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The map label for this gene is trxA

Identifier: 15835440

GI number: 15835440

Start: 958259

End: 958567

Strand: Direct

Name: trxA

Synonym: TC0826

Alternate gene names: 15835440

Gene position: 958259-958567 (Clockwise)

Preceding gene: 15835400

Following gene: 15835445

Centisome position: 89.31

GC content: 41.1

Gene sequence:

>309_bases
ATGGTCCAAATTGTATCTCAAGATAATTTCGCTGATAGCATTGCTTCTGGGCTAGTCCTTGTCGATTTTTTTGCTGAATG
GTGTGGCCCTTGTAAAATGCTTACCCCAGTATTAGAAGCATTGGCAGCAGAACTTCCTTATGTAACTATCCTGAAATTGG
ATATTGATGCTTCTCCCCGCCCTGCAGAACAATTTGGCGTTTCCTCCATTCCAACGCTCATCCTCTTTAAAGATGGAAAA
GAAGTAGAGCGCAGCGTCGGCTTGAAAGATAAAGATTCTCTAGTCAAGCTTATTTCTAAACATCAATAA

Upstream 100 bases:

>100_bases
TTTCAGAACACGGCTAACTCCGTTTGCTAGCAGTTCTTAGGGAAGCCCTGAAACCTCCCTGCAAGGATTTATATAGATTT
TTAAATTAGGAATAAGTTTT

Downstream 100 bases:

>100_bases
AGTGATTCATAAAAAAGGCCGAGAGTTTCTCGGCCTTAAGATACTTCAAAATAAATTCTGATAATTTTGTCGAGCCACTT
CATACATAACAATCCCTACA

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 102; Mature: 102

Protein sequence:

>102_residues
MVQIVSQDNFADSIASGLVLVDFFAEWCGPCKMLTPVLEALAAELPYVTILKLDIDASPRPAEQFGVSSIPTLILFKDGK
EVERSVGLKDKDSLVKLISKHQ

Sequences:

>Translated_102_residues
MVQIVSQDNFADSIASGLVLVDFFAEWCGPCKMLTPVLEALAAELPYVTILKLDIDASPRPAEQFGVSSIPTLILFKDGK
EVERSVGLKDKDSLVKLISKHQ
>Mature_102_residues
MVQIVSQDNFADSIASGLVLVDFFAEWCGPCKMLTPVLEALAAELPYVTILKLDIDASPRPAEQFGVSSIPTLILFKDGK
EVERSVGLKDKDSLVKLISKHQ

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI42794771, Length=101, Percent_Identity=36.6336633663366, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI224493972, Length=101, Percent_Identity=36.6336633663366, Blast_Score=74, Evalue=2e-14,
Organism=Homo sapiens, GI21361657, Length=102, Percent_Identity=39.2156862745098, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=40, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI95113651, Length=87, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=41, Blast_Score=84, Evalue=1e-18,
Organism=Escherichia coli, GI1788936, Length=66, Percent_Identity=39.3939393939394, Blast_Score=62, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=33.7078651685393, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17510299, Length=104, Percent_Identity=33.6538461538462, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=37.037037037037, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507915, Length=95, Percent_Identity=35.7894736842105, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=89, Percent_Identity=47.1910112359551, Blast_Score=86, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323072, Length=88, Percent_Identity=44.3181818181818, Blast_Score=82, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=69, Percent_Identity=42.0289855072464, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639826, Length=85, Percent_Identity=40, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859803, Length=99, Percent_Identity=37.3737373737374, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=44.3037974683544, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=44.3037974683544, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24658597, Length=84, Percent_Identity=38.0952380952381, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573567, Length=83, Percent_Identity=40.9638554216867, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358065, Length=77, Percent_Identity=44.1558441558442, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664269, Length=89, Percent_Identity=39.3258426966292, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_CHLMU (Q9PJK3)

Other databases:

- EMBL:   AE002160
- PIR:   C81660
- RefSeq:   NP_297199.1
- ProteinModelPortal:   Q9PJK3
- SMR:   Q9PJK3
- GeneID:   1246194
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0826
- TIGR:   TC_0826
- HOGENOM:   HBG493509
- OMA:   ELANEMQ
- PhylomeDB:   Q9PJK3
- ProtClustDB:   CLSK871432
- BioCyc:   CMUR243161:TC_0826-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11147; Mature: 11147

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQIVSQDNFADSIASGLVLVDFFAEWCGPCKMLTPVLEALAAELPYVTILKLDIDASPR
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
PAEQFGVSSIPTLILFKDGKEVERSVGLKDKDSLVKLISKHQ
CHHHCCCCCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MVQIVSQDNFADSIASGLVLVDFFAEWCGPCKMLTPVLEALAAELPYVTILKLDIDASPR
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
PAEQFGVSSIPTLILFKDGKEVERSVGLKDKDSLVKLISKHQ
CHHHCCCCCCCEEEEEECCHHHHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935