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The map label for this gene is uraA

Identifier: 15601883

GI number: 15601883

Start: 14619

End: 15872

Strand: Reverse

Name: uraA

Synonym: PM0018

Alternate gene names: 15601883

Gene position: 15872-14619 (Counterclockwise)

Preceding gene: 15601884

Following gene: 15601882

Centisome position: 0.7

GC content: 43.3

Gene sequence:

>1254_bases
ATGACAAATCAAAATCCCCCTGTTCTTCTAGAACAAAATCACGCAAAACAAGCCTTCGTTGGGCTACAAATGCTTTTTGT
TGCCTTCGGTGCTTTAGTCCTTGTTCCCCTGATTACAGGTTTAAATGCCAATACTGCCTTATTGACCGCAGGGATTGGGA
CACTCTTATTCCAGCTTTGTACTGGACGCCAAGTCCCAATTTTCTTAGCCTCTTCCTTTGCTTTTATTGCACCAATTCAA
TATGGCGTGACAACGTGGGGCATTGCTACCACTATGGGGGGGCTGGTGTTTACTGGGCTGGTTTATTTTGCCCTCAGTAC
GTTAGTCAAAATTAAAGGTGCTGGTGCTTTACAAAAAGTCTTTCCGCCAGTAGTTGTTGGTCCCGTTATTATCATCATCG
GTATGGGACTCGCCCCTGTTGCCGTGGACATGGCATTAGGTAAAAACAGCACTTATCAATATAACGATGCTGTATTCGTT
TCGATGGCAACATTACTGACAACGTTAGGTGTTGCGGTGTTTGCTAAAGGCATGATGAAATTAATTCCTATCATGTTTGG
TATTGTCGTCGGCTATATCCTCTGCTTATTCTTAGGCTTAATTAATTTCCAACCTGTCATTGATGCACCTTGGTTTAGTG
TGCCAGAAATTACTACCCCTGAATTTAAATTAGAAGCTATTCTTTATTTATTGCCGATTGCTATCGCCCCAGCAGTTGAG
CATGTCGGTGGGATCATGGCAATCAGTTCGGTGACAGGGAAAGACTTCCTACAAAAACCAGGATTACATCGCACTTTATT
AGGGGATGGTATTGCAACGAGTGCCGCCTCATTCTTAGGAGGACCACCTAATACAACTTATGCTGAAGTCACTGGTGCTG
TCATGCTTACGCGCAACTTTAACCCTAAAATCATGACATGGGCAGCCGTTTGGGCAATTGCGATTTCCTTCTGTGGTAAA
GTCGGGGCTTTCCTCTCTACCATTCCAACTATTGTCATGGGTGGCATTATGATGTTAGTGTTTGGCTCTATCGCCGTAGT
CGGTATGAGTACACTTATCCGTGGTAAAGTGGATGTAACAGAAGCGCGTAATCTGTGTATTATTTCCGTTGTGATGACAT
TTGGCATCGGTGGTATGTTTGTGAACTTTGGAGAAGTCTCCTTAAAAGGGATTAGTTTATGCGCCGTTGTCGCGATTTTA
CTCAACTTAATCTTACCCAAAGCCAAAAACACCCCAATAGAAGAAAATCGATAA

Upstream 100 bases:

>100_bases
TTATGCCGCTTTTTTCCGTTCAATTTATAGCGCTTACAATCTTAACAGCTTGAACACTATAAAATGAAAAGTTAATTCAG
ACAGAGAGTTGAAACTTAAC

Downstream 100 bases:

>100_bases
GAGAAAATTAAGGGTTAAGTCTTGCTTAACCCTTCATTTTTCGTTTATCCTTATTCTCCTTTTTTCGATTTTGTAGGTTG
CTTTTTGTTAGAAAATTTCC

Product: hypothetical protein

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTNQNPPVLLEQNHAKQAFVGLQMLFVAFGALVLVPLITGLNANTALLTAGIGTLLFQLCTGRQVPIFLASSFAFIAPIQ
YGVTTWGIATTMGGLVFTGLVYFALSTLVKIKGAGALQKVFPPVVVGPVIIIIGMGLAPVAVDMALGKNSTYQYNDAVFV
SMATLLTTLGVAVFAKGMMKLIPIMFGIVVGYILCLFLGLINFQPVIDAPWFSVPEITTPEFKLEAILYLLPIAIAPAVE
HVGGIMAISSVTGKDFLQKPGLHRTLLGDGIATSAASFLGGPPNTTYAEVTGAVMLTRNFNPKIMTWAAVWAIAISFCGK
VGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDVTEARNLCIISVVMTFGIGGMFVNFGEVSLKGISLCAVVAIL
LNLILPKAKNTPIEENR

Sequences:

>Translated_417_residues
MTNQNPPVLLEQNHAKQAFVGLQMLFVAFGALVLVPLITGLNANTALLTAGIGTLLFQLCTGRQVPIFLASSFAFIAPIQ
YGVTTWGIATTMGGLVFTGLVYFALSTLVKIKGAGALQKVFPPVVVGPVIIIIGMGLAPVAVDMALGKNSTYQYNDAVFV
SMATLLTTLGVAVFAKGMMKLIPIMFGIVVGYILCLFLGLINFQPVIDAPWFSVPEITTPEFKLEAILYLLPIAIAPAVE
HVGGIMAISSVTGKDFLQKPGLHRTLLGDGIATSAASFLGGPPNTTYAEVTGAVMLTRNFNPKIMTWAAVWAIAISFCGK
VGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDVTEARNLCIISVVMTFGIGGMFVNFGEVSLKGISLCAVVAIL
LNLILPKAKNTPIEENR
>Mature_416_residues
TNQNPPVLLEQNHAKQAFVGLQMLFVAFGALVLVPLITGLNANTALLTAGIGTLLFQLCTGRQVPIFLASSFAFIAPIQY
GVTTWGIATTMGGLVFTGLVYFALSTLVKIKGAGALQKVFPPVVVGPVIIIIGMGLAPVAVDMALGKNSTYQYNDAVFVS
MATLLTTLGVAVFAKGMMKLIPIMFGIVVGYILCLFLGLINFQPVIDAPWFSVPEITTPEFKLEAILYLLPIAIAPAVEH
VGGIMAISSVTGKDFLQKPGLHRTLLGDGIATSAASFLGGPPNTTYAEVTGAVMLTRNFNPKIMTWAAVWAIAISFCGKV
GAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDVTEARNLCIISVVMTFGIGGMFVNFGEVSLKGISLCAVVAILL
NLILPKAKNTPIEENR

Specific function: Transport of uracil in the cell

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily

Homologues:

Organism=Homo sapiens, GI44680148, Length=429, Percent_Identity=22.3776223776224, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI40316845, Length=429, Percent_Identity=22.3776223776224, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI44680143, Length=432, Percent_Identity=22.9166666666667, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI44680145, Length=430, Percent_Identity=22.5581395348837, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788843, Length=404, Percent_Identity=37.8712871287129, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI87081818, Length=409, Percent_Identity=34.718826405868, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI87082181, Length=383, Percent_Identity=26.8929503916449, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082178, Length=329, Percent_Identity=24.9240121580547, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17558856, Length=213, Percent_Identity=27.2300469483568, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356175, Length=437, Percent_Identity=24.4851258581236, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URAA_PASMU (Q9CPL9)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_244955.1
- GeneID:   1243365
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0018
- NMPDR:   fig|272843.1.peg.18
- HOGENOM:   HBG470187
- OMA:   WLAMPNF
- ProtClustDB:   CLSK869935
- BioCyc:   PMUL272843:PM0018-MONOMER
- InterPro:   IPR006042
- InterPro:   IPR006043
- PANTHER:   PTHR11119:SF3
- PANTHER:   PTHR11119
- TIGRFAMs:   TIGR00801

Pfam domain/function: PF00860 Xan_ur_permease

EC number: NA

Molecular weight: Translated: 43933; Mature: 43802

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xaf75210)-; HASH(0xbb697ac)-; HASH(0xbaf84c0)-; HASH(0xbb05c00)-; HASH(0xbb114ac)-; HASH(0xbaf25dc)-; HASH(0xb018644)-; HASH(0xbb15a0c)-; HASH(0xbb13628)-; HASH(0xbb0f530)-; HASH(0xbb8fdac)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQNPPVLLEQNHAKQAFVGLQMLFVAFGALVLVPLITGLNANTALLTAGIGTLLFQLC
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TGRQVPIFLASSFAFIAPIQYGVTTWGIATTMGGLVFTGLVYFALSTLVKIKGAGALQKV
CCCCCEEHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
FPPVVVGPVIIIIGMGLAPVAVDMALGKNSTYQYNDAVFVSMATLLTTLGVAVFAKGMMK
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LIPIMFGIVVGYILCLFLGLINFQPVIDAPWFSVPEITTPEFKLEAILYLLPIAIAPAVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HVGGIMAISSVTGKDFLQKPGLHRTLLGDGIATSAASFLGGPPNTTYAEVTGAVMLTRNF
HHCHHHHHHCCCCHHHHHCCCCCHHHHCCCHHHHHHHHCCCCCCCCHHHHHCEEEEEECC
NPKIMTWAAVWAIAISFCGKVGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDVT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
EARNLCIISVVMTFGIGGMFVNFGEVSLKGISLCAVVAILLNLILPKAKNTPIEENR
HHCCHHHHHHHHHHCCCHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
>Mature Secondary Structure 
TNQNPPVLLEQNHAKQAFVGLQMLFVAFGALVLVPLITGLNANTALLTAGIGTLLFQLC
CCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
TGRQVPIFLASSFAFIAPIQYGVTTWGIATTMGGLVFTGLVYFALSTLVKIKGAGALQKV
CCCCCEEHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
FPPVVVGPVIIIIGMGLAPVAVDMALGKNSTYQYNDAVFVSMATLLTTLGVAVFAKGMMK
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
LIPIMFGIVVGYILCLFLGLINFQPVIDAPWFSVPEITTPEFKLEAILYLLPIAIAPAVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
HVGGIMAISSVTGKDFLQKPGLHRTLLGDGIATSAASFLGGPPNTTYAEVTGAVMLTRNF
HHCHHHHHHCCCCHHHHHCCCCCHHHHCCCHHHHHHHHCCCCCCCCHHHHHCEEEEEECC
NPKIMTWAAVWAIAISFCGKVGAFLSTIPTIVMGGIMMLVFGSIAVVGMSTLIRGKVDVT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
EARNLCIISVVMTFGIGGMFVNFGEVSLKGISLCAVVAILLNLILPKAKNTPIEENR
HHCCHHHHHHHHHHCCCHHEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100