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The map label for this gene is parC [H]

Identifier: 15602234

GI number: 15602234

Start: 431181

End: 433433

Strand: Reverse

Name: parC [H]

Synonym: PM0369

Alternate gene names: 15602234

Gene position: 433433-431181 (Counterclockwise)

Preceding gene: 15602235

Following gene: 15602231

Centisome position: 19.2

GC content: 43.63

Gene sequence:

>2253_bases
ATGAATATAATCAACTACGAAGGCATTGAACAAACCCCATTACGCGAGTTTACTGAAAAAGCCTATCTCAACTACTCCAT
GTACGTCATTATGGATCGCGCATTGCCTTTTATTGGCGACGGCTTAAAACCGGTACAACGTCGTATTATTTATGCCATGT
CTGAACTTGGCTTAAATGCTGCGGCAAAATATAAAAAATCGGCGCGGACTGTCGGTGATGTGCTCGGTAAATTTCACCCA
CATGGTGATTCAGCTTGTTATGAAGCCATGGTCTTGATGGCACAACCCTTTTCTTATCGTTACCCATTAGTGGATGGACA
AGGTAACTGGGGCGCACCTGATGATCCGAAATCCTTTGCTGCGATGCGTTATACTGAATCGCGGCTCGCCAAAATTGCTG
ATATTTTATTATCTGAGTTAGGGCAAGGGACAGTGGACTATCAACCGAATTTTGATGGTACATTAGAAGAACCCCAATAT
TTACCAGCTCGACTGCCACATATTTTATTGAATGGTACAACCGGTATTGCTGTGGGTATGGCGACCGATATTCCACCTCA
TAATATCAATGAGCTTGCTGAAGCCGCTGTGATGCTAATTGATAACCCAAAAGCGAGCTTGGATGATCTGTTAACTGTGG
TACAAGGTCCAGACTACCCAACAGAAGCGGAAATCATCTCATCGAAAGAGGATATTCGTAAACTCTATGAACAAGGTCGT
GGATCGGTAAGAATGCGCGCAGTGTGGAAAAAAGAAGACGGCGAAATCATTATTACTGCTCTACCACATCAAGCCTCACC
ATCAAAAGTCATTGCACAAATTGCCGAACAAATGAGTGCTAAAAAATTGCCGATGGTTGAAGATATTCGCGATGAGGCGG
ATCACGAAAACCCAATTCGGATTGTGTTGATACCCCGTTCTAACCGTGTGGATGTGGATGCTTTAATGGCACACTTATTT
GCTACCACCGATCTTGAAAAAAGTTATCGTGTCAACATGAACATGATTGGTTTAGATAATAGACCTGCGGTGAAAAATCT
GGTGCAAATTCTGACGGAATGGCTACAGTTCCGTCGTACCACTGTAACGCGTCGCTTGCAATATCGTCTCAATAAAGTAT
TAGATCGTCTGCATATTTTACAAGGTTTACTGATTGCTTATCTGAATATTGACGAAGTAATCCACGTTATTCGTCATGAA
GATGAGCCTAAAGCCGCGTTAATCGATCGTTTCGGATTAAGTGAAACACAAGCAGAAGCGATTTTGAATTTACGCTTACG
CCACTTAGCCAAATTAGAAGAAAACGAATTACAAGCGGAAAAAGATCGTCTAGAAGAAGAACGTGACAGTTTACAGCTGA
TCTTAGGGTCTGAACGCCGTTTAAATACGCTAATCAAAAAAGAAATTCAGCAAGACGCTCAAACTTATGCGAGTCCGCGT
TTGTCACCATTAGTCCAACGCGCAGAAGCCAAAGCAATCTCCGAAAGCGACATGACGCCTGCTGAGCCTGTCACCGTTAT
TCTGTCTGAAATGGGTTGGGTACGTTGTGCCAAAGGGCATGATATCGATGTGCAAAATCTCAGCTATAAAGCCGGTGATA
AATACTTATCCCATGCTTATGGTAAGAGTAATCAAGCCGCCGTATTTATCGACAGCACAGGACGAAGTTACGCTTTAGAT
CCGTTAAGTTTACCTTCTGCTCGCTCACAAGGCGAACCGCTCACAGGCAAACTCAGCTTGCCTGCAGGTGCTAGTGTTGA
GCATGTGTTAATGGAACAAGACAAGCAAGCACTCCTGATGGCATCTGATGCTGGCTATGGATTTATTTGTCAATTTGATG
ATCTGATTGCGCGGAATAAAGCCGGTAAAGCCCTGATTTCATTACCTGAGAATGCCAAAGTCTTAACCCCTCTGCGAATA
GATAATGAAAATGCCCGTTTGGTTGCCTTAACCTCGGCAGGCAGAATGTTGATTTTCCCAGTGAAAGATTTGCCTTCTTT
AGCGAAGGGGAAAGGCAATAAAATTGTGACGATTCCTGCCGCACATGCGAAGGCACGAACAGAGCTATTAGTTCGGTTAT
TTTTAATTAACGAACAAACCAGCCTCGTTTTCCATGCTGGCAAACGGAAAATCACGTTAAAGCCTGAAGATTGGCAGAAA
TTCAGTGCAGAGCGTGGACGTAAAGGCACGCAATTACCACGTGGTTTGCACAGTCATGCAGATATTGAATTGCTCACACC
AGACAGTGAGTAG

Upstream 100 bases:

>100_bases
GATTTGATAAAGATATAGAACAATAAAAGTGCGGTGCTTTTTTAAAAAATTTCTCCGCTATTAGTAAAATCTGATTTAAA
AGTAAAAATAAAACATCATT

Downstream 100 bases:

>100_bases
AAAAAAGAGGGATGGTCACATCCCTCTTAATTATTGTAGGCGAGATAAACGCTCTTGGGCTAATGCTGCTAATTCATTTT
GCTGAACGGACACCTTCTGA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MNIINYEGIEQTPLREFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLAKIADILLSELGQGTVDYQPNFDGTLEEPQY
LPARLPHILLNGTTGIAVGMATDIPPHNINELAEAAVMLIDNPKASLDDLLTVVQGPDYPTEAEIISSKEDIRKLYEQGR
GSVRMRAVWKKEDGEIIITALPHQASPSKVIAQIAEQMSAKKLPMVEDIRDEADHENPIRIVLIPRSNRVDVDALMAHLF
ATTDLEKSYRVNMNMIGLDNRPAVKNLVQILTEWLQFRRTTVTRRLQYRLNKVLDRLHILQGLLIAYLNIDEVIHVIRHE
DEPKAALIDRFGLSETQAEAILNLRLRHLAKLEENELQAEKDRLEEERDSLQLILGSERRLNTLIKKEIQQDAQTYASPR
LSPLVQRAEAKAISESDMTPAEPVTVILSEMGWVRCAKGHDIDVQNLSYKAGDKYLSHAYGKSNQAAVFIDSTGRSYALD
PLSLPSARSQGEPLTGKLSLPAGASVEHVLMEQDKQALLMASDAGYGFICQFDDLIARNKAGKALISLPENAKVLTPLRI
DNENARLVALTSAGRMLIFPVKDLPSLAKGKGNKIVTIPAAHAKARTELLVRLFLINEQTSLVFHAGKRKITLKPEDWQK
FSAERGRKGTQLPRGLHSHADIELLTPDSE

Sequences:

>Translated_750_residues
MNIINYEGIEQTPLREFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLAKIADILLSELGQGTVDYQPNFDGTLEEPQY
LPARLPHILLNGTTGIAVGMATDIPPHNINELAEAAVMLIDNPKASLDDLLTVVQGPDYPTEAEIISSKEDIRKLYEQGR
GSVRMRAVWKKEDGEIIITALPHQASPSKVIAQIAEQMSAKKLPMVEDIRDEADHENPIRIVLIPRSNRVDVDALMAHLF
ATTDLEKSYRVNMNMIGLDNRPAVKNLVQILTEWLQFRRTTVTRRLQYRLNKVLDRLHILQGLLIAYLNIDEVIHVIRHE
DEPKAALIDRFGLSETQAEAILNLRLRHLAKLEENELQAEKDRLEEERDSLQLILGSERRLNTLIKKEIQQDAQTYASPR
LSPLVQRAEAKAISESDMTPAEPVTVILSEMGWVRCAKGHDIDVQNLSYKAGDKYLSHAYGKSNQAAVFIDSTGRSYALD
PLSLPSARSQGEPLTGKLSLPAGASVEHVLMEQDKQALLMASDAGYGFICQFDDLIARNKAGKALISLPENAKVLTPLRI
DNENARLVALTSAGRMLIFPVKDLPSLAKGKGNKIVTIPAAHAKARTELLVRLFLINEQTSLVFHAGKRKITLKPEDWQK
FSAERGRKGTQLPRGLHSHADIELLTPDSE
>Mature_750_residues
MNIINYEGIEQTPLREFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNAAAKYKKSARTVGDVLGKFHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLAKIADILLSELGQGTVDYQPNFDGTLEEPQY
LPARLPHILLNGTTGIAVGMATDIPPHNINELAEAAVMLIDNPKASLDDLLTVVQGPDYPTEAEIISSKEDIRKLYEQGR
GSVRMRAVWKKEDGEIIITALPHQASPSKVIAQIAEQMSAKKLPMVEDIRDEADHENPIRIVLIPRSNRVDVDALMAHLF
ATTDLEKSYRVNMNMIGLDNRPAVKNLVQILTEWLQFRRTTVTRRLQYRLNKVLDRLHILQGLLIAYLNIDEVIHVIRHE
DEPKAALIDRFGLSETQAEAILNLRLRHLAKLEENELQAEKDRLEEERDSLQLILGSERRLNTLIKKEIQQDAQTYASPR
LSPLVQRAEAKAISESDMTPAEPVTVILSEMGWVRCAKGHDIDVQNLSYKAGDKYLSHAYGKSNQAAVFIDSTGRSYALD
PLSLPSARSQGEPLTGKLSLPAGASVEHVLMEQDKQALLMASDAGYGFICQFDDLIARNKAGKALISLPENAKVLTPLRI
DNENARLVALTSAGRMLIFPVKDLPSLAKGKGNKIVTIPAAHAKARTELLVRLFLINEQTSLVFHAGKRKITLKPEDWQK
FSAERGRKGTQLPRGLHSHADIELLTPDSE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=738, Percent_Identity=71.2737127371274, Blast_Score=1122, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=748, Percent_Identity=34.6256684491979, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI212645845, Length=223, Percent_Identity=26.457399103139, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=383, Percent_Identity=24.2819843342037, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83699; Mature: 83699

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIINYEGIEQTPLREFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNA
CCCCCCCCCCCCHHHHHHHHHHHCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCH
AAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLAKIADILLSELGQGTVDYQPNFDGTLEEPQYLPARLPHILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEEEECCCCEEEEE
ATDIPPHNINELAEAAVMLIDNPKASLDDLLTVVQGPDYPTEAEIISSKEDIRKLYEQGR
ECCCCCCCHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHCCC
GSVRMRAVWKKEDGEIIITALPHQASPSKVIAQIAEQMSAKKLPMVEDIRDEADHENPIR
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEE
IVLIPRSNRVDVDALMAHLFATTDLEKSYRVNMNMIGLDNRPAVKNLVQILTEWLQFRRT
EEEECCCCCCCHHHHHHHHHHHCCCCCCEEECEEEEECCCCHHHHHHHHHHHHHHHHHHH
TVTRRLQYRLNKVLDRLHILQGLLIAYLNIDEVIHVIRHEDEPKAALIDRFGLSETQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHH
ILNLRLRHLAKLEENELQAEKDRLEEERDSLQLILGSERRLNTLIKKEIQQDAQTYASPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
LSPLVQRAEAKAISESDMTPAEPVTVILSEMGWVRCAKGHDIDVQNLSYKAGDKYLSHAY
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHC
GKSNQAAVFIDSTGRSYALDPLSLPSARSQGEPLTGKLSLPAGASVEHVLMEQDKQALLM
CCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCEEEE
ASDAGYGFICQFDDLIARNKAGKALISLPENAKVLTPLRIDNENARLVALTSAGRMLIFP
ECCCCCEEEEEHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCEEEEEECCCCEEEEE
VKDLPSLAKGKGNKIVTIPAAHAKARTELLVRLFLINEQTSLVFHAGKRKITLKPEDWQK
CCCCCHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCHHHHH
FSAERGRKGTQLPRGLHSHADIELLTPDSE
HHHHCCCCCCCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure
MNIINYEGIEQTPLREFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIIYAMSELGLNA
CCCCCCCCCCCCHHHHHHHHHHHCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCH
AAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLAKIADILLSELGQGTVDYQPNFDGTLEEPQYLPARLPHILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCEEEEECCCCEEEEE
ATDIPPHNINELAEAAVMLIDNPKASLDDLLTVVQGPDYPTEAEIISSKEDIRKLYEQGR
ECCCCCCCHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHHCCC
GSVRMRAVWKKEDGEIIITALPHQASPSKVIAQIAEQMSAKKLPMVEDIRDEADHENPIR
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEE
IVLIPRSNRVDVDALMAHLFATTDLEKSYRVNMNMIGLDNRPAVKNLVQILTEWLQFRRT
EEEECCCCCCCHHHHHHHHHHHCCCCCCEEECEEEEECCCCHHHHHHHHHHHHHHHHHHH
TVTRRLQYRLNKVLDRLHILQGLLIAYLNIDEVIHVIRHEDEPKAALIDRFGLSETQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHH
ILNLRLRHLAKLEENELQAEKDRLEEERDSLQLILGSERRLNTLIKKEIQQDAQTYASPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHCCCC
LSPLVQRAEAKAISESDMTPAEPVTVILSEMGWVRCAKGHDIDVQNLSYKAGDKYLSHAY
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHC
GKSNQAAVFIDSTGRSYALDPLSLPSARSQGEPLTGKLSLPAGASVEHVLMEQDKQALLM
CCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCEEEE
ASDAGYGFICQFDDLIARNKAGKALISLPENAKVLTPLRIDNENARLVALTSAGRMLIFP
ECCCCCEEEEEHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCCEEEEEECCCCEEEEE
VKDLPSLAKGKGNKIVTIPAAHAKARTELLVRLFLINEQTSLVFHAGKRKITLKPEDWQK
CCCCCHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCHHHHH
FSAERGRKGTQLPRGLHSHADIELLTPDSE
HHHHCCCCCCCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]