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Identifier: 15835509

GI number: 15835509

Start: 1038591

End: 1039220

Strand: Direct

Name: Not Available

Synonym: TC0895

Alternate gene names: 15835509

Gene position: 1038591-1039220 (Clockwise)

Preceding gene: 15835505

Following gene: 15835512

Centisome position: 96.8

GC content: 41.43

Gene sequence:

>630_bases
ATGAAAATTCTTATAGCCAGTTCCCATGGATATAAGGTACGCGAAACCAAAGCTTTTCTAAAAAAAATAGGAGAGTTTGA
CATCTTCTCTTTAGTGGACTACCCCTCTTACACCCCTCCTAAAGAGACTGGTGAAACTCCAGAAGAAAATGCGATTCAAA
AAGGAGTATTTGCTGCCCAAACCTTCCGGTGTTGGACAATTGCTGATGATTCTATGCTAATCATTCCTGCTTTAGGAGGC
CTTCCAGGGAAACTATCTGCCTCCTTTTCAGGAGAGCACGCTAGCGATAAAGATCACCGTAAAAAGCTTCTGGAGGAAAT
GCTTCTTTTAGAAAATCCTATTGATCGATCCGCTTATTTTGAATGCTGTGTTGTTCTCGTCTCCCCTTTTGGGAAGATCT
TCAAAGCTCACGCTTCTTGTGAAGGAACCATTGTCTTTAAAGAGAGAGGGTCTTCTGGATTTGGATATGATCCGTTATTT
TCAAAGCATGATTACAAACAAACGTACGCGGAACTTCCAGAAGAAATCAAAAACCAGGTATCCCATAGAGCAAAAGCCTT
AGCTAAGTTACAGCCCTACGTAGAAATGGCTTTTGCTAATCACTTACTCGCGAGGAATGAGAGTCTCTAA

Upstream 100 bases:

>100_bases
AAAAAGCTTGGTGAAAGAAAATTCTTGTCGACGCTATCATCCCATACCATACTCTCTGTAGATAAACACACGTTGATTAT
TTGTTATCTAAAGGATTTTT

Downstream 100 bases:

>100_bases
GGACTGCTCTAGGCTAGAACGAATTTCTTGCATTTCAGCAAGAATCTGCTCTGCCCGAATGAAATCTGCTTCCAGCTTTG
CACTTGCTGAAGCCCCCTCT

Product: putative deoxyribonucleotide triphosphate pyrophosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MKILIASSHGYKVRETKAFLKKIGEFDIFSLVDYPSYTPPKETGETPEENAIQKGVFAAQTFRCWTIADDSMLIIPALGG
LPGKLSASFSGEHASDKDHRKKLLEEMLLLENPIDRSAYFECCVVLVSPFGKIFKAHASCEGTIVFKERGSSGFGYDPLF
SKHDYKQTYAELPEEIKNQVSHRAKALAKLQPYVEMAFANHLLARNESL

Sequences:

>Translated_209_residues
MKILIASSHGYKVRETKAFLKKIGEFDIFSLVDYPSYTPPKETGETPEENAIQKGVFAAQTFRCWTIADDSMLIIPALGG
LPGKLSASFSGEHASDKDHRKKLLEEMLLLENPIDRSAYFECCVVLVSPFGKIFKAHASCEGTIVFKERGSSGFGYDPLF
SKHDYKQTYAELPEEIKNQVSHRAKALAKLQPYVEMAFANHLLARNESL
>Mature_209_residues
MKILIASSHGYKVRETKAFLKKIGEFDIFSLVDYPSYTPPKETGETPEENAIQKGVFAAQTFRCWTIADDSMLIIPALGG
LPGKLSASFSGEHASDKDHRKKLLEEMLLLENPIDRSAYFECCVVLVSPFGKIFKAHASCEGTIVFKERGSSGFGYDPLF
SKHDYKQTYAELPEEIKNQVSHRAKALAKLQPYVEMAFANHLLARNESL

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=198, Percent_Identity=33.8383838383838, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI31657144, Length=167, Percent_Identity=36.5269461077844, Blast_Score=78, Evalue=7e-15,
Organism=Escherichia coli, GI1789324, Length=196, Percent_Identity=39.2857142857143, Blast_Score=107, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17556833, Length=196, Percent_Identity=31.1224489795918, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19920712, Length=153, Percent_Identity=35.9477124183007, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_CHLMU (Q9PJD4)

Other databases:

- EMBL:   AE002160
- PIR:   H81651
- RefSeq:   NP_297268.1
- ProteinModelPortal:   Q9PJD4
- SMR:   Q9PJD4
- GeneID:   1246264
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0895
- TIGR:   TC_0895
- HOGENOM:   HBG697237
- OMA:   ESSTRLT
- ProtClustDB:   PRK00120
- BioCyc:   CMUR243161:TC_0895-MONOMER
- BRENDA:   3.6.1.15
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 23383; Mature: 23383

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIASSHGYKVRETKAFLKKIGEFDIFSLVDYPSYTPPKETGETPEENAIQKGVFAAQ
CEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
TFRCWTIADDSMLIIPALGGLPGKLSASFSGEHASDKDHRKKLLEEMLLLENPIDRSAYF
HEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
ECCVVLVSPFGKIFKAHASCEGTIVFKERGSSGFGYDPLFSKHDYKQTYAELPEEIKNQV
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SHRAKALAKLQPYVEMAFANHLLARNESL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKILIASSHGYKVRETKAFLKKIGEFDIFSLVDYPSYTPPKETGETPEENAIQKGVFAAQ
CEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
TFRCWTIADDSMLIIPALGGLPGKLSASFSGEHASDKDHRKKLLEEMLLLENPIDRSAYF
HEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
ECCVVLVSPFGKIFKAHASCEGTIVFKERGSSGFGYDPLFSKHDYKQTYAELPEEIKNQV
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SHRAKALAKLQPYVEMAFANHLLARNESL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935