATTGATGAAATGTTACGTATGGTTGATGCG
CTACAGTTCCATGAAGAACATGGTGATGTCTGCCCTGCACAATGGGAAAAAGGAAAAGAAGGCATGACTGGTAGCCCTGA
AGGTGTGGCAAAATACTTAAAACAGCATGCTGATCAACTGTAA

Upstream 100 bases:

>100_bases
CCTGTCAAAATGCCTCAACATTCTTTAGAATAGAAAGACAATTTTGCTTATTCTCGCAAAGCAAAATTTTTCGTTTAATT
TTTAACAGGAGATTAATACT

Downstream 100 bases:

>100_bases
TTTTTTCAGTTAAGTATTTCTAAAAGGATTAGCCTCTTGCTAATCCTTTTTCATCTATATCAATGTGATATTGGCAAAAT
AAAAAAGATCAACGCATAAC

Product: TsaA

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MVLVTRQAPDFTAAAVLGNGEIVDNFNFKQHIAGKAAVVFFYPLDFTFVCPSELIAFDHRYEEFQKRGVEVVGISIDSEF
SHNAWRKTPVENGGIGEVKYALVADIKHEIAQAFGIEHPEAGVALRASFLIDKDGVVRHQVVNDLPLGRNIDEMLRMVDA
LQFHEEHGDVCPAQWEKGKEGMTGSPEGVAKYLKQHADQL

Sequences:

>Translated_200_residues
MVLVTRQAPDFTAAAVLGNGEIVDNFNFKQHIAGKAAVVFFYPLDFTFVCPSELIAFDHRYEEFQKRGVEVVGISIDSEF
SHNAWRKTPVENGGIGEVKYALVADIKHEIAQAFGIEHPEAGVALRASFLIDKDGVVRHQVVNDLPLGRNIDEMLRMVDA
LQFHEEHGDVCPAQWEKGKEGMTGSPEGVAKYLKQHADQL
>Mature_200_residues
MVLVTRQAPDFTAAAVLGNGEIVDNFNFKQHIAGKAAVVFFYPLDFTFVCPSELIAFDHRYEEFQKRGVEVVGISIDSEF
SHNAWRKTPVENGGIGEVKYALVADIKHEIAQAFGIEHPEAGVALRASFLIDKDGVVRHQVVNDLPLGRNIDEMLRMVDA
LQFHEEHGDVCPAQWEKGKEGMTGSPEGVAKYLKQHADQL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=194, Percent_Identity=44.8453608247423, Blast_Score=187, Evalue=7e-48,
Organism=Homo sapiens, GI5802974, Length=196, Percent_Identity=44.8979591836735, Blast_Score=183, Evalue=8e-47,
Organism=Homo sapiens, GI4505591, Length=189, Percent_Identity=44.973544973545, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI32455266, Length=189, Percent_Identity=44.973544973545, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI32455264, Length=189, Percent_Identity=44.973544973545, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI32483377, Length=195, Percent_Identity=44.6153846153846, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI5453549, Length=196, Percent_Identity=43.3673469387755, Blast_Score=178, Evalue=3e-45,
Organism=Homo sapiens, GI33188454, Length=83, Percent_Identity=53.0120481927711, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI4758638, Length=208, Percent_Identity=29.8076923076923, Blast_Score=78, Evalue=4e-15,
Organism=Escherichia coli, GI1786822, Length=192, Percent_Identity=34.8958333333333, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17554494, Length=168, Percent_Identity=48.8095238095238, Blast_Score=177, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI32565831, Length=194, Percent_Identity=43.298969072165, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI193204376, Length=194, Percent_Identity=43.298969072165, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI25153706, Length=180, Percent_Identity=30.5555555555556, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323613, Length=191, Percent_Identity=40.3141361256544, Blast_Score=159, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6320661, Length=192, Percent_Identity=36.9791666666667, Blast_Score=147, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319407, Length=181, Percent_Identity=29.8342541436464, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=45.360824742268, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=45.360824742268, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17738015, Length=198, Percent_Identity=42.9292929292929, Blast_Score=180, Evalue=5e-46,
Organism=Drosophila melanogaster, GI21357347, Length=194, Percent_Identity=42.7835051546392, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17157991, Length=197, Percent_Identity=40.6091370558376, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24641739, Length=197, Percent_Identity=40.6091370558376, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24581278, Length=182, Percent_Identity=33.5164835164835, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17975518, Length=182, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24652434, Length=182, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24652436, Length=182, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22218; Mature: 22218

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLVTRQAPDFTAAAVLGNGEIVDNFNFKQHIAGKAAVVFFYPLDFTFVCPSELIAFDHR
CEEEECCCCCCEEEEEECCCCEEECCCHHHHHCCCEEEEEEEECCEEEECHHHHHHHHHH
YEEFQKRGVEVVGISIDSEFSHNAWRKTPVENGGIGEVKYALVADIKHEIAQAFGIEHPE
HHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
AGVALRASFLIDKDGVVRHQVVNDLPLGRNIDEMLRMVDALQFHEEHGDVCPAQWEKGKE
CCEEEEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCC
GMTGSPEGVAKYLKQHADQL
CCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVLVTRQAPDFTAAAVLGNGEIVDNFNFKQHIAGKAAVVFFYPLDFTFVCPSELIAFDHR
CEEEECCCCCCEEEEEECCCCEEECCCHHHHHCCCEEEEEEEECCEEEECHHHHHHHHHH
YEEFQKRGVEVVGISIDSEFSHNAWRKTPVENGGIGEVKYALVADIKHEIAQAFGIEHPE
HHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
AGVALRASFLIDKDGVVRHQVVNDLPLGRNIDEMLRMVDALQFHEEHGDVCPAQWEKGKE
CCEEEEEEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCC
GMTGSPEGVAKYLKQHADQL
CCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]