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The map label for this gene is mutL

Identifier: 15835478

GI number: 15835478

Start: 999826

End: 1001556

Strand: Reverse

Name: mutL

Synonym: TC0864

Alternate gene names: 15835478

Gene position: 1001556-999826 (Counterclockwise)

Preceding gene: 15835483

Following gene: 15835477

Centisome position: 93.35

GC content: 41.77

Gene sequence:

>1731_bases
GTGTCATTGTCCTCTTCTCGGATTCGGTTGTTAGATAGTGCAACAGTTAACCAGATTGCTGCTGGTGAAGTTATAGAAAA
TGCGGCTTCTGTGGTTAAGGAATTGATAGAGAACGCATTGGATGCTGGTGCGGATGAAATTAGTATTGAAACCCTTGGTG
GTGGTAAGGGGCAGATTGTCGTTCGAGACAATGGAATAGGCATGGATGCAGATGAGGTGGCCGTAGCTATCCAGCGTCAT
GCAACATCGAAAATTTCTCATTTTGCTGACATTTTTTCTCTTGCAAGTTTCGGCTTTCGAGGGGAGGCTTTACCAGCCAT
AGCCTCTATTTCTAAGATGGAAATTCATACAGCTAAAGTAAATGGATTGGGATCTAAGACTTTGATCGAAAAGGGGGAGC
CAGTTTGTTGCGAAGCATGTCCTAGACAGCCAGGAACTACCATTTCAGTAAATTCCCTTTTCTATAACGTTCCTATGAGG
CAGTCTTTTCAAAAATCTCCGCAAATGGATCGGTTAGCTATTCGTCGATTACTAGAAAATAGCATTCTATCTACAGAAGG
AATTAAATGGACTTGGATTAGTGAGCGGCGTCAAGAGTTAAATATTGCTAAAAATCAAGGTTTTACAGAACGCGTGGCTT
TGGTGATGGGGGAAGCTTTTGTTAACGAGGCATTCCTTATTGATAAACGACAGAATGAGCTCCATTTAACAGGATTTTTA
GGATCTCCGAGTATGCATCGGTCCACAAGACAGGGCCAGCGGTTATTTATCAATAACCGTGCTGTGGAATCTTCTTTCAT
ATCCAGAAAGGTAGCAGAAGCCTATGCTTGGATGCTCCCAGCACAGCGGTATCCTGCGTTTGTGTTAAAACTCTCCGTCC
CCCCTATGTGGTGTGATTTTAATGTGCATCCTCAAAAAACAGAGGTTCGATTATTACAAGAAGGACAAATAGGGGCTCTT
CTTGTAGAGGCGATCTCCGAAGTATTATTACATCGATCTCCGTCTTTAGAAGAGAAGATGGTAGAGCCTACTATGGAGAG
CCCTTTAATCGAGAATGGAGGATTAGAAATCCCATCGATTCGACCTGTAGCAATCTCTACGCCGCTCTCTTGCCCAAATT
TTCTCCAACAGTCTTTTGTGGAAACAGAAGCAAATAGGGCTTTATGTAAAGAGCAAGAAAACCTTGCTCTCCCTATTATT
GAGAGGGTGCGTTTTCTTGCTTCTTTAGGAAAAGTGATCTTAGTAGAAGATTCCGAAGGGGTGCATGCCTTATTTGTACA
GGCTGCTCGTAAGCACTTATTTTATATTTCTTTATTATCTAAACGTTCGGATTCTCTTTTAGCTTGTCAGATGTTTCTTG
TCCCTCCAACTGTACAAATGACTAAGTTGGAAGCCGATTTTTTACAGACTCGACTGGAATCACTCGCTGCACAGGGAATA
GAACTATGCCGCATTAGTCCGGATAGTTTTGCAATAGAAAGTGCGCCTCCTTTTATTCAAGAAGAGGAATTAAAAGAGTG
GATTATTTCTTTAGCTCATGAGGGAGCTTTTCAGGTGAATGAGTCTTTTGAACAGCTTGTTGAAAATACTGTTCAGAAAT
TGGCTTTTTCTAAAAATACGCGAGCCTTCGATCATTCTTGGATCAATGTATTATGGCAAATAGGAAAACCTGAAAAAGCA
TTTGACGGGGAGACAATACGTCGGTTAGTTTTGGAGGAGGACTTTATGTAG

Upstream 100 bases:

>100_bases
GGGAGGTACCGTTAACTCCTGTGCGAAAGGCTCGGATCTGGTGTTTTCTCTCGTGCTGTCTCTTTTTAATTATTAATGTT
TAATAGGTTGGAGATACTTA

Downstream 100 bases:

>100_bases
GAGAGGGGAATGAATCAAAATCCGATCACGCGACTACAACACTTATTATCAGGTTATGCTCTTGATGCTTTTCTAATAGA
GAAAGACGAGGATATTAGTT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 575

Protein sequence:

>576_residues
MSLSSSRIRLLDSATVNQIAAGEVIENAASVVKELIENALDAGADEISIETLGGGKGQIVVRDNGIGMDADEVAVAIQRH
ATSKISHFADIFSLASFGFRGEALPAIASISKMEIHTAKVNGLGSKTLIEKGEPVCCEACPRQPGTTISVNSLFYNVPMR
QSFQKSPQMDRLAIRRLLENSILSTEGIKWTWISERRQELNIAKNQGFTERVALVMGEAFVNEAFLIDKRQNELHLTGFL
GSPSMHRSTRQGQRLFINNRAVESSFISRKVAEAYAWMLPAQRYPAFVLKLSVPPMWCDFNVHPQKTEVRLLQEGQIGAL
LVEAISEVLLHRSPSLEEKMVEPTMESPLIENGGLEIPSIRPVAISTPLSCPNFLQQSFVETEANRALCKEQENLALPII
ERVRFLASLGKVILVEDSEGVHALFVQAARKHLFYISLLSKRSDSLLACQMFLVPPTVQMTKLEADFLQTRLESLAAQGI
ELCRISPDSFAIESAPPFIQEEELKEWIISLAHEGAFQVNESFEQLVENTVQKLAFSKNTRAFDHSWINVLWQIGKPEKA
FDGETIRRLVLEEDFM

Sequences:

>Translated_576_residues
MSLSSSRIRLLDSATVNQIAAGEVIENAASVVKELIENALDAGADEISIETLGGGKGQIVVRDNGIGMDADEVAVAIQRH
ATSKISHFADIFSLASFGFRGEALPAIASISKMEIHTAKVNGLGSKTLIEKGEPVCCEACPRQPGTTISVNSLFYNVPMR
QSFQKSPQMDRLAIRRLLENSILSTEGIKWTWISERRQELNIAKNQGFTERVALVMGEAFVNEAFLIDKRQNELHLTGFL
GSPSMHRSTRQGQRLFINNRAVESSFISRKVAEAYAWMLPAQRYPAFVLKLSVPPMWCDFNVHPQKTEVRLLQEGQIGAL
LVEAISEVLLHRSPSLEEKMVEPTMESPLIENGGLEIPSIRPVAISTPLSCPNFLQQSFVETEANRALCKEQENLALPII
ERVRFLASLGKVILVEDSEGVHALFVQAARKHLFYISLLSKRSDSLLACQMFLVPPTVQMTKLEADFLQTRLESLAAQGI
ELCRISPDSFAIESAPPFIQEEELKEWIISLAHEGAFQVNESFEQLVENTVQKLAFSKNTRAFDHSWINVLWQIGKPEKA
FDGETIRRLVLEEDFM
>Mature_575_residues
SLSSSRIRLLDSATVNQIAAGEVIENAASVVKELIENALDAGADEISIETLGGGKGQIVVRDNGIGMDADEVAVAIQRHA
TSKISHFADIFSLASFGFRGEALPAIASISKMEIHTAKVNGLGSKTLIEKGEPVCCEACPRQPGTTISVNSLFYNVPMRQ
SFQKSPQMDRLAIRRLLENSILSTEGIKWTWISERRQELNIAKNQGFTERVALVMGEAFVNEAFLIDKRQNELHLTGFLG
SPSMHRSTRQGQRLFINNRAVESSFISRKVAEAYAWMLPAQRYPAFVLKLSVPPMWCDFNVHPQKTEVRLLQEGQIGALL
VEAISEVLLHRSPSLEEKMVEPTMESPLIENGGLEIPSIRPVAISTPLSCPNFLQQSFVETEANRALCKEQENLALPIIE
RVRFLASLGKVILVEDSEGVHALFVQAARKHLFYISLLSKRSDSLLACQMFLVPPTVQMTKLEADFLQTRLESLAAQGIE
LCRISPDSFAIESAPPFIQEEELKEWIISLAHEGAFQVNESFEQLVENTVQKLAFSKNTRAFDHSWINVLWQIGKPEKAF
DGETIRRLVLEEDFM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=339, Percent_Identity=31.5634218289086, Blast_Score=159, Evalue=9e-39,
Organism=Homo sapiens, GI310128478, Length=395, Percent_Identity=28.8607594936709, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4505913, Length=395, Percent_Identity=28.8607594936709, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4505911, Length=326, Percent_Identity=30.3680981595092, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI189458898, Length=326, Percent_Identity=30.3680981595092, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI189458896, Length=319, Percent_Identity=29.7805642633229, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI310128480, Length=344, Percent_Identity=27.3255813953488, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI91992160, Length=266, Percent_Identity=27.8195488721804, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI91992162, Length=266, Percent_Identity=27.8195488721804, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI263191589, Length=238, Percent_Identity=26.890756302521, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790612, Length=334, Percent_Identity=34.4311377245509, Blast_Score=178, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=364, Percent_Identity=28.2967032967033, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71991825, Length=389, Percent_Identity=26.2210796915167, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=328, Percent_Identity=28.6585365853659, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324247, Length=371, Percent_Identity=24.7978436657682, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325093, Length=373, Percent_Identity=22.5201072386059, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136968, Length=321, Percent_Identity=31.7757009345794, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI17136970, Length=353, Percent_Identity=26.9121813031161, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_CHLMU (Q9PJG5)

Other databases:

- EMBL:   AE002160
- PIR:   G81657
- RefSeq:   NP_297237.1
- ProteinModelPortal:   Q9PJG5
- GeneID:   1246232
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0864
- TIGR:   TC_0864
- HOGENOM:   HBG414122
- PhylomeDB:   Q9PJG5
- ProtClustDB:   PRK00095
- BioCyc:   CMUR243161:TC_0864-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 64145; Mature: 64014

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSSSRIRLLDSATVNQIAAGEVIENAASVVKELIENALDAGADEISIETLGGGKGQIV
CCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEE
VRDNGIGMDADEVAVAIQRHATSKISHFADIFSLASFGFRGEALPAIASISKMEIHTAKV
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEEEE
NGLGSKTLIEKGEPVCCEACPRQPGTTISVNSLFYNVPMRQSFQKSPQMDRLAIRRLLEN
CCCCCHHHHHCCCCCCHHCCCCCCCCEEEECCEEEECCCHHHHHCCCCHHHHHHHHHHHH
SILSTEGIKWTWISERRQELNIAKNQGFTERVALVMGEAFVNEAFLIDKRQNELHLTGFL
HHCCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEC
GSPSMHRSTRQGQRLFINNRAVESSFISRKVAEAYAWMLPAQRYPAFVLKLSVPPMWCDF
CCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECC
NVHPQKTEVRLLQEGQIGALLVEAISEVLLHRSPSLEEKMVEPTMESPLIENGGLEIPSI
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCHHCCCCCCCCCCCCCCC
RPVAISTPLSCPNFLQQSFVETEANRALCKEQENLALPIIERVRFLASLGKVILVEDSEG
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCC
VHALFVQAARKHLFYISLLSKRSDSLLACQMFLVPPTVQMTKLEADFLQTRLESLAAQGI
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
ELCRISPDSFAIESAPPFIQEEELKEWIISLAHEGAFQVNESFEQLVENTVQKLAFSKNT
CEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
RAFDHSWINVLWQIGKPEKAFDGETIRRLVLEEDFM
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLSSSRIRLLDSATVNQIAAGEVIENAASVVKELIENALDAGADEISIETLGGGKGQIV
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEE
VRDNGIGMDADEVAVAIQRHATSKISHFADIFSLASFGFRGEALPAIASISKMEIHTAKV
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEEEE
NGLGSKTLIEKGEPVCCEACPRQPGTTISVNSLFYNVPMRQSFQKSPQMDRLAIRRLLEN
CCCCCHHHHHCCCCCCHHCCCCCCCCEEEECCEEEECCCHHHHHCCCCHHHHHHHHHHHH
SILSTEGIKWTWISERRQELNIAKNQGFTERVALVMGEAFVNEAFLIDKRQNELHLTGFL
HHCCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEEC
GSPSMHRSTRQGQRLFINNRAVESSFISRKVAEAYAWMLPAQRYPAFVLKLSVPPMWCDF
CCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECC
NVHPQKTEVRLLQEGQIGALLVEAISEVLLHRSPSLEEKMVEPTMESPLIENGGLEIPSI
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCHHCCCCCCCCCCCCCCC
RPVAISTPLSCPNFLQQSFVETEANRALCKEQENLALPIIERVRFLASLGKVILVEDSEG
CCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCC
VHALFVQAARKHLFYISLLSKRSDSLLACQMFLVPPTVQMTKLEADFLQTRLESLAAQGI
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
ELCRISPDSFAIESAPPFIQEEELKEWIISLAHEGAFQVNESFEQLVENTVQKLAFSKNT
CEEEECCCCEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCC
RAFDHSWINVLWQIGKPEKAFDGETIRRLVLEEDFM
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935