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The map label for this gene is ung

Identifier: 15835511

GI number: 15835511

Start: 1039418

End: 1040107

Strand: Reverse

Name: ung

Synonym: TC0897

Alternate gene names: 15835511

Gene position: 1040107-1039418 (Counterclockwise)

Preceding gene: 15835514

Following gene: 15835510

Centisome position: 96.94

GC content: 42.17

Gene sequence:

>690_bases
ATGCATGAGGCTTTTACTATAGAGCAACTCCCCCAGTCTTGGCAAGAACAGCTTAAAGATGAGTGGTCCCAGCCATATTG
GTCTCAGCTGCTTACTTTTTTAAAGAGCGAGTATGCGAATGCCACTGTCTATCCTAAAAAGGAGCATGTGTTTTCTGCTT
TGCGAAGCACACCTTTTGATCAAGTGAAAGTAGTTATTCTTGGACAGGATCCTTATCATGGAGAAGGGCAGGCGCATGGA
TTAAGTTTTAGCGTTCCGAAGGGGCAGGCGTTGCCTCCTTCGCTGAGAAATATTTTTCAGGAATTGCAAGCCGATTTGGG
TATCCGTAATGAAACCGGATGTTTACAAACATGGGCGGATCAAGGAGTCCTCCTTTTGAATACGGTATTGACGGTTCGCG
CTGGAGAAGCTTTTTCTCATGCCGGACGCGGATGGGAACATTTTACTGATGCTATTGTCACTAAATTAATTCAAAATAGA
ACTCACATAATTTTTGTTTTATGGGGAAGTGCTGCAAGAAAAAAATGCGATCTTCTTTTTCAAACTAAGCACCAACATGC
GATTCTGGCTTGTCCTCATCCTTCACCATTAGCTGCGCATAGAGGATTCTTTGGATGTTGCCACTTTTCAAAAATTAATT
ATCTGCTTAAAAAACAGGGAAAGCCGATGATTAATTGGAAGATAGCATGA

Upstream 100 bases:

>100_bases
TTTAATTCGGATGTAAGCATACGTACGTAATATATTTTTCAGGTTCGAAGAAAATTTTCGAGAATGCATATACTCTATGC
ATTAGATTAAGGAGAGCGAT

Downstream 100 bases:

>100_bases
TCGACGGGATTCAAACGTGTTCTTTCGGAGCTACGCATCGTCTCACTGCGAAATCTACAGTGAGTTTAGAGATGCCTTTA
GCAACGCATAATCTTCAAGA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MHEAFTIEQLPQSWQEQLKDEWSQPYWSQLLTFLKSEYANATVYPKKEHVFSALRSTPFDQVKVVILGQDPYHGEGQAHG
LSFSVPKGQALPPSLRNIFQELQADLGIRNETGCLQTWADQGVLLLNTVLTVRAGEAFSHAGRGWEHFTDAIVTKLIQNR
THIIFVLWGSAARKKCDLLFQTKHQHAILACPHPSPLAAHRGFFGCCHFSKINYLLKKQGKPMINWKIA

Sequences:

>Translated_229_residues
MHEAFTIEQLPQSWQEQLKDEWSQPYWSQLLTFLKSEYANATVYPKKEHVFSALRSTPFDQVKVVILGQDPYHGEGQAHG
LSFSVPKGQALPPSLRNIFQELQADLGIRNETGCLQTWADQGVLLLNTVLTVRAGEAFSHAGRGWEHFTDAIVTKLIQNR
THIIFVLWGSAARKKCDLLFQTKHQHAILACPHPSPLAAHRGFFGCCHFSKINYLLKKQGKPMINWKIA
>Mature_229_residues
MHEAFTIEQLPQSWQEQLKDEWSQPYWSQLLTFLKSEYANATVYPKKEHVFSALRSTPFDQVKVVILGQDPYHGEGQAHG
LSFSVPKGQALPPSLRNIFQELQADLGIRNETGCLQTWADQGVLLLNTVLTVRAGEAFSHAGRGWEHFTDAIVTKLIQNR
THIIFVLWGSAARKKCDLLFQTKHQHAILACPHPSPLAAHRGFFGCCHFSKINYLLKKQGKPMINWKIA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=218, Percent_Identity=50.9174311926605, Blast_Score=214, Evalue=6e-56,
Organism=Homo sapiens, GI6224979, Length=218, Percent_Identity=50.9174311926605, Blast_Score=213, Evalue=1e-55,
Organism=Escherichia coli, GI1788934, Length=217, Percent_Identity=51.6129032258064, Blast_Score=221, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17556304, Length=219, Percent_Identity=45.2054794520548, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6323620, Length=241, Percent_Identity=43.9834024896266, Blast_Score=197, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_CHLMU (Q9PJD2)

Other databases:

- EMBL:   AE002160
- PIR:   B81652
- RefSeq:   NP_297270.1
- ProteinModelPortal:   Q9PJD2
- SMR:   Q9PJD2
- GeneID:   1246266
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0897
- TIGR:   TC_0897
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   Q9PJD2
- ProtClustDB:   PRK05254
- BioCyc:   CMUR243161:TC_0897-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25972; Mature: 25972

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEAFTIEQLPQSWQEQLKDEWSQPYWSQLLTFLKSEYANATVYPKKEHVFSALRSTPFD
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCC
QVKVVILGQDPYHGEGQAHGLSFSVPKGQALPPSLRNIFQELQADLGIRNETGCLQTWAD
CEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHC
QGVLLLNTVLTVRAGEAFSHAGRGWEHFTDAIVTKLIQNRTHIIFVLWGSAARKKCDLLF
CCEEEEHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHE
QTKHQHAILACPHPSPLAAHRGFFGCCHFSKINYLLKKQGKPMINWKIA
ECCCCCEEEECCCCCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MHEAFTIEQLPQSWQEQLKDEWSQPYWSQLLTFLKSEYANATVYPKKEHVFSALRSTPFD
CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCC
QVKVVILGQDPYHGEGQAHGLSFSVPKGQALPPSLRNIFQELQADLGIRNETGCLQTWAD
CEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHC
QGVLLLNTVLTVRAGEAFSHAGRGWEHFTDAIVTKLIQNRTHIIFVLWGSAARKKCDLLF
CCEEEEHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHE
QTKHQHAILACPHPSPLAAHRGFFGCCHFSKINYLLKKQGKPMINWKIA
ECCCCCEEEECCCCCCHHHHCCCCEEEHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935