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Identifier: 15835531

GI number: 15835531

Start: 1069379

End: 1070035

Strand: Reverse

Name: Not Available

Synonym: TC0918

Alternate gene names: 15835531

Gene position: 1070035-1069379 (Counterclockwise)

Preceding gene: 15835532

Following gene: 15835530

Centisome position: 99.73

GC content: 40.64

Gene sequence:

>657_bases
GTGTTTAAATACCAGACTATGCTGTATCAGGAGCTTAGTATGGTTTTAGCTTCCTCTTTATTTTCCCCTGAAGAATTTCT
TTATCCAGAGATTGTGAGCCAGGCTGAATTTGTTTGGTCCATTTTAACTCTTTTGGAACAAAAGCTGTCTTCTCATTCTT
TTTCTGGAATACAAGGACATCTTGAAGAAGGTGTATATTTAAAAAACAAAGAGACCATCGAAATCCAGGAAGGAGCTTAT
GTGGAGTCGGGGGCATATCTTTGTGGCCCTTGTATTATCGGACCTTATACTCAAGTTCGTCACGGAGCTTATATTCGAGG
TGGAGTAATAACTGGTGCTCATTGTGTGGTTGGACACTGTTCTGAGATCAAAAATAGCTATTTAGGGCATTATGCGAAAG
CTGCTCACTTTGCTTATGTGGGAGATTCTGTTTTGGGCTCTCGGGTCAATTTAGGTGCAGGGGTTCGTTGCGCGAATTTT
CGATTGGATGGGGGTAACATTTTTCTCCGTTATTCTGGAGATCGCTATGATACACAGAGAAAGAAATTAGGCGCTTTCTT
GGGTAAGGGAGTGAGTATTGGGTGTAATACCGTACTTAATCCAGGATGTTGTGTGGTTAGTGCTACAAAGATTCTTCCTA
ATCAAACTATTTATTAG

Upstream 100 bases:

>100_bases
ATAGAATCGTCACTGTACGTGGAGTGGGGTATCTATTTTCCGATGACGAAGAGAAAAATTCTTCGCAAGAAGATACAAAG
CTTTCTTAAAACAACTAGGG

Downstream 100 bases:

>100_bases
GAGTAAATCTTTGTTGAGAGGACTTTGATGAGAAAAAGTAGGCGGTTGCTCAAATATGGATGATTTCAATGTTTATCGAT
CGAAAATAGAAAAAAGGCTC

Product: UDP-N-acetylglucosamine pyrophosphorylase GlmU-related enzyme

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MFKYQTMLYQELSMVLASSLFSPEEFLYPEIVSQAEFVWSILTLLEQKLSSHSFSGIQGHLEEGVYLKNKETIEIQEGAY
VESGAYLCGPCIIGPYTQVRHGAYIRGGVITGAHCVVGHCSEIKNSYLGHYAKAAHFAYVGDSVLGSRVNLGAGVRCANF
RLDGGNIFLRYSGDRYDTQRKKLGAFLGKGVSIGCNTVLNPGCCVVSATKILPNQTIY

Sequences:

>Translated_218_residues
MFKYQTMLYQELSMVLASSLFSPEEFLYPEIVSQAEFVWSILTLLEQKLSSHSFSGIQGHLEEGVYLKNKETIEIQEGAY
VESGAYLCGPCIIGPYTQVRHGAYIRGGVITGAHCVVGHCSEIKNSYLGHYAKAAHFAYVGDSVLGSRVNLGAGVRCANF
RLDGGNIFLRYSGDRYDTQRKKLGAFLGKGVSIGCNTVLNPGCCVVSATKILPNQTIY
>Mature_218_residues
MFKYQTMLYQELSMVLASSLFSPEEFLYPEIVSQAEFVWSILTLLEQKLSSHSFSGIQGHLEEGVYLKNKETIEIQEGAY
VESGAYLCGPCIIGPYTQVRHGAYIRGGVITGAHCVVGHCSEIKNSYLGHYAKAAHFAYVGDSVLGSRVNLGAGVRCANF
RLDGGNIFLRYSGDRYDTQRKKLGAFLGKGVSIGCNTVLNPGCCVVSATKILPNQTIY

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=123, Percent_Identity=37.3983739837398, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 23856; Mature: 23856

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKYQTMLYQELSMVLASSLFSPEEFLYPEIVSQAEFVWSILTLLEQKLSSHSFSGIQGH
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEEGVYLKNKETIEIQEGAYVESGAYLCGPCIIGPYTQVRHGAYIRGGVITGAHCVVGHC
HHCCEEECCCCEEEEECCCEEECCCEEECCEEECCHHHHHCCCEEECCEEECCHHHHHHH
SEIKNSYLGHYAKAAHFAYVGDSVLGSRVNLGAGVRCANFRLDGGNIFLRYSGDRYDTQR
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEEEECCCEEEEEECCCCCHHHH
KKLGAFLGKGVSIGCNTVLNPGCCVVSATKILPNQTIY
HHHHHHHCCCCEECCCCCCCCCCCEEEHHHHCCCCCCC
>Mature Secondary Structure
MFKYQTMLYQELSMVLASSLFSPEEFLYPEIVSQAEFVWSILTLLEQKLSSHSFSGIQGH
CCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
LEEGVYLKNKETIEIQEGAYVESGAYLCGPCIIGPYTQVRHGAYIRGGVITGAHCVVGHC
HHCCEEECCCCEEEEECCCEEECCCEEECCEEECCHHHHHCCCEEECCEEECCHHHHHHH
SEIKNSYLGHYAKAAHFAYVGDSVLGSRVNLGAGVRCANFRLDGGNIFLRYSGDRYDTQR
HHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCEEEEEEEECCCEEEEEECCCCCHHHH
KKLGAFLGKGVSIGCNTVLNPGCCVVSATKILPNQTIY
HHHHHHHCCCCEECCCCCCCCCCCEEEHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]