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The map label for this gene is pepP

Identifier: 15835477

GI number: 15835477

Start: 998746

End: 999816

Strand: Reverse

Name: pepP

Synonym: TC0863

Alternate gene names: 15835477

Gene position: 999816-998746 (Counterclockwise)

Preceding gene: 15835478

Following gene: 15835476

Centisome position: 93.18

GC content: 43.51

Gene sequence:

>1071_bases
ATGAATCAAAATCCGATCACGCGACTACAACACTTATTATCAGGTTATGCTCTTGATGCTTTTCTAATAGAGAAAGACGA
GGATATTAGTTATTTTCTACAAGATCAGGCTAAATCCGGAGCTTTACTGGTCTCTAGTGATGAAGTGGTGTTTTTTGTTT
CTCCTCTAGATCGGGATCTTTATGCGCACATACAGGATGTTTCGCTAGTTTTTTGTTCCAAAAATATAGATCAACACTTG
TTTGCATACATTGAAGAAAAGGGATTAAAAACCATCGGGTTCGATAGCGAATATACTTCTTATGGAACTGCGCAAAAACG
CATGAGAAGTGGTCTGACGTTTTCCCCTCAAAGTTTAGTTACAGAGAAGCTGCGCTGTGTGAAGAGCCCGAATGAAATTC
AAAAGATGATGCGTGCAGCAGAAATTGGTTCCGCAGGATATGACTTTGTGCTAGCGGCGCTACGTCCCGGTATTACGGAA
AAAGAGCTGGTACGGTTGCTTCATGTTTTTTGGGCTAATCTTGGCATAGAGAAGCTCTCTTTCCCTCCCATTATTGCGTT
TGGAGAGAACGCGGCTTTCCCACATGCGATTCCTACAAATCGATCTTTGAAAAAAGGGGACGTGGTTTTGATCGATATTG
GTGTTTGCTACGAAGGATATTGTTCGGATATGACCCGAACGGTTGCTTTCGGGGAAGCTCCAGAACAGCAGCTATTGGAT
GGATACCTCGCTGTAGCGGAAGCGCAACGTCGATCCATAGAGTTGTGTCGAGAGGGGGTCTCCTGTCGAGCTGTCCATGA
AGAGGCTGTGCGCGTTTTGCGGGAATATGGAATGGAAAAAGCATTTATTCATGGATTAGGGCATGGTGTAGGTAGAGAGG
TGCATGAATACCCTCGTTTGTCGCTTTTTTCCGATGCGGAATTGCAATTAAATATGGCCGTGACTGTGGAGCCCGGTGTC
TATTTCCCTGGCGTTGGGGGAATTCGCATTGAAGACACAATCGTGATAGGTATTAATGAAAATTTAAATTTAACAAATCG
CAAAGTCTCCCCAGAGATAATTATCATTTAA

Upstream 100 bases:

>100_bases
GATCAATGTATTATGGCAAATAGGAAAACCTGAAAAAGCATTTGACGGGGAGACAATACGTCGGTTAGTTTTGGAGGAGG
ACTTTATGTAGGAGAGGGGA

Downstream 100 bases:

>100_bases
TTTCATATAAAAGCCGTTTTTTATTTTAAAAATATAAAAACGGCTTTTTCTTGTTTTTTGTAAAAATTGATTTTTTTTCT
CAAATCAGTTACTTTATATA

Product: proline dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MNQNPITRLQHLLSGYALDAFLIEKDEDISYFLQDQAKSGALLVSSDEVVFFVSPLDRDLYAHIQDVSLVFCSKNIDQHL
FAYIEEKGLKTIGFDSEYTSYGTAQKRMRSGLTFSPQSLVTEKLRCVKSPNEIQKMMRAAEIGSAGYDFVLAALRPGITE
KELVRLLHVFWANLGIEKLSFPPIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFGEAPEQQLLD
GYLAVAEAQRRSIELCREGVSCRAVHEEAVRVLREYGMEKAFIHGLGHGVGREVHEYPRLSLFSDAELQLNMAVTVEPGV
YFPGVGGIRIEDTIVIGINENLNLTNRKVSPEIIII

Sequences:

>Translated_356_residues
MNQNPITRLQHLLSGYALDAFLIEKDEDISYFLQDQAKSGALLVSSDEVVFFVSPLDRDLYAHIQDVSLVFCSKNIDQHL
FAYIEEKGLKTIGFDSEYTSYGTAQKRMRSGLTFSPQSLVTEKLRCVKSPNEIQKMMRAAEIGSAGYDFVLAALRPGITE
KELVRLLHVFWANLGIEKLSFPPIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFGEAPEQQLLD
GYLAVAEAQRRSIELCREGVSCRAVHEEAVRVLREYGMEKAFIHGLGHGVGREVHEYPRLSLFSDAELQLNMAVTVEPGV
YFPGVGGIRIEDTIVIGINENLNLTNRKVSPEIIII
>Mature_356_residues
MNQNPITRLQHLLSGYALDAFLIEKDEDISYFLQDQAKSGALLVSSDEVVFFVSPLDRDLYAHIQDVSLVFCSKNIDQHL
FAYIEEKGLKTIGFDSEYTSYGTAQKRMRSGLTFSPQSLVTEKLRCVKSPNEIQKMMRAAEIGSAGYDFVLAALRPGITE
KELVRLLHVFWANLGIEKLSFPPIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFGEAPEQQLLD
GYLAVAEAQRRSIELCREGVSCRAVHEEAVRVLREYGMEKAFIHGLGHGVGREVHEYPRLSLFSDAELQLNMAVTVEPGV
YFPGVGGIRIEDTIVIGINENLNLTNRKVSPEIIII

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=260, Percent_Identity=29.6153846153846, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI264681563, Length=184, Percent_Identity=37.5, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI93141226, Length=166, Percent_Identity=34.9397590361446, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI149589008, Length=278, Percent_Identity=27.3381294964029, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI260593665, Length=278, Percent_Identity=27.3381294964029, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI40385867, Length=205, Percent_Identity=26.8292682926829, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788728, Length=341, Percent_Identity=33.1378299120235, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1789275, Length=284, Percent_Identity=32.7464788732394, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786364, Length=217, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=288, Percent_Identity=28.125, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71989583, Length=241, Percent_Identity=29.045643153527, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17509539, Length=168, Percent_Identity=33.9285714285714, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6320922, Length=269, Percent_Identity=28.996282527881, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323273, Length=205, Percent_Identity=25.8536585365854, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321118, Length=291, Percent_Identity=23.0240549828179, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357079, Length=321, Percent_Identity=29.2834890965732, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19920384, Length=274, Percent_Identity=28.8321167883212, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39665; Mature: 39665

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNPITRLQHLLSGYALDAFLIEKDEDISYFLQDQAKSGALLVSSDEVVFFVSPLDRDL
CCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCCCEEEEECCCEEEEECCCCCHH
YAHIQDVSLVFCSKNIDQHLFAYIEEKGLKTIGFDSEYTSYGTAQKRMRSGLTFSPQSLV
HHHHHHHEEEEECCCHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHCCCCCCHHHHH
TEKLRCVKSPNEIQKMMRAAEIGSAGYDFVLAALRPGITEKELVRLLHVFWANLGIEKLS
HHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
FPPIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFGEAPEQQLLD
CCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCHHHHHH
GYLAVAEAQRRSIELCREGVSCRAVHEEAVRVLREYGMEKAFIHGLGHGVGREVHEYPRL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHCCCC
SLFSDAELQLNMAVTVEPGVYFPGVGGIRIEDTIVIGINENLNLTNRKVSPEIIII
EEECCCCEEEEEEEEECCCEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEC
>Mature Secondary Structure
MNQNPITRLQHLLSGYALDAFLIEKDEDISYFLQDQAKSGALLVSSDEVVFFVSPLDRDL
CCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCCCEEEEECCCEEEEECCCCCHH
YAHIQDVSLVFCSKNIDQHLFAYIEEKGLKTIGFDSEYTSYGTAQKRMRSGLTFSPQSLV
HHHHHHHEEEEECCCHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHCCCCCCHHHHH
TEKLRCVKSPNEIQKMMRAAEIGSAGYDFVLAALRPGITEKELVRLLHVFWANLGIEKLS
HHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
FPPIIAFGENAAFPHAIPTNRSLKKGDVVLIDIGVCYEGYCSDMTRTVAFGEAPEQQLLD
CCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCHHHHHH
GYLAVAEAQRRSIELCREGVSCRAVHEEAVRVLREYGMEKAFIHGLGHGVGREVHEYPRL
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHCCCC
SLFSDAELQLNMAVTVEPGVYFPGVGGIRIEDTIVIGINENLNLTNRKVSPEIIII
EEECCCCEEEEEEEEECCCEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]