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The map label for this gene is ccmA

Identifier: 15601870

GI number: 15601870

Start: 5567

End: 6208

Strand: Direct

Name: ccmA

Synonym: PM0005

Alternate gene names: 15601870

Gene position: 5567-6208 (Clockwise)

Preceding gene: 15601869

Following gene: 15601871

Centisome position: 0.25

GC content: 42.68

Gene sequence:

>642_bases
ATGTCTATGTCTTATCAATTAAAAACCAAAAAGCTTGCTTGTCAACGAGGCGATAATGTCTTGTTTACGGACTTTAATTT
TGTCTGGAACAGCGGCGATTTTGTGCAAATCGAAGGGCACAATGGCATTGGCAAAACTAGCTTATTGCGCATTTTAATTG
GCTTGGCGCAACAACGCGAAGGCGAGGTATTTTGGAATGGTATCCCGATCCAAACGCAACGCGAAACCTTTCAGTATGAT
TTGTTGTATTTAGGTCATCATTCCGGTATCAAACCGGAATTAACCGCGTGGGAAAATTTGAAGTTTTATCAACAAATGAG
TGCCTGTGAGCTCGGTGAAGATAAGTTATGGCAGGTATTAGAAACGGTTGGACTTTTGGGGCGTGAAGATATTCCTGCCG
CGCAACTTTCCGCCGGTCAGCAACGGCGTATTGCGTTAGCACGTTTATGGCTTTCTAAAGCACCTTTGTGGATTTTGGAT
GAGCCGTTTACTGCGATTGATAAGCATGGTGTTCAAGTGCTCACCACCTTATTTGAACAGCATGCTACGCAAGGGGGGAT
CGTGATTTTTACCAGCCACCAAGATGTACAAAGTCGATTATTGAAAAAAGTGCGGTTAGAAAATTATAAATTTACGGAAT
AG

Upstream 100 bases:

>100_bases
TCCACCTCTAAAGAGGTAGGATTTTAACCGGCTAATCACTACGCCACGGTTATGCCTTATGATAGAATGCGAGCCATTAA
CTTGGCTTATTCCTGAAATG

Downstream 100 bases:

>100_bases
TTCCTTGCAGAAAGAGCAGCAAATAGCATGATATTTTTAGCCATTATCAAAAGAGAGTTACAAATTGCGATGCGTAAGCA
AGCGGAGATTTTAAATCCGT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 213; Mature: 212

Protein sequence:

>213_residues
MSMSYQLKTKKLACQRGDNVLFTDFNFVWNSGDFVQIEGHNGIGKTSLLRILIGLAQQREGEVFWNGIPIQTQRETFQYD
LLYLGHHSGIKPELTAWENLKFYQQMSACELGEDKLWQVLETVGLLGREDIPAAQLSAGQQRRIALARLWLSKAPLWILD
EPFTAIDKHGVQVLTTLFEQHATQGGIVIFTSHQDVQSRLLKKVRLENYKFTE

Sequences:

>Translated_213_residues
MSMSYQLKTKKLACQRGDNVLFTDFNFVWNSGDFVQIEGHNGIGKTSLLRILIGLAQQREGEVFWNGIPIQTQRETFQYD
LLYLGHHSGIKPELTAWENLKFYQQMSACELGEDKLWQVLETVGLLGREDIPAAQLSAGQQRRIALARLWLSKAPLWILD
EPFTAIDKHGVQVLTTLFEQHATQGGIVIFTSHQDVQSRLLKKVRLENYKFTE
>Mature_212_residues
SMSYQLKTKKLACQRGDNVLFTDFNFVWNSGDFVQIEGHNGIGKTSLLRILIGLAQQREGEVFWNGIPIQTQRETFQYDL
LYLGHHSGIKPELTAWENLKFYQQMSACELGEDKLWQVLETVGLLGREDIPAAQLSAGQQRRIALARLWLSKAPLWILDE
PFTAIDKHGVQVLTTLFEQHATQGGIVIFTSHQDVQSRLLKKVRLENYKFTE

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI105990541, Length=159, Percent_Identity=30.8176100628931, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI46592956, Length=184, Percent_Identity=27.7173913043478, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI46592915, Length=184, Percent_Identity=27.7173913043478, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI46592978, Length=184, Percent_Identity=27.7173913043478, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI46592964, Length=184, Percent_Identity=27.7173913043478, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI46592971, Length=184, Percent_Identity=27.7173913043478, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI46592898, Length=196, Percent_Identity=27.0408163265306, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI215820660, Length=199, Percent_Identity=25.6281407035176, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI20143975, Length=199, Percent_Identity=25.6281407035176, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI116734710, Length=180, Percent_Identity=25.5555555555556, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI21536376, Length=167, Percent_Identity=27.5449101796407, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI87082064, Length=206, Percent_Identity=48.5436893203884, Blast_Score=180, Evalue=7e-47,
Organism=Escherichia coli, GI87081709, Length=155, Percent_Identity=31.6129032258064, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1786703, Length=205, Percent_Identity=30.2439024390244, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1790467, Length=196, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI87081834, Length=201, Percent_Identity=26.3681592039801, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788761, Length=158, Percent_Identity=30.379746835443, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787370, Length=163, Percent_Identity=28.8343558282209, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1789873, Length=176, Percent_Identity=26.1363636363636, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789593, Length=196, Percent_Identity=25, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787029, Length=207, Percent_Identity=25.6038647342995, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786872, Length=162, Percent_Identity=27.1604938271605, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI87081791, Length=154, Percent_Identity=29.2207792207792, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788225, Length=177, Percent_Identity=29.9435028248588, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788506, Length=192, Percent_Identity=28.125, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786563, Length=174, Percent_Identity=28.1609195402299, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786654, Length=178, Percent_Identity=29.2134831460674, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789586, Length=207, Percent_Identity=26.5700483091787, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1789991, Length=201, Percent_Identity=24.8756218905473, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI48994943, Length=188, Percent_Identity=25, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1787105, Length=174, Percent_Identity=28.1609195402299, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI87082267, Length=190, Percent_Identity=25.7894736842105, Blast_Score=61, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19920532, Length=178, Percent_Identity=29.2134831460674, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24580930, Length=178, Percent_Identity=29.2134831460674, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24641342, Length=172, Percent_Identity=31.3953488372093, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574744, Length=173, Percent_Identity=28.9017341040462, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574150, Length=163, Percent_Identity=24.5398773006135, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI116007328, Length=163, Percent_Identity=24.5398773006135, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24648314, Length=194, Percent_Identity=25.7731958762887, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28574533, Length=193, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_PASMU (Q9CPN2)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_244942.1
- ProteinModelPortal:   Q9CPN2
- SMR:   Q9CPN2
- GeneID:   1243352
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0005
- NMPDR:   fig|272843.1.peg.5
- HOGENOM:   HBG758042
- OMA:   ARLWHND
- ProtClustDB:   PRK13538
- BioCyc:   PMUL272843:PM0005-MONOMER
- BRENDA:   3.6.3.41
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 24393; Mature: 24262

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSYQLKTKKLACQRGDNVLFTDFNFVWNSGDFVQIEGHNGIGKTSLLRILIGLAQQRE
CCCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCC
GEVFWNGIPIQTQRETFQYDLLYLGHHSGIKPELTAWENLKFYQQMSACELGEDKLWQVL
CCEEECCCCCCCCCCHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
ETVGLLGREDIPAAQLSAGQQRRIALARLWLSKAPLWILDEPFTAIDKHGVQVLTTLFEQ
HHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
HATQGGIVIFTSHQDVQSRLLKKVRLENYKFTE
HCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SMSYQLKTKKLACQRGDNVLFTDFNFVWNSGDFVQIEGHNGIGKTSLLRILIGLAQQRE
CCCCCHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCC
GEVFWNGIPIQTQRETFQYDLLYLGHHSGIKPELTAWENLKFYQQMSACELGEDKLWQVL
CCEEECCCCCCCCCCHHEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
ETVGLLGREDIPAAQLSAGQQRRIALARLWLSKAPLWILDEPFTAIDKHGVQVLTTLFEQ
HHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHH
HATQGGIVIFTSHQDVQSRLLKKVRLENYKFTE
HCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11248100