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The map label for this gene is lpxB

Identifier: 15835307

GI number: 15835307

Start: 823167

End: 824990

Strand: Direct

Name: lpxB

Synonym: TC0692

Alternate gene names: 15835307

Gene position: 823167-824990 (Clockwise)

Preceding gene: 15835306

Following gene: 15835308

Centisome position: 76.72

GC content: 39.64

Gene sequence:

>1824_bases
ATGTTTCCCCAGAAAATCACGCTTTGGTTATACCCTTTAGGACTTTTTGCTAATCTTTTCTTTGGTACAGCCTTTTGTGT
GCAGTGGTTCTTAATTAAGAAGAGGGGCTGTTCTTTTGTTCCTAAAATTTTCTGGCATCTGTCTTGCTCTGGCGCTGTTT
TGATGATCTGCCATGGATTTATTCAAAGTCAGTATCCTATTGCGCTACTCCATTCTTTTAATCTCATTATTTATTTCCGG
AACCTTAACATAGCTTCCTCAACCCCGCTCCCCATCTCCAAAATAGTCTCATTGTTGGTCGTTTCTGCAACAGCCATTAC
TCTATCTTTTGCAATTGGCACACAGTACCTTCCACACATGACGTGGATGGCTTCTCCAAACATTTTACACTTAAATCTTC
CGGAAGCTAATTTTTTGTGGCAACTCATAGGCTGCATTGGATTGACTATCTTTTCCTTAAGATTTTTTATCCAATGGTTC
TACCTAGAATACAAAAACCAATCCTCTTTACCTACTCCTTTCTGGAAAGCTAGTTTGGTAGGAGGATCCATCTGTCTCAT
TTACTTTTTACGGACTGGAGACATTGTCAATGTCTTGTGCTATGGATGTGGCTTATTCCCTTCCCTAGCGAACCTTCGCA
TAGCTTCTCGAGAAGCTATCCAAAAACCGTTTAGCTGCAGTTGCTTCATCTCCGCAGGAGAACATAGCGGAGATACTTTA
GGAGGAAATTTATTAAAAGAAATCCATGCAAAATATCCTGATATTCACTGCTTTGGCGTAGGAGGCCCGCAAATGCGGGC
GCAAAACTTTTGCACGCTTTTTTCTATGGAAAAATTTCAAATCAGTGGATTTTGGGAAGTTCTTCTTGCCCTACCCAAAC
TATGGTATAGACGCCGTATTCTGTATAAAACGATTCTTAAAAGAAATCCTCAAGCTGTTATCTGCATTGACTTCCCTGAT
TTTCATTTTTTATTAATAAAAAAACTCCGTTCTCTCGGATATAAAGGGAAAATCGTCCACTATGTGTGCCCTAGCATATG
GGCTTGGAGACCATCAAGGAAAACTACTTTAGAAAAGTATTTGGACCTTCTTCTTTTAATACTTCCTTTCGAACAAAAAT
TATTCAAAGATTCTCCCCTTCGTACGGTATACATAGGGCATCCTCTCTCAGAAACTATCAAACTTTTCTGCCCTAAGCAG
AATTGGAAAGAACGGCTCCATCTTCCAACCGATAAACCCTTTGTCGCTGCCTTTCCGGGTAGCCGTCACAGTGATATTCT
GCGCAATCTTACGATTCAGGTACAAGCTTTTCAAGCATCAGATTTTGCATCCACACATCATTTACTTGTATCGTCCGCGA
ATCCTGCGTATGACCATCTCATTCTAGAAATCCTACAACAAAATCGCTGTTTGCATAGCAATATTGTTCCTTCTCAATTT
CGATATGAACTAATGAGGGAGTGTGATTGTGCTCTTGCTAAATGCGGAACCATTGTTTTAGAAACAGCTCTTAATCTTAC
TCCAACAATAGTTACCTGCCAACTCCGCCCTCTAGATACGTTTTTAGCGAAATACATATTCAATATTATCCTCCCAGCCT
ACTCTCTCCCCAATATTATTCTAGGAAGAACCATTTTCCCAGAGTTTATAGGAGGCAAAAAAGATTTTCGGTATGAGGAT
GTCGCTGCTGCTCTGAACATTCTTAAAACATCTCAAGCTCAAGAAAAACAAAAAAATGCCTGTAAGGATGTTTATCAGGC
AATAAACGAATCTGCATCGACTATAAAAGAGTGCCTTCCTTTCATATTTGAAGCTTCTTATTAA

Upstream 100 bases:

>100_bases
GTATGAGGAGTGGCTCAACCAGTATGAACGAATTTCGGAGTAATCATTCCTAGTTAAAATTAGGAAAATTCTTCTCCCCA
CGGATTTATAGTTAGTTGTT

Downstream 100 bases:

>100_bases
TTCTATATCAATGACTTGCGACAAATTCTAGAGTCGATAGAAAAGGAGTTTTCCGTTTATAGTTCCTGTTCACAATCGTG
CCACAAGCGCTTATAATAAA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MFPQKITLWLYPLGLFANLFFGTAFCVQWFLIKKRGCSFVPKIFWHLSCSGAVLMICHGFIQSQYPIALLHSFNLIIYFR
NLNIASSTPLPISKIVSLLVVSATAITLSFAIGTQYLPHMTWMASPNILHLNLPEANFLWQLIGCIGLTIFSLRFFIQWF
YLEYKNQSSLPTPFWKASLVGGSICLIYFLRTGDIVNVLCYGCGLFPSLANLRIASREAIQKPFSCSCFISAGEHSGDTL
GGNLLKEIHAKYPDIHCFGVGGPQMRAQNFCTLFSMEKFQISGFWEVLLALPKLWYRRRILYKTILKRNPQAVICIDFPD
FHFLLIKKLRSLGYKGKIVHYVCPSIWAWRPSRKTTLEKYLDLLLLILPFEQKLFKDSPLRTVYIGHPLSETIKLFCPKQ
NWKERLHLPTDKPFVAAFPGSRHSDILRNLTIQVQAFQASDFASTHHLLVSSANPAYDHLILEILQQNRCLHSNIVPSQF
RYELMRECDCALAKCGTIVLETALNLTPTIVTCQLRPLDTFLAKYIFNIILPAYSLPNIILGRTIFPEFIGGKKDFRYED
VAAALNILKTSQAQEKQKNACKDVYQAINESASTIKECLPFIFEASY

Sequences:

>Translated_607_residues
MFPQKITLWLYPLGLFANLFFGTAFCVQWFLIKKRGCSFVPKIFWHLSCSGAVLMICHGFIQSQYPIALLHSFNLIIYFR
NLNIASSTPLPISKIVSLLVVSATAITLSFAIGTQYLPHMTWMASPNILHLNLPEANFLWQLIGCIGLTIFSLRFFIQWF
YLEYKNQSSLPTPFWKASLVGGSICLIYFLRTGDIVNVLCYGCGLFPSLANLRIASREAIQKPFSCSCFISAGEHSGDTL
GGNLLKEIHAKYPDIHCFGVGGPQMRAQNFCTLFSMEKFQISGFWEVLLALPKLWYRRRILYKTILKRNPQAVICIDFPD
FHFLLIKKLRSLGYKGKIVHYVCPSIWAWRPSRKTTLEKYLDLLLLILPFEQKLFKDSPLRTVYIGHPLSETIKLFCPKQ
NWKERLHLPTDKPFVAAFPGSRHSDILRNLTIQVQAFQASDFASTHHLLVSSANPAYDHLILEILQQNRCLHSNIVPSQF
RYELMRECDCALAKCGTIVLETALNLTPTIVTCQLRPLDTFLAKYIFNIILPAYSLPNIILGRTIFPEFIGGKKDFRYED
VAAALNILKTSQAQEKQKNACKDVYQAINESASTIKECLPFIFEASY
>Mature_607_residues
MFPQKITLWLYPLGLFANLFFGTAFCVQWFLIKKRGCSFVPKIFWHLSCSGAVLMICHGFIQSQYPIALLHSFNLIIYFR
NLNIASSTPLPISKIVSLLVVSATAITLSFAIGTQYLPHMTWMASPNILHLNLPEANFLWQLIGCIGLTIFSLRFFIQWF
YLEYKNQSSLPTPFWKASLVGGSICLIYFLRTGDIVNVLCYGCGLFPSLANLRIASREAIQKPFSCSCFISAGEHSGDTL
GGNLLKEIHAKYPDIHCFGVGGPQMRAQNFCTLFSMEKFQISGFWEVLLALPKLWYRRRILYKTILKRNPQAVICIDFPD
FHFLLIKKLRSLGYKGKIVHYVCPSIWAWRPSRKTTLEKYLDLLLLILPFEQKLFKDSPLRTVYIGHPLSETIKLFCPKQ
NWKERLHLPTDKPFVAAFPGSRHSDILRNLTIQVQAFQASDFASTHHLLVSSANPAYDHLILEILQQNRCLHSNIVPSQF
RYELMRECDCALAKCGTIVLETALNLTPTIVTCQLRPLDTFLAKYIFNIILPAYSLPNIILGRTIFPEFIGGKKDFRYED
VAAALNILKTSQAQEKQKNACKDVYQAINESASTIKECLPFIFEASY

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=346, Percent_Identity=29.4797687861272, Blast_Score=148, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_CHLMU (Q9PJY4)

Other databases:

- EMBL:   AE002160
- PIR:   E81676
- RefSeq:   NP_297066.1
- ProteinModelPortal:   Q9PJY4
- GeneID:   1246053
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0692
- TIGR:   TC_0692
- HOGENOM:   HBG414066
- OMA:   CALAKCG
- PhylomeDB:   Q9PJY4
- ProtClustDB:   PRK01021
- BioCyc:   CMUR243161:TC_0692-MONOMER
- BRENDA:   2.4.1.182
- HAMAP:   MF_00392
- InterPro:   IPR003835
- InterPro:   IPR011499
- ProDom:   PD339292
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF07578 LAB_N; PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 69198; Mature: 69198

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPQKITLWLYPLGLFANLFFGTAFCVQWFLIKKRGCSFVPKIFWHLSCSGAVLMICHGF
CCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHH
IQSQYPIALLHSFNLIIYFRNLNIASSTPLPISKIVSLLVVSATAITLSFAIGTQYLPHM
HCCCCCEEEEECCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
TWMASPNILHLNLPEANFLWQLIGCIGLTIFSLRFFIQWFYLEYKNQSSLPTPFWKASLV
EEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHC
GGSICLIYFLRTGDIVNVLCYGCGLFPSLANLRIASREAIQKPFSCSCFISAGEHSGDTL
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCEEHHHHHHCCCCCEEEEEECCCCCCCCC
GGNLLKEIHAKYPDIHCFGVGGPQMRAQNFCTLFSMEKFQISGFWEVLLALPKLWYRRRI
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHH
LYKTILKRNPQAVICIDFPDFHFLLIKKLRSLGYKGKIVHYVCPSIWAWRPSRKTTLEKY
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCHHHHHHH
LDLLLLILPFEQKLFKDSPLRTVYIGHPLSETIKLFCPKQNWKERLHLPTDKPFVAAFPG
HHHHHHHHCCHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHCCCCCCCCEEEECCC
SRHSDILRNLTIQVQAFQASDFASTHHLLVSSANPAYDHLILEILQQNRCLHSNIVPSQF
CCHHHHHHCCEEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHCCCCCHHH
RYELMRECDCALAKCGTIVLETALNLTPTIVTCQLRPLDTFLAKYIFNIILPAYSLPNII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHH
LGRTIFPEFIGGKKDFRYEDVAAALNILKTSQAQEKQKNACKDVYQAINESASTIKECLP
HCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIFEASY
HHHCCCC
>Mature Secondary Structure
MFPQKITLWLYPLGLFANLFFGTAFCVQWFLIKKRGCSFVPKIFWHLSCSGAVLMICHGF
CCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHH
IQSQYPIALLHSFNLIIYFRNLNIASSTPLPISKIVSLLVVSATAITLSFAIGTQYLPHM
HCCCCCEEEEECCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
TWMASPNILHLNLPEANFLWQLIGCIGLTIFSLRFFIQWFYLEYKNQSSLPTPFWKASLV
EEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHC
GGSICLIYFLRTGDIVNVLCYGCGLFPSLANLRIASREAIQKPFSCSCFISAGEHSGDTL
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCEEHHHHHHCCCCCEEEEEECCCCCCCCC
GGNLLKEIHAKYPDIHCFGVGGPQMRAQNFCTLFSMEKFQISGFWEVLLALPKLWYRRRI
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHH
LYKTILKRNPQAVICIDFPDFHFLLIKKLRSLGYKGKIVHYVCPSIWAWRPSRKTTLEKY
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCHHHHHHH
LDLLLLILPFEQKLFKDSPLRTVYIGHPLSETIKLFCPKQNWKERLHLPTDKPFVAAFPG
HHHHHHHHCCHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHCCCCCCCCEEEECCC
SRHSDILRNLTIQVQAFQASDFASTHHLLVSSANPAYDHLILEILQQNRCLHSNIVPSQF
CCHHHHHHCCEEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCHHCCCCCHHH
RYELMRECDCALAKCGTIVLETALNLTPTIVTCQLRPLDTFLAKYIFNIILPAYSLPNII
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHH
LGRTIFPEFIGGKKDFRYEDVAAALNILKTSQAQEKQKNACKDVYQAINESASTIKECLP
HCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIFEASY
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935