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The map label for this gene is grxD

Identifier: 15602647

GI number: 15602647

Start: 925918

End: 926247

Strand: Reverse

Name: grxD

Synonym: PM0782

Alternate gene names: 15602647

Gene position: 926247-925918 (Counterclockwise)

Preceding gene: 15602648

Following gene: 15602638

Centisome position: 41.03

GC content: 38.48

Gene sequence:

>330_bases
ATGGAAACCTTAGATAAAATCAAAAAACAAATCAGTGAAAACCCTATTCTTATTTACATGAAAGGCTCACCAAAATTCCC
ATCATGCGGTTTCTCTGCACGTGCCGTAGAAGCCCTTATGCATTGCAAAGTGCCTTTTGGTTATGTGGATATCTTACAAC
ATCCAGATATTCGTGCTGAGTTACCAGCTTATGCAAATTGGCCAACTTTCCCACAATTATGGGTTGATGGAGAATTAGTC
GGTGGTTGTGACATTATTTTAGAAATGTTCCAACAAGGTGAGTTACAAACGCTATTAGCTGATGTTGCAGCAAAATATCC
TCAGGAATAA

Upstream 100 bases:

>100_bases
CGGTGGAAGTTGGTGAGTAGTTGATTATTTTAGTCGGGTTATTGGTTGCGCTTTTTCTGTATGCTACAATAACACCGTTT
CATTACTTTTGAGGAAAATT

Downstream 100 bases:

>100_bases
AAGTCAAAATAAAACCCGCGATAAGCGGGTTTTTGTTATTTGGTTTGTAATGCATTATTATGAAATTGATATGCAATATC
AATGGAATTGAAATGATGCA

Product: hypothetical protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin

Number of amino acids: Translated: 109; Mature: 109

Protein sequence:

>109_residues
METLDKIKKQISENPILIYMKGSPKFPSCGFSARAVEALMHCKVPFGYVDILQHPDIRAELPAYANWPTFPQLWVDGELV
GGCDIILEMFQQGELQTLLADVAAKYPQE

Sequences:

>Translated_109_residues
METLDKIKKQISENPILIYMKGSPKFPSCGFSARAVEALMHCKVPFGYVDILQHPDIRAELPAYANWPTFPQLWVDGELV
GGCDIILEMFQQGELQTLLADVAAKYPQE
>Mature_109_residues
METLDKIKKQISENPILIYMKGSPKFPSCGFSARAVEALMHCKVPFGYVDILQHPDIRAELPAYANWPTFPQLWVDGELV
GGCDIILEMFQQGELQTLLADVAAKYPQE

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain

Homologues:

Organism=Homo sapiens, GI95113651, Length=93, Percent_Identity=44.0860215053763, Blast_Score=91, Evalue=1e-19,
Organism=Homo sapiens, GI42516576, Length=95, Percent_Identity=38.9473684210526, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787943, Length=107, Percent_Identity=73.8317757009346, Blast_Score=176, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71988159, Length=80, Percent_Identity=45, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71988153, Length=80, Percent_Identity=45, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17556042, Length=111, Percent_Identity=32.4324324324324, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325198, Length=111, Percent_Identity=37.8378378378378, Blast_Score=92, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320303, Length=87, Percent_Identity=42.5287356321839, Blast_Score=90, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321022, Length=87, Percent_Identity=41.3793103448276, Blast_Score=89, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24642023, Length=93, Percent_Identity=40.8602150537634, Blast_Score=92, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19921242, Length=95, Percent_Identity=38.9473684210526, Blast_Score=89, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLRX4_PASMU (Q9CMN5)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245719.1
- HSSP:   Q9CQM9
- ProteinModelPortal:   Q9CMN5
- SMR:   Q9CMN5
- GeneID:   1244129
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0782
- NMPDR:   fig|272843.1.peg.782
- HOGENOM:   HBG728471
- OMA:   ILIELYQ
- BioCyc:   PMUL272843:PM0782-MONOMER
- GO:   GO:0005737
- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10293
- PIRSF:   PIRSF005894
- TIGRFAMs:   TIGR00365

Pfam domain/function: PF00462 Glutaredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 12255; Mature: 12255

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS51354 GLUTAREDOXIN_2

Important sites: BINDING 21-21 BINDING 58-58 BINDING 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLDKIKKQISENPILIYMKGSPKFPSCGFSARAVEALMHCKVPFGYVDILQHPDIRAE
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCC
LPAYANWPTFPQLWVDGELVGGCDIILEMFQQGELQTLLADVAAKYPQE
CCCCCCCCCCCCEEECCCEECHHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
METLDKIKKQISENPILIYMKGSPKFPSCGFSARAVEALMHCKVPFGYVDILQHPDIRAE
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCC
LPAYANWPTFPQLWVDGELVGGCDIILEMFQQGELQTLLADVAAKYPQE
CCCCCCCCCCCCEEECCCEECHHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100