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The map label for this gene is uppS

Identifier: 15835350

GI number: 15835350

Start: 877237

End: 877998

Strand: Direct

Name: uppS

Synonym: TC0735

Alternate gene names: 15835350

Gene position: 877237-877998 (Clockwise)

Preceding gene: 15835344

Following gene: 15835351

Centisome position: 81.76

GC content: 41.47

Gene sequence:

>762_bases
ATGTCTCTAGCTTTAGAACAGGCGAACCCAATTCAAGAAAATTTTCTACGAGAGCCCCCTCTCCCTAAGCATATCGCCAT
CATCATGGATGGAAACCGTCGATGGCAAAAGAAACATGAACAATTTTGTAAAAGCAATGCCATCTCCGGTCACCGTCGAG
GAGCTGACAGCATCCCGCAAATTGTTGATACAGCTGCACTCCTAGGAGTAGAAGCTCTCACCTTGTTCGCGTTCTCTACA
GAAAACTTTTCTAGATCAAAAACAGAAGTCGCTGAATTATTTTCCTTATTTAACTCACAGTTGCATAGTAAACTCTCTTT
TCTGCACGATCGGGAAATCCGGCTACGATGTATCGGAGACTTATCCAAACTCCCTCAAGAATTGCAAAATAACATTGCAA
AAGCAGTCTCCGCCACAACACACTACTCCCATATGGAATTAATTTTTGCGATTAACTATGGAAGTAAAAACGAATTAGTT
CGTGCGTTCAAGGAATTGCATCAGGACCTTACAAACAAAAAAATCTCTATCAATGAAATTTCTGAAGAGCTTATCAGCTC
TTACTTAGACACATCTGGCCTCCCTGACCCGGATTTGCTTATTCGTACAGGAGGTGAAATGCGTGTCAGTAATTTTCTCT
TATGGCAAATAGCTTATACAGAACTTTACGTAACAGATGTGTTATGGCCTGATTTCACGGCCCACGACTTGTTAGAAGCA
ATTAAAACATACCAACAACGATCAAGGCGCGGAGGGAAATAA

Upstream 100 bases:

>100_bases
ATGGGAGTCGTTGCTTAGAAAAAACCAGAGGATCATGGATCCTCCTCCATGATCCTCTGAGGACAGCCAAATCTCCAGCC
AATAGAATGTCAGACTGCGT

Downstream 100 bases:

>100_bases
ACGCTATGTTCGACTCGGATAAAAACTCCATTCTTCAAAGTGATTTTTGTCAGCGCTTAGTTGTCCATTCGCTTCTTCTG
GTCTTCCTTGTTATCCTTCT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSLALEQANPIQENFLREPPLPKHIAIIMDGNRRWQKKHEQFCKSNAISGHRRGADSIPQIVDTAALLGVEALTLFAFST
ENFSRSKTEVAELFSLFNSQLHSKLSFLHDREIRLRCIGDLSKLPQELQNNIAKAVSATTHYSHMELIFAINYGSKNELV
RAFKELHQDLTNKKISINEISEELISSYLDTSGLPDPDLLIRTGGEMRVSNFLLWQIAYTELYVTDVLWPDFTAHDLLEA
IKTYQQRSRRGGK

Sequences:

>Translated_253_residues
MSLALEQANPIQENFLREPPLPKHIAIIMDGNRRWQKKHEQFCKSNAISGHRRGADSIPQIVDTAALLGVEALTLFAFST
ENFSRSKTEVAELFSLFNSQLHSKLSFLHDREIRLRCIGDLSKLPQELQNNIAKAVSATTHYSHMELIFAINYGSKNELV
RAFKELHQDLTNKKISINEISEELISSYLDTSGLPDPDLLIRTGGEMRVSNFLLWQIAYTELYVTDVLWPDFTAHDLLEA
IKTYQQRSRRGGK
>Mature_252_residues
SLALEQANPIQENFLREPPLPKHIAIIMDGNRRWQKKHEQFCKSNAISGHRRGADSIPQIVDTAALLGVEALTLFAFSTE
NFSRSKTEVAELFSLFNSQLHSKLSFLHDREIRLRCIGDLSKLPQELQNNIAKAVSATTHYSHMELIFAINYGSKNELVR
AFKELHQDLTNKKISINEISEELISSYLDTSGLPDPDLLIRTGGEMRVSNFLLWQIAYTELYVTDVLWPDFTAHDLLEAI
KTYQQRSRRGGK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=235, Percent_Identity=39.5744680851064, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI45580742, Length=235, Percent_Identity=39.5744680851064, Blast_Score=168, Evalue=6e-42,
Organism=Escherichia coli, GI1786371, Length=230, Percent_Identity=43.4782608695652, Blast_Score=192, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71993029, Length=236, Percent_Identity=36.4406779661017, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319474, Length=217, Percent_Identity=35.9447004608295, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=30.8370044052863, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI18857969, Length=233, Percent_Identity=36.0515021459227, Blast_Score=145, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_CHLMU (Q9PJU2)

Other databases:

- EMBL:   AE002160
- PIR:   C81670
- RefSeq:   NP_297109.1
- ProteinModelPortal:   Q9PJU2
- SMR:   Q9PJU2
- GeneID:   1246098
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0735
- TIGR:   TC_0735
- HOGENOM:   HBG627837
- OMA:   LPAHIAI
- ProtClustDB:   PRK14840
- BioCyc:   CMUR243161:TC_0735-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 28855; Mature: 28724

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 30-30

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLALEQANPIQENFLREPPLPKHIAIIMDGNRRWQKKHEQFCKSNAISGHRRGADSIPQ
CCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IVDTAALLGVEALTLFAFSTENFSRSKTEVAELFSLFNSQLHSKLSFLHDREIRLRCIGD
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LSKLPQELQNNIAKAVSATTHYSHMELIFAINYGSKNELVRAFKELHQDLTNKKISINEI
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHH
SEELISSYLDTSGLPDPDLLIRTGGEMRVSNFLLWQIAYTELYVTDVLWPDFTAHDLLEA
HHHHHHHHHHCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IKTYQQRSRRGGK
HHHHHHHHHCCCC
>Mature Secondary Structure 
SLALEQANPIQENFLREPPLPKHIAIIMDGNRRWQKKHEQFCKSNAISGHRRGADSIPQ
CCCCCCCCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IVDTAALLGVEALTLFAFSTENFSRSKTEVAELFSLFNSQLHSKLSFLHDREIRLRCIGD
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LSKLPQELQNNIAKAVSATTHYSHMELIFAINYGSKNELVRAFKELHQDLTNKKISINEI
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHH
SEELISSYLDTSGLPDPDLLIRTGGEMRVSNFLLWQIAYTELYVTDVLWPDFTAHDLLEA
HHHHHHHHHHCCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
IKTYQQRSRRGGK
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935