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The map label for this gene is hktE [H]

Identifier: 15601897

GI number: 15601897

Start: 29585

End: 31039

Strand: Direct

Name: hktE [H]

Synonym: PM0032

Alternate gene names: 15601897

Gene position: 29585-31039 (Clockwise)

Preceding gene: 15601896

Following gene: 15601899

Centisome position: 1.31

GC content: 43.71

Gene sequence:

>1455_bases
ATGTCTAAATGCCCATTTGACCATGGTTCAAAAACCTTAACGAATGCAGCTGGTGCACCTATTGTTGAAAACGACAACAC
CATGTCTGCGGGTCCTAAAGGTCCATTACTTTTACAAGATGTTTGGTTCCAAGAGAAATTAGCACACTTTGCACGTGAGC
GTATTCCTGAGCGTGTTGTTCATGCAAAAGGTTCAGCAGCGTACGGTACATTCACTGTGACACACGATATCAGCAAATAC
ACCAAAGCGGATTTATTCAATGGTATCGGTAAACAAACACAAGTCTTATTACGTTTCTCAACAGTAGCGGGTGAGCGCGG
TGCGGCAGACGCTGAGCGTGATGTGCGTGGTTTCGCATTAAAATTCTACACTGAACAAGGTAACTGGGACTTAGTGGGTA
ACAACACACCCGTATTCTTTATCCGTGATCCATTGAAATTCCCAGATTTCATTCATACTCAAAAACGTAATCCACAAACT
AACTTGCGTGATGCAAACGCGGCATGGGATTTCTGGTCACGTCATCCTGAATCATTACACCAAATCATGATTCTTTTCAG
TGATCGTGGTATTCCAACTGACTTACGTCATATGAACGGTTACGGTAGCCATACATATAGCTTTATTAACGCACAAAATG
AGCGTTTCTGGGTGAAATTCCACTTCAAAACACAACAAGGTCACAAATTCTATACTAATGAAGAAGCGGCTAAAGTGGTG
GGTGAAAACCGTGAGTCAAGCCAACAAGATTTATACGAAGCGATTGAGCGTGGCGAATTCCCACGTTGGAATGTTCAAGT
GCAAATCATGCCAGAAGCAGATGCACACAAACATAACTATGCGTTTGACTTAACTAAAGTATGGCCACACAAAGATTATC
CGATGATCGAAGTGGGTGTATTAGAGTTAAACCAAAACCCAATTAACTACTTCGCAGAAGTGGAACAAGCTGCGTTTGCA
CCTTCTAACATCGTACCGGGAATTGGTTTCTCACCAGACCGTATGTTACAAGGTCGTCTTTTCTCATACCAAGACGCGCA
ACGTTATCGTTTAGGGGTTAACCATCACCAAATCCCAGTGAACGCACCAAAATGCCCATACCACACCACTCACCGTGATG
GCGCAATGCGTGTAGATAACAATGGTGGTACACACCCTAACTATGCACCGAACCGTTTTGATACTTATGTGCCGACTCAC
CAACAAGAGCCTGCATTAGAGTTAGAGCGTTCAGCAGCACACTTTAACTTCCGTGAGTATGATGAAGACTACTACACACA
ACCTGCCGCACTTTACAACTTATTCGATGTGGATCAAAAAGCACGTGTGGCAGCCAACTTCGCAGCGGGCTTAGCAGGTG
TTACAGAACCTGCGATTGTTGAAAGACAATTAGCCCACTTCGACAAAGTAAGCAAAGAATTAGCTGATGCAATTCGTGCG
AACTTAGCGAAATAA

Upstream 100 bases:

>100_bases
AGCCCACAAGGTACTCAGCTAGTGATATTTACTCGCTAATGGAGTATCCCGTTCATAAATTCAGAATCTTCGATTTCTAT
TATTTGAGAGGAATTTTATT

Downstream 100 bases:

>100_bases
TCCGTTTGGAACTTTATGATTCAGGCTTGAGACAACTCAAGCCTTTTTTTATGGTATGTGGCGTTTAATCCAGTAACGTT
GAATGATTTTTCCTTGTCTT

Product: HktE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSKCPFDHGSKTLTNAAGAPIVENDNTMSAGPKGPLLLQDVWFQEKLAHFARERIPERVVHAKGSAAYGTFTVTHDISKY
TKADLFNGIGKQTQVLLRFSTVAGERGAADAERDVRGFALKFYTEQGNWDLVGNNTPVFFIRDPLKFPDFIHTQKRNPQT
NLRDANAAWDFWSRHPESLHQIMILFSDRGIPTDLRHMNGYGSHTYSFINAQNERFWVKFHFKTQQGHKFYTNEEAAKVV
GENRESSQQDLYEAIERGEFPRWNVQVQIMPEADAHKHNYAFDLTKVWPHKDYPMIEVGVLELNQNPINYFAEVEQAAFA
PSNIVPGIGFSPDRMLQGRLFSYQDAQRYRLGVNHHQIPVNAPKCPYHTTHRDGAMRVDNNGGTHPNYAPNRFDTYVPTH
QQEPALELERSAAHFNFREYDEDYYTQPAALYNLFDVDQKARVAANFAAGLAGVTEPAIVERQLAHFDKVSKELADAIRA
NLAK

Sequences:

>Translated_484_residues
MSKCPFDHGSKTLTNAAGAPIVENDNTMSAGPKGPLLLQDVWFQEKLAHFARERIPERVVHAKGSAAYGTFTVTHDISKY
TKADLFNGIGKQTQVLLRFSTVAGERGAADAERDVRGFALKFYTEQGNWDLVGNNTPVFFIRDPLKFPDFIHTQKRNPQT
NLRDANAAWDFWSRHPESLHQIMILFSDRGIPTDLRHMNGYGSHTYSFINAQNERFWVKFHFKTQQGHKFYTNEEAAKVV
GENRESSQQDLYEAIERGEFPRWNVQVQIMPEADAHKHNYAFDLTKVWPHKDYPMIEVGVLELNQNPINYFAEVEQAAFA
PSNIVPGIGFSPDRMLQGRLFSYQDAQRYRLGVNHHQIPVNAPKCPYHTTHRDGAMRVDNNGGTHPNYAPNRFDTYVPTH
QQEPALELERSAAHFNFREYDEDYYTQPAALYNLFDVDQKARVAANFAAGLAGVTEPAIVERQLAHFDKVSKELADAIRA
NLAK
>Mature_483_residues
SKCPFDHGSKTLTNAAGAPIVENDNTMSAGPKGPLLLQDVWFQEKLAHFARERIPERVVHAKGSAAYGTFTVTHDISKYT
KADLFNGIGKQTQVLLRFSTVAGERGAADAERDVRGFALKFYTEQGNWDLVGNNTPVFFIRDPLKFPDFIHTQKRNPQTN
LRDANAAWDFWSRHPESLHQIMILFSDRGIPTDLRHMNGYGSHTYSFINAQNERFWVKFHFKTQQGHKFYTNEEAAKVVG
ENRESSQQDLYEAIERGEFPRWNVQVQIMPEADAHKHNYAFDLTKVWPHKDYPMIEVGVLELNQNPINYFAEVEQAAFAP
SNIVPGIGFSPDRMLQGRLFSYQDAQRYRLGVNHHQIPVNAPKCPYHTTHRDGAMRVDNNGGTHPNYAPNRFDTYVPTHQ
QEPALELERSAAHFNFREYDEDYYTQPAALYNLFDVDQKARVAANFAAGLAGVTEPAIVERQLAHFDKVSKELADAIRAN
LAK

Specific function: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide [H]

COG id: COG0753

COG function: function code P; Catalase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the catalase family [H]

Homologues:

Organism=Homo sapiens, GI4557014, Length=483, Percent_Identity=52.5879917184265, Blast_Score=494, Evalue=1e-140,
Organism=Escherichia coli, GI48994891, Length=497, Percent_Identity=42.4547283702213, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71998444, Length=480, Percent_Identity=52.0833333333333, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI25147792, Length=480, Percent_Identity=50.4166666666667, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI25151141, Length=478, Percent_Identity=50.6276150627615, Blast_Score=482, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6320462, Length=485, Percent_Identity=49.0721649484536, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321525, Length=508, Percent_Identity=37.4015748031496, Blast_Score=328, Evalue=9e-91,
Organism=Drosophila melanogaster, GI17981717, Length=483, Percent_Identity=48.8612836438923, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI19920968, Length=388, Percent_Identity=49.7422680412371, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002226
- InterPro:   IPR020835
- InterPro:   IPR010582
- InterPro:   IPR018028
- InterPro:   IPR011614 [H]

Pfam domain/function: PF00199 Catalase; PF06628 Catalase-rel [H]

EC number: =1.11.1.6 [H]

Molecular weight: Translated: 55128; Mature: 54997

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00437 CATALASE_1 ; PS00438 CATALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKCPFDHGSKTLTNAAGAPIVENDNTMSAGPKGPLLLQDVWFQEKLAHFARERIPERVV
CCCCCCCCCCCHHHHCCCCCEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
HAKGSAAYGTFTVTHDISKYTKADLFNGIGKQTQVLLRFSTVAGERGAADAERDVRGFAL
HCCCCCCEEEEEEECCHHHHHHHHHHHCCCHHHEEEEEEEHHCCCCCCCCCHHCCCEEEE
KFYTEQGNWDLVGNNTPVFFIRDPLKFPDFIHTQKRNPQTNLRDANAAWDFWSRHPESLH
EEEEECCCEEEECCCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHH
QIMILFSDRGIPTDLRHMNGYGSHTYSFINAQNERFWVKFHFKTQQGHKFYTNEEAAKVV
HEEEEEECCCCCHHHHHCCCCCCCEEEEEECCCCEEEEEEEEECCCCCEEECCHHHHHHH
GENRESSQQDLYEAIERGEFPRWNVQVQIMPEADAHKHNYAFDLTKVWPHKDYPMIEVGV
CCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEE
LELNQNPINYFAEVEQAAFAPSNIVPGIGFSPDRMLQGRLFSYQDAQRYRLGVNHHQIPV
EEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCC
NAPKCPYHTTHRDGAMRVDNNGGTHPNYAPNRFDTYVPTHQQEPALELERSAAHFNFREY
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHC
DEDYYTQPAALYNLFDVDQKARVAANFAAGLAGVTEPAIVERQLAHFDKVSKELADAIRA
CHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLAK
HCCC
>Mature Secondary Structure 
SKCPFDHGSKTLTNAAGAPIVENDNTMSAGPKGPLLLQDVWFQEKLAHFARERIPERVV
CCCCCCCCCCHHHHCCCCCEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
HAKGSAAYGTFTVTHDISKYTKADLFNGIGKQTQVLLRFSTVAGERGAADAERDVRGFAL
HCCCCCCEEEEEEECCHHHHHHHHHHHCCCHHHEEEEEEEHHCCCCCCCCCHHCCCEEEE
KFYTEQGNWDLVGNNTPVFFIRDPLKFPDFIHTQKRNPQTNLRDANAAWDFWSRHPESLH
EEEEECCCEEEECCCCCEEEEECCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHCCHHHHH
QIMILFSDRGIPTDLRHMNGYGSHTYSFINAQNERFWVKFHFKTQQGHKFYTNEEAAKVV
HEEEEEECCCCCHHHHHCCCCCCCEEEEEECCCCEEEEEEEEECCCCCEEECCHHHHHHH
GENRESSQQDLYEAIERGEFPRWNVQVQIMPEADAHKHNYAFDLTKVWPHKDYPMIEVGV
CCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEE
LELNQNPINYFAEVEQAAFAPSNIVPGIGFSPDRMLQGRLFSYQDAQRYRLGVNHHQIPV
EEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHCCCCCCCCCC
NAPKCPYHTTHRDGAMRVDNNGGTHPNYAPNRFDTYVPTHQQEPALELERSAAHFNFREY
CCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHC
DEDYYTQPAALYNLFDVDQKARVAANFAAGLAGVTEPAIVERQLAHFDKVSKELADAIRA
CHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NLAK
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]