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The map label for this gene is metC_2 [H]

Identifier: 15602659

GI number: 15602659

Start: 938809

End: 940005

Strand: Reverse

Name: metC_2 [H]

Synonym: PM0794

Alternate gene names: 15602659

Gene position: 940005-938809 (Counterclockwise)

Preceding gene: 15602661

Following gene: 15602657

Centisome position: 41.64

GC content: 42.52

Gene sequence:

>1197_bases
ATGTCAGAAAAACAAACATTATCAACACAATTTATTCATACAGGACGTAGAAAACCCTTTTTACAGGGGGGAGTGAATCC
TGTGATTCAACGCGCTTCATCATTGGTTTTTGACAGTTTAGCCCATAAAAAACAAGCGACCATTGGGCGTGCACAGGGAG
AATTATTTTACGGGCGTCGAGGAACTTTAACCCATTTTGCCTTGCAAGAAGCGATGGCGGAATTAGAAGGCGGAGAAGGT
TGTTATTTGTATCCTTGTGGTGCCGCAGCGGTCACACAAAGTATTTTATCTTTTGTCCAAAGCGGTGATCATATTTTAAT
GACGGGTGCGGCTTATGAGCCGACGCAAGAGTTTTGTAATTGTGTTTTGAAGAAAATGCAAATAGACACGACTTATTACG
ATCCCATGATAGGTGAAGGCATTGCTGAGCTTGTACAAGAAAATACTAAAGTACTTTTTTTGGAGGCACCAAGTTCACTG
ACAATGGAGGTTTCAGATATACCGGCGATTGTTAAAGCCGCACGTCGTGTTAATCCTGATATCGTGATCATGATCGATAA
TACATGGTCAGCGGGTGTGTTCTTTAAGGCACTTGAACAAGGTATTGATATCTCGATTCAAGCTGGAACCAAATATTTAG
TGGGACATTCCGATGTGATGATTGGTACTGCGGTGGCGAATAAACGTTGTTGGGCACAATTACGAGAGCATTCTTATTTA
ATGGGACAAATGGTAGATGCGGAAAGTGCTTATATGACCGCACGAGGTATTCGAACATTGGGGATTCGCTTGAAACAACA
TGAAGAAAATGCGTTGAAGGTGGCACACTGGTTAGCGGCACAACCTGAAGTAAAAGCCGTTTATCATCCCGCATTAGAAA
GCTGTCCCGGACATCAATTTTTTAAGCGTGATTTTAGTGGGGCAACAGGCTTGTTCTCATTTGAGTTGAATCAAAGACTA
AACCCGCAACAATTAGCGAGGTTTATGGATCATTTTACGTTATTTAGCATGGCATATTCTTGGGGAGGATTTGAATCGTT
GATTTTACATTATCAACCGGAAGAGATCATGGCGATGCGTCCGAATATCACACGTCAGCTGAACGGGACATTGATTCGTG
TTCATATTGGCTTAGAAGATCCGGTTGACTTAATCGCTGATCTAGAAGCCGGGTTTGCGCGCTTAAACGCGATGTGA

Upstream 100 bases:

>100_bases
TTGAGGCATTTTGACAGGAGTTTTTGCCTATCTCCTTATTTATTTTTAACTTTTTATTAACTTATCTTTATTTCTTACTT
CAGATCAAGGATGCAACACA

Downstream 100 bases:

>100_bases
GTACACTGTGTGCCAGTAGAAAAATGAAAAAAACAGACCGCACTTGATAGCATAGGCGAGAAAGTGCGGTCTTTTTGTTT
CGTGATACGAAATTAAAAGA

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSEKQTLSTQFIHTGRRKPFLQGGVNPVIQRASSLVFDSLAHKKQATIGRAQGELFYGRRGTLTHFALQEAMAELEGGEG
CYLYPCGAAAVTQSILSFVQSGDHILMTGAAYEPTQEFCNCVLKKMQIDTTYYDPMIGEGIAELVQENTKVLFLEAPSSL
TMEVSDIPAIVKAARRVNPDIVIMIDNTWSAGVFFKALEQGIDISIQAGTKYLVGHSDVMIGTAVANKRCWAQLREHSYL
MGQMVDAESAYMTARGIRTLGIRLKQHEENALKVAHWLAAQPEVKAVYHPALESCPGHQFFKRDFSGATGLFSFELNQRL
NPQQLARFMDHFTLFSMAYSWGGFESLILHYQPEEIMAMRPNITRQLNGTLIRVHIGLEDPVDLIADLEAGFARLNAM

Sequences:

>Translated_398_residues
MSEKQTLSTQFIHTGRRKPFLQGGVNPVIQRASSLVFDSLAHKKQATIGRAQGELFYGRRGTLTHFALQEAMAELEGGEG
CYLYPCGAAAVTQSILSFVQSGDHILMTGAAYEPTQEFCNCVLKKMQIDTTYYDPMIGEGIAELVQENTKVLFLEAPSSL
TMEVSDIPAIVKAARRVNPDIVIMIDNTWSAGVFFKALEQGIDISIQAGTKYLVGHSDVMIGTAVANKRCWAQLREHSYL
MGQMVDAESAYMTARGIRTLGIRLKQHEENALKVAHWLAAQPEVKAVYHPALESCPGHQFFKRDFSGATGLFSFELNQRL
NPQQLARFMDHFTLFSMAYSWGGFESLILHYQPEEIMAMRPNITRQLNGTLIRVHIGLEDPVDLIADLEAGFARLNAM
>Mature_397_residues
SEKQTLSTQFIHTGRRKPFLQGGVNPVIQRASSLVFDSLAHKKQATIGRAQGELFYGRRGTLTHFALQEAMAELEGGEGC
YLYPCGAAAVTQSILSFVQSGDHILMTGAAYEPTQEFCNCVLKKMQIDTTYYDPMIGEGIAELVQENTKVLFLEAPSSLT
MEVSDIPAIVKAARRVNPDIVIMIDNTWSAGVFFKALEQGIDISIQAGTKYLVGHSDVMIGTAVANKRCWAQLREHSYLM
GQMVDAESAYMTARGIRTLGIRLKQHEENALKVAHWLAAQPEVKAVYHPALESCPGHQFFKRDFSGATGLFSFELNQRLN
PQQLARFMDHFTLFSMAYSWGGFESLILHYQPEEIMAMRPNITRQLNGTLIRVHIGLEDPVDLIADLEAGFARLNAM

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=345, Percent_Identity=30.4347826086957, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI299473759, Length=345, Percent_Identity=27.8260869565217, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI25453487, Length=345, Percent_Identity=28.4057971014493, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=64.5569620253165, Blast_Score=555, Evalue=1e-159,
Organism=Escherichia coli, GI1790375, Length=343, Percent_Identity=33.5276967930029, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17538055, Length=346, Percent_Identity=32.6589595375723, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=333, Percent_Identity=32.7327327327327, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71980708, Length=397, Percent_Identity=29.2191435768262, Blast_Score=167, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6321170, Length=340, Percent_Identity=41.7647058823529, Blast_Score=279, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6319307, Length=404, Percent_Identity=27.970297029703, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323333, Length=433, Percent_Identity=26.0969976905312, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=363, Percent_Identity=24.5179063360882, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321904, Length=400, Percent_Identity=26.25, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI19922554, Length=390, Percent_Identity=31.7948717948718, Blast_Score=183, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44258; Mature: 44127

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKQTLSTQFIHTGRRKPFLQGGVNPVIQRASSLVFDSLAHKKQATIGRAQGELFYGRR
CCCCHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
GTLTHFALQEAMAELEGGEGCYLYPCGAAAVTQSILSFVQSGDHILMTGAAYEPTQEFCN
CCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
CVLKKMQIDTTYYDPMIGEGIAELVQENTKVLFLEAPSSLTMEVSDIPAIVKAARRVNPD
HHHHHHHCCCHHCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHHHHHHHCCCC
IVIMIDNTWSAGVFFKALEQGIDISIQAGTKYLVGHSDVMIGTAVANKRCWAQLREHSYL
EEEEECCCCCHHHHHHHHHCCCCEEEECCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHH
MGQMVDAESAYMTARGIRTLGIRLKQHEENALKVAHWLAAQPEVKAVYHPALESCPGHQF
HHHHCCCHHHHHHHCCHHHHCEEEECCHHHHHHHHHHHCCCCCHHHHCCHHHHCCCCHHH
FKRDFSGATGLFSFELNQRLNPQQLARFMDHFTLFSMAYSWGGFESLILHYQPEEIMAMR
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCHHHHEEC
PNITRQLNGTLIRVHIGLEDPVDLIADLEAGFARLNAM
CCCCEECCCEEEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEKQTLSTQFIHTGRRKPFLQGGVNPVIQRASSLVFDSLAHKKQATIGRAQGELFYGRR
CCCHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
GTLTHFALQEAMAELEGGEGCYLYPCGAAAVTQSILSFVQSGDHILMTGAAYEPTQEFCN
CCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
CVLKKMQIDTTYYDPMIGEGIAELVQENTKVLFLEAPSSLTMEVSDIPAIVKAARRVNPD
HHHHHHHCCCHHCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHHHHHHHHHHHCCCC
IVIMIDNTWSAGVFFKALEQGIDISIQAGTKYLVGHSDVMIGTAVANKRCWAQLREHSYL
EEEEECCCCCHHHHHHHHHCCCCEEEECCCEEEECCCCEEEEHHHHHHHHHHHHHHHHHH
MGQMVDAESAYMTARGIRTLGIRLKQHEENALKVAHWLAAQPEVKAVYHPALESCPGHQF
HHHHCCCHHHHHHHCCHHHHCEEEECCHHHHHHHHHHHCCCCCHHHHCCHHHHCCCCHHH
FKRDFSGATGLFSFELNQRLNPQQLARFMDHFTLFSMAYSWGGFESLILHYQPEEIMAMR
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHEEEEECCHHHHEEC
PNITRQLNGTLIRVHIGLEDPVDLIADLEAGFARLNAM
CCCCEECCCEEEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]