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The map label for this gene is fadR

Identifier: 15601913

GI number: 15601913

Start: 52112

End: 52837

Strand: Direct

Name: fadR

Synonym: PM0048

Alternate gene names: 15601913

Gene position: 52112-52837 (Clockwise)

Preceding gene: 15601910

Following gene: 15601918

Centisome position: 2.31

GC content: 39.94

Gene sequence:

>726_bases
ATGAATAATGATCAACCTCTTTTAAAAGCACAGAGTCCGGCTGGTTTAGCGGAAGAATATATTGTCAGAAGTATCTGGAA
TAATCATTTCCCACCAGGCTCCGATTTGCCGGCTGAACGTGAGTTGGCAGAGAAAATTGGGGTGACGCGTACCACGTTAC
GTGAAGTGCTACAACGCCTGGCGCGTGACGGTTGGTTGAATATTCAACATGGGAAACCAACCAAAGTGAATAATATTTGG
GAAACTTCGGGCTTGAATATTTTAGAGGTATTAGTACGTTTAGATAGCACCAAGTTACCTAGTTTCATTTCTAACATCCT
GTCCGCGCGAACCAATATTTCGGCAATCTATATTCAAAAAGCCTTCAAAGTAGAACCACAGAAATCACTCGAAGCGTTTA
AGGATCTTGATACTCTAGCAGATACAGCAGAAGCTTATACTAATTTTGATTATGATCTTTTCCGTAAATTAGCATTTGCA
TCTGATAATCCTGTGTATGGTTTGATTTTAAATAGTTTGAAAGGGTTATATACACGTGTAGGGTTGTTTTATTTTGCCAA
TCCATCGGCGCGTGAGTTAGCGAAACGCTTTTATCTTTCGCTAAAGACGTTGTGTCAAACACAGCAAGTGAACGATGTCA
AAGAGTGTATCCGTCAATATGGTAAAGACAGTGGGGTGATTTGGGCAAATATGCAGGCATATTTACCGGCTAATTTTAAT
GAATAG

Upstream 100 bases:

>100_bases
ATTGGAATCATTGTAATATATACTGCATTACACGATAATACTTAAAATAACTATTTGTTATCTGTATCACATTTTAAATT
TAATCGACTAGAAGAAACGT

Downstream 100 bases:

>100_bases
TCCTTTTTAAACCAGATAACACATCTTGCGAAATCTGCACTCGTATTCAGTACGGTGCAGATTTTTTATTACGTTACAAT
AAAAAAGCGGGCTAGATGTC

Product: fatty acid metabolism regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MNNDQPLLKAQSPAGLAEEYIVRSIWNNHFPPGSDLPAERELAEKIGVTRTTLREVLQRLARDGWLNIQHGKPTKVNNIW
ETSGLNILEVLVRLDSTKLPSFISNILSARTNISAIYIQKAFKVEPQKSLEAFKDLDTLADTAEAYTNFDYDLFRKLAFA
SDNPVYGLILNSLKGLYTRVGLFYFANPSARELAKRFYLSLKTLCQTQQVNDVKECIRQYGKDSGVIWANMQAYLPANFN
E

Sequences:

>Translated_241_residues
MNNDQPLLKAQSPAGLAEEYIVRSIWNNHFPPGSDLPAERELAEKIGVTRTTLREVLQRLARDGWLNIQHGKPTKVNNIW
ETSGLNILEVLVRLDSTKLPSFISNILSARTNISAIYIQKAFKVEPQKSLEAFKDLDTLADTAEAYTNFDYDLFRKLAFA
SDNPVYGLILNSLKGLYTRVGLFYFANPSARELAKRFYLSLKTLCQTQQVNDVKECIRQYGKDSGVIWANMQAYLPANFN
E
>Mature_241_residues
MNNDQPLLKAQSPAGLAEEYIVRSIWNNHFPPGSDLPAERELAEKIGVTRTTLREVLQRLARDGWLNIQHGKPTKVNNIW
ETSGLNILEVLVRLDSTKLPSFISNILSARTNISAIYIQKAFKVEPQKSLEAFKDLDTLADTAEAYTNFDYDLFRKLAFA
SDNPVYGLILNSLKGLYTRVGLFYFANPSARELAKRFYLSLKTLCQTQQVNDVKECIRQYGKDSGVIWANMQAYLPANFN
E

Specific function: Multifunctional regulator of fatty acid metabolism

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787436, Length=233, Percent_Identity=63.0901287553648, Blast_Score=314, Evalue=4e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FADR_PASMU (Q9CPJ0)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_244985.1
- ProteinModelPortal:   Q9CPJ0
- SMR:   Q9CPJ0
- GeneID:   1243395
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0048
- NMPDR:   fig|272843.1.peg.48
- HOGENOM:   HBG296777
- OMA:   IVRSIWE
- ProtClustDB:   PRK04984
- BioCyc:   PMUL272843:PM0048-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00696
- InterPro:   IPR014178
- InterPro:   IPR008920
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00345
- TIGRFAMs:   TIGR02812

Pfam domain/function: PF07840 FadR_C; PF00392 GntR; SSF48008 FadR_C

EC number: NA

Molecular weight: Translated: 27339; Mature: 27339

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDQPLLKAQSPAGLAEEYIVRSIWNNHFPPGSDLPAERELAEKIGVTRTTLREVLQRL
CCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
ARDGWLNIQHGKPTKVNNIWETSGLNILEVLVRLDSTKLPSFISNILSARTNISAIYIQK
HHCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHEEEHH
AFKVEPQKSLEAFKDLDTLADTAEAYTNFDYDLFRKLAFASDNPVYGLILNSLKGLYTRV
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GLFYFANPSARELAKRFYLSLKTLCQTQQVNDVKECIRQYGKDSGVIWANMQAYLPANFN
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEECCCCCC
E
C
>Mature Secondary Structure
MNNDQPLLKAQSPAGLAEEYIVRSIWNNHFPPGSDLPAERELAEKIGVTRTTLREVLQRL
CCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
ARDGWLNIQHGKPTKVNNIWETSGLNILEVLVRLDSTKLPSFISNILSARTNISAIYIQK
HHCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHEEEHH
AFKVEPQKSLEAFKDLDTLADTAEAYTNFDYDLFRKLAFASDNPVYGLILNSLKGLYTRV
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GLFYFANPSARELAKRFYLSLKTLCQTQQVNDVKECIRQYGKDSGVIWANMQAYLPANFN
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEECCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100