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The map label for this gene is groEL-2

Identifier: 15835507

GI number: 15835507

Start: 1035482

End: 1037086

Strand: Reverse

Name: groEL-2

Synonym: TC0893

Alternate gene names: 15835507

Gene position: 1037086-1035482 (Counterclockwise)

Preceding gene: 15835508

Following gene: 15835506

Centisome position: 96.66

GC content: 42.46

Gene sequence:

>1605_bases
GTGGCCAATAGCTTTCGTAACCAACAACAGGGTCTACAGGCAGTTCTTAGTGCCGCGCGTGTGATATCTCAAATGTTCTC
TCAGACAATCGGTCCATATAGATTCGGAACCATTGTTCATAATGTTCAGAAACCTCAAATTACCCTAGATAGTCAGCGAA
TGCTTAAAGATGTTCTTTCATCTGACGTCTTTGAAAATATGGGGATGAAACTGATTCGAGATGCGGCCTTGCAAACGCGG
AACCGCTGTGGAGACGGAGCAAAAACAACGGCTTTGTTAATAGAGGCTTTATTAGAAGAGGGGTTAGCAGGTATTCAAAG
AGGAGTGGATCCGCAAGAATTTCGTAAAGGGATGCTTCTTGCTGAAAAGAAAATCCAAAAGATTTTTTACAGAGAAGCCT
TTTCTATAACGGATCTTGAACATTTGGTCTGCGTGTCCAATGTAGCACGGCGTTTCAATGCAGATATAGCGTCTGTTTTG
TCTAGCGCTGTTCGCTATGGAGGGGGAAATGGTTATTATATTTTAGAAGAAAAGGAGGGAGAGAGCTCTCATTGGTTTGC
AGAAGAGCATTCTGTATGGGATTTTGGATATGCTTCTCCCTATTTCATCACTCATGCTGAAACTGGAACTGTAGAGTATA
GTCAAGTCTATATTCTCGTTAGTGAAAGTCCTTTACATTCTTCTGATCAGGCTTTTTTAGCATTTCTTGAAGCGGTTGTG
CAGGCAGGGAAAACTCCTCTTGTTATTTTAGCAGAAGCTTTTGATCGAGATCTATTGGCTACACTAGAGATTAACCAAAT
AGAAGGCGGTTTCCCTGTTTGTGCGGTGCGTGTGGGAGGAAAGCATGCTCGAGAATCTTTAGAAGACATTGCGGTATTAA
CTGGAGCAAGCTTGTTATCAGAAGCTTCTTTTGGAGAAATCTCGGCAGAGCGTATTACGAATCACTTAGGATTTGTAGAA
GGAATTTGTATTTCTTCAACAAGCTTGTGCATTCCAAGGGAAGTAGCCAATAAGAAAAGATTAGCGGCGCATTGTTCCTT
ATTGCAGGATAAATTAGAGCATTTACATGGAGAAGAGTCTCGGGCTTGGTTGAGGAAGCGATTGGCTAGACTTTCATCGG
GGGAGGTGCGCATTTGCATTGCTGAGGAATCCGTTAATCAGGAAGAGTTGGCTNACATGACTTCCTCTGTAAAAGCTATG
ACTGAATTGTTGCGATCAGGATGTTTACCGGGAGGAGGATGTTCCTTAATTCGTGCTGCTAGAGGAGTTCCGGTTCCCTT
ATCTCTTTCTAATGGAGAGCGAGCGGGGTTTCTTGCAGTGCTCCATGCTGTAGAAAGACCTTTTCGTGCCGTTGTTGCTA
GAAGCGGTAAACCTGTAGACGAAGTGTTTTCTCAAGTTTTTTCTAATGCAGACTGGCGTATAGGATTTAACGGTCTAACT
GGATCTGTAGAAGATATTGTTGCTCAAGGAATTTGTGATGGCTTGTCTTGCATTCAGCATGCTTTACATCATGCAGTAGG
AACTGTGGGTTTATTGTTAATATCTGCCTTGTTTTTTGCTTCTCAAGAGGAAACTTTTAAAGAAGAAGAGAGCTACGAAG
AATAG

Upstream 100 bases:

>100_bases
TTGCAGAATATACCCAACAGTAATGAGAGGTATGTTTGACAAGAATAAATAGCATTTCTATATCCGAGACAAAATACTGC
ATCTGATAGAGGAGCTGGGT

Downstream 100 bases:

>100_bases
GAACTGGTTTTATAAAAAAACTTTGATTCAAGATTTTTTCTTTTTCTAAGGAGAATTACTTGATCATTTAGCAGAAGCGA
GGTATTCTTCTCCCTAAAGT

Product: 60 kDa chaperonin

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MANSFRNQQQGLQAVLSAARVISQMFSQTIGPYRFGTIVHNVQKPQITLDSQRMLKDVLSSDVFENMGMKLIRDAALQTR
NRCGDGAKTTALLIEALLEEGLAGIQRGVDPQEFRKGMLLAEKKIQKIFYREAFSITDLEHLVCVSNVARRFNADIASVL
SSAVRYGGGNGYYILEEKEGESSHWFAEEHSVWDFGYASPYFITHAETGTVEYSQVYILVSESPLHSSDQAFLAFLEAVV
QAGKTPLVILAEAFDRDLLATLEINQIEGGFPVCAVRVGGKHARESLEDIAVLTGASLLSEASFGEISAERITNHLGFVE
GICISSTSLCIPREVANKKRLAAHCSLLQDKLEHLHGEESRAWLRKRLARLSSGEVRICIAEESVNQEELAXMTSSVKAM
TELLRSGCLPGGGCSLIRAARGVPVPLSLSNGERAGFLAVLHAVERPFRAVVARSGKPVDEVFSQVFSNADWRIGFNGLT
GSVEDIVAQGICDGLSCIQHALHHAVGTVGLLLISALFFASQEETFKEEESYEE

Sequences:

>Translated_534_residues
MANSFRNQQQGLQAVLSAARVISQMFSQTIGPYRFGTIVHNVQKPQITLDSQRMLKDVLSSDVFENMGMKLIRDAALQTR
NRCGDGAKTTALLIEALLEEGLAGIQRGVDPQEFRKGMLLAEKKIQKIFYREAFSITDLEHLVCVSNVARRFNADIASVL
SSAVRYGGGNGYYILEEKEGESSHWFAEEHSVWDFGYASPYFITHAETGTVEYSQVYILVSESPLHSSDQAFLAFLEAVV
QAGKTPLVILAEAFDRDLLATLEINQIEGGFPVCAVRVGGKHARESLEDIAVLTGASLLSEASFGEISAERITNHLGFVE
GICISSTSLCIPREVANKKRLAAHCSLLQDKLEHLHGEESRAWLRKRLARLSSGEVRICIAEESVNQEELAXMTSSVKAM
TELLRSGCLPGGGCSLIRAARGVPVPLSLSNGERAGFLAVLHAVERPFRAVVARSGKPVDEVFSQVFSNADWRIGFNGLT
GSVEDIVAQGICDGLSCIQHALHHAVGTVGLLLISALFFASQEETFKEEESYEE
>Mature_533_residues
ANSFRNQQQGLQAVLSAARVISQMFSQTIGPYRFGTIVHNVQKPQITLDSQRMLKDVLSSDVFENMGMKLIRDAALQTRN
RCGDGAKTTALLIEALLEEGLAGIQRGVDPQEFRKGMLLAEKKIQKIFYREAFSITDLEHLVCVSNVARRFNADIASVLS
SAVRYGGGNGYYILEEKEGESSHWFAEEHSVWDFGYASPYFITHAETGTVEYSQVYILVSESPLHSSDQAFLAFLEAVVQ
AGKTPLVILAEAFDRDLLATLEINQIEGGFPVCAVRVGGKHARESLEDIAVLTGASLLSEASFGEISAERITNHLGFVEG
ICISSTSLCIPREVANKKRLAAHCSLLQDKLEHLHGEESRAWLRKRLARLSSGEVRICIAEESVNQEELAXMTSSVKAMT
ELLRSGCLPGGGCSLIRAARGVPVPLSLSNGERAGFLAVLHAVERPFRAVVARSGKPVDEVFSQVFSNADWRIGFNGLTG
SVEDIVAQGICDGLSCIQHALHHAVGTVGLLLISALFFASQEETFKEEESYEE

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=524, Percent_Identity=24.8091603053435, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI31542947, Length=524, Percent_Identity=24.8091603053435, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1790586, Length=507, Percent_Identity=26.8244575936884, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17555558, Length=509, Percent_Identity=26.7190569744597, Blast_Score=189, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=26.1450381679389, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24641193, Length=505, Percent_Identity=25.9405940594059, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24641191, Length=505, Percent_Identity=25.9405940594059, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45550936, Length=505, Percent_Identity=24.950495049505, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI45550132, Length=505, Percent_Identity=24.950495049505, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI45550935, Length=505, Percent_Identity=24.950495049505, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI17864606, Length=500, Percent_Identity=24.2, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24584129, Length=537, Percent_Identity=23.6499068901304, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19921262, Length=537, Percent_Identity=23.6499068901304, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58313; Mature: 58182

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANSFRNQQQGLQAVLSAARVISQMFSQTIGPYRFGTIVHNVQKPQITLDSQRMLKDVLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECHHHHHHHHHH
SDVFENMGMKLIRDAALQTRNRCGDGAKTTALLIEALLEEGLAGIQRGVDPQEFRKGMLL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AEKKIQKIFYREAFSITDLEHLVCVSNVARRFNADIASVLSSAVRYGGGNGYYILEEKEG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCC
ESSHWFAEEHSVWDFGYASPYFITHAETGTVEYSQVYILVSESPLHSSDQAFLAFLEAVV
CCCCCCCCCCCCEECCCCCCEEEEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHH
QAGKTPLVILAEAFDRDLLATLEINQIEGGFPVCAVRVGGKHARESLEDIAVLTGASLLS
HCCCCCEEEEECHHCCHHEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
EASFGEISAERITNHLGFVEGICISSTSLCIPREVANKKRLAAHCSLLQDKLEHLHGEES
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RAWLRKRLARLSSGEVRICIAEESVNQEELAXMTSSVKAMTELLRSGCLPGGGCSLIRAA
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
RGVPVPLSLSNGERAGFLAVLHAVERPFRAVVARSGKPVDEVFSQVFSNADWRIGFNGLT
CCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECCCCC
GSVEDIVAQGICDGLSCIQHALHHAVGTVGLLLISALFFASQEETFKEEESYEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure 
ANSFRNQQQGLQAVLSAARVISQMFSQTIGPYRFGTIVHNVQKPQITLDSQRMLKDVLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECHHHHHHHHHH
SDVFENMGMKLIRDAALQTRNRCGDGAKTTALLIEALLEEGLAGIQRGVDPQEFRKGMLL
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
AEKKIQKIFYREAFSITDLEHLVCVSNVARRFNADIASVLSSAVRYGGGNGYYILEEKEG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCC
ESSHWFAEEHSVWDFGYASPYFITHAETGTVEYSQVYILVSESPLHSSDQAFLAFLEAVV
CCCCCCCCCCCCEECCCCCCEEEEECCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHH
QAGKTPLVILAEAFDRDLLATLEINQIEGGFPVCAVRVGGKHARESLEDIAVLTGASLLS
HCCCCCEEEEECHHCCHHEEEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
EASFGEISAERITNHLGFVEGICISSTSLCIPREVANKKRLAAHCSLLQDKLEHLHGEES
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
RAWLRKRLARLSSGEVRICIAEESVNQEELAXMTSSVKAMTELLRSGCLPGGGCSLIRAA
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
RGVPVPLSLSNGERAGFLAVLHAVERPFRAVVARSGKPVDEVFSQVFSNADWRIGFNGLT
CCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEECCCCC
GSVEDIVAQGICDGLSCIQHALHHAVGTVGLLLISALFFASQEETFKEEESYEE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]