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The map label for this gene is thrC [H]

Identifier: 15601980

GI number: 15601980

Start: 140879

End: 142153

Strand: Direct

Name: thrC [H]

Synonym: PM0115

Alternate gene names: 15601980

Gene position: 140879-142153 (Clockwise)

Preceding gene: 15601979

Following gene: 15601981

Centisome position: 6.24

GC content: 42.98

Gene sequence:

>1275_bases
ATGAATTTATACAACATTAAACATCCAGAAGAACAAGTCAATTTTGCGCAAGCGGTACGTCAAGGATTAGGCAAAAACCA
AGGGTTATTTTTTCCAGAAACCCTACCGCACTTTGAGGATATGGATGCGCTGTTAGCGTTACCATTGGTGGAGCGTAGCC
AGAAGATTTTATCTGCGTTAATTGGTGAGGAAATTTCGCCAACCCAGTTAGCAAAAATGGTAGAAAATGCCTTTACTTTC
CCAGCACCTGTAGCAAAAGTGGAAGAGGGGGTTTATGCATTGGAGTTATTTCATGGTCCAACCTTAGCCTTCAAAGACTT
TGGTGGTCGTTTTATGGCGCAAGCCTTAGCTACAGTACGTGGTGAGGGCAAAATTACGATTTTAACGGCAACGTCAGGGG
ATACTGGAGCGGCGGTTGCCCACGCTTTTTATGGTTTAGAAAACATTGATGTGGTGATTTTATATCCACAAGGCAAAATC
AGCCCGCTACAAGAAAAGTTATTCTGTACGCTTGGTGGCAATATTCGTACGATTGCAATCAACGGGGATTTTGATGATTG
TCAGGCATTAGTGAAACAAGCGTTTGATGATGCAGAGTTGCGTCAAGCGATTGGCTTAAACTCAGCAAATTCGATCAATA
TCAGCCGTTTATTAGCGCAGGTTTGTTATTACTTTGAGGCGGTTGCGCAATTACCAAAAGCGGCACGCGATAATCTTGTG
GTATCGGTACCAAGTGGTAACTTTGGTAACCTGACCGCAGGCTTAATTGCCAAGTCTTTAGGCTTGCCAATTAAACGTTT
TGTAGCGTCAACCAATGTGAATGATACCGTACCGCGTTATTTACGCAGTGGCAATTGGCAACCGCATGACACGGTGGCGA
CGTTATCCAATGCAATGGATGTGAGTCGTCCAAATAACTGGCCACGGGTTGAAGAGTTATTTAAACGCAATGGTTGGGCG
CTATCAGATTTGCATTCTGATGCCGTAAATGACAATGAAACGGAACAAACTTTAAAAGATATGTATGCCAAAGGGTACTT
GTGTGAACCACATGGTGCGGTGGCTTATCGTGTGTTAAAACAAGATTTACAGCCAGGTGAAACCGGCTTATTCCTCTGTA
CGGCTCATCCTGCGAAATTTAAAGAAAGTGTTGAACGTATTTTAGCGCTTGAATTACCTTTACCCGATGCATTAGCAAAA
CACGCGGCTTTACCGTTGCTTTCGGATATCATGGAAAATGATTTTGCTAAATTACGTGCGTATTTGTTAGCTTAA

Upstream 100 bases:

>100_bases
GAAAACCATTATTTACAAAACAATGAAGGGTTTGTGCATATTTGTAAAGTTGATAATCAAGGTGCGAGAGCGCTCGATTA
ATTGAATAACGGAAAAGCAT

Downstream 100 bases:

>100_bases
CGTTCTTCGCCCTCTCTGATTTAGAGAGGGCATAGCATATCCAACATCAGATGATGCATCATTTATTTCACGCCAGTACG
AGTGGGCTTCGTAGCACAAG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MNLYNIKHPEEQVNFAQAVRQGLGKNQGLFFPETLPHFEDMDALLALPLVERSQKILSALIGEEISPTQLAKMVENAFTF
PAPVAKVEEGVYALELFHGPTLAFKDFGGRFMAQALATVRGEGKITILTATSGDTGAAVAHAFYGLENIDVVILYPQGKI
SPLQEKLFCTLGGNIRTIAINGDFDDCQALVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAARDNLV
VSVPSGNFGNLTAGLIAKSLGLPIKRFVASTNVNDTVPRYLRSGNWQPHDTVATLSNAMDVSRPNNWPRVEELFKRNGWA
LSDLHSDAVNDNETEQTLKDMYAKGYLCEPHGAVAYRVLKQDLQPGETGLFLCTAHPAKFKESVERILALELPLPDALAK
HAALPLLSDIMENDFAKLRAYLLA

Sequences:

>Translated_424_residues
MNLYNIKHPEEQVNFAQAVRQGLGKNQGLFFPETLPHFEDMDALLALPLVERSQKILSALIGEEISPTQLAKMVENAFTF
PAPVAKVEEGVYALELFHGPTLAFKDFGGRFMAQALATVRGEGKITILTATSGDTGAAVAHAFYGLENIDVVILYPQGKI
SPLQEKLFCTLGGNIRTIAINGDFDDCQALVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAARDNLV
VSVPSGNFGNLTAGLIAKSLGLPIKRFVASTNVNDTVPRYLRSGNWQPHDTVATLSNAMDVSRPNNWPRVEELFKRNGWA
LSDLHSDAVNDNETEQTLKDMYAKGYLCEPHGAVAYRVLKQDLQPGETGLFLCTAHPAKFKESVERILALELPLPDALAK
HAALPLLSDIMENDFAKLRAYLLA
>Mature_424_residues
MNLYNIKHPEEQVNFAQAVRQGLGKNQGLFFPETLPHFEDMDALLALPLVERSQKILSALIGEEISPTQLAKMVENAFTF
PAPVAKVEEGVYALELFHGPTLAFKDFGGRFMAQALATVRGEGKITILTATSGDTGAAVAHAFYGLENIDVVILYPQGKI
SPLQEKLFCTLGGNIRTIAINGDFDDCQALVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAARDNLV
VSVPSGNFGNLTAGLIAKSLGLPIKRFVASTNVNDTVPRYLRSGNWQPHDTVATLSNAMDVSRPNNWPRVEELFKRNGWA
LSDLHSDAVNDNETEQTLKDMYAKGYLCEPHGAVAYRVLKQDLQPGETGLFLCTAHPAKFKESVERILALELPLPDALAK
HAALPLLSDIMENDFAKLRAYLLA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=421, Percent_Identity=31.353919239905, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI153792148, Length=433, Percent_Identity=29.3302540415704, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1786185, Length=425, Percent_Identity=69.4117647058823, Blast_Score=574, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319901, Length=446, Percent_Identity=33.6322869955157, Blast_Score=222, Evalue=1e-58,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46411; Mature: 46411

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLYNIKHPEEQVNFAQAVRQGLGKNQGLFFPETLPHFEDMDALLALPLVERSQKILSAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IGEEISPTQLAKMVENAFTFPAPVAKVEEGVYALELFHGPTLAFKDFGGRFMAQALATVR
HCCCCCHHHHHHHHHHHCCCCCCHHHHHCCEEEEEEECCCCEEHHHCCHHHHHHHHHHHC
GEGKITILTATSGDTGAAVAHAFYGLENIDVVILYPQGKISPLQEKLFCTLGGNIRTIAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHEEEECCCEEEEEE
NGDFDDCQALVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAARDNLV
ECCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
VSVPSGNFGNLTAGLIAKSLGLPIKRFVASTNVNDTVPRYLRSGNWQPHDTVATLSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
VSRPNNWPRVEELFKRNGWALSDLHSDAVNDNETEQTLKDMYAKGYLCEPHGAVAYRVLK
CCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCEECCCHHHHHHHHH
QDLQPGETGLFLCTAHPAKFKESVERILALELPLPDALAKHAALPLLSDIMENDFAKLRA
HHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLLA
HHCC
>Mature Secondary Structure
MNLYNIKHPEEQVNFAQAVRQGLGKNQGLFFPETLPHFEDMDALLALPLVERSQKILSAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IGEEISPTQLAKMVENAFTFPAPVAKVEEGVYALELFHGPTLAFKDFGGRFMAQALATVR
HCCCCCHHHHHHHHHHHCCCCCCHHHHHCCEEEEEEECCCCEEHHHCCHHHHHHHHHHHC
GEGKITILTATSGDTGAAVAHAFYGLENIDVVILYPQGKISPLQEKLFCTLGGNIRTIAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHEEEECCCEEEEEE
NGDFDDCQALVKQAFDDAELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKAARDNLV
ECCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEE
VSVPSGNFGNLTAGLIAKSLGLPIKRFVASTNVNDTVPRYLRSGNWQPHDTVATLSNAMD
EECCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
VSRPNNWPRVEELFKRNGWALSDLHSDAVNDNETEQTLKDMYAKGYLCEPHGAVAYRVLK
CCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCEECCCHHHHHHHHH
QDLQPGETGLFLCTAHPAKFKESVERILALELPLPDALAKHAALPLLSDIMENDFAKLRA
HHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
YLLA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]