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The map label for this gene is ndk

Identifier: 15835401

GI number: 15835401

Start: 931859

End: 932284

Strand: Reverse

Name: ndk

Synonym: TC0787

Alternate gene names: 15835401

Gene position: 932284-931859 (Counterclockwise)

Preceding gene: 15835402

Following gene: 15835397

Centisome position: 86.89

GC content: 40.38

Gene sequence:

>426_bases
ATGGAACAAACATTATCAATTATCAAACCAGATTCTGTAGGCAAAGCTCATATCGGGGAGATTGTCTCTATTTTTGAAAA
GGCTGGGCTACGAATTGCTGCCATGAAAATGGTACATCTTTCTGTGAAAGAAGCAGAAGGATTTTATGCTGTTCATAAAG
AAAGACCTTTTTTCCAAGAGCTCGTGGATTTCATGATTTCTGGTCCTGTTGTAGTTATGGTGCTGCAAGGGGAAAATGCT
GTTGCTCGTAACAGAGAACTGATGGGAGCAACGAATCCTAAAGAGGCTGCGGAAGGCTCCATTCGAGCTTTATTCGGAGA
GTCTATAGGGGTTAATGCTGTTCATGGATCTGATAGTTTAGAAAACGCTGCTATTGAAGTAAGTTATTTCTTTGCCAAAA
CAGAAATCGTTAATGCTCTAGCGTAA

Upstream 100 bases:

>100_bases
GTTATAGTCTTCTTAAAATTGTGTTGTAAAACAACCTCTTTTTCATTTCTAGCGAGAGATAATATTCGAATAAGTGAAGG
GGAGGTAAAAAGGAGAATAT

Downstream 100 bases:

>100_bases
TGTTTTTGACATTTTGCGAACCCCCTCTCTGCACAAAGCTAAGAGGGAGTATTTTTTTTAAAGAATTTGTGTGGCTCGTC
GGTGAGGTAGGTTTAACGCC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MEQTLSIIKPDSVGKAHIGEIVSIFEKAGLRIAAMKMVHLSVKEAEGFYAVHKERPFFQELVDFMISGPVVVMVLQGENA
VARNRELMGATNPKEAAEGSIRALFGESIGVNAVHGSDSLENAAIEVSYFFAKTEIVNALA

Sequences:

>Translated_141_residues
MEQTLSIIKPDSVGKAHIGEIVSIFEKAGLRIAAMKMVHLSVKEAEGFYAVHKERPFFQELVDFMISGPVVVMVLQGENA
VARNRELMGATNPKEAAEGSIRALFGESIGVNAVHGSDSLENAAIEVSYFFAKTEIVNALA
>Mature_141_residues
MEQTLSIIKPDSVGKAHIGEIVSIFEKAGLRIAAMKMVHLSVKEAEGFYAVHKERPFFQELVDFMISGPVVVMVLQGENA
VARNRELMGATNPKEAAEGSIRALFGESIGVNAVHGSDSLENAAIEVSYFFAKTEIVNALA

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=44.1176470588235, Blast_Score=122, Evalue=8e-29,
Organism=Homo sapiens, GI66392203, Length=138, Percent_Identity=42.7536231884058, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392227, Length=138, Percent_Identity=42.7536231884058, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392205, Length=138, Percent_Identity=42.7536231884058, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI4505409, Length=138, Percent_Identity=42.7536231884058, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI66392192, Length=138, Percent_Identity=42.7536231884058, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI38045913, Length=137, Percent_Identity=41.6058394160584, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4557797, Length=137, Percent_Identity=41.6058394160584, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI37574614, Length=136, Percent_Identity=43.3823529411765, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI7019465, Length=136, Percent_Identity=43.3823529411765, Blast_Score=112, Evalue=7e-26,
Organism=Homo sapiens, GI4826862, Length=137, Percent_Identity=37.2262773722628, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=35.2941176470588, Blast_Score=81, Evalue=2e-16,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=34.0579710144928, Blast_Score=73, Evalue=7e-14,
Organism=Homo sapiens, GI30023828, Length=136, Percent_Identity=33.8235294117647, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=54.014598540146, Blast_Score=159, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=40.7407407407407, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=137, Percent_Identity=41.6058394160584, Blast_Score=121, Evalue=4e-29,
Organism=Drosophila melanogaster, GI45549037, Length=137, Percent_Identity=40.8759124087591, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=35.8208955223881, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_CHLMU (Q9PJP1)

Other databases:

- EMBL:   AE002160
- PIR:   C81666
- RefSeq:   NP_297160.1
- ProteinModelPortal:   Q9PJP1
- SMR:   Q9PJP1
- GeneID:   1246153
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0787
- TIGR:   TC_0787
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q9PJP1
- ProtClustDB:   PRK00668
- BioCyc:   CMUR243161:TC_0787-MONOMER
- BRENDA:   2.7.4.6
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15235; Mature: 15235

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTLSIIKPDSVGKAHIGEIVSIFEKAGLRIAAMKMVHLSVKEAEGFYAVHKERPFFQE
CCCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEECCCCCHHHH
LVDFMISGPVVVMVLQGENAVARNRELMGATNPKEAAEGSIRALFGESIGVNAVHGSDSL
HHHHHHCCCEEEEEECCCCCHHHCCHHCCCCCCHHHHCCCCEEEECCCCCCEEEECCCCC
ENAAIEVSYFFAKTEIVNALA
CCCEEEEEHHHHHHHHHHHCC
>Mature Secondary Structure
MEQTLSIIKPDSVGKAHIGEIVSIFEKAGLRIAAMKMVHLSVKEAEGFYAVHKERPFFQE
CCCCCCEECCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEECCCCCHHHH
LVDFMISGPVVVMVLQGENAVARNRELMGATNPKEAAEGSIRALFGESIGVNAVHGSDSL
HHHHHHCCCEEEEEECCCCCHHHCCHHCCCCCCHHHHCCCCEEEECCCCCCEEEECCCCC
ENAAIEVSYFFAKTEIVNALA
CCCEEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935