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The map label for this gene is uvrB

Identifier: 15835489

GI number: 15835489

Start: 1012726

End: 1014756

Strand: Direct

Name: uvrB

Synonym: TC0875

Alternate gene names: 15835489

Gene position: 1012726-1014756 (Clockwise)

Preceding gene: 15835488

Following gene: 15835490

Centisome position: 94.39

GC content: 43.53

Gene sequence:

>2031_bases
ATGACGCATTACCATAATCCTTTGAATGGGAGGAAAGTTCTGAATCAGCAGTTTGTATTACAAGCCCCTTTCCTCCCTTG
TGGAGATCAGCCTGAGGCAATTCGTCAGCTTTCTCGAGGAATTTTAGATGGGATTCCCTCACAGGTTCTTCTAGGAACCA
CTGGATCTGGAAAGACATTTACCATGGCGAACGTAATTGCCAACGTCAATGTCCCTACCTTAGTACTCGCGCATAATAAA
ACACTGGCCGCTCAGTTGTACCAAGAATTTAAAGCATTCTTTCCTGAAAATGCTGTTGAATACTTTATTTCCTATTACGA
TTACTACCAACCCGAAGCTTATATTGCGCGTAGCGATACCTATATCGAAAAAAGCCTGCTCATCAATGACGAAATTGACA
AACTTCGCCTTTCTGCGACGCGATCTATTTTAGAACGAAGGGATACTTTAATCGTCTCCTCTATTTCTTGTATTTACGGC
ATTGGCTCTCCCGACAACTACTCTTCTATGGCTCTTATATTAGAAGTTGGAAAAGAATATCCTCGTTCCCAGCTCTCTGC
CCAACTCGTACGCATGCACTATCAAGCTTCTGCCTCCCCTCAACGCAGTGCCTTTCGCGAACGAGGTAGCGTCATAGATA
TTTTCCTTGCTTATGAAAGTGATCTTGCCGTTCGGCTTGAATTCGTCAACGATACACTTGTTTCCATAGAATATACAGAT
CCGTTGACCATGATCCCCTCTCATACGGTCCCGTCCGTTACTCTTTATCCTGGATCTCACTACGTTACTCCCGAAGCAGT
TCGTGAACAAGCCATTCGTACCATCCGCGAAGAATTAGAGCAGCGTCTGCTGTTTTTTGAAGGACGGCCTGTAGAACAAG
AAAGACTATTTCAACGCACCACGCACGATATAGAAATGATCAAGGAAATCGGGTTCTGTAAAGGGATTGAAAATTACTCG
AGACACTTTACTGGAGCAGCTCCAGGAGAACCTCCAACTTGTCTTCTTGACTATTTCCCAGAAGATTTCCTTTTAATCAT
CGATGAGTCCCACCAGACACTTCCTCAGTTGCGTGCCATGTATCGCGGAGATCAATCTCGCAAACAGTCTCTTGTTGAAT
ATGGATTCCGTCTTCCCTCTGCTTTTGATAATAGACCGCTTACTTATGAGGAAGCTCGGCGATATTTTCGTCGCGTAGTT
TATGTATCGGCTACTCCTGGAGAACTCGAAGTCCAAGAAAGCCGAGGACATATCATAGAACAAATCATTCGTCCTACAGG
GATTCCTGATCCACTGCCAGAAATTCGCCCAGCGACAGGACAGATAGATGACCTCTTAGAAGAAATTCGTCAGAGACTTC
GCAAAGATCAAGAAAAAATATTAGTCGTCTCTGTCACAAAAAAATTAGCTGAAGACATCGCAGCCTTCTTAGCTGAACTG
GGAATCGCTGCCGCCTATCTTCATTCAGGTATTGAAACCGCAGAAAGGACACAAATTCTTACAGATTTACGGTTAGGAAC
GATAGATGTTCTTATTGGAGTAAACCTTCTTCGAGAAGGAATCGATTTACCCGAAGTGTCATTAGTCGCGATTCTTGACG
CAGATAAAGAAGGTTTTCTACGTAGTAGCGCCTCCCTTATTCAATTCTGCGGACGAGCCGCACGCAATGTCCATGGAAAA
GTCATTTTTTATGCCGACCGCATCACCCCTTCCATGGATCATATGCTCAAAGAAACAGAACGACGCAGACAAATACAACT
CGATTACAATAAAAAACATAATATCACCCCTAAGCCCATTATTAAACCCATCTTAGCTAACCCCATTACTAAAGAGGGCG
CTCAAGAAGATTCCCGTCCAGAAACCCAATCTACTGAAGATCTCGAATCTTCTATCAAGCAATACGAAGAAGCGATGTAT
AAAGCTGCTCAAGATTTTCAGTTTGATGAAGCAGCCAAGTACCGTGATTTGATGAATGCGGCGAAACGCCAACTGCTTTT
TAAACAAGGAGAGGATGGAAATTCAAAATGA

Upstream 100 bases:

>100_bases
GTACGGAAAAAATGCGATCAGTAGCACGGGAAACTATGGAAGAAGTCCATAACAACCTAGGATTAAGCCGCAAGTGGCGC
TCTATTCTAGCTTCTTCTAA

Downstream 100 bases:

>100_bases
AAAGGATACCACAGAATTTAGTCCCTCGCTATGATCCTTTTCTTGAAGCAAATCACCTCCGGGCTTCTCTTTATTTAGTA
CCGTAAGATTCTTATCGGAG

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MTHYHNPLNGRKVLNQQFVLQAPFLPCGDQPEAIRQLSRGILDGIPSQVLLGTTGSGKTFTMANVIANVNVPTLVLAHNK
TLAAQLYQEFKAFFPENAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKLRLSATRSILERRDTLIVSSISCIYG
IGSPDNYSSMALILEVGKEYPRSQLSAQLVRMHYQASASPQRSAFRERGSVIDIFLAYESDLAVRLEFVNDTLVSIEYTD
PLTMIPSHTVPSVTLYPGSHYVTPEAVREQAIRTIREELEQRLLFFEGRPVEQERLFQRTTHDIEMIKEIGFCKGIENYS
RHFTGAAPGEPPTCLLDYFPEDFLLIIDESHQTLPQLRAMYRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEARRYFRRVV
YVSATPGELEVQESRGHIIEQIIRPTGIPDPLPEIRPATGQIDDLLEEIRQRLRKDQEKILVVSVTKKLAEDIAAFLAEL
GIAAAYLHSGIETAERTQILTDLRLGTIDVLIGVNLLREGIDLPEVSLVAILDADKEGFLRSSASLIQFCGRAARNVHGK
VIFYADRITPSMDHMLKETERRRQIQLDYNKKHNITPKPIIKPILANPITKEGAQEDSRPETQSTEDLESSIKQYEEAMY
KAAQDFQFDEAAKYRDLMNAAKRQLLFKQGEDGNSK

Sequences:

>Translated_676_residues
MTHYHNPLNGRKVLNQQFVLQAPFLPCGDQPEAIRQLSRGILDGIPSQVLLGTTGSGKTFTMANVIANVNVPTLVLAHNK
TLAAQLYQEFKAFFPENAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKLRLSATRSILERRDTLIVSSISCIYG
IGSPDNYSSMALILEVGKEYPRSQLSAQLVRMHYQASASPQRSAFRERGSVIDIFLAYESDLAVRLEFVNDTLVSIEYTD
PLTMIPSHTVPSVTLYPGSHYVTPEAVREQAIRTIREELEQRLLFFEGRPVEQERLFQRTTHDIEMIKEIGFCKGIENYS
RHFTGAAPGEPPTCLLDYFPEDFLLIIDESHQTLPQLRAMYRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEARRYFRRVV
YVSATPGELEVQESRGHIIEQIIRPTGIPDPLPEIRPATGQIDDLLEEIRQRLRKDQEKILVVSVTKKLAEDIAAFLAEL
GIAAAYLHSGIETAERTQILTDLRLGTIDVLIGVNLLREGIDLPEVSLVAILDADKEGFLRSSASLIQFCGRAARNVHGK
VIFYADRITPSMDHMLKETERRRQIQLDYNKKHNITPKPIIKPILANPITKEGAQEDSRPETQSTEDLESSIKQYEEAMY
KAAQDFQFDEAAKYRDLMNAAKRQLLFKQGEDGNSK
>Mature_675_residues
THYHNPLNGRKVLNQQFVLQAPFLPCGDQPEAIRQLSRGILDGIPSQVLLGTTGSGKTFTMANVIANVNVPTLVLAHNKT
LAAQLYQEFKAFFPENAVEYFISYYDYYQPEAYIARSDTYIEKSLLINDEIDKLRLSATRSILERRDTLIVSSISCIYGI
GSPDNYSSMALILEVGKEYPRSQLSAQLVRMHYQASASPQRSAFRERGSVIDIFLAYESDLAVRLEFVNDTLVSIEYTDP
LTMIPSHTVPSVTLYPGSHYVTPEAVREQAIRTIREELEQRLLFFEGRPVEQERLFQRTTHDIEMIKEIGFCKGIENYSR
HFTGAAPGEPPTCLLDYFPEDFLLIIDESHQTLPQLRAMYRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEARRYFRRVVY
VSATPGELEVQESRGHIIEQIIRPTGIPDPLPEIRPATGQIDDLLEEIRQRLRKDQEKILVVSVTKKLAEDIAAFLAELG
IAAAYLHSGIETAERTQILTDLRLGTIDVLIGVNLLREGIDLPEVSLVAILDADKEGFLRSSASLIQFCGRAARNVHGKV
IFYADRITPSMDHMLKETERRRQIQLDYNKKHNITPKPIIKPILANPITKEGAQEDSRPETQSTEDLESSIKQYEEAMYK
AAQDFQFDEAAKYRDLMNAAKRQLLFKQGEDGNSK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=52.1084337349398, Blast_Score=672, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_CHLMU (Q9PJF4)

Other databases:

- EMBL:   AE002160
- PIR:   D81654
- RefSeq:   NP_297248.1
- ProteinModelPortal:   Q9PJF4
- GeneID:   1246243
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0875
- TIGR:   TC_0875
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   CMUR243161:TC_0875-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 76825; Mature: 76694

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHYHNPLNGRKVLNQQFVLQAPFLPCGDQPEAIRQLSRGILDGIPSQVLLGTTGSGKTF
CCCCCCCCCHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEE
TMANVIANVNVPTLVLAHNKTLAAQLYQEFKAFFPENAVEYFISYYDYYQPEAYIARSDT
EHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCH
YIEKSLLINDEIDKLRLSATRSILERRDTLIVSSISCIYGIGSPDNYSSMALILEVGKEY
HHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHC
PRSQLSAQLVRMHYQASASPQRSAFRERGSVIDIFLAYESDLAVRLEFVNDTLVSIEYTD
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCEEEEEEECC
PLTMIPSHTVPSVTLYPGSHYVTPEAVREQAIRTIREELEQRLLFFEGRPVEQERLFQRT
CCEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
THDIEMIKEIGFCKGIENYSRHFTGAAPGEPPTCLLDYFPEDFLLIIDESHQTLPQLRAM
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHCCCCCCEEEEECCCHHHHHHHHHH
YRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEARRYFRRVVYVSATPGELEVQESRGHIIE
HCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCEEEHHHHHHHHH
QIIRPTGIPDPLPEIRPATGQIDDLLEEIRQRLRKDQEKILVVSVTKKLAEDIAAFLAEL
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHCEEEHHHHHHHHHHHHHHHHHH
GIAAAYLHSGIETAERTQILTDLRLGTIDVLIGVNLLREGIDLPEVSLVAILDADKEGFL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHH
RSSASLIQFCGRAARNVHGKVIFYADRITPSMDHMLKETERRRQIQLDYNKKHNITPKPI
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEECCCCCCCCCCHHH
IKPILANPITKEGAQEDSRPETQSTEDLESSIKQYEEAMYKAAQDFQFDEAAKYRDLMNA
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AKRQLLFKQGEDGNSK
HHHHHHHHCCCCCCCC
>Mature Secondary Structure 
THYHNPLNGRKVLNQQFVLQAPFLPCGDQPEAIRQLSRGILDGIPSQVLLGTTGSGKTF
CCCCCCCCHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEE
TMANVIANVNVPTLVLAHNKTLAAQLYQEFKAFFPENAVEYFISYYDYYQPEAYIARSDT
EHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCH
YIEKSLLINDEIDKLRLSATRSILERRDTLIVSSISCIYGIGSPDNYSSMALILEVGKEY
HHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHC
PRSQLSAQLVRMHYQASASPQRSAFRERGSVIDIFLAYESDLAVRLEFVNDTLVSIEYTD
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCEEEEEEECC
PLTMIPSHTVPSVTLYPGSHYVTPEAVREQAIRTIREELEQRLLFFEGRPVEQERLFQRT
CCEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
THDIEMIKEIGFCKGIENYSRHFTGAAPGEPPTCLLDYFPEDFLLIIDESHQTLPQLRAM
HHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHCCCCCCEEEEECCCHHHHHHHHHH
YRGDQSRKQSLVEYGFRLPSAFDNRPLTYEEARRYFRRVVYVSATPGELEVQESRGHIIE
HCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCCEEEHHHHHHHHH
QIIRPTGIPDPLPEIRPATGQIDDLLEEIRQRLRKDQEKILVVSVTKKLAEDIAAFLAEL
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHCEEEHHHHHHHHHHHHHHHHHH
GIAAAYLHSGIETAERTQILTDLRLGTIDVLIGVNLLREGIDLPEVSLVAILDADKEGFL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHH
RSSASLIQFCGRAARNVHGKVIFYADRITPSMDHMLKETERRRQIQLDYNKKHNITPKPI
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEECCCCCCCCCCHHH
IKPILANPITKEGAQEDSRPETQSTEDLESSIKQYEEAMYKAAQDFQFDEAAKYRDLMNA
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AKRQLLFKQGEDGNSK
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935