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Identifier: 15835437

GI number: 15835437

Start: 955612

End: 956364

Strand: Reverse

Name: Not Available

Synonym: TC0823

Alternate gene names: 15835437

Gene position: 956364-955612 (Counterclockwise)

Preceding gene: 15835438

Following gene: 15835436

Centisome position: 89.13

GC content: 37.45

Gene sequence:

>753_bases
GTGGTATTGTTGAAAGATATAGAGTTCGTTTGTTTGGATTGTGAAACGACAGGATTGGATGTAAAAAAAGATCGAGTTAT
TGAATTTGCTGCGATTCGGTTTACATTCGATGAAGTAATTGATTCTGTGGAGTTTCTTATTCATCCAGAGCGTGCTGTTT
CAGCGGAGTCTCAAAAGATTCATAAGATTTCTGATGCCATGTTAAAAGACAAACCGAAATTTAGTGAGGTATTCTCTACA
ATCAAGGGTTTCTTTAAGGAACGGGATTATATTGTTGGGCACCATGTAGGGTTTGATTTACAAGTGCTTTCGCAAGAAAG
TGAGCGTTTGGGAGAGACTCTTCTTCCGAAGCAGCATTATGTGATTGATACTTTGCGTTTGGCGAAAGAATATGGCGATA
GCCCTAATAATTCTTTAGAAGCCCTAGCGAGGCATTTCAATGTTCCTCATCAAGGGAATCACCGAGCAATGAAAGATGTG
GAAATGAATGTTAAGGTGTTTAAACACTTAACAAAAAGATTCCGTACTTTGTCCCAAGTAACACATATTCTGTCTAAACC
TATTAAAATGAAATATATGCCATTAGGGAAGTATAAAGGACGGTTGTTCACAGATATTCCGCTAGAATATCTATTATGGG
CTTCAAAAATGGACTTTGATCAGGACCTTTTATTTTCTATTCGTAGCGAGATCAAATCTCGGAAAAAGGGCACAGGGTTT
ACTCAAGCAAATAATCCTTTTTTAGGATTGTAG

Upstream 100 bases:

>100_bases
TTGTGTGCATATGTGTCTTCTTGCGGATTCGCAGAGGGAAGTGGTTATAGAAGTCGCAGAAGATTGTGACTTAGGCTTTT
TTATGGGGAAAGATTAGAGC

Downstream 100 bases:

>100_bases
TCTTCCAAGGAATTCCTTGCTTTTCTTCTATTCCGGTACTACTATCCGCTACAGAGCAGGCTGGGGGATAGAGAGGGATC
AATAACTCTAAGACTGGTCG

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MVLLKDIEFVCLDCETTGLDVKKDRVIEFAAIRFTFDEVIDSVEFLIHPERAVSAESQKIHKISDAMLKDKPKFSEVFST
IKGFFKERDYIVGHHVGFDLQVLSQESERLGETLLPKQHYVIDTLRLAKEYGDSPNNSLEALARHFNVPHQGNHRAMKDV
EMNVKVFKHLTKRFRTLSQVTHILSKPIKMKYMPLGKYKGRLFTDIPLEYLLWASKMDFDQDLLFSIRSEIKSRKKGTGF
TQANNPFLGL

Sequences:

>Translated_250_residues
MVLLKDIEFVCLDCETTGLDVKKDRVIEFAAIRFTFDEVIDSVEFLIHPERAVSAESQKIHKISDAMLKDKPKFSEVFST
IKGFFKERDYIVGHHVGFDLQVLSQESERLGETLLPKQHYVIDTLRLAKEYGDSPNNSLEALARHFNVPHQGNHRAMKDV
EMNVKVFKHLTKRFRTLSQVTHILSKPIKMKYMPLGKYKGRLFTDIPLEYLLWASKMDFDQDLLFSIRSEIKSRKKGTGF
TQANNPFLGL
>Mature_250_residues
MVLLKDIEFVCLDCETTGLDVKKDRVIEFAAIRFTFDEVIDSVEFLIHPERAVSAESQKIHKISDAMLKDKPKFSEVFST
IKGFFKERDYIVGHHVGFDLQVLSQESERLGETLLPKQHYVIDTLRLAKEYGDSPNNSLEALARHFNVPHQGNHRAMKDV
EMNVKVFKHLTKRFRTLSQVTHILSKPIKMKYMPLGKYKGRLFTDIPLEYLLWASKMDFDQDLLFSIRSEIKSRKKGTGF
TQANNPFLGL

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

Organism=Escherichia coli, GI1788149, Length=201, Percent_Identity=27.363184079602, Blast_Score=74, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 28924; Mature: 28924

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLLKDIEFVCLDCETTGLDVKKDRVIEFAAIRFTFDEVIDSVEFLIHPERAVSAESQKI
CEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HKISDAMLKDKPKFSEVFSTIKGFFKERDYIVGHHVGFDLQVLSQESERLGETLLPKQHY
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHH
VIDTLRLAKEYGDSPNNSLEALARHFNVPHQGNHRAMKDVEMNVKVFKHLTKRFRTLSQV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
THILSKPIKMKYMPLGKYKGRLFTDIPLEYLLWASKMDFDQDLLFSIRSEIKSRKKGTGF
HHHHCCCCEEEEEECCCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
TQANNPFLGL
CCCCCCCCCC
>Mature Secondary Structure
MVLLKDIEFVCLDCETTGLDVKKDRVIEFAAIRFTFDEVIDSVEFLIHPERAVSAESQKI
CEEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
HKISDAMLKDKPKFSEVFSTIKGFFKERDYIVGHHVGFDLQVLSQESERLGETLLPKQHY
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHH
VIDTLRLAKEYGDSPNNSLEALARHFNVPHQGNHRAMKDVEMNVKVFKHLTKRFRTLSQV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
THILSKPIKMKYMPLGKYKGRLFTDIPLEYLLWASKMDFDQDLLFSIRSEIKSRKKGTGF
HHHHCCCCEEEEEECCCCCCCEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
TQANNPFLGL
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7489915 [H]