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The map label for this gene is dppA [H]

Identifier: 15602101

GI number: 15602101

Start: 265895

End: 267493

Strand: Direct

Name: dppA [H]

Synonym: PM0236

Alternate gene names: 15602101

Gene position: 265895-267493 (Clockwise)

Preceding gene: 15602100

Following gene: 15602102

Centisome position: 11.78

GC content: 41.34

Gene sequence:

>1599_bases
ATGAAAAAATTAACAAAACTCTCTCTTGCCGTTTTAGCGATGACGTCCACAGCTGCGTTTGCGGCTGCACCGAAAACCTT
TGTGTATTGTTCGGAAGCCTCCCCGTCTTATTTAAGCCCTGTGTTAGGCACCGATGGGGCAACTATTGATGCCTCAGGTC
AAGCAATGTTTAATGGGCTAACTACGTTTGAACGTGGTACCACTAATGTCATTCCTGCCTTAGCTGAAAAATGGGATGTA
TCTGAAGATGGGAAAACCTATGTCTTCCATTTACGTAAAGGTGTGAAATTCCATAGCAATAAAGATTTTAAACCAACACG
TGATTTTAATGCCGATGATGTGGTGTTCTCTTTCAATCGTCAATTAGACCCAAATCACCCTTATCACAAAGTGTCAGGTG
GTAGCTATGAATATTTTATCGGTATGGATATGCAAAATATCATTGATAAGGTTGAAAAAGTCGATGACTATACCGTCAAA
ATCAGCTTAAAAGTGCCAAATGCGCCATTTTTAGCGAACTTAGCGATGGATTTTGCTTCGATTTATTCAGCACAGTATGC
CGATGCCATGGCAAAAGCCAAAACACCAGAAAAATTGGATAGTGCACCAATTGGTACAGGACCATTTGAATTTGTTTCTT
ACCAAAAAGACTCTGCTGTACGCTATAAAGCCTTTGAAAACTATTGGCAAGGCAAAGCAAAAATTGATCGCTTAGTGTTT
TCGATCACGCCAGATGCTTCAGTGCGTTATGCCAAATTACAAAAGGGTGAATGCCATGCAGCGCCTTATCCAAATCCAGC
GGATATTGCTAAATTAAAAGCAGATAGCAATATCACTTTGTTAACTAAACCGGGATTAAATGTGGGTTATTTAAACTTTA
ATGTACAAAAAGCCCCGTTTGATAATGTGAAAGTGCGTCAAGCATTGAACTACGCAGTCAACAAAGACGCGATCATTGAA
TCAGTGTATCAAGGTGCGGGTCAAGTTGCGAAAAACCCAATTCCACCAACAATGTGGTCATATAATGATGAAGTGAAAGA
TTACGCCTATGATCCAGAAAAAGCTAAAGCCTTATTAAAAGAAGCCGGGTTTGAAAATGGCTTTGAAACGGATTTATGGG
CAATGCCTGTTTCACGTCCCTATAACCCAAATGCCCGTCGTATGGCGGAATTGGTGCAAGCTGACTGGGAAAAAGTCGGT
GTGAAAGCAAAAATTGTGAGCTATGAATGGGGAGAATACCTCAAACGTATGCGTGCCGGCGATCACCAAACTGGTATGAT
GGGGTGGACGGGTGACAATGGTGATCCAGATAACTTCTTGAATACCTTATTAAGTTGTGCGGCTGTTGAGTCTGGGTCTA
ACTATGCGAATTTCTGTCACAAAGAATTTAACGATTTAGTGACAAAAGCTGCCCAAGTCACTGATCCAGCAGAGCGTACT
GCACTTTATCAACAAGCTCAGTTGGTCTTCAAAGAACAAGCACCTTGGATTACGATTGCACACTCCACAACCTATTTCCC
AGTGCGTAAAGAAGTTAAAGGCTATGTCATCGATCCATTTGGTTTACATAACTTCTACGCGGTTGAGCTAGAGAAGTAA

Upstream 100 bases:

>100_bases
AAGGATTGCTATTTTATTTAAAACTTGACATATTCATAGGTGCTTATGCAAACAAAAGGTGCATGTTTTGCACTCAACTA
ACAACATCCCGGAGTGAAAA

Downstream 100 bases:

>100_bases
TGTCGCCTTAAGTGCGGTCAAGTTTTTTCGCATTTCTTAAGAATAGGATAGGACGAGCAGAAAGGCTTGTGCTATCCTAC
TTTAGATCTTATTTGCTATC

Product: hypothetical protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MKKLTKLSLAVLAMTSTAAFAAAPKTFVYCSEASPSYLSPVLGTDGATIDASGQAMFNGLTTFERGTTNVIPALAEKWDV
SEDGKTYVFHLRKGVKFHSNKDFKPTRDFNADDVVFSFNRQLDPNHPYHKVSGGSYEYFIGMDMQNIIDKVEKVDDYTVK
ISLKVPNAPFLANLAMDFASIYSAQYADAMAKAKTPEKLDSAPIGTGPFEFVSYQKDSAVRYKAFENYWQGKAKIDRLVF
SITPDASVRYAKLQKGECHAAPYPNPADIAKLKADSNITLLTKPGLNVGYLNFNVQKAPFDNVKVRQALNYAVNKDAIIE
SVYQGAGQVAKNPIPPTMWSYNDEVKDYAYDPEKAKALLKEAGFENGFETDLWAMPVSRPYNPNARRMAELVQADWEKVG
VKAKIVSYEWGEYLKRMRAGDHQTGMMGWTGDNGDPDNFLNTLLSCAAVESGSNYANFCHKEFNDLVTKAAQVTDPAERT
ALYQQAQLVFKEQAPWITIAHSTTYFPVRKEVKGYVIDPFGLHNFYAVELEK

Sequences:

>Translated_532_residues
MKKLTKLSLAVLAMTSTAAFAAAPKTFVYCSEASPSYLSPVLGTDGATIDASGQAMFNGLTTFERGTTNVIPALAEKWDV
SEDGKTYVFHLRKGVKFHSNKDFKPTRDFNADDVVFSFNRQLDPNHPYHKVSGGSYEYFIGMDMQNIIDKVEKVDDYTVK
ISLKVPNAPFLANLAMDFASIYSAQYADAMAKAKTPEKLDSAPIGTGPFEFVSYQKDSAVRYKAFENYWQGKAKIDRLVF
SITPDASVRYAKLQKGECHAAPYPNPADIAKLKADSNITLLTKPGLNVGYLNFNVQKAPFDNVKVRQALNYAVNKDAIIE
SVYQGAGQVAKNPIPPTMWSYNDEVKDYAYDPEKAKALLKEAGFENGFETDLWAMPVSRPYNPNARRMAELVQADWEKVG
VKAKIVSYEWGEYLKRMRAGDHQTGMMGWTGDNGDPDNFLNTLLSCAAVESGSNYANFCHKEFNDLVTKAAQVTDPAERT
ALYQQAQLVFKEQAPWITIAHSTTYFPVRKEVKGYVIDPFGLHNFYAVELEK
>Mature_532_residues
MKKLTKLSLAVLAMTSTAAFAAAPKTFVYCSEASPSYLSPVLGTDGATIDASGQAMFNGLTTFERGTTNVIPALAEKWDV
SEDGKTYVFHLRKGVKFHSNKDFKPTRDFNADDVVFSFNRQLDPNHPYHKVSGGSYEYFIGMDMQNIIDKVEKVDDYTVK
ISLKVPNAPFLANLAMDFASIYSAQYADAMAKAKTPEKLDSAPIGTGPFEFVSYQKDSAVRYKAFENYWQGKAKIDRLVF
SITPDASVRYAKLQKGECHAAPYPNPADIAKLKADSNITLLTKPGLNVGYLNFNVQKAPFDNVKVRQALNYAVNKDAIIE
SVYQGAGQVAKNPIPPTMWSYNDEVKDYAYDPEKAKALLKEAGFENGFETDLWAMPVSRPYNPNARRMAELVQADWEKVG
VKAKIVSYEWGEYLKRMRAGDHQTGMMGWTGDNGDPDNFLNTLLSCAAVESGSNYANFCHKEFNDLVTKAAQVTDPAERT
ALYQQAQLVFKEQAPWITIAHSTTYFPVRKEVKGYVIDPFGLHNFYAVELEK

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=528, Percent_Identity=67.6136363636364, Blast_Score=749, Evalue=0.0,
Organism=Escherichia coli, GI1787551, Length=535, Percent_Identity=35.1401869158879, Blast_Score=351, Evalue=7e-98,
Organism=Escherichia coli, GI1787052, Length=537, Percent_Identity=31.098696461825, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1787762, Length=520, Percent_Identity=27.8846153846154, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1789397, Length=534, Percent_Identity=28.2771535580524, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1789887, Length=538, Percent_Identity=28.2527881040892, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787495, Length=484, Percent_Identity=26.4462809917355, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI87081878, Length=539, Percent_Identity=24.6753246753247, Blast_Score=102, Evalue=6e-23,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 59299; Mature: 59299

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTKLSLAVLAMTSTAAFAAAPKTFVYCSEASPSYLSPVLGTDGATIDASGQAMFNGL
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCHHHCCCCCEEECCCCHHHHCH
TTFERGTTNVIPALAEKWDVSEDGKTYVFHLRKGVKFHSNKDFKPTRDFNADDVVFSFNR
HHHCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCEEEEECC
QLDPNHPYHKVSGGSYEYFIGMDMQNIIDKVEKVDDYTVKISLKVPNAPFLANLAMDFAS
CCCCCCCCEECCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHH
IYSAQYADAMAKAKTPEKLDSAPIGTGPFEFVSYQKDSAVRYKAFENYWQGKAKIDRLVF
HHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHEECCCCCHHHHHHHHHHCCHHEEEEEEE
SITPDASVRYAKLQKGECHAAPYPNPADIAKLKADSNITLLTKPGLNVGYLNFNVQKAPF
EECCCCCEEEEEECCCCCCCCCCCCHHHHHEEECCCCEEEEECCCCEEEEEEEEEECCCC
DNVKVRQALNYAVNKDAIIESVYQGAGQVAKNPIPPTMWSYNDEVKDYAYDPEKAKALLK
CCHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHH
EAGFENGFETDLWAMPVSRPYNPNARRMAELVQADWEKVGVKAKIVSYEWGEYLKRMRAG
HCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHCC
DHQTGMMGWTGDNGDPDNFLNTLLSCAAVESGSNYANFCHKEFNDLVTKAAQVTDPAERT
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
ALYQQAQLVFKEQAPWITIAHSTTYFPVRKEVKGYVIDPFGLHNFYAVELEK
HHHHHHHHHHHCCCCEEEEECCCEECCCHHCCCCEEECCCCCCCEEEEEECC
>Mature Secondary Structure
MKKLTKLSLAVLAMTSTAAFAAAPKTFVYCSEASPSYLSPVLGTDGATIDASGQAMFNGL
CCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCHHHCCCCCEEECCCCHHHHCH
TTFERGTTNVIPALAEKWDVSEDGKTYVFHLRKGVKFHSNKDFKPTRDFNADDVVFSFNR
HHHCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCEEEEECC
QLDPNHPYHKVSGGSYEYFIGMDMQNIIDKVEKVDDYTVKISLKVPNAPFLANLAMDFAS
CCCCCCCCEECCCCCEEEEECCCHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHH
IYSAQYADAMAKAKTPEKLDSAPIGTGPFEFVSYQKDSAVRYKAFENYWQGKAKIDRLVF
HHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHEECCCCCHHHHHHHHHHCCHHEEEEEEE
SITPDASVRYAKLQKGECHAAPYPNPADIAKLKADSNITLLTKPGLNVGYLNFNVQKAPF
EECCCCCEEEEEECCCCCCCCCCCCHHHHHEEECCCCEEEEECCCCEEEEEEEEEECCCC
DNVKVRQALNYAVNKDAIIESVYQGAGQVAKNPIPPTMWSYNDEVKDYAYDPEKAKALLK
CCHHHHHHHHHHCCHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHH
EAGFENGFETDLWAMPVSRPYNPNARRMAELVQADWEKVGVKAKIVSYEWGEYLKRMRAG
HCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHCC
DHQTGMMGWTGDNGDPDNFLNTLLSCAAVESGSNYANFCHKEFNDLVTKAAQVTDPAERT
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
ALYQQAQLVFKEQAPWITIAHSTTYFPVRKEVKGYVIDPFGLHNFYAVELEK
HHHHHHHHHHHCCCCEEEEECCCEECCCHHCCCCEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]