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Identifier: 15835395

GI number: 15835395

Start: 923615

End: 924613

Strand: Reverse

Name: Not Available

Synonym: TC0781

Alternate gene names: 15835395

Gene position: 924613-923615 (Counterclockwise)

Preceding gene: 15835396

Following gene: 15835394

Centisome position: 86.17

GC content: 41.74

Gene sequence:

>999_bases
ATGAAGAATTTTTTTCGATTTTTATTAAAAGGGTTCTTATCTGCCTGCGGATTGTTCGTAGGTGTTCTGGGAGCTATGAG
CTTCATTTTTATTTTACTTTCTTTGTGTGTGATGGGCAAAGACTCGGCTTTATTTGTGAGTCTTCCTAATGCTCAAGGAG
TAGTTCAAGAGCTGGGGAAAACATCTCCGATTCTAGCTATCATTGAGATTAATGATGCTATTATGGCTAACAGCGGGTCA
GCTAAACGATTGCAATCTACTTTACAGTCTTTGAGTGAAGCCCCGTATAAGGGAAGAGTGAAGGGACTTTTAATTAAAAT
GGATTGCCCTGGAGGAGAAATTTTTGAAATTGATCGTATGAGTGCAGCGCTTTCTTTTTGGAAGCAGAAATTAGGAATCC
CGGTACACGTTTTTGTATCAGGTCTTTGTGCTTCTGGAGGATACTATGTTGCTTGCATAGCTGATCGAATTGGAACCACC
TCTACTTCCCTGATTGGATCGATTGGGGTGCGATCAGGTCCATATTTTAACATTAAGGAAGGACTTCAGAGACTTGGGGT
GGAAACCGCCATTCTCACTGCGGGAGATGATAAGGCTCCTCTGAATCCATTTTCTCCATGGACTGAAGAAGAGTATGCGG
AGCGACAAGGTATAGTAGATGCGCTTTATGAACAGTTTGTGGATCATGTTGTTAAACATCGTTCACAATTATCTAAAGAG
CATGTGACTCAGGTTTTAGGAGCCCGTGTGTTTATTGCAAAGCAGGCTTTGGAAGAGGGGCTTGTTGATATTGTTAACCA
AACTCAAGAGCAAGCTTTAGATGACCTTGCTGGAGTTTGCGGAGTCAAAGAAGATTATCGAGTTATTGGATTGAGTTCTG
GGCATTTTCTGAGACGTTTTTCTAGCTGTTTGAGCAACAGTCCTCTTGTGACAGGTAAGCTTCAATTGGCTGTGTTGCCT
GATCAACAACAAAAATCTCTGTGGTACATAGGTGAGTGA

Upstream 100 bases:

>100_bases
TTTAGGTTTTTTTGCTTAAAAATTCTTTTTATAATCCTCATGTTTTAGTACCGTTTTATTCCTAACGCGAAAAGCGATTA
ATAGATTTATTTGGGTTTTC

Downstream 100 bases:

>100_bases
CTAAAATAGCAATATGAAAAAACTTTTTATTTTAGACGCTTCAGGATTTATTTTTAGGGCATATTTTGCTCTCCCAGAGA
TGCGAGGGCCGAATGGGGGA

Product: protease IV, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MKNFFRFLLKGFLSACGLFVGVLGAMSFIFILLSLCVMGKDSALFVSLPNAQGVVQELGKTSPILAIIEINDAIMANSGS
AKRLQSTLQSLSEAPYKGRVKGLLIKMDCPGGEIFEIDRMSAALSFWKQKLGIPVHVFVSGLCASGGYYVACIADRIGTT
STSLIGSIGVRSGPYFNIKEGLQRLGVETAILTAGDDKAPLNPFSPWTEEEYAERQGIVDALYEQFVDHVVKHRSQLSKE
HVTQVLGARVFIAKQALEEGLVDIVNQTQEQALDDLAGVCGVKEDYRVIGLSSGHFLRRFSSCLSNSPLVTGKLQLAVLP
DQQQKSLWYIGE

Sequences:

>Translated_332_residues
MKNFFRFLLKGFLSACGLFVGVLGAMSFIFILLSLCVMGKDSALFVSLPNAQGVVQELGKTSPILAIIEINDAIMANSGS
AKRLQSTLQSLSEAPYKGRVKGLLIKMDCPGGEIFEIDRMSAALSFWKQKLGIPVHVFVSGLCASGGYYVACIADRIGTT
STSLIGSIGVRSGPYFNIKEGLQRLGVETAILTAGDDKAPLNPFSPWTEEEYAERQGIVDALYEQFVDHVVKHRSQLSKE
HVTQVLGARVFIAKQALEEGLVDIVNQTQEQALDDLAGVCGVKEDYRVIGLSSGHFLRRFSSCLSNSPLVTGKLQLAVLP
DQQQKSLWYIGE
>Mature_332_residues
MKNFFRFLLKGFLSACGLFVGVLGAMSFIFILLSLCVMGKDSALFVSLPNAQGVVQELGKTSPILAIIEINDAIMANSGS
AKRLQSTLQSLSEAPYKGRVKGLLIKMDCPGGEIFEIDRMSAALSFWKQKLGIPVHVFVSGLCASGGYYVACIADRIGTT
STSLIGSIGVRSGPYFNIKEGLQRLGVETAILTAGDDKAPLNPFSPWTEEEYAERQGIVDALYEQFVDHVVKHRSQLSKE
HVTQVLGARVFIAKQALEEGLVDIVNQTQEQALDDLAGVCGVKEDYRVIGLSSGHFLRRFSSCLSNSPLVTGKLQLAVLP
DQQQKSLWYIGE

Specific function: Digestion of cleaved signal peptides. Required for efficient processing of precursors under conditions of hyper-secretion [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=206, Percent_Identity=28.6407766990291, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 36072; Mature: 36072

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFFRFLLKGFLSACGLFVGVLGAMSFIFILLSLCVMGKDSALFVSLPNAQGVVQELGK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCC
TSPILAIIEINDAIMANSGSAKRLQSTLQSLSEAPYKGRVKGLLIKMDCPGGEIFEIDRM
CCCEEEEEEECCCEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEEHHHH
SAALSFWKQKLGIPVHVFVSGLCASGGYYVACIADRIGTTSTSLIGSIGVRSGPYFNIKE
HHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEHHHCCCHHHHHHHCCCCCCCCCCHHH
GLQRLGVETAILTAGDDKAPLNPFSPWTEEEYAERQGIVDALYEQFVDHVVKHRSQLSKE
HHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVTQVLGARVFIAKQALEEGLVDIVNQTQEQALDDLAGVCGVKEDYRVIGLSSGHFLRRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
SSCLSNSPLVTGKLQLAVLPDQQQKSLWYIGE
HHHHCCCCEEEEEEEEEECCCCCCCCEEECCC
>Mature Secondary Structure
MKNFFRFLLKGFLSACGLFVGVLGAMSFIFILLSLCVMGKDSALFVSLPNAQGVVQELGK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCC
TSPILAIIEINDAIMANSGSAKRLQSTLQSLSEAPYKGRVKGLLIKMDCPGGEIFEIDRM
CCCEEEEEEECCCEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEEHHHH
SAALSFWKQKLGIPVHVFVSGLCASGGYYVACIADRIGTTSTSLIGSIGVRSGPYFNIKE
HHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEHHHCCCHHHHHHHCCCCCCCCCCHHH
GLQRLGVETAILTAGDDKAPLNPFSPWTEEEYAERQGIVDALYEQFVDHVVKHRSQLSKE
HHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVTQVLGARVFIAKQALEEGLVDIVNQTQEQALDDLAGVCGVKEDYRVIGLSSGHFLRRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
SSCLSNSPLVTGKLQLAVLPDQQQKSLWYIGE
HHHHCCCCEEEEEEEEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10455123 [H]