Click here to switch to the map view.

The map label for this gene is lpxA

Identifier: 15835432

GI number: 15835432

Start: 951031

End: 951873

Strand: Reverse

Name: lpxA

Synonym: TC0818

Alternate gene names: 15835432

Gene position: 951873-951031 (Counterclockwise)

Preceding gene: 15835433

Following gene: 15835431

Centisome position: 88.72

GC content: 43.77

Gene sequence:

>843_bases
ATGACCAACATTCATCCTACAGCTATTGTGGAAGATGGGGCGCAGATTGGAAATAATGTAACTATAGAGCCCTATGCTAT
TGTAAAAAAGAATGTGAAGCTTTGCGATGATGTAGTGGTCAAATCTTATGCGTATATCGACGGGTTTACAACGATTGGTC
GAGGGACAACGATCTGGCCTTCTGCGATGATCGGGAATAAACCCCAAGATCTAAAATTTAAGGGTGAAAAGACCTTTGTT
GAAATTGGAGAGCATTGCGAAATTCGTGAGTTTGCTATGATAACCTCCTCTACATTTGAGGGGACTACAGTTTCCATAGG
CAACAATTGCTTAATTATGCCTTGGGCTCACATTGCTCATAACTGTTCTGTAGGTAACAATGTTGTGTTTAGTACACATG
TGCAGCTTGCTGGGCATGTGCAGGTCGGGGATTGTGTGACTATAGGCAGTATGGTTGGAGTGCACCAGTTTGTCCGTATA
GGATCTTATGCAATGGTTGGTGCTATGAGTGGTATTCGCCGTGACATACCTCCTTTTACCATAGGAACAGGCAATCCTTA
TGCTTTAGGGGGTGTTAATAAGGTCGGATTGCAACGGCGCCGTGTGCCTTTTGAAACACGTTTGGCACTAATTAAGACAT
TTAAACGTGTCTTCCGTTCAGGGGAGTCTTTTCAAGACTCCTTGGGAAGTGTGTTGGAAGATTTTGGAGACGTCCCTGAA
GTGCGGCATTTCGTTGAATTTTGTCGGCAGCCAAGCAAACGTGGTATAGAGAGAGGCATCGATTGCGAAGCATCTTTGGA
TGAGCCGATAGATAAAAAAGAAGGAGCTTTTGTTGAATCTTAG

Upstream 100 bases:

>100_bases
GGAAGGCTATAGCACAAGCTTTTGTCGGTTCTCAGATTGTAGCTGAAGGAGAGCTTAGCTTTGTTCTTGTTAAAAAAGAG
TCTATATAAAGAGGCAGAGT

Downstream 100 bases:

>100_bases
AGTCGTTTATCTGGGGACCCCCCAGTTTGCGGCTACTGTTTTAGAAACACTGGTAGATGCACGTATTCATGTTGTTGGTG
TCGTTACACGGGCTGATAAA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTNIHPTAIVEDGAQIGNNVTIEPYAIVKKNVKLCDDVVVKSYAYIDGFTTIGRGTTIWPSAMIGNKPQDLKFKGEKTFV
EIGEHCEIREFAMITSSTFEGTTVSIGNNCLIMPWAHIAHNCSVGNNVVFSTHVQLAGHVQVGDCVTIGSMVGVHQFVRI
GSYAMVGAMSGIRRDIPPFTIGTGNPYALGGVNKVGLQRRRVPFETRLALIKTFKRVFRSGESFQDSLGSVLEDFGDVPE
VRHFVEFCRQPSKRGIERGIDCEASLDEPIDKKEGAFVES

Sequences:

>Translated_280_residues
MTNIHPTAIVEDGAQIGNNVTIEPYAIVKKNVKLCDDVVVKSYAYIDGFTTIGRGTTIWPSAMIGNKPQDLKFKGEKTFV
EIGEHCEIREFAMITSSTFEGTTVSIGNNCLIMPWAHIAHNCSVGNNVVFSTHVQLAGHVQVGDCVTIGSMVGVHQFVRI
GSYAMVGAMSGIRRDIPPFTIGTGNPYALGGVNKVGLQRRRVPFETRLALIKTFKRVFRSGESFQDSLGSVLEDFGDVPE
VRHFVEFCRQPSKRGIERGIDCEASLDEPIDKKEGAFVES
>Mature_279_residues
TNIHPTAIVEDGAQIGNNVTIEPYAIVKKNVKLCDDVVVKSYAYIDGFTTIGRGTTIWPSAMIGNKPQDLKFKGEKTFVE
IGEHCEIREFAMITSSTFEGTTVSIGNNCLIMPWAHIAHNCSVGNNVVFSTHVQLAGHVQVGDCVTIGSMVGVHQFVRIG
SYAMVGAMSGIRRDIPPFTIGTGNPYALGGVNKVGLQRRRVPFETRLALIKTFKRVFRSGESFQDSLGSVLEDFGDVPEV
RHFVEFCRQPSKRGIERGIDCEASLDEPIDKKEGAFVES

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=256, Percent_Identity=42.1875, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI1786376, Length=210, Percent_Identity=25.7142857142857, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_CHLMU (Q9PJL1)

Other databases:

- EMBL:   AE002160
- PIR:   G81661
- RefSeq:   NP_297191.1
- ProteinModelPortal:   Q9PJL1
- SMR:   Q9PJL1
- GeneID:   1246185
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0818
- TIGR:   TC_0818
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- PhylomeDB:   Q9PJL1
- ProtClustDB:   PRK05289
- BioCyc:   CMUR243161:TC_0818-MONOMER
- BRENDA:   2.3.1.129
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 30672; Mature: 30541

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIHPTAIVEDGAQIGNNVTIEPYAIVKKNVKLCDDVVVKSYAYIDGFTTIGRGTTIWP
CCCCCCCEEECCHHHHCCCCEECCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEECC
SAMIGNKPQDLKFKGEKTFVEIGEHCEIREFAMITSSTFEGTTVSIGNNCLIMPWAHIAH
HHHHCCCCCCCEECCCHHHHHHCCCCCHHHHHEEECCCCCCEEEEECCCEEEEEHHHHHC
NCSVGNNVVFSTHVQLAGHVQVGDCVTIGSMVGVHQFVRIGSYAMVGAMSGIRRDIPPFT
CCCCCCCEEEEEEEEEEECEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEE
IGTGNPYALGGVNKVGLQRRRVPFETRLALIKTFKRVFRSGESFQDSLGSVLEDFGDVPE
ECCCCCEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHH
VRHFVEFCRQPSKRGIERGIDCEASLDEPIDKKEGAFVES
HHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNIHPTAIVEDGAQIGNNVTIEPYAIVKKNVKLCDDVVVKSYAYIDGFTTIGRGTTIWP
CCCCCCEEECCHHHHCCCCEECCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEECC
SAMIGNKPQDLKFKGEKTFVEIGEHCEIREFAMITSSTFEGTTVSIGNNCLIMPWAHIAH
HHHHCCCCCCCEECCCHHHHHHCCCCCHHHHHEEECCCCCCEEEEECCCEEEEEHHHHHC
NCSVGNNVVFSTHVQLAGHVQVGDCVTIGSMVGVHQFVRIGSYAMVGAMSGIRRDIPPFT
CCCCCCCEEEEEEEEEEECEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEE
IGTGNPYALGGVNKVGLQRRRVPFETRLALIKTFKRVFRSGESFQDSLGSVLEDFGDVPE
ECCCCCEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHH
VRHFVEFCRQPSKRGIERGIDCEASLDEPIDKKEGAFVES
HHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935