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The map label for this gene is purM

Identifier: 15601886

GI number: 15601886

Start: 17407

End: 18444

Strand: Reverse

Name: purM

Synonym: PM0021

Alternate gene names: 15601886

Gene position: 18444-17407 (Counterclockwise)

Preceding gene: 15601898

Following gene: 15601885

Centisome position: 0.82

GC content: 42.1

Gene sequence:

>1038_bases
GTGAGCAAACAATCATTAAGTTACAAAGATGCTGGCGTTGATATCAATGCCGGTAATGCTTTAGTCGAAAAAATCAAAGC
CGATGTCAAACGCACAACCCGCCCTGAAGTCATCGGTGGCTTAGGCGGTTTTGGTGCTTTATGTGCGATACCAACAAAAT
ACAAAGAACCGATTTTAGTTTCTGGCACAGATGGTGTAGGAACCAAACTGCGTTTAGCGATTGATTTAAATCGTCATGAT
AGCATTGGTATTGATTTGGTCGCGATGTGTGTTAATGACCTTGTAGTACAAGGCGCAGAACCATTATTCTTTTTAGATTA
TTATGCTACCGGTAAATTAGATGTGGATGTTGCTGCCAGTGTGATTAAAGGCATTGCTAACGGTTGTGAACAATCTGGCT
GTGCATTGGTAGGGGGAGAAACCGCTGAAATGCCGGGAATGTATCATGCTGGTGATTATGACTTAGCAGGATTTTGTGTC
GGTGTCGTCGAAAAGTCAGACATCATTGATGGCAGTAAAGTCCGCGTAGGTGACGTATTAATCGCCTTAGGATCAAGTGG
TCCACATTCAAATGGCTATTCTTTAATTCGTAAGGTCATTGAGGTAGCAGGCATCAATCCAGCAGAAGAACAACTCGCAG
GTAAACCACTTGCGGATCAAGTGCTTGCTCCAACTAAAATTTATGTCAAATCTATTCTACAATTAATTAAACACGCCGAT
GTCCATGCAATTTGTCATTTAACTGGCGGTGGTTTCTGGGAAAATATTCCACGCGTCCTTCCAAAAAATGTTAAAGCTGT
CATCGATGAAAGCAGCTGGGAATGGCAACCTGTCTTCAAATGGCTACAAGAAAAAGGCAATATTGACACCCATGAAATGT
ATCGTACCTTCAACTGTGGCGTGGGCATGATTATTGCATTACCACAAGAAGATGTGGATACGGCACTTGGCTTATTAAAA
CAAACAGGTGAAAAAGCTTGGGTCATTGGTCAAATTGAACACGCCACTGATGGCGAAGAACAAGTGATTATTCGCTAA

Upstream 100 bases:

>100_bases
GACGCGTAAAAATTCTTAAACAACTATCGCAAACGTTTGCTTAGGCATGCTACAATTTAGCAGATTTAAATTTATTTTCT
CTAACTTATAGGAAATCATT

Downstream 100 bases:

>100_bases
TGAAAAAAATTGTTGTTTTAGTGTCAGGACATGGCAGTAATTTACAGGCATTAATCGATGCCTGTCATAGCGGACAGATT
GCAGGTAAAATCGTTGCTGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSKQSLSYKDAGVDINAGNALVEKIKADVKRTTRPEVIGGLGGFGALCAIPTKYKEPILVSGTDGVGTKLRLAIDLNRHD
SIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDVAASVIKGIANGCEQSGCALVGGETAEMPGMYHAGDYDLAGFCV
GVVEKSDIIDGSKVRVGDVLIALGSSGPHSNGYSLIRKVIEVAGINPAEEQLAGKPLADQVLAPTKIYVKSILQLIKHAD
VHAICHLTGGGFWENIPRVLPKNVKAVIDESSWEWQPVFKWLQEKGNIDTHEMYRTFNCGVGMIIALPQEDVDTALGLLK
QTGEKAWVIGQIEHATDGEEQVIIR

Sequences:

>Translated_345_residues
MSKQSLSYKDAGVDINAGNALVEKIKADVKRTTRPEVIGGLGGFGALCAIPTKYKEPILVSGTDGVGTKLRLAIDLNRHD
SIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDVAASVIKGIANGCEQSGCALVGGETAEMPGMYHAGDYDLAGFCV
GVVEKSDIIDGSKVRVGDVLIALGSSGPHSNGYSLIRKVIEVAGINPAEEQLAGKPLADQVLAPTKIYVKSILQLIKHAD
VHAICHLTGGGFWENIPRVLPKNVKAVIDESSWEWQPVFKWLQEKGNIDTHEMYRTFNCGVGMIIALPQEDVDTALGLLK
QTGEKAWVIGQIEHATDGEEQVIIR
>Mature_344_residues
SKQSLSYKDAGVDINAGNALVEKIKADVKRTTRPEVIGGLGGFGALCAIPTKYKEPILVSGTDGVGTKLRLAIDLNRHDS
IGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDVAASVIKGIANGCEQSGCALVGGETAEMPGMYHAGDYDLAGFCVG
VVEKSDIIDGSKVRVGDVLIALGSSGPHSNGYSLIRKVIEVAGINPAEEQLAGKPLADQVLAPTKIYVKSILQLIKHADV
HAICHLTGGGFWENIPRVLPKNVKAVIDESSWEWQPVFKWLQEKGNIDTHEMYRTFNCGVGMIIALPQEDVDTALGLLKQ
TGEKAWVIGQIEHATDGEEQVIIR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=347, Percent_Identity=47.5504322766571, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI209869995, Length=347, Percent_Identity=47.5504322766571, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI209869993, Length=347, Percent_Identity=47.5504322766571, Blast_Score=337, Evalue=1e-92,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=76.6763848396501, Blast_Score=546, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=41.399416909621, Blast_Score=259, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6321203, Length=343, Percent_Identity=47.5218658892128, Blast_Score=314, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24582400, Length=305, Percent_Identity=42.2950819672131, Blast_Score=245, Evalue=3e-65,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_PASMU (Q9CPL6)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_244958.1
- ProteinModelPortal:   Q9CPL6
- SMR:   Q9CPL6
- GeneID:   1243368
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0021
- NMPDR:   fig|272843.1.peg.21
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   PMUL272843:PM0021-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36936; Mature: 36805

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQSLSYKDAGVDINAGNALVEKIKADVKRTTRPEVIGGLGGFGALCAIPTKYKEPILV
CCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCCCCCCEEE
SGTDGVGTKLRLAIDLNRHDSIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDVAAS
ECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHH
VIKGIANGCEQSGCALVGGETAEMPGMYHAGDYDLAGFCVGVVEKSDIIDGSKVRVGDVL
HHHHHHHCCCCCCCEEECCCCCCCCCCEECCCCCHHHHHEEHHHHCCCCCCCCEEECEEE
IALGSSGPHSNGYSLIRKVIEVAGINPAEEQLAGKPLADQVLAPTKIYVKSILQLIKHAD
EEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHCCC
VHAICHLTGGGFWENIPRVLPKNVKAVIDESSWEWQPVFKWLQEKGNIDTHEMYRTFNCG
EEEEEEECCCCHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCC
VGMIIALPQEDVDTALGLLKQTGEKAWVIGQIEHATDGEEQVIIR
CEEEEEECCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEC
>Mature Secondary Structure 
SKQSLSYKDAGVDINAGNALVEKIKADVKRTTRPEVIGGLGGFGALCAIPTKYKEPILV
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCCCCCCEEE
SGTDGVGTKLRLAIDLNRHDSIGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLDVDVAAS
ECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHH
VIKGIANGCEQSGCALVGGETAEMPGMYHAGDYDLAGFCVGVVEKSDIIDGSKVRVGDVL
HHHHHHHCCCCCCCEEECCCCCCCCCCEECCCCCHHHHHEEHHHHCCCCCCCCEEECEEE
IALGSSGPHSNGYSLIRKVIEVAGINPAEEQLAGKPLADQVLAPTKIYVKSILQLIKHAD
EEECCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHCCC
VHAICHLTGGGFWENIPRVLPKNVKAVIDESSWEWQPVFKWLQEKGNIDTHEMYRTFNCG
EEEEEEECCCCHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCC
VGMIIALPQEDVDTALGLLKQTGEKAWVIGQIEHATDGEEQVIIR
CEEEEEECCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100