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The map label for this gene is folK/P

Identifier: 15835517

GI number: 15835517

Start: 1045368

End: 1046720

Strand: Reverse

Name: folK/P

Synonym: TC0903

Alternate gene names: 15835517

Gene position: 1046720-1045368 (Counterclockwise)

Preceding gene: 15835518

Following gene: 15835516

Centisome position: 97.56

GC content: 43.16

Gene sequence:

>1353_bases
GTGACTACTTGGAATTTTGTGTGTTTAGGGTTGGGTTCGAATTTGGGGAATCGCCATGAGTACATTAAACGTGCTTATGA
GAGTTTAAAGAAGGCAGGGATAAGAAATTTAAAAAGTTCCGTGATTCTTGAGACCAAAGCTTTGCTATTAGAAGGATCTC
CCAAAGAATGGGATCTTCCATATTTTAATTGCGTGGCTATTGGGGAAACACAGTTATCTCCAGATGAGCTGGTCAAAGAG
ATTAAAATGATTGAAAATAGGCTGAGCAGAGACTCTTCATTGAAATGGGGGCCTCGGTCTATTGACATAGATGTTCTTCT
TTATGGAGACGAGAGCTATTCTTGTTGTAGTGAAAGGTGCATAATTCCACATCCTAGGTTGTTAGAAAGGCCTTTCCTTC
TTTCAATGATGGCTTCCTTATGTCCTTATCGATACTTCCGTCTTAGGGGATCTCCTTATGATGGCAAAACGTTTGCAGAA
CTTGCTGCCATCTACCCATTAACAGAAAAGGATGTTCTGGGAAGCTTTGCTCCCACGACCCAAATTATGGGAATTGTCAA
CGTTACCGATGACTCGATATCAGATACAGGGCTATTCTTGGAGGCTAAAAGAGCGGCAGCACATGCAGAGCGTTTGTTTG
CAGAAGGGGCTTCCATTATTGATCTAGGAGCGCAAGCCACAAATCCTCGAGTAAGAGATTTAGGCAGTGTAGAACAGGAG
TGGGAGCGCCTAGAACCTGTTTTGCAGATACTAGCAGAGAGCTGGAAAGACGCTAAACAATACCCAGATGTATCGATAGA
TACTTTCAGACCAGAGGTCATTAGACGAGCTATCCAAGTATTTCCGATCCGTTGGATAAATGATGTTTCTGGAGGATCTT
TAGAAATGGCTCATTTAGCGAAGGATTTGGGATTACGGTTATTAATCAATCATTCCTGCTCTTTGCCCCCAAGGCCTGAT
TGTGTGCTTTCCTATGAAGAATCTCCTGTTACGCAAATGTTGCGTTGGGGGGAATCGCAGTTAGAAACTTTTGCTCAAAT
TGGTTTGGATACTAGCTGGCAGGTAGTTTTCGATCCAGGCATAGGATTTGGGAAAACTCCGGTTCAATCGATGCAGCTTA
TGGAGGGTGTGGCGAAGTTCAAGCACATTTTAAAGTGTCCTGTATTGATTGGACATTCTAGAAAATCCTGTTTAAGTCTT
TTGGGACGATTCAGCAGTCAAGATCGAGACTGGGAAACTATCGGATGTTCTGTGGCTCTTCATAATCAAGGTGTTGATTA
CTTGCGTGTACACCAAGTGGAAGGAAATAGACGCGTTCTAGCTGCTGCTGCATGGTCTGGAATGCCTGTATGA

Upstream 100 bases:

>100_bases
CACAATTTGTGTGTAAAATTGACCTGCGAGTAAGTAAAGAGCGTCCTCCAATTCCCAATTTATTAAGTCCAGTGAGTTTT
AGCATAAGTAAAGAGGTTCC

Downstream 100 bases:

>100_bases
TTCAAGCGACAGGAATCGTTGCTATAGATCCTCGAGGAGTTATGGGGGGGGCTGGAAAGCTCCCATGGAACTATCCAGAG
GATTTGCGTTTCTTTTCAGA

Product: 2-amino-4-hydroxy-6-hydroxymethyldihydropterin pyrophosphokinase/dihydropteroate synthase

Products: NA

Alternate protein names: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; Dihydropteroate synthase; DHPS; Dihydropteroate pyrophosphorylase

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTTWNFVCLGLGSNLGNRHEYIKRAYESLKKAGIRNLKSSVILETKALLLEGSPKEWDLPYFNCVAIGETQLSPDELVKE
IKMIENRLSRDSSLKWGPRSIDIDVLLYGDESYSCCSERCIIPHPRLLERPFLLSMMASLCPYRYFRLRGSPYDGKTFAE
LAAIYPLTEKDVLGSFAPTTQIMGIVNVTDDSISDTGLFLEAKRAAAHAERLFAEGASIIDLGAQATNPRVRDLGSVEQE
WERLEPVLQILAESWKDAKQYPDVSIDTFRPEVIRRAIQVFPIRWINDVSGGSLEMAHLAKDLGLRLLINHSCSLPPRPD
CVLSYEESPVTQMLRWGESQLETFAQIGLDTSWQVVFDPGIGFGKTPVQSMQLMEGVAKFKHILKCPVLIGHSRKSCLSL
LGRFSSQDRDWETIGCSVALHNQGVDYLRVHQVEGNRRVLAAAAWSGMPV

Sequences:

>Translated_450_residues
MTTWNFVCLGLGSNLGNRHEYIKRAYESLKKAGIRNLKSSVILETKALLLEGSPKEWDLPYFNCVAIGETQLSPDELVKE
IKMIENRLSRDSSLKWGPRSIDIDVLLYGDESYSCCSERCIIPHPRLLERPFLLSMMASLCPYRYFRLRGSPYDGKTFAE
LAAIYPLTEKDVLGSFAPTTQIMGIVNVTDDSISDTGLFLEAKRAAAHAERLFAEGASIIDLGAQATNPRVRDLGSVEQE
WERLEPVLQILAESWKDAKQYPDVSIDTFRPEVIRRAIQVFPIRWINDVSGGSLEMAHLAKDLGLRLLINHSCSLPPRPD
CVLSYEESPVTQMLRWGESQLETFAQIGLDTSWQVVFDPGIGFGKTPVQSMQLMEGVAKFKHILKCPVLIGHSRKSCLSL
LGRFSSQDRDWETIGCSVALHNQGVDYLRVHQVEGNRRVLAAAAWSGMPV
>Mature_449_residues
TTWNFVCLGLGSNLGNRHEYIKRAYESLKKAGIRNLKSSVILETKALLLEGSPKEWDLPYFNCVAIGETQLSPDELVKEI
KMIENRLSRDSSLKWGPRSIDIDVLLYGDESYSCCSERCIIPHPRLLERPFLLSMMASLCPYRYFRLRGSPYDGKTFAEL
AAIYPLTEKDVLGSFAPTTQIMGIVNVTDDSISDTGLFLEAKRAAAHAERLFAEGASIIDLGAQATNPRVRDLGSVEQEW
ERLEPVLQILAESWKDAKQYPDVSIDTFRPEVIRRAIQVFPIRWINDVSGGSLEMAHLAKDLGLRLLINHSCSLPPRPDC
VLSYEESPVTQMLRWGESQLETFAQIGLDTSWQVVFDPGIGFGKTPVQSMQLMEGVAKFKHILKCPVLIGHSRKSCLSLL
GRFSSQDRDWETIGCSVALHNQGVDYLRVHQVEGNRRVLAAAAWSGMPV

Specific function: Dhps Catalyzes The Formation Of The Immediate Precursor Of Folic Acid. It Is Implicated In Resistance To Sulfonamide. [C]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain

Homologues:

Organism=Escherichia coli, GI87082224, Length=261, Percent_Identity=32.5670498084291, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324073, Length=541, Percent_Identity=25.8780036968577, Blast_Score=126, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLKP_CHLMU (P82602)

Other databases:

- EMBL:   AE002160
- PIR:   G81652
- RefSeq:   NP_297276.1
- ProteinModelPortal:   P82602
- SMR:   P82602
- GeneID:   1246272
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0903
- TIGR:   TC_0903
- HOGENOM:   HBG665963
- OMA:   QATNPKV
- PhylomeDB:   P82602
- ProtClustDB:   CLSK871487
- BioCyc:   CMUR243161:TC_0903-MONOMER
- BRENDA:   2.5.1.15
- BRENDA:   2.7.6.3
- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000550
- InterPro:   IPR000489
- Gene3D:   G3DSA:3.20.20.20
- Gene3D:   G3DSA:3.30.70.560
- PANTHER:   PTHR20941:SF1
- TIGRFAMs:   TIGR01496
- TIGRFAMs:   TIGR01498

Pfam domain/function: PF01288 HPPK; PF00809 Pterin_bind; SSF51717 DHP_synth_like; SSF55083 Hppk

EC number: =2.7.6.3; =2.5.1.15

Molecular weight: Translated: 50449; Mature: 50317

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00792 DHPS_1; PS00793 DHPS_2; PS00794 HPPK; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTWNFVCLGLGSNLGNRHEYIKRAYESLKKAGIRNLKSSVILETKALLLEGSPKEWDLP
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCC
YFNCVAIGETQLSPDELVKEIKMIENRLSRDSSLKWGPRSIDIDVLLYGDESYSCCSERC
CEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHCCC
IIPHPRLLERPFLLSMMASLCPYRYFRLRGSPYDGKTFAELAAIYPLTEKDVLGSFAPTT
CCCCCHHHCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHCCCCCHH
QIMGIVNVTDDSISDTGLFLEAKRAAAHAERLFAEGASIIDLGAQATNPRVRDLGSVEQE
HEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHCCHHHHH
WERLEPVLQILAESWKDAKQYPDVSIDTFRPEVIRRAIQVFPIRWINDVSGGSLEMAHLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCHHHHHH
KDLGLRLLINHSCSLPPRPDCVLSYEESPVTQMLRWGESQLETFAQIGLDTSWQVVFDPG
HHCCEEEEEECCCCCCCCCCEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECC
IGFGKTPVQSMQLMEGVAKFKHILKCPVLIGHSRKSCLSLLGRFSSQDRDWETIGCSVAL
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEE
HNQGVDYLRVHQVEGNRRVLAAAAWSGMPV
ECCCCCEEEEEEECCCCEEEEEECCCCCCC
>Mature Secondary Structure 
TTWNFVCLGLGSNLGNRHEYIKRAYESLKKAGIRNLKSSVILETKALLLEGSPKEWDLP
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCC
YFNCVAIGETQLSPDELVKEIKMIENRLSRDSSLKWGPRSIDIDVLLYGDESYSCCSERC
CEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHCCC
IIPHPRLLERPFLLSMMASLCPYRYFRLRGSPYDGKTFAELAAIYPLTEKDVLGSFAPTT
CCCCCHHHCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHCCCCCHH
QIMGIVNVTDDSISDTGLFLEAKRAAAHAERLFAEGASIIDLGAQATNPRVRDLGSVEQE
HEEEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHCCHHHHH
WERLEPVLQILAESWKDAKQYPDVSIDTFRPEVIRRAIQVFPIRWINDVSGGSLEMAHLA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCHHHHHH
KDLGLRLLINHSCSLPPRPDCVLSYEESPVTQMLRWGESQLETFAQIGLDTSWQVVFDPG
HHCCEEEEEECCCCCCCCCCEEEECCCCHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECC
IGFGKTPVQSMQLMEGVAKFKHILKCPVLIGHSRKSCLSLLGRFSSQDRDWETIGCSVAL
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEE
HNQGVDYLRVHQVEGNRRVLAAAAWSGMPV
ECCCCCEEEEEEECCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935