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The map label for this gene is thrS

Identifier: 15835484

GI number: 15835484

Start: 1007058

End: 1008965

Strand: Direct

Name: thrS

Synonym: TC0870

Alternate gene names: 15835484

Gene position: 1007058-1008965 (Clockwise)

Preceding gene: 15835482

Following gene: 15835485

Centisome position: 93.86

GC content: 42.77

Gene sequence:

>1908_bases
ATGATCCACGTAACTTGTAATCAAGAAGCTTTCGAACTACCAGAAGGCGCCTCAGCGATGGATCTTGCAAGCAAGATGAA
AAACTCTCATTGCTTTGCAGGGGCCCTTATTAACGACCAAGAAAAGGATCTTTCCACCACCTTAAAAGACGGAGATACCG
TTCTCTTTCTCACTTGGGATGACCCACAAGGTCGAGAAATCTTTTTACATACTTCCGCACATATCTTAGCCCAAGCAGTA
CTACGCTTATGGCCTTCAGCACAACCCACAATAGGTCCGGTTATTGATCAGGGGTTCTATTACGATTTTGCAAACCTTTC
TATCAGCGAAGAAGATTTTCCTGCTATAGAAGCTATGGCCAAAGCCATCGCGGAAGAAAAATTGGCGATCTCACGTCAAG
TTTTCTCGGATAAAGAGGAGACTCTCGCCTATTTTTCTGATAATCCATTTAAAATCGAACTCATCACGGAACTTCCGGAA
GAAGCCACGATTTCCGCTTATAAACAGGGAGAGTTTTTAGACTTATGTCGCGGCCCCCATCTCCCTTCAACAGCTCCCGT
GAAGGCTTTTAAACTGTTACGTACATCCGCAGCCTATTGGAGAGGAGATCCTTCTAAAGAATCTCTAATCCGAATATACG
GAATCGCCTTCCCGACAACTAAGGAGCTAAAAGAACACCTCCACCAGTTGGAAGAGGCAAAAAAACGTGATCACCGTGTA
CTCGGGACTAAATTAGATCTGTTCTCACAACAATCCTACTCTGCAGGGATGCCTTTTTTCCATCCTCGAGGAATGGTAAT
TTGGAACGCTTTAATCGATTATTGGAAACGGCTTCATCAACTTGCTGGCTATCAACAAATCCAAACCCCTCAACTTATGA
GTAGGGAGTTATGGGAGATTTCCGGCCACTGGGAAAATTATAAAGAAAACATGTACACCTTAACAGTGGATGAAGAAGAT
TACGCAATCAAACCCATGAACTGCCCTGGATGTATGTTGTATTACAAGACACAACTACATAGTTACCGGGAGTTCCCGCT
GCGCATTGCAGAAATCGGCCATGTGCACAGACACGAGCTATCCGGAGCTCTATCTGGGCTGATGCGAGTACGTACATTCC
ATCAAGATGATGCCCATGTATTTTTAACTCCTGAACAAGTGGAAGAAGAAACTCTGAATATCCTTAATCTTGTTTCCGAA
CTATATGGAACCTTTGGGTTAGACTATCACTTAGAACTTTCCACTCGACCTGAACAAGGAACAATCGGAAGCGATGATCT
TTGGGAACTGGCAACAGAAGCTTTGAAGAACGCTCTGGTCAAATCACAAAAACCCTTTATTATTAGTCCTGGGGAAGGCG
CCTTTTACGGTCCAAAAATTGATATTCATGTGAAAGATGCCATTAATAGAACTTGGCAGTGCGGCACTATTCAATTGGAT
ATGTTTCTCCCAGAACGATTCGATCTGAAATATACGAACCCTCAAGGGGAGAAAAGCACTCCTATTATGCTTCATAGAGC
TTTATTTGGATCTATAGAACGCTTTTTAGGTATTCTGATCGAACACTTTAAAGGGCGCTTCCCTCTGTGGCTAAGTCCAG
AGCACGTACGTATCATTACTGTAGCAGATCGCCATGAAGCTCGTGCTCAAGAATTAGCAAAATATTTCACTCAACAGGGA
ATTCTTGCCACAGTGGATCAAGCGAGTGAATCTGTCAGTAAAAAAATTCGCAATGCTCAAAACATGCAAGTAAACTATAT
GATTACTATTGGCGACAAAGAGCTAGAAACCCAACTACTGGCGGTACGCACACGAGACAATCGTGTGTTAAATGACATTT
CTGTCGAACATTTCACTAATACAATTCTTGAAGAGCTTCGTTCTTTATCTTTAACCTCTTCGTTGTAA

Upstream 100 bases:

>100_bases
CTTTTGCTTAGTTCCGTGAAACGCTACAATAGCGAATACTCCACGTAAAACGAGAAAGATTTTCACGGGAGCGTTTAAAA
TTTTTATTTATGGAGAAGGA

Downstream 100 bases:

>100_bases
AATCCTGGCTTGCATAGGTAACTTTATCTATGCAAGCCTCCTACTCTCTCCTATTCACTCCAGTAGTCTTCTTTATAAAC
GATCATAGATTTCAAATAGT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MIHVTCNQEAFELPEGASAMDLASKMKNSHCFAGALINDQEKDLSTTLKDGDTVLFLTWDDPQGREIFLHTSAHILAQAV
LRLWPSAQPTIGPVIDQGFYYDFANLSISEEDFPAIEAMAKAIAEEKLAISRQVFSDKEETLAYFSDNPFKIELITELPE
EATISAYKQGEFLDLCRGPHLPSTAPVKAFKLLRTSAAYWRGDPSKESLIRIYGIAFPTTKELKEHLHQLEEAKKRDHRV
LGTKLDLFSQQSYSAGMPFFHPRGMVIWNALIDYWKRLHQLAGYQQIQTPQLMSRELWEISGHWENYKENMYTLTVDEED
YAIKPMNCPGCMLYYKTQLHSYREFPLRIAEIGHVHRHELSGALSGLMRVRTFHQDDAHVFLTPEQVEEETLNILNLVSE
LYGTFGLDYHLELSTRPEQGTIGSDDLWELATEALKNALVKSQKPFIISPGEGAFYGPKIDIHVKDAINRTWQCGTIQLD
MFLPERFDLKYTNPQGEKSTPIMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHVRIITVADRHEARAQELAKYFTQQG
ILATVDQASESVSKKIRNAQNMQVNYMITIGDKELETQLLAVRTRDNRVLNDISVEHFTNTILEELRSLSLTSSL

Sequences:

>Translated_635_residues
MIHVTCNQEAFELPEGASAMDLASKMKNSHCFAGALINDQEKDLSTTLKDGDTVLFLTWDDPQGREIFLHTSAHILAQAV
LRLWPSAQPTIGPVIDQGFYYDFANLSISEEDFPAIEAMAKAIAEEKLAISRQVFSDKEETLAYFSDNPFKIELITELPE
EATISAYKQGEFLDLCRGPHLPSTAPVKAFKLLRTSAAYWRGDPSKESLIRIYGIAFPTTKELKEHLHQLEEAKKRDHRV
LGTKLDLFSQQSYSAGMPFFHPRGMVIWNALIDYWKRLHQLAGYQQIQTPQLMSRELWEISGHWENYKENMYTLTVDEED
YAIKPMNCPGCMLYYKTQLHSYREFPLRIAEIGHVHRHELSGALSGLMRVRTFHQDDAHVFLTPEQVEEETLNILNLVSE
LYGTFGLDYHLELSTRPEQGTIGSDDLWELATEALKNALVKSQKPFIISPGEGAFYGPKIDIHVKDAINRTWQCGTIQLD
MFLPERFDLKYTNPQGEKSTPIMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHVRIITVADRHEARAQELAKYFTQQG
ILATVDQASESVSKKIRNAQNMQVNYMITIGDKELETQLLAVRTRDNRVLNDISVEHFTNTILEELRSLSLTSSL
>Mature_635_residues
MIHVTCNQEAFELPEGASAMDLASKMKNSHCFAGALINDQEKDLSTTLKDGDTVLFLTWDDPQGREIFLHTSAHILAQAV
LRLWPSAQPTIGPVIDQGFYYDFANLSISEEDFPAIEAMAKAIAEEKLAISRQVFSDKEETLAYFSDNPFKIELITELPE
EATISAYKQGEFLDLCRGPHLPSTAPVKAFKLLRTSAAYWRGDPSKESLIRIYGIAFPTTKELKEHLHQLEEAKKRDHRV
LGTKLDLFSQQSYSAGMPFFHPRGMVIWNALIDYWKRLHQLAGYQQIQTPQLMSRELWEISGHWENYKENMYTLTVDEED
YAIKPMNCPGCMLYYKTQLHSYREFPLRIAEIGHVHRHELSGALSGLMRVRTFHQDDAHVFLTPEQVEEETLNILNLVSE
LYGTFGLDYHLELSTRPEQGTIGSDDLWELATEALKNALVKSQKPFIISPGEGAFYGPKIDIHVKDAINRTWQCGTIQLD
MFLPERFDLKYTNPQGEKSTPIMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHVRIITVADRHEARAQELAKYFTQQG
ILATVDQASESVSKKIRNAQNMQVNYMITIGDKELETQLLAVRTRDNRVLNDISVEHFTNTILEELRSLSLTSSL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=605, Percent_Identity=41.3223140495868, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI38202255, Length=600, Percent_Identity=41, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI20070344, Length=612, Percent_Identity=38.0718954248366, Blast_Score=427, Evalue=1e-119,
Organism=Escherichia coli, GI1788013, Length=618, Percent_Identity=40.6148867313916, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI71984192, Length=586, Percent_Identity=41.1262798634812, Blast_Score=493, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71984184, Length=586, Percent_Identity=41.1262798634812, Blast_Score=493, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322112, Length=590, Percent_Identity=40, Blast_Score=488, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=40.75, Blast_Score=297, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24583839, Length=594, Percent_Identity=41.7508417508418, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24583842, Length=594, Percent_Identity=41.7508417508418, Blast_Score=497, Evalue=1e-140,
Organism=Drosophila melanogaster, GI28574141, Length=594, Percent_Identity=41.7508417508418, Blast_Score=497, Evalue=1e-140,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_CHLMU (Q9PJF9)

Other databases:

- EMBL:   AE002160
- PIR:   A81656
- RefSeq:   NP_297243.1
- ProteinModelPortal:   Q9PJF9
- SMR:   Q9PJF9
- GeneID:   1246238
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0870
- TIGR:   TC_0870
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   Q9PJF9
- ProtClustDB:   PRK00413
- BioCyc:   CMUR243161:TC_0870-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72555; Mature: 72555

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHVTCNQEAFELPEGASAMDLASKMKNSHCFAGALINDQEKDLSTTLKDGDTVLFLTWD
CEEEEECCHHHCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCEEEEEEEC
DPQGREIFLHTSAHILAQAVLRLWPSAQPTIGPVIDQGFYYDFANLSISEEDFPAIEAMA
CCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCCEECCCCCHHHHHHH
KAIAEEKLAISRQVFSDKEETLAYFSDNPFKIELITELPEEATISAYKQGEFLDLCRGPH
HHHHHHHHHHHHHHHCCHHHHEEEECCCCEEEEEEECCCCHHHHHHHCCCCHHHHHCCCC
LPSTAPVKAFKLLRTSAAYWRGDPSKESLIRIYGIAFPTTKELKEHLHQLEEAKKRDHRV
CCCCCHHHHHHHHHHHHHHHCCCCCHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LGTKLDLFSQQSYSAGMPFFHPRGMVIWNALIDYWKRLHQLAGYQQIQTPQLMSRELWEI
HCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SGHWENYKENMYTLTVDEEDYAIKPMNCPGCMLYYKTQLHSYREFPLRIAEIGHVHRHEL
CCCHHCCCCCEEEEEECCCCCEECCCCCCCEEEEEHHHHHHHHHCCCHHHHHCCHHHHHH
SGALSGLMRVRTFHQDDAHVFLTPEQVEEETLNILNLVSELYGTFGLDYHLELSTRPEQG
HHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
TIGSDDLWELATEALKNALVKSQKPFIISPGEGAFYGPKIDIHVKDAINRTWQCGTIQLD
CCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCEEEEEEHHHHCCCCCCCEEEEE
MFLPERFDLKYTNPQGEKSTPIMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHVRIIT
EECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEE
VADRHEARAQELAKYFTQQGILATVDQASESVSKKIRNAQNMQVNYMITIGDKELETQLL
EECCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHCCEE
AVRTRDNRVLNDISVEHFTNTILEELRSLSLTSSL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIHVTCNQEAFELPEGASAMDLASKMKNSHCFAGALINDQEKDLSTTLKDGDTVLFLTWD
CEEEEECCHHHCCCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCEEEEEEEC
DPQGREIFLHTSAHILAQAVLRLWPSAQPTIGPVIDQGFYYDFANLSISEEDFPAIEAMA
CCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCHHHCCCCEEEECCCEECCCCCHHHHHHH
KAIAEEKLAISRQVFSDKEETLAYFSDNPFKIELITELPEEATISAYKQGEFLDLCRGPH
HHHHHHHHHHHHHHHCCHHHHEEEECCCCEEEEEEECCCCHHHHHHHCCCCHHHHHCCCC
LPSTAPVKAFKLLRTSAAYWRGDPSKESLIRIYGIAFPTTKELKEHLHQLEEAKKRDHRV
CCCCCHHHHHHHHHHHHHHHCCCCCHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
LGTKLDLFSQQSYSAGMPFFHPRGMVIWNALIDYWKRLHQLAGYQQIQTPQLMSRELWEI
HCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
SGHWENYKENMYTLTVDEEDYAIKPMNCPGCMLYYKTQLHSYREFPLRIAEIGHVHRHEL
CCCHHCCCCCEEEEEECCCCCEECCCCCCCEEEEEHHHHHHHHHCCCHHHHHCCHHHHHH
SGALSGLMRVRTFHQDDAHVFLTPEQVEEETLNILNLVSELYGTFGLDYHLELSTRPEQG
HHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
TIGSDDLWELATEALKNALVKSQKPFIISPGEGAFYGPKIDIHVKDAINRTWQCGTIQLD
CCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCEEEEEEHHHHCCCCCCCEEEEE
MFLPERFDLKYTNPQGEKSTPIMLHRALFGSIERFLGILIEHFKGRFPLWLSPEHVRIIT
EECCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEEE
VADRHEARAQELAKYFTQQGILATVDQASESVSKKIRNAQNMQVNYMITIGDKELETQLL
EECCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHCCEE
AVRTRDNRVLNDISVEHFTNTILEELRSLSLTSSL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935