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The map label for this gene is hemH

Identifier: 15602654

GI number: 15602654

Start: 933338

End: 934318

Strand: Direct

Name: hemH

Synonym: PM0789

Alternate gene names: 15602654

Gene position: 933338-934318 (Clockwise)

Preceding gene: 15602653

Following gene: 15602656

Centisome position: 41.34

GC content: 40.67

Gene sequence:

>981_bases
ATGAATAAAGCAAAAACTGGGGTTTTATTGGTGAATTTAGGTACACCAGAAAGCCCTACACCAAAGGCTATCTCTCGTTA
TTTATGGCAATTTTTAACTGATCCTCGTGTCGTCGATTTACCGCGTTATAAATGGTTTCCTTTATTAAAAGGGATTATTT
TGCCGTTACGCGCTAAACGTGTCGCCAAAAATTACGCTTCAATTTGGACTGAGCAAGGTTCTCCACTTTTAACCATTACC
CGAGAACAACAACACGCCTTACAAACCTATTTTAAACAACAAGAAAAAAATATTGTCGTTGAAGTCGCGATGACTTACGG
AGAACCCTCCATAAAATCAGCAATGCAACGCTTATCCACACAGCAGGTGGATAACCTCATCGTGTTTCCACTCTATCCAC
AATATAGTAGCTCAACCACAGGCGCGGTCTTTGATGCCTTTGCTCAAGTGCTAAAAACACAACGTGGTGTCTTACCCTTT
GATTTTATTCATTCTTATCATACCAATGAGGACTATATTGCAGCTTTAGTTACTACGATTCAGGAGCACTTCCAGCCGGA
TGAGTTTTTGTTATTCTCTTTCCATGGCATTCCTGTGCGTTATGAAAATATGGGGGATTATTACCGCGAGCATTGTAAAC
AAACCGTGTTGGCTGTCATTGACCGTTTAGGACTCACCGAGAATCAATGGGGGCTTTCCTTTCAATCTCGCTTTGGTAAA
GAAGAATGGTTACAACCTTATACAGACCAATTCCTAGCCCAAGCACCGAGCCAGAATATTCAGAAAATGGCGGTTATCTG
TCCTGGCTTTGCAGCAGATTGTTTGGAAACACTAGAGGAAATTGAGGAAGAAAATAAAGAGATCTTCCTTGCTAATGGTG
GAATCTCATATCGTTACATTCCTGCGCTCAATGCACGCCCAGAACACATTCAAATGATGGCGAATTTGATTCTGAATAAA
CTCAATCAAACAAGTAAATAA

Upstream 100 bases:

>100_bases
ATTCATTTAGGCACACGAACACAGGTTTGGCAAATTGAAATCAAAGATCAGCAAGATCAACTTTGTTGTCTTTCTCGTTT
AACGCTTTCAGTGGGGAATC

Downstream 100 bases:

>100_bases
CAAAAAAATCCCAAGTCTTTCACTTGGGATTTTCACTTTCATAGTCAGTTTAAAGCACCGTGATTAAAATTGGGCTGTCA
TGTTCTTTGGCAAATAATCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MNKAKTGVLLVNLGTPESPTPKAISRYLWQFLTDPRVVDLPRYKWFPLLKGIILPLRAKRVAKNYASIWTEQGSPLLTIT
REQQHALQTYFKQQEKNIVVEVAMTYGEPSIKSAMQRLSTQQVDNLIVFPLYPQYSSSTTGAVFDAFAQVLKTQRGVLPF
DFIHSYHTNEDYIAALVTTIQEHFQPDEFLLFSFHGIPVRYENMGDYYREHCKQTVLAVIDRLGLTENQWGLSFQSRFGK
EEWLQPYTDQFLAQAPSQNIQKMAVICPGFAADCLETLEEIEEENKEIFLANGGISYRYIPALNARPEHIQMMANLILNK
LNQTSK

Sequences:

>Translated_326_residues
MNKAKTGVLLVNLGTPESPTPKAISRYLWQFLTDPRVVDLPRYKWFPLLKGIILPLRAKRVAKNYASIWTEQGSPLLTIT
REQQHALQTYFKQQEKNIVVEVAMTYGEPSIKSAMQRLSTQQVDNLIVFPLYPQYSSSTTGAVFDAFAQVLKTQRGVLPF
DFIHSYHTNEDYIAALVTTIQEHFQPDEFLLFSFHGIPVRYENMGDYYREHCKQTVLAVIDRLGLTENQWGLSFQSRFGK
EEWLQPYTDQFLAQAPSQNIQKMAVICPGFAADCLETLEEIEEENKEIFLANGGISYRYIPALNARPEHIQMMANLILNK
LNQTSK
>Mature_326_residues
MNKAKTGVLLVNLGTPESPTPKAISRYLWQFLTDPRVVDLPRYKWFPLLKGIILPLRAKRVAKNYASIWTEQGSPLLTIT
REQQHALQTYFKQQEKNIVVEVAMTYGEPSIKSAMQRLSTQQVDNLIVFPLYPQYSSSTTGAVFDAFAQVLKTQRGVLPF
DFIHSYHTNEDYIAALVTTIQEHFQPDEFLLFSFHGIPVRYENMGDYYREHCKQTVLAVIDRLGLTENQWGLSFQSRFGK
EEWLQPYTDQFLAQAPSQNIQKMAVICPGFAADCLETLEEIEEENKEIFLANGGISYRYIPALNARPEHIQMMANLILNK
LNQTSK

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=336, Percent_Identity=25.8928571428571, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI60499021, Length=334, Percent_Identity=26.0479041916168, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786681, Length=321, Percent_Identity=51.0903426791277, Blast_Score=335, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=25.4437869822485, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17864156, Length=334, Percent_Identity=24.8502994011976, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24651774, Length=261, Percent_Identity=26.4367816091954, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_PASMU (P57874)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245726.1
- ProteinModelPortal:   P57874
- SMR:   P57874
- GeneID:   1244136
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0789
- NMPDR:   fig|272843.1.peg.789
- HOGENOM:   HBG697135
- OMA:   GLPERHL
- ProtClustDB:   PRK00035
- BioCyc:   PMUL272843:PM0789-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 37421; Mature: 37421

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAKTGVLLVNLGTPESPTPKAISRYLWQFLTDPRVVDLPRYKWFPLLKGIILPLRAKR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHH
VAKNYASIWTEQGSPLLTITREQQHALQTYFKQQEKNIVVEVAMTYGEPSIKSAMQRLST
HHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHH
QQVDNLIVFPLYPQYSSSTTGAVFDAFAQVLKTQRGVLPFDFIHSYHTNEDYIAALVTTI
HHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHH
QEHFQPDEFLLFSFHGIPVRYENMGDYYREHCKQTVLAVIDRLGLTENQWGLSFQSRFGK
HHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCH
EEWLQPYTDQFLAQAPSQNIQKMAVICPGFAADCLETLEEIEEENKEIFLANGGISYRYI
HHHCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEE
PALNARPEHIQMMANLILNKLNQTSK
CCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKAKTGVLLVNLGTPESPTPKAISRYLWQFLTDPRVVDLPRYKWFPLLKGIILPLRAKR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHH
VAKNYASIWTEQGSPLLTITREQQHALQTYFKQQEKNIVVEVAMTYGEPSIKSAMQRLST
HHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHH
QQVDNLIVFPLYPQYSSSTTGAVFDAFAQVLKTQRGVLPFDFIHSYHTNEDYIAALVTTI
HHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHH
QEHFQPDEFLLFSFHGIPVRYENMGDYYREHCKQTVLAVIDRLGLTENQWGLSFQSRFGK
HHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCH
EEWLQPYTDQFLAQAPSQNIQKMAVICPGFAADCLETLEEIEEENKEIFLANGGISYRYI
HHHCCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEE
PALNARPEHIQMMANLILNKLNQTSK
CCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100