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Identifier: 15835506

GI number: 15835506

Start: 1034691

End: 1035278

Strand: Reverse

Name: Not Available

Synonym: TC0892

Alternate gene names: 15835506

Gene position: 1035278-1034691 (Counterclockwise)

Preceding gene: 15835507

Following gene: 15835498

Centisome position: 96.49

GC content: 42.52

Gene sequence:

>588_bases
ATGGGATCACTAGTTGGAAAGCAAGCTCCGGATTTTTCGGGCAAAGCGATTGTATGTGGAGAGGAGAAGGAGATTTCTCT
TTCTGATTTCCGTGGTAAATATGTGATTCTTTTCTTTTATCCTAAAGATTTTACCTACGTTTGCCCAACAGAGTTGCATG
CTTTTCAAGATAGATTAGGTGATTTTGAAGAGCGTGGCGCGGTTGTGATTGGGTGCTCAGTTGATGATATAGAGACGCAC
TCTCGTTGGCTAGCAGTAGAAAGAAGAGCGGGAGGAATACAAGGGACCCAATATCCTTTGTTAGCTGATGACTCTTTAGA
AATATCTAAGGCTTTCGGGGTTTTGAATCCTGAAGGGTCTGTTGCCTTAAGAGCGACTTTTTTGATCGATAAAGATGGGG
TTATTCGGCACGCAGTTATTAATGATCTTCCTCTAGGACGTTCAATAGAAGAGGAGCTTCGTGTTTTGGACTCGCAGATT
TTCTTTGAGAATCATGGCATGGTTTGCCCAGCAAACTGGCAATCTGGAGAACGTGGTATGGTGCCTTCTGAAGAAGGACT
AAAAGAATATTTCCAGACGATAGATTAA

Upstream 100 bases:

>100_bases
CTATGCACCAGTAGCTCAGTGGATAGAGTACCTGGCTACGAACCAGGTGGTCAGAGGTTCAAATCCTCTCTGGTGCGTTT
TTTCTTCTGGGAGGAGTACC

Downstream 100 bases:

>100_bases
GTGTCTTGAAAGGTCAGAAAATCGTACAGGTCTTGGTCGGAAAAGAGGAGAATACTTTTTAGTTTTCGACAAAGAGCTAG
AGAAGCTTCGATTACGTTGT

Product: anti-oxidant AhpCTSA family protein

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MGSLVGKQAPDFSGKAIVCGEEKEISLSDFRGKYVILFFYPKDFTYVCPTELHAFQDRLGDFEERGAVVIGCSVDDIETH
SRWLAVERRAGGIQGTQYPLLADDSLEISKAFGVLNPEGSVALRATFLIDKDGVIRHAVINDLPLGRSIEEELRVLDSQI
FFENHGMVCPANWQSGERGMVPSEEGLKEYFQTID

Sequences:

>Translated_195_residues
MGSLVGKQAPDFSGKAIVCGEEKEISLSDFRGKYVILFFYPKDFTYVCPTELHAFQDRLGDFEERGAVVIGCSVDDIETH
SRWLAVERRAGGIQGTQYPLLADDSLEISKAFGVLNPEGSVALRATFLIDKDGVIRHAVINDLPLGRSIEEELRVLDSQI
FFENHGMVCPANWQSGERGMVPSEEGLKEYFQTID
>Mature_194_residues
GSLVGKQAPDFSGKAIVCGEEKEISLSDFRGKYVILFFYPKDFTYVCPTELHAFQDRLGDFEERGAVVIGCSVDDIETHS
RWLAVERRAGGIQGTQYPLLADDSLEISKAFGVLNPEGSVALRATFLIDKDGVIRHAVINDLPLGRSIEEELRVLDSQIF
FENHGMVCPANWQSGERGMVPSEEGLKEYFQTID

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5802974, Length=191, Percent_Identity=46.0732984293194, Blast_Score=189, Evalue=1e-48,
Organism=Homo sapiens, GI32483377, Length=188, Percent_Identity=46.8085106382979, Blast_Score=189, Evalue=1e-48,
Organism=Homo sapiens, GI32189392, Length=188, Percent_Identity=46.8085106382979, Blast_Score=188, Evalue=3e-48,
Organism=Homo sapiens, GI5453549, Length=191, Percent_Identity=43.455497382199, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI4505591, Length=188, Percent_Identity=42.5531914893617, Blast_Score=174, Evalue=4e-44,
Organism=Homo sapiens, GI32455266, Length=188, Percent_Identity=42.5531914893617, Blast_Score=174, Evalue=4e-44,
Organism=Homo sapiens, GI32455264, Length=188, Percent_Identity=42.5531914893617, Blast_Score=174, Evalue=4e-44,
Organism=Homo sapiens, GI33188454, Length=79, Percent_Identity=56.9620253164557, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4758638, Length=203, Percent_Identity=28.0788177339901, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI1786822, Length=182, Percent_Identity=31.8681318681319, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1788825, Length=139, Percent_Identity=29.4964028776978, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193204376, Length=190, Percent_Identity=44.2105263157895, Blast_Score=181, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI32565831, Length=190, Percent_Identity=44.2105263157895, Blast_Score=181, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17554494, Length=186, Percent_Identity=44.6236559139785, Blast_Score=178, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI25153706, Length=185, Percent_Identity=26.4864864864865, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=195, Percent_Identity=43.5897435897436, Blast_Score=168, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6320661, Length=195, Percent_Identity=41.025641025641, Blast_Score=158, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6319407, Length=187, Percent_Identity=28.3422459893048, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17157991, Length=187, Percent_Identity=45.4545454545455, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24641739, Length=187, Percent_Identity=45.4545454545455, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17738015, Length=189, Percent_Identity=46.031746031746, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21357347, Length=188, Percent_Identity=42.5531914893617, Blast_Score=180, Evalue=7e-46,
Organism=Drosophila melanogaster, GI24656348, Length=189, Percent_Identity=44.4444444444444, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17864676, Length=189, Percent_Identity=44.4444444444444, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24581278, Length=184, Percent_Identity=32.0652173913043, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17975518, Length=187, Percent_Identity=28.8770053475936, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24652436, Length=187, Percent_Identity=28.8770053475936, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24652434, Length=187, Percent_Identity=28.8770053475936, Blast_Score=85, Evalue=3e-17,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21694; Mature: 21563

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSLVGKQAPDFSGKAIVCGEEKEISLSDFRGKYVILFFYPKDFTYVCPTELHAFQDRLG
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCEEECCHHHHHHHHHHC
DFEERGAVVIGCSVDDIETHSRWLAVERRAGGIQGTQYPLLADDSLEISKAFGVLNPEGS
CHHHCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCCHHHHHCCCCCCCC
VALRATFLIDKDGVIRHAVINDLPLGRSIEEELRVLDSQIFFENHGMVCPANWQSGERGM
EEEEEEEEECCCCCEEEHHHCCCCCCCCHHHHHHHHHHHEEECCCCEEEECCCCCCCCCC
VPSEEGLKEYFQTID
CCCHHHHHHHHHHCC
>Mature Secondary Structure 
GSLVGKQAPDFSGKAIVCGEEKEISLSDFRGKYVILFFYPKDFTYVCPTELHAFQDRLG
CCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCEEECCHHHHHHHHHHC
DFEERGAVVIGCSVDDIETHSRWLAVERRAGGIQGTQYPLLADDSLEISKAFGVLNPEGS
CHHHCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCEEECCCCCHHHHHCCCCCCCC
VALRATFLIDKDGVIRHAVINDLPLGRSIEEELRVLDSQIFFENHGMVCPANWQSGERGM
EEEEEEEEECCCCCEEEHHHCCCCCCCCHHHHHHHHHHHEEECCCCEEEECCCCCCCCCC
VPSEEGLKEYFQTID
CCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]