Click here to switch to the map view.

The map label for this gene is mdh_1 [H]

Identifier: 15601867

GI number: 15601867

Start: 983

End: 3259

Strand: Reverse

Name: mdh_1 [H]

Synonym: PM0002

Alternate gene names: 15601867

Gene position: 3259-983 (Counterclockwise)

Preceding gene: 15601882

Following gene: 15601866

Centisome position: 0.14

GC content: 43.39

Gene sequence:

>2277_bases
ATGGATGCACAATTACGTCAAGCTGCTCTCGATTTTCATGAATTTCCAACACCGGGAAAAATAGAAGTGACCCCGACCAA
ATCGCTGGCAACACAGCGTGATTTAGCGCTCGCCTATTCCCCCGGTGTTGCGGTCCCCTGTTTAGAAATCCAAGCAGATC
CCGCTGCCTCTTATCGTTATACCTCCAGAGGCAATTTAGTTGCTGTGATTTCCAATGGCACGGCGGTTTTAGGTTTAGGC
AACATTGGTGCATTAGCGGGAAAACCGGTAATGGAAGGGAAAGGGGTGTTATTCAAAAAATTTGCCGGTGTCAACGTATT
TGATATCGAAATTGACGAAAGAGATCCAGATAAATTAGTCGATATTATTGCTTCGCTAGAACCCACTTTTGGTGGCATTA
ACTTGGAAGATATTAAAGCCCCAGAATGTTTCTATATTGAACAAAAATTACGTGAGCGGATGAAAATTCCTGTTTTCCAT
GATGACCAACATGGTACCGCTATTATCAGTGCTGCTGCGATTTTGAATGGCTTACGTATCGTGAAAAAAGACATTGCCAA
GGTTAAATTGATTGCCTCGGGCGCGGGTGCCGCATCGATTGCGTGTTTAAATTTATTGGTCAGTTTAGGTTTACCGCGTG
AAAATATTATCGTCTGTGATTCAAAAGGGGTGATTTTCCATGGTCGCGATGAACGCATGGATGAAACTAAAAAATTATAT
GCAATTGAAGACAATGGTAAACGTACGTTAGCGGAAGTCATCAACGATGCGGATATTTTCTTAGGTTGCTCTGCGGCGGG
AACATTAACCCAAGACATGGTAAAAACCATGGCGGCCAACCCATTAATCCTTGCGTTAGCTAACCCTGATCCCGAAATTT
TACCACCTTTAGCGAAAGCCGTTCGTCCAGATGCAATTGTTTGCACGGGACGTTCTGATTACCCAAACCAAGTCAATAAC
GTACTCTGTTTCCCATTTATTTTCCGTGGGGCATTAGATGTGAGTGCAACAGCAATCAACGAAGAGATGAAACTCGCGGC
AGTGCATGCCATTGCGGATCTTGCACTTGCCGAACAAAGTGAAGTGGTTACCTCAGCTTATGGCGAAACGGAATTATCTT
TTGGTCCAGAATATTTAATTCCTAAGCCGTTTGATCCCCGTTTAATTGTCAAAATTGCCCCGGCGGTAGCCAAAGCAGCC
ATGGATTCGGGGGTCGCTACGCGTCCAATTAAAGATTTTGATGCTTACATTGAAAAACTCACGCAGTTTGTGTACAAAAC
AAACTTGTTCATGAAACCGGTGTTCGCTCAAGCGAAGCAAAATAAAAAACGTGTTTTACTCACCGATGGTGAAGAATCTC
GTGTTTTACATGCTGTGCAAGAAATCGCAACATTAGGTATTGCAACCCCAATTTTATTGGGTCGTCCAAGTGTCATCGCA
CAAAAGATTAAACAGCTTGGTTTACACATTCAAGAAGGGCGTGATTTTGAATTAGTGGACATCGAAAACAACCCTTATTT
TGAGGAATGTTATAAAACTTACCACAACTTGCTTAAACGCAAAGGCATTACGCCAGCCGGTGCGCAACGTAAAATGCTAC
ATAATCCGACTGTGATTGGTGCAACCTTGCTCCAACTCGGCAAAGCCGATGCCATGTTATGTGGTTTAGTCGGTCCTTAT
GCTTCACATTTAAGCAATATTAAAGAAGTGATTGGTGTCCAACCTTGTGTCCCAACGCCCGCGACAGTAAATGGGCTCGT
GTTGCCAACAGGTAACTTATTCATTACAGATACCTTTGTTAACCACAACCCAACTGCACAAGAATTAGCTGAGATCACCA
TTATGGCAGCCAATGAAGTAAGCCGTTTCGGTATTGAACCTAAAGTTGCCTTAGTCTCCCATTCTAATTTTGGCACCTTT
GATGATCCAAGTGCGGTCAAAATGCGCGAAGTTTTACACTTAGTAAAAGAAAAAGCACCAGACTTGATCATTGATGGCGA
AATGCACTGTGATGTCGCTTTAAATGAGAAATTGCGTCAGGACATCATGCCAGACAGTCCATTAAAAGGTGCGGCAAACT
TATTGGTGATGCCAAATATGGAAGCTGCACGGATCAGTTTGAACCTATTACAGGGCACTGCTACCCCAATTACAGTCGGA
CCAATTTTAATGGGGATGAATAAACCTGTTCATATTCTCACCTCCGCGTCTTCTGTACGCCGGATCATTAATATGGTCGC
AATTGCGGCAGCCAATGTTGAACCCACTTGTAAGTAG

Upstream 100 bases:

>100_bases
AAATCCCAATACTGTGTTTTAGGTCACGTTTTTTATTCTCAATTTATTTATAATGGTTTGTCTATTACGATAATTTATTT
ACTCACAAGAGGACTGTTTT

Downstream 100 bases:

>100_bases
TGGATAGCAAAATCAGGGCAGAGGTAAAAATCTGCCCTGAGATTTTTGGTGTTAACTGCAGAGAAATAATGATCTTAATC
AAGTTTCCTGTTAAAATCTT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MDAQLRQAALDFHEFPTPGKIEVTPTKSLATQRDLALAYSPGVAVPCLEIQADPAASYRYTSRGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGVNVFDIEIDERDPDKLVDIIASLEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIISAAAILNGLRIVKKDIAKVKLIASGAGAASIACLNLLVSLGLPRENIIVCDSKGVIFHGRDERMDETKKLY
AIEDNGKRTLAEVINDADIFLGCSAAGTLTQDMVKTMAANPLILALANPDPEILPPLAKAVRPDAIVCTGRSDYPNQVNN
VLCFPFIFRGALDVSATAINEEMKLAAVHAIADLALAEQSEVVTSAYGETELSFGPEYLIPKPFDPRLIVKIAPAVAKAA
MDSGVATRPIKDFDAYIEKLTQFVYKTNLFMKPVFAQAKQNKKRVLLTDGEESRVLHAVQEIATLGIATPILLGRPSVIA
QKIKQLGLHIQEGRDFELVDIENNPYFEECYKTYHNLLKRKGITPAGAQRKMLHNPTVIGATLLQLGKADAMLCGLVGPY
ASHLSNIKEVIGVQPCVPTPATVNGLVLPTGNLFITDTFVNHNPTAQELAEITIMAANEVSRFGIEPKVALVSHSNFGTF
DDPSAVKMREVLHLVKEKAPDLIIDGEMHCDVALNEKLRQDIMPDSPLKGAANLLVMPNMEAARISLNLLQGTATPITVG
PILMGMNKPVHILTSASSVRRIINMVAIAAANVEPTCK

Sequences:

>Translated_758_residues
MDAQLRQAALDFHEFPTPGKIEVTPTKSLATQRDLALAYSPGVAVPCLEIQADPAASYRYTSRGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGVNVFDIEIDERDPDKLVDIIASLEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIISAAAILNGLRIVKKDIAKVKLIASGAGAASIACLNLLVSLGLPRENIIVCDSKGVIFHGRDERMDETKKLY
AIEDNGKRTLAEVINDADIFLGCSAAGTLTQDMVKTMAANPLILALANPDPEILPPLAKAVRPDAIVCTGRSDYPNQVNN
VLCFPFIFRGALDVSATAINEEMKLAAVHAIADLALAEQSEVVTSAYGETELSFGPEYLIPKPFDPRLIVKIAPAVAKAA
MDSGVATRPIKDFDAYIEKLTQFVYKTNLFMKPVFAQAKQNKKRVLLTDGEESRVLHAVQEIATLGIATPILLGRPSVIA
QKIKQLGLHIQEGRDFELVDIENNPYFEECYKTYHNLLKRKGITPAGAQRKMLHNPTVIGATLLQLGKADAMLCGLVGPY
ASHLSNIKEVIGVQPCVPTPATVNGLVLPTGNLFITDTFVNHNPTAQELAEITIMAANEVSRFGIEPKVALVSHSNFGTF
DDPSAVKMREVLHLVKEKAPDLIIDGEMHCDVALNEKLRQDIMPDSPLKGAANLLVMPNMEAARISLNLLQGTATPITVG
PILMGMNKPVHILTSASSVRRIINMVAIAAANVEPTCK
>Mature_758_residues
MDAQLRQAALDFHEFPTPGKIEVTPTKSLATQRDLALAYSPGVAVPCLEIQADPAASYRYTSRGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFAGVNVFDIEIDERDPDKLVDIIASLEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIISAAAILNGLRIVKKDIAKVKLIASGAGAASIACLNLLVSLGLPRENIIVCDSKGVIFHGRDERMDETKKLY
AIEDNGKRTLAEVINDADIFLGCSAAGTLTQDMVKTMAANPLILALANPDPEILPPLAKAVRPDAIVCTGRSDYPNQVNN
VLCFPFIFRGALDVSATAINEEMKLAAVHAIADLALAEQSEVVTSAYGETELSFGPEYLIPKPFDPRLIVKIAPAVAKAA
MDSGVATRPIKDFDAYIEKLTQFVYKTNLFMKPVFAQAKQNKKRVLLTDGEESRVLHAVQEIATLGIATPILLGRPSVIA
QKIKQLGLHIQEGRDFELVDIENNPYFEECYKTYHNLLKRKGITPAGAQRKMLHNPTVIGATLLQLGKADAMLCGLVGPY
ASHLSNIKEVIGVQPCVPTPATVNGLVLPTGNLFITDTFVNHNPTAQELAEITIMAANEVSRFGIEPKVALVSHSNFGTF
DDPSAVKMREVLHLVKEKAPDLIIDGEMHCDVALNEKLRQDIMPDSPLKGAANLLVMPNMEAARISLNLLQGTATPITVG
PILMGMNKPVHILTSASSVRRIINMVAIAAANVEPTCK

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI62420882, Length=343, Percent_Identity=27.4052478134111, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI62420880, Length=343, Percent_Identity=27.4052478134111, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI239049447, Length=343, Percent_Identity=27.4052478134111, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4505143, Length=389, Percent_Identity=25.4498714652956, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI4505145, Length=378, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI270265879, Length=325, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788806, Length=755, Percent_Identity=70.9933774834437, Blast_Score=1127, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=341, Percent_Identity=31.6715542521994, Blast_Score=162, Evalue=9e-41,
Organism=Escherichia coli, GI1788800, Length=313, Percent_Identity=32.5878594249201, Blast_Score=145, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17537199, Length=357, Percent_Identity=26.3305322128852, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=27.6119402985075, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356279, Length=506, Percent_Identity=25.8893280632411, Blast_Score=88, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281362674, Length=493, Percent_Identity=25.9634888438134, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281362672, Length=493, Percent_Identity=25.9634888438134, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646388, Length=345, Percent_Identity=27.2463768115942, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=27.2463768115942, Blast_Score=76, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81792; Mature: 81792

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAQLRQAALDFHEFPTPGKIEVTPTKSLATQRDLALAYSPGVAVPCLEIQADPAASYRY
CCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCEEEEECCCCCCEEEEEECCCCCCEEE
TSRGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGVNVFDIEIDERDPDKLV
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCHHHHH
DIIASLEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIISAAAILNGLRI
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHH
VKKDIAKVKLIASGAGAASIACLNLLVSLGLPRENIIVCDSKGVIFHGRDERMDETKKLY
HHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCCCCCEEE
AIEDNGKRTLAEVINDADIFLGCSAAGTLTQDMVKTMAANPLILALANPDPEILPPLAKA
EEECCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
VRPDAIVCTGRSDYPNQVNNVLCFPFIFRGALDVSATAINEEMKLAAVHAIADLALAEQS
CCCCEEEEECCCCCCHHHCCEEEEHHHHCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHH
EVVTSAYGETELSFGPEYLIPKPFDPRLIVKIAPAVAKAAMDSGVATRPIKDFDAYIEKL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHH
TQFVYKTNLFMKPVFAQAKQNKKRVLLTDGEESRVLHAVQEIATLGIATPILLGRPSVIA
HHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QKIKQLGLHIQEGRDFELVDIENNPYFEECYKTYHNLLKRKGITPAGAQRKMLHNPTVIG
HHHHHHCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHH
ATLLQLGKADAMLCGLVGPYASHLSNIKEVIGVQPCVPTPATVNGLVLPTGNLFITDTFV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEEEC
NHNPTAQELAEITIMAANEVSRFGIEPKVALVSHSNFGTFDDPSAVKMREVLHLVKEKAP
CCCCCHHHHHHEEEEECCHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
DLIIDGEMHCDVALNEKLRQDIMPDSPLKGAANLLVMPNMEAARISLNLLQGTATPITVG
CEEECCCEEECCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHEEEEEEECCCCCCEEEC
PILMGMNKPVHILTSASSVRRIINMVAIAAANVEPTCK
HHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDAQLRQAALDFHEFPTPGKIEVTPTKSLATQRDLALAYSPGVAVPCLEIQADPAASYRY
CCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCEEEEECCCCCCEEEEEECCCCCCEEE
TSRGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFAGVNVFDIEIDERDPDKLV
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCHHHHH
DIIASLEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIISAAAILNGLRI
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHH
VKKDIAKVKLIASGAGAASIACLNLLVSLGLPRENIIVCDSKGVIFHGRDERMDETKKLY
HHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCCCCCCCEEE
AIEDNGKRTLAEVINDADIFLGCSAAGTLTQDMVKTMAANPLILALANPDPEILPPLAKA
EEECCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
VRPDAIVCTGRSDYPNQVNNVLCFPFIFRGALDVSATAINEEMKLAAVHAIADLALAEQS
CCCCEEEEECCCCCCHHHCCEEEEHHHHCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHH
EVVTSAYGETELSFGPEYLIPKPFDPRLIVKIAPAVAKAAMDSGVATRPIKDFDAYIEKL
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHH
TQFVYKTNLFMKPVFAQAKQNKKRVLLTDGEESRVLHAVQEIATLGIATPILLGRPSVIA
HHHHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
QKIKQLGLHIQEGRDFELVDIENNPYFEECYKTYHNLLKRKGITPAGAQRKMLHNPTVIG
HHHHHHCCEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHH
ATLLQLGKADAMLCGLVGPYASHLSNIKEVIGVQPCVPTPATVNGLVLPTGNLFITDTFV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEEEC
NHNPTAQELAEITIMAANEVSRFGIEPKVALVSHSNFGTFDDPSAVKMREVLHLVKEKAP
CCCCCHHHHHHEEEEECCHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
DLIIDGEMHCDVALNEKLRQDIMPDSPLKGAANLLVMPNMEAARISLNLLQGTATPITVG
CEEECCCEEECCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHEEEEEEECCCCCCEEEC
PILMGMNKPVHILTSASSVRRIINMVAIAAANVEPTCK
HHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]