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The map label for this gene is sdhA

Identifier: 15835495

GI number: 15835495

Start: 1023954

End: 1025831

Strand: Reverse

Name: sdhA

Synonym: TC0881

Alternate gene names: 15835495

Gene position: 1025831-1023954 (Counterclockwise)

Preceding gene: 15835496

Following gene: 15835494

Centisome position: 95.61

GC content: 41.75

Gene sequence:

>1878_bases
ATGAATAAGCCTTGTCGAGTCATTATTATTGGGGGAGGACTTGCTGGACTCTCTGCTGCTATGCAACTTGCTGATAGAGG
AATGTTAGTAGAGCTTTTCTCTTTGACAAAAGTAAAACGATCTCATTCTGTATGTGCGCAGGGAGGCATCAATGCAGCTT
TAAATTTAAAGGACGAGAACGATTCTCCTTATATTCATGCTTACGACACGATAAAAGGTGGAGATTTTTTAGCGGATCAG
CCTCCAGTTTTGGAAATGTGCTTAACTGCTCCTCGTATTATTCACATGTTGGATAGGTTTGGTTGTCCATTTAACCGAGA
TGCTCAAGGGAATTTGGATGTACGGCGTTTCGGAGGAACCTTGTATTATCGCACTGTATTTTGTGGCGCCTCTACAGGAC
AGCAATTGATGTACACTATGGATGAACAAGTGCGTCGTCGTGAATGTCAAGGGAAGATTATCAAAAGAGAGAATCACGAG
TTCGTTCGATTAATTACCAACGAAGAAGGGCGAGCTTGTGGTGTTGTTGTCATGAATTTATTTAACAACCGTTTAGAGGT
TGTACAAGGTGATGCAGTCATTATTGCAACGGGTGGACTAGGAGTGATTTTTAAAATGTCCACTAACTCGACTATTTGCA
CAGGAGCAGCAAATGGACGATTGTTTATGCAAGGCATGCATTATGCCAATCCAGAATTCATTCAAATTCATCCTACAGCC
ATACCTGGAATCGATAAGCTCCGCTTAATTTCTGAGTCTGTTCGAGGAGAAGGAGGAAGGGTTTGGGTGCCGGGGTGTTC
ATCCAAGACCATTATTTTCCCCGATGGTTCTCGACGTCCTTGTGGGGAAACAGGTAAACCCTGGTACTTTTTAGAAGAAA
TGTATCCTGCCTATGGAAATTTAGTGAGTCGAGATGTAGGAGCTCGGGCTATTTTGCAGGTTTGCGAGGCTGGGATGGGG
ATTGATGGGCGTTATGAAGTATTTTTAGACGTTACCCATTTGCCTATAGAAACTTTGAACAAGCTAGAGGTTGTTTTAGA
TATCTATTATAAGTTCACAGGAGAGGATCCTAAAAAGGTTCCTATGAGAATTTTCCCCGCGGTGCACTACTCTATGGGAG
GTGCTTGGGTGGATTGGCCAGCGAGTGATGATGAGGATCGGAATAGTCGTTATCGACATATGACAAATATCCCAGGTTGT
TTTAACTGTGGAGAGTCCGATTTTCAATATCATGGAGCAAATCGTTTAGGAGCAAATTCTTTATTATCTTGCTTATATGC
AGGATTAGTCGCTGGAGATGAAGCTGCGCGATTTATCGAATCTTTTGGAAGCAGTCCCTACTCGCAGCAAGATCTTAAAC
ACGCCTTGCAACAGGAAGAAGAGCTCTCCCAGGAAATTTTATCGCGTAAAGGAGGGGAAAACATTTTTTCCTTACATGAA
GAGATCGCGCGAGTGATGGTTAATAATGTTACCGTGAAAAGAGAGAATAACGCTCTTGTAGAAACCTTGCAGAAGTTAAA
AGAGTTTAGGGAAAGATTGAAAAAAGTTTCCGTACATGATTCTTCTCGATTTGCTAATAAGACTTTCCATTTTGTTCGAC
AAATGGAGCCTATGTTAGAACTAGCTTTAGCGATCACTAAAGGGGCGTTATTGAGAAACGAATTTCGAGGATCTCATTAT
AAACCGGAATTCCCGAAACGGGATGATGTGAATTGGTTAAAAACGACCATTGCTACCTATTCTGTAGACGAGCCTGAAAT
TTCTTATAAGCCAGTAGACACTCGTCATGTGAACCCAGAATTACGAGATTATACACAACGGGGAGAGAAAGACGTAGTGT
TAGAGAATATTCCAACGAATATTCATTTCCCTATATAG

Upstream 100 bases:

>100_bases
GGTCGCGGTATTTACGATTGTGTCAAATCTTATGCTACATAGGCATGTTTGTTGTAATGGCTATGGGTGTCAGCGTAATT
TGGAATATATATTTGTTATG

Downstream 100 bases:

>100_bases
GAGGCTATTGTGCAAGAAACGTTTATATTGAATATATACAGAGGCGTTCCTGGAAAACAGTATTGGGAAAGTTTTGAGTT
GGAGTTGCATCCCGGAGAGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 625

Protein sequence:

>625_residues
MNKPCRVIIIGGGLAGLSAAMQLADRGMLVELFSLTKVKRSHSVCAQGGINAALNLKDENDSPYIHAYDTIKGGDFLADQ
PPVLEMCLTAPRIIHMLDRFGCPFNRDAQGNLDVRRFGGTLYYRTVFCGASTGQQLMYTMDEQVRRRECQGKIIKRENHE
FVRLITNEEGRACGVVVMNLFNNRLEVVQGDAVIIATGGLGVIFKMSTNSTICTGAANGRLFMQGMHYANPEFIQIHPTA
IPGIDKLRLISESVRGEGGRVWVPGCSSKTIIFPDGSRRPCGETGKPWYFLEEMYPAYGNLVSRDVGARAILQVCEAGMG
IDGRYEVFLDVTHLPIETLNKLEVVLDIYYKFTGEDPKKVPMRIFPAVHYSMGGAWVDWPASDDEDRNSRYRHMTNIPGC
FNCGESDFQYHGANRLGANSLLSCLYAGLVAGDEAARFIESFGSSPYSQQDLKHALQQEEELSQEILSRKGGENIFSLHE
EIARVMVNNVTVKRENNALVETLQKLKEFRERLKKVSVHDSSRFANKTFHFVRQMEPMLELALAITKGALLRNEFRGSHY
KPEFPKRDDVNWLKTTIATYSVDEPEISYKPVDTRHVNPELRDYTQRGEKDVVLENIPTNIHFPI

Sequences:

>Translated_625_residues
MNKPCRVIIIGGGLAGLSAAMQLADRGMLVELFSLTKVKRSHSVCAQGGINAALNLKDENDSPYIHAYDTIKGGDFLADQ
PPVLEMCLTAPRIIHMLDRFGCPFNRDAQGNLDVRRFGGTLYYRTVFCGASTGQQLMYTMDEQVRRRECQGKIIKRENHE
FVRLITNEEGRACGVVVMNLFNNRLEVVQGDAVIIATGGLGVIFKMSTNSTICTGAANGRLFMQGMHYANPEFIQIHPTA
IPGIDKLRLISESVRGEGGRVWVPGCSSKTIIFPDGSRRPCGETGKPWYFLEEMYPAYGNLVSRDVGARAILQVCEAGMG
IDGRYEVFLDVTHLPIETLNKLEVVLDIYYKFTGEDPKKVPMRIFPAVHYSMGGAWVDWPASDDEDRNSRYRHMTNIPGC
FNCGESDFQYHGANRLGANSLLSCLYAGLVAGDEAARFIESFGSSPYSQQDLKHALQQEEELSQEILSRKGGENIFSLHE
EIARVMVNNVTVKRENNALVETLQKLKEFRERLKKVSVHDSSRFANKTFHFVRQMEPMLELALAITKGALLRNEFRGSHY
KPEFPKRDDVNWLKTTIATYSVDEPEISYKPVDTRHVNPELRDYTQRGEKDVVLENIPTNIHFPI
>Mature_625_residues
MNKPCRVIIIGGGLAGLSAAMQLADRGMLVELFSLTKVKRSHSVCAQGGINAALNLKDENDSPYIHAYDTIKGGDFLADQ
PPVLEMCLTAPRIIHMLDRFGCPFNRDAQGNLDVRRFGGTLYYRTVFCGASTGQQLMYTMDEQVRRRECQGKIIKRENHE
FVRLITNEEGRACGVVVMNLFNNRLEVVQGDAVIIATGGLGVIFKMSTNSTICTGAANGRLFMQGMHYANPEFIQIHPTA
IPGIDKLRLISESVRGEGGRVWVPGCSSKTIIFPDGSRRPCGETGKPWYFLEEMYPAYGNLVSRDVGARAILQVCEAGMG
IDGRYEVFLDVTHLPIETLNKLEVVLDIYYKFTGEDPKKVPMRIFPAVHYSMGGAWVDWPASDDEDRNSRYRHMTNIPGC
FNCGESDFQYHGANRLGANSLLSCLYAGLVAGDEAARFIESFGSSPYSQQDLKHALQQEEELSQEILSRKGGENIFSLHE
EIARVMVNNVTVKRENNALVETLQKLKEFRERLKKVSVHDSSRFANKTFHFVRQMEPMLELALAITKGALLRNEFRGSHY
KPEFPKRDDVNWLKTTIATYSVDEPEISYKPVDTRHVNPELRDYTQRGEKDVVLENIPTNIHFPI

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=612, Percent_Identity=27.9411764705882, Blast_Score=193, Evalue=4e-49,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=30.4123711340206, Blast_Score=239, Evalue=5e-64,
Organism=Escherichia coli, GI1786942, Length=617, Percent_Identity=30.7941653160454, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI1788928, Length=579, Percent_Identity=27.8065630397237, Blast_Score=162, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17550100, Length=629, Percent_Identity=27.8219395866455, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17505833, Length=633, Percent_Identity=27.3301737756714, Blast_Score=191, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI71986328, Length=484, Percent_Identity=26.6528925619835, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322416, Length=577, Percent_Identity=29.8093587521664, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322701, Length=576, Percent_Identity=29.6875, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24663005, Length=584, Percent_Identity=31.8493150684932, Blast_Score=213, Evalue=5e-55,
Organism=Drosophila melanogaster, GI17137288, Length=545, Percent_Identity=29.7247706422018, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24655642, Length=545, Percent_Identity=29.7247706422018, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24655647, Length=545, Percent_Identity=29.7247706422018, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70225; Mature: 70225

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPCRVIIIGGGLAGLSAAMQLADRGMLVELFSLTKVKRSHSVCAQGGINAALNLKDEN
CCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
DSPYIHAYDTIKGGDFLADQPPVLEMCLTAPRIIHMLDRFGCPFNRDAQGNLDVRRFGGT
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCE
LYYRTVFCGASTGQQLMYTMDEQVRRRECQGKIIKRENHEFVRLITNEEGRACGVVVMNL
EEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCHHHHHHHH
FNNRLEVVQGDAVIIATGGLGVIFKMSTNSTICTGAANGRLFMQGMHYANPEFIQIHPTA
HCCCEEEEECCEEEEEECCCEEEEEECCCCEEEECCCCCEEEEECCCCCCCCEEEEECCC
IPGIDKLRLISESVRGEGGRVWVPGCSSKTIIFPDGSRRPCGETGKPWYFLEEMYPAYGN
CCCCHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCEEEHHHHHHHHHH
LVSRDVGARAILQVCEAGMGIDGRYEVFLDVTHLPIETLNKLEVVLDIYYKFTGEDPKKV
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHEEHEECCCCCCCC
PMRIFPAVHYSMGGAWVDWPASDDEDRNSRYRHMTNIPGCFNCGESDFQYHGANRLGANS
CCEEEEEHHHHCCCEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEECCCCCCCHHH
LLSCLYAGLVAGDEAARFIESFGSSPYSQQDLKHALQQEEELSQEILSRKGGENIFSLHE
HHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EIARVMVNNVTVKRENNALVETLQKLKEFRERLKKVSVHDSSRFANKTFHFVRQMEPMLE
HHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LALAITKGALLRNEFRGSHYKPEFPKRDDVNWLKTTIATYSVDEPEISYKPVDTRHVNPE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCCCCCCCCHH
LRDYTQRGEKDVVLENIPTNIHFPI
HHHHHHCCCCCEEEECCCCCEECCC
>Mature Secondary Structure
MNKPCRVIIIGGGLAGLSAAMQLADRGMLVELFSLTKVKRSHSVCAQGGINAALNLKDEN
CCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
DSPYIHAYDTIKGGDFLADQPPVLEMCLTAPRIIHMLDRFGCPFNRDAQGNLDVRRFGGT
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCE
LYYRTVFCGASTGQQLMYTMDEQVRRRECQGKIIKRENHEFVRLITNEEGRACGVVVMNL
EEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCHHHHHHHH
FNNRLEVVQGDAVIIATGGLGVIFKMSTNSTICTGAANGRLFMQGMHYANPEFIQIHPTA
HCCCEEEEECCEEEEEECCCEEEEEECCCCEEEECCCCCEEEEECCCCCCCCEEEEECCC
IPGIDKLRLISESVRGEGGRVWVPGCSSKTIIFPDGSRRPCGETGKPWYFLEEMYPAYGN
CCCCHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCEEEHHHHHHHHHH
LVSRDVGARAILQVCEAGMGIDGRYEVFLDVTHLPIETLNKLEVVLDIYYKFTGEDPKKV
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHEEHEECCCCCCCC
PMRIFPAVHYSMGGAWVDWPASDDEDRNSRYRHMTNIPGCFNCGESDFQYHGANRLGANS
CCEEEEEHHHHCCCEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCCCEECCCCCCCHHH
LLSCLYAGLVAGDEAARFIESFGSSPYSQQDLKHALQQEEELSQEILSRKGGENIFSLHE
HHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
EIARVMVNNVTVKRENNALVETLQKLKEFRERLKKVSVHDSSRFANKTFHFVRQMEPMLE
HHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LALAITKGALLRNEFRGSHYKPEFPKRDDVNWLKTTIATYSVDEPEISYKPVDTRHVNPE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCCCCCCCCCHH
LRDYTQRGEKDVVLENIPTNIHFPI
HHHHHHCCCCCEEEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]