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The map label for this gene is obgE

Identifier: 15835314

GI number: 15835314

Start: 840605

End: 841612

Strand: Reverse

Name: obgE

Synonym: TC0699

Alternate gene names: 15835314

Gene position: 841612-840605 (Counterclockwise)

Preceding gene: 15835315

Following gene: 15835300

Centisome position: 78.44

GC content: 41.67

Gene sequence:

>1008_bases
ATGTTTGTTGATCAAATTACTTTAGAGTTACGCGCAGGGAAAGGCGGTAATGGTGTTGTAGCTTGGAGAAAGGAAAAGTA
TCTCCCCAAAGGAGGCCCTTATGGCGGTAATGGAGGGAATGGTGGCTCTATCCTTATCGAGGCTGTTACGAACATGTATT
CGTTCGAGGAATACCGTAACCTTCGTTTTCTTAAAGCAGGTGATGGTCAAGCTGGGGCTAGTAATAATCGCACGGGAAAA
AATGGCAAAGATTTCGTTTTAAAAGTTCCTGAAGGGACTCTCTTACGAGATGCTGAGACTGGCGAGCTAATACACGATTT
CACTAAGGATGGGGAGCGTATTGTTGTTTGCCAGGGTGGTAGAGGAGGTAAAGGAAACGTGTTCTTTAAAACCTCTACTA
ACCGAGCTCCAACAAAAGCGACTCCAGGTAAGCCTGGAGAGATTCGTTTAGTTGAATTGGAACTTAAACTTATAGCTGAT
ATTGGTCTTGTCGGGTTCCCTAATGCTGGGAAATCCACTTTGTTTAATACCCTTGCGCGAACAGAAGTTAAAGTGGGCGC
CTATCCATTTACAACATTACACCCTTCTTTAGGGTTGGTTCATCAAGAAGGATATCTTTATCAAAAGCCTTGGATCATGG
CAGATATTCCCGGTATTATTGAAGGAGCTTCTCAAAATCGGGGATTGGGATTAGACTTCCTTCGTCATATTGAGCGTACG
CGATTGTTGTTGTTTGTAGTGGACATCTCTGGGATAGAAAGAAGCTCTCCTGAAAAAGATCTTCAAATCTTGATAGGGGA
ACTCTTAGCTTATAAAGAAGATCTCAAGAATAAAAGTATGGTAATTGCTTTAAATAAGATTGACCAACTATTACCCGATG
AGCGCGAGGAACGCTTAGCTCTTTTAAAACAACAGTTTCCAGATCAAGAGTTTATTTTGCTTTCAGGACTTACTGGAGAA
GGCGTGGATGTATTACACGATCTTTTTAAAAGTAAACTTAGCGAATAG

Upstream 100 bases:

>100_bases
AAGCTTAGTCTAGTTTTATTTATAATTCAGTTTGTTCGAGCTCTGTTTTTGCATAAACGTAAAAATAGGGCTTTTTTTTA
TTTGTCTCAGGACTTGTTTC

Downstream 100 bases:

>100_bases
GCTATTCCCATTAGGATCGCTATAATAGGTCCAACTGGTAGATCCAAGATATAGGCCAGAATAATTCCTAGAAATGAGCA
GCAGATATTTAAAATAGATG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSILIEAVTNMYSFEEYRNLRFLKAGDGQAGASNNRTGK
NGKDFVLKVPEGTLLRDAETGELIHDFTKDGERIVVCQGGRGGKGNVFFKTSTNRAPTKATPGKPGEIRLVELELKLIAD
IGLVGFPNAGKSTLFNTLARTEVKVGAYPFTTLHPSLGLVHQEGYLYQKPWIMADIPGIIEGASQNRGLGLDFLRHIERT
RLLLFVVDISGIERSSPEKDLQILIGELLAYKEDLKNKSMVIALNKIDQLLPDEREERLALLKQQFPDQEFILLSGLTGE
GVDVLHDLFKSKLSE

Sequences:

>Translated_335_residues
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSILIEAVTNMYSFEEYRNLRFLKAGDGQAGASNNRTGK
NGKDFVLKVPEGTLLRDAETGELIHDFTKDGERIVVCQGGRGGKGNVFFKTSTNRAPTKATPGKPGEIRLVELELKLIAD
IGLVGFPNAGKSTLFNTLARTEVKVGAYPFTTLHPSLGLVHQEGYLYQKPWIMADIPGIIEGASQNRGLGLDFLRHIERT
RLLLFVVDISGIERSSPEKDLQILIGELLAYKEDLKNKSMVIALNKIDQLLPDEREERLALLKQQFPDQEFILLSGLTGE
GVDVLHDLFKSKLSE
>Mature_335_residues
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSILIEAVTNMYSFEEYRNLRFLKAGDGQAGASNNRTGK
NGKDFVLKVPEGTLLRDAETGELIHDFTKDGERIVVCQGGRGGKGNVFFKTSTNRAPTKATPGKPGEIRLVELELKLIAD
IGLVGFPNAGKSTLFNTLARTEVKVGAYPFTTLHPSLGLVHQEGYLYQKPWIMADIPGIIEGASQNRGLGLDFLRHIERT
RLLLFVVDISGIERSSPEKDLQILIGELLAYKEDLKNKSMVIALNKIDQLLPDEREERLALLKQQFPDQEFILLSGLTGE
GVDVLHDLFKSKLSE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=258, Percent_Identity=46.8992248062016, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI111955139, Length=359, Percent_Identity=37.6044568245125, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI111955063, Length=195, Percent_Identity=38.974358974359, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI4758796, Length=91, Percent_Identity=41.7582417582418, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1789574, Length=330, Percent_Identity=45.1515151515152, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI1787454, Length=172, Percent_Identity=30.2325581395349, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=307, Percent_Identity=36.4820846905537, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17552324, Length=328, Percent_Identity=32.0121951219512, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17509631, Length=132, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17555344, Length=91, Percent_Identity=41.7582417582418, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6321962, Length=175, Percent_Identity=44, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319281, Length=111, Percent_Identity=38.7387387387387, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6321612, Length=106, Percent_Identity=35.8490566037736, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI20129375, Length=287, Percent_Identity=39.3728222996516, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24585318, Length=294, Percent_Identity=38.7755102040816, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24640873, Length=139, Percent_Identity=34.5323741007194, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640877, Length=139, Percent_Identity=34.5323741007194, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640875, Length=139, Percent_Identity=34.5323741007194, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356473, Length=106, Percent_Identity=35.8490566037736, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921908, Length=169, Percent_Identity=32.5443786982249, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_CHLMU (Q9PJX7)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_297073.1
- HSSP:   P44681
- ProteinModelPortal:   Q9PJX7
- SMR:   Q9PJX7
- GeneID:   1246061
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0699
- TIGR:   TC_0699
- HOGENOM:   HBG716038
- OMA:   ATCEHAG
- PhylomeDB:   Q9PJX7
- ProtClustDB:   PRK12299
- BioCyc:   CMUR243161:TC_0699-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 36767; Mature: 36767

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSILIEAVTNMYSFEEYRN
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
LRFLKAGDGQAGASNNRTGKNGKDFVLKVPEGTLLRDAETGELIHDFTKDGERIVVCQGG
EEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEEEEECC
RGGKGNVFFKTSTNRAPTKATPGKPGEIRLVELELKLIADIGLVGFPNAGKSTLFNTLAR
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEHHCCCEECCCCCHHHHHHHHHH
TEVKVGAYPFTTLHPSLGLVHQEGYLYQKPWIMADIPGIIEGASQNRGLGLDFLRHIERT
CEEEECCCCCEEECCCCCEEECCCEEEECCEEEECCCHHHCCCCCCCCCCHHHHHHHHHC
RLLLFVVDISGIERSSPEKDLQILIGELLAYKEDLKNKSMVIALNKIDQLLPDEREERLA
EEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCHHHHHH
LLKQQFPDQEFILLSGLTGEGVDVLHDLFKSKLSE
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFVDQITLELRAGKGGNGVVAWRKEKYLPKGGPYGGNGGNGGSILIEAVTNMYSFEEYRN
CCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
LRFLKAGDGQAGASNNRTGKNGKDFVLKVPEGTLLRDAETGELIHDFTKDGERIVVCQGG
EEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEEEEECC
RGGKGNVFFKTSTNRAPTKATPGKPGEIRLVELELKLIADIGLVGFPNAGKSTLFNTLAR
CCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEEEEEEHHCCCEECCCCCHHHHHHHHHH
TEVKVGAYPFTTLHPSLGLVHQEGYLYQKPWIMADIPGIIEGASQNRGLGLDFLRHIERT
CEEEECCCCCEEECCCCCEEECCCEEEECCEEEECCCHHHCCCCCCCCCCHHHHHHHHHC
RLLLFVVDISGIERSSPEKDLQILIGELLAYKEDLKNKSMVIALNKIDQLLPDEREERLA
EEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCHHHHHH
LLKQQFPDQEFILLSGLTGEGVDVLHDLFKSKLSE
HHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935