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The map label for this gene is upp

Identifier: 15835447

GI number: 15835447

Start: 968582

End: 969493

Strand: Direct

Name: upp

Synonym: TC0833

Alternate gene names: 15835447

Gene position: 968582-969493 (Clockwise)

Preceding gene: 15835446

Following gene: 15835449

Centisome position: 90.27

GC content: 41.89

Gene sequence:

>912_bases
TTGCACATCATAATGAAAACTATTCTCGCTACTTTATGCCTAATCTTATGCGCTTCCTGCTGTTCAAAAGGAGCTTGCGA
AACTCGCATCAAACACACTTTTTCAGAAAAAAAATTTCAAAAATACTCTCCCGTTCCTAAACACCCTTTGTCTGAGCAAA
CCCACCTGTATGCTAAATCGTGTTCTATAGAACTAGAACAGACGCAACTTCCTACAAGTACCCTCACACGTTACGTCTCT
TCGACCCCTACTGATTCTTTGTCTTCTAAACCTTTAGCAGCAGTCTATGTACTAAGCCACCCTCTGATACAGCATAAAGC
TTCGCTTCTTCGGAATAAAAACACGAAGTCTAAAATATTCCGTGAATGCCTAAAAGAAATCTCTTTAGGCGTTTGCTATG
AAGCAACCCGCGATCTCGCCCTTAAAAATATCTCTATTCAAACCCCCTTAATGCAAGCAGAATGCCCTCATCTTACTGGG
ACTAAAATTGTTGTTATTCCAGTATTAAGAGCTGGACTCGGAATGGTGGATGGATTCCTTGCTCTGGTTCCTAATGCTAA
AGTAGGACTTATTGGCATGAGTCGAAATCACGAGACATTCCAACCCTCTTCCTACTGTTGCAAACTACCTGAAGACATTG
CTGACTGCCACGTGTTTATCGTTGATCCCATGTTAGCAACTGGTGGATCGGCTTCAGCAACTATTCAACTAGTGAAGGAA
CATGGCGCTAAAAACATTACTCTACTCAATGTTTTAGCAGTGCCCGAAGGAATCGAACGCATTCAAAAAGATCACCCTGA
TGTAACTATCTATGTAGCCTCTCTCGATGAAAAATTGAATGAATCCGCTTATATTCTTCCTGGATTAGGTGATGCCGGAG
ATCGTCTCTGTGGGACATCCAATCCATCCTAA

Upstream 100 bases:

>100_bases
CTATAAATCTTCTCTGTCGCTATTGTGGGCGGGTTTTTAATATCTTAATTGACACGCTTAAAAAACTTCTTTAATATTTA
GAGAATTTGTTTTTTTTAGG

Downstream 100 bases:

>100_bases
TCTGTTTTTGAAGAAAGATTTAATAAACGAGGGGGCTGCATTTCCACCCTCGTTTTTTTAGGGAGATAAAAAGAGAAAGA
GAAGAGTACTCAATAGAGAT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MHIIMKTILATLCLILCASCCSKGACETRIKHTFSEKKFQKYSPVPKHPLSEQTHLYAKSCSIELEQTQLPTSTLTRYVS
STPTDSLSSKPLAAVYVLSHPLIQHKASLLRNKNTKSKIFRECLKEISLGVCYEATRDLALKNISIQTPLMQAECPHLTG
TKIVVIPVLRAGLGMVDGFLALVPNAKVGLIGMSRNHETFQPSSYCCKLPEDIADCHVFIVDPMLATGGSASATIQLVKE
HGAKNITLLNVLAVPEGIERIQKDHPDVTIYVASLDEKLNESAYILPGLGDAGDRLCGTSNPS

Sequences:

>Translated_303_residues
MHIIMKTILATLCLILCASCCSKGACETRIKHTFSEKKFQKYSPVPKHPLSEQTHLYAKSCSIELEQTQLPTSTLTRYVS
STPTDSLSSKPLAAVYVLSHPLIQHKASLLRNKNTKSKIFRECLKEISLGVCYEATRDLALKNISIQTPLMQAECPHLTG
TKIVVIPVLRAGLGMVDGFLALVPNAKVGLIGMSRNHETFQPSSYCCKLPEDIADCHVFIVDPMLATGGSASATIQLVKE
HGAKNITLLNVLAVPEGIERIQKDHPDVTIYVASLDEKLNESAYILPGLGDAGDRLCGTSNPS
>Mature_303_residues
MHIIMKTILATLCLILCASCCSKGACETRIKHTFSEKKFQKYSPVPKHPLSEQTHLYAKSCSIELEQTQLPTSTLTRYVS
STPTDSLSSKPLAAVYVLSHPLIQHKASLLRNKNTKSKIFRECLKEISLGVCYEATRDLALKNISIQTPLMQAECPHLTG
TKIVVIPVLRAGLGMVDGFLALVPNAKVGLIGMSRNHETFQPSSYCCKLPEDIADCHVFIVDPMLATGGSASATIQLVKE
HGAKNITLLNVLAVPEGIERIQKDHPDVTIYVASLDEKLNESAYILPGLGDAGDRLCGTSNPS

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI57863312, Length=207, Percent_Identity=28.0193236714976, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI301129207, Length=207, Percent_Identity=28.0193236714976, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI87082118, Length=202, Percent_Identity=48.019801980198, Blast_Score=203, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17539894, Length=205, Percent_Identity=23.9024390243902, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17539892, Length=205, Percent_Identity=23.9024390243902, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=213, Percent_Identity=34.7417840375587, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45550449, Length=227, Percent_Identity=29.0748898678414, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28573516, Length=226, Percent_Identity=29.2035398230088, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28573514, Length=226, Percent_Identity=29.2035398230088, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28573512, Length=226, Percent_Identity=29.2035398230088, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_CHLMU (Q9PJJ6)

Other databases:

- EMBL:   AE002160
- PIR:   H81658
- RefSeq:   NP_297206.1
- ProteinModelPortal:   Q9PJJ6
- SMR:   Q9PJJ6
- GeneID:   1246201
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0833
- TIGR:   TC_0833
- HOGENOM:   HBG326432
- OMA:   LRAGNGF
- PhylomeDB:   Q9PJJ6
- BioCyc:   CMUR243161:TC_0833-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 32970; Mature: 32970

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: BINDING 170-170 BINDING 195-195 BINDING 285-285 BINDING 291-291

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIIMKTILATLCLILCASCCSKGACETRIKHTFSEKKFQKYSPVPKHPLSEQTHLYAKS
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEHHH
CSIELEQTQLPTSTLTRYVSSTPTDSLSSKPLAAVYVLSHPLIQHKASLLRNKNTKSKIF
CCEEEHHHHCCHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHH
RECLKEISLGVCYEATRDLALKNISIQTPLMQAECPHLTGTKIVVIPVLRAGLGMVDGFL
HHHHHHCCCCHHHHHHHHHHHHCCEECCCCHHCCCCCCCCCEEEEEEHHHHHHHHHHHHH
ALVPNAKVGLIGMSRNHETFQPSSYCCKLPEDIADCHVFIVDPMLATGGSASATIQLVKE
HHCCCCCEEEEEECCCCCCCCCCHHHHCCCHHHHCCEEEEECCHHHCCCCCHHHHHHHHH
HGAKNITLLNVLAVPEGIERIQKDHPDVTIYVASLDEKLNESAYILPGLGDAGDRLCGTS
CCCCCEEEEEEECCCHHHHHHHHCCCCEEEEEEECHHHCCCCEEEECCCCCCCCCCCCCC
NPS
CCC
>Mature Secondary Structure
MHIIMKTILATLCLILCASCCSKGACETRIKHTFSEKKFQKYSPVPKHPLSEQTHLYAKS
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHEEHHH
CSIELEQTQLPTSTLTRYVSSTPTDSLSSKPLAAVYVLSHPLIQHKASLLRNKNTKSKIF
CCEEEHHHHCCHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHH
RECLKEISLGVCYEATRDLALKNISIQTPLMQAECPHLTGTKIVVIPVLRAGLGMVDGFL
HHHHHHCCCCHHHHHHHHHHHHCCEECCCCHHCCCCCCCCCEEEEEEHHHHHHHHHHHHH
ALVPNAKVGLIGMSRNHETFQPSSYCCKLPEDIADCHVFIVDPMLATGGSASATIQLVKE
HHCCCCCEEEEEECCCCCCCCCCHHHHCCCHHHHCCEEEEECCHHHCCCCCHHHHHHHHH
HGAKNITLLNVLAVPEGIERIQKDHPDVTIYVASLDEKLNESAYILPGLGDAGDRLCGTS
CCCCCEEEEEEECCCHHHHHHHHCCCCEEEEEEECHHHCCCCEEEECCCCCCCCCCCCCC
NPS
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935