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Identifier: 15835453

GI number: 15835453

Start: 973160

End: 974476

Strand: Direct

Name: Not Available

Synonym: TC0839

Alternate gene names: 15835453

Gene position: 973160-974476 (Clockwise)

Preceding gene: 15835451

Following gene: 15835454

Centisome position: 90.7

GC content: 44.04

Gene sequence:

>1317_bases
ATGCGTATTCTTTCTTTGTTGTGCAGGTTCTTTATCTGCTCAAGTCCTCTTTTTCTACAGCCCGCTTCTTTGCTAGCCGC
TTCTCCCGCCATCACAACAAAAGGATTAGCCGCCGCAGTCATGCACGCAGATTCCGGAGCTATTCTTAAAGAAAAGAACC
TAGATCAAAAGATTTTCCCTGCAAGCATGACAAAGATTGCCACAGCCTTGCTCATCTTACGAAAACACCCTGATGTTTTA
ACTCGATTTATCACTATCCGAAGAGAACCTCTTACCTCCATCACCCCTCAGGCAAAACAACAATCCGGATACCGAAGTCC
TCCCCACTGGCTGGAAACGGATGGTGTGGCCATCCAATTAAAATCCAAAGAAGAAGTTTCTGGTTGGGATCTTTTCCACG
CACTTCTAATTAGTTCTGCCAACGATGCTGCTAATGTTCTGGCAGATGCTTGTTGTCAAAGTGTTCCCGCTTTCATGCAT
CAGCTCAATGATTTCTTAAAAGAGATTGGCTGTCAAAATACCCACTTTAATTCTCCTCACGGCCTCCACCACCCTGACCA
CTACACTACCGCTAGAGATCTAGCTATCATTATGAAAGAAGCGTTAAAAGAACCCCTATTCTGTCAGGTCATTCGCACAG
CCTCCTATACCATGGAGTCAACAAATCTAAGCCCAGAAAGAACGCTATCTTCCACCAATCGCCTTCTTTCCTCTTCTTCA
ACCTACTTTTATCCTCCCTGTTTAGGAGGGAAAACAGGCACAACCAAAAGCGCAGGGAAAAATATTGTCTTTGCAGCAGA
AAAGAATAACCGTTCGATTATCGTCGTGGCAGCCGGCTATTTTGGTCCTGCAGCACAACTTTACCAAGATGCTATCGCTG
TATGTGAAGATTTATTCAATGAGCAGCTATTACGTTGCTTCTTGCTCCCTCCTGCTAGTCAGTACTCCGTGAAAACCAAA
TTTGGACCCATAACTGCCCCGGTATCTCAAGGAATTTATTATGACTTTTATCCTTCCGAAGGGGACCCCCTCTTATCCCT
TTCTCTGGAATCGTCTAAAATCGCTTTCCCTATTCGACAAGGAGATCTTTTAGGTCACTGGATTCTATCCTCCCCCTCAG
GAGAAAAAGTTCATTCCATCCCATTCCTAGCAGAAAGCGATATCCTTCCCTCCTTTAAGCAACGGATTCTTTTAACCAGT
CTGCGAATCCTTACCTCGTATCGGACCTATGTCCTTATCTTGCTTTTCTTTTTGCTCAATCGAAAGAAAAAACATTCCCG
AGCCACTAAAACTTTTTCTAACCCTTTTTTCTCTTAA

Upstream 100 bases:

>100_bases
TCCTCTTTCTCAAGGGTAATTTTTTATTAAAAGCGCCGTCAAGAGCTTTTTTGATATTCGTAACTGGAAGTTCTTAGAAA
GCAGACCATCAGCAGGTTCT

Downstream 100 bases:

>100_bases
CTCTCTATCTTGGAAATCTTTAGCGGACTTTTTTTCCGCTTTTTTCTAAGATTTTTGCGTTGTTAGAGAAAGTCTTTTTC
CTTTCCTGTTCTTTCTCAAG

Product: D-alanyl-D-alanine carboxypeptidase, putative

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 5*; PBP-5* [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRILSLLCRFFICSSPLFLQPASLLAASPAITTKGLAAAVMHADSGAILKEKNLDQKIFPASMTKIATALLILRKHPDVL
TRFITIRREPLTSITPQAKQQSGYRSPPHWLETDGVAIQLKSKEEVSGWDLFHALLISSANDAANVLADACCQSVPAFMH
QLNDFLKEIGCQNTHFNSPHGLHHPDHYTTARDLAIIMKEALKEPLFCQVIRTASYTMESTNLSPERTLSSTNRLLSSSS
TYFYPPCLGGKTGTTKSAGKNIVFAAEKNNRSIIVVAAGYFGPAAQLYQDAIAVCEDLFNEQLLRCFLLPPASQYSVKTK
FGPITAPVSQGIYYDFYPSEGDPLLSLSLESSKIAFPIRQGDLLGHWILSSPSGEKVHSIPFLAESDILPSFKQRILLTS
LRILTSYRTYVLILLFFLLNRKKKHSRATKTFSNPFFS

Sequences:

>Translated_438_residues
MRILSLLCRFFICSSPLFLQPASLLAASPAITTKGLAAAVMHADSGAILKEKNLDQKIFPASMTKIATALLILRKHPDVL
TRFITIRREPLTSITPQAKQQSGYRSPPHWLETDGVAIQLKSKEEVSGWDLFHALLISSANDAANVLADACCQSVPAFMH
QLNDFLKEIGCQNTHFNSPHGLHHPDHYTTARDLAIIMKEALKEPLFCQVIRTASYTMESTNLSPERTLSSTNRLLSSSS
TYFYPPCLGGKTGTTKSAGKNIVFAAEKNNRSIIVVAAGYFGPAAQLYQDAIAVCEDLFNEQLLRCFLLPPASQYSVKTK
FGPITAPVSQGIYYDFYPSEGDPLLSLSLESSKIAFPIRQGDLLGHWILSSPSGEKVHSIPFLAESDILPSFKQRILLTS
LRILTSYRTYVLILLFFLLNRKKKHSRATKTFSNPFFS
>Mature_438_residues
MRILSLLCRFFICSSPLFLQPASLLAASPAITTKGLAAAVMHADSGAILKEKNLDQKIFPASMTKIATALLILRKHPDVL
TRFITIRREPLTSITPQAKQQSGYRSPPHWLETDGVAIQLKSKEEVSGWDLFHALLISSANDAANVLADACCQSVPAFMH
QLNDFLKEIGCQNTHFNSPHGLHHPDHYTTARDLAIIMKEALKEPLFCQVIRTASYTMESTNLSPERTLSSTNRLLSSSS
TYFYPPCLGGKTGTTKSAGKNIVFAAEKNNRSIIVVAAGYFGPAAQLYQDAIAVCEDLFNEQLLRCFLLPPASQYSVKTK
FGPITAPVSQGIYYDFYPSEGDPLLSLSLESSKIAFPIRQGDLLGHWILSSPSGEKVHSIPFLAESDILPSFKQRILLTS
LRILTSYRTYVLILLFFLLNRKKKHSRATKTFSNPFFS

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors. Required specifically for the synthesis of the spore form of peptidoglycan (cortex) [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Forespore outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=282, Percent_Identity=30.8510638297872, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI87082022, Length=281, Percent_Identity=26.3345195729537, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786851, Length=287, Percent_Identity=26.1324041811847, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 48491; Mature: 48491

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILSLLCRFFICSSPLFLQPASLLAASPAITTKGLAAAVMHADSGAILKEKNLDQKIFP
CHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHEECCCCCEEECCCCCCCCCH
ASMTKIATALLILRKHPDVLTRFITIRREPLTSITPQAKQQSGYRSPPHWLETDGVAIQL
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEEE
KSKEEVSGWDLFHALLISSANDAANVLADACCQSVPAFMHQLNDFLKEIGCQNTHFNSPH
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GLHHPDHYTTARDLAIIMKEALKEPLFCQVIRTASYTMESTNLSPERTLSSTNRLLSSSS
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCC
TYFYPPCLGGKTGTTKSAGKNIVFAAEKNNRSIIVVAAGYFGPAAQLYQDAIAVCEDLFN
CEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
EQLLRCFLLPPASQYSVKTKFGPITAPVSQGIYYDFYPSEGDPLLSLSLESSKIAFPIRQ
HHHHHHHCCCCCCCCEEEECCCCCCCHHHCCEEEEECCCCCCCEEEEEECCCEEEEEECC
GDLLGHWILSSPSGEKVHSIPFLAESDILPSFKQRILLTSLRILTSYRTYVLILLFFLLN
CCEEEEEEECCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RKKKHSRATKTFSNPFFS
CHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRILSLLCRFFICSSPLFLQPASLLAASPAITTKGLAAAVMHADSGAILKEKNLDQKIFP
CHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHEECCCCCEEECCCCCCCCCH
ASMTKIATALLILRKHPDVLTRFITIRREPLTSITPQAKQQSGYRSPPHWLETDGVAIQL
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEEE
KSKEEVSGWDLFHALLISSANDAANVLADACCQSVPAFMHQLNDFLKEIGCQNTHFNSPH
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GLHHPDHYTTARDLAIIMKEALKEPLFCQVIRTASYTMESTNLSPERTLSSTNRLLSSSS
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCC
TYFYPPCLGGKTGTTKSAGKNIVFAAEKNNRSIIVVAAGYFGPAAQLYQDAIAVCEDLFN
CEEECCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
EQLLRCFLLPPASQYSVKTKFGPITAPVSQGIYYDFYPSEGDPLLSLSLESSKIAFPIRQ
HHHHHHHCCCCCCCCEEEECCCCCCCHHHCCEEEEECCCCCCCEEEEEECCCEEEEEECC
GDLLGHWILSSPSGEKVHSIPFLAESDILPSFKQRILLTSLRILTSYRTYVLILLFFLLN
CCEEEEEEECCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RKKKHSRATKTFSNPFFS
CHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1548223; 7934829; 9384377 [H]