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Identifier: 15835306

GI number: 15835306

Start: 821832

End: 823109

Strand: Direct

Name: Not Available

Synonym: TC0691

Alternate gene names: 15835306

Gene position: 821832-823109 (Clockwise)

Preceding gene: 15835305

Following gene: 15835307

Centisome position: 76.6

GC content: 38.73

Gene sequence:

>1278_bases
ATGATGGCTTGCAACCAAGAACTTCTTTCGCCTAGAGGCTTAGATTTGCTCAGCAAAAATTCTCATTCTAATCTTACTCC
TACGATATTCTATCCGTCGGACCACAATATTGATCTGCAAAGCTTCTCTCCTCATGCCCTTTCCGTTGTGAGAACTTTAA
AAAAAGCTGGGTATGAGGCCTATATCGTTGGAGGATGTATTCGTGATCTCCTACTAAAAACGGAGCCTAAAGATTTCGAT
GTCTCTACTTCTGCCAAACCTGAAGAAGTTAAAGCCTTATTCAAAAATTGTATTCTCGTAGGCAAACGTTTTCGTTTAGC
TCATATCCGCTTCCCCAATCAAATCATAGAAGTCTCTACCTTTAGATCCGGTAGTAACGAAGAAGATTCTTTAATTACAA
AAGATAATCTTTGGGGATCCGCTGAAGAGGATGTACTGCGAAGAGACTTTACTATTAATGGCCTTTTCTATGATCCGAGC
TCCGAAGTCATCATTGACTACACGGGAGGGGTGGAAGACTTAAAAAATCGCTATTTAAGAACCATTGGCGATCCTTTTCT
CCGATTCAAACAAGACCCTGTGCGCATGCTGCGCCTATTAAAAATCTTGTCTCGCTACGCCTTTACTGTGGATCCAAAAA
CTCTTGAAGCTCTTCGAGAGTCTCGCCATGAGCTAATAAAAAGCTCTCAACCAAGAGTATTTGAAGAGCTTATAAAAGTA
TTAAGCTCCGGAGAATCCACTATTTTTTTCCAGCTAGCTTCAGAATATCGGATCTTAGAAATTCTGTTCCCTTATATGTC
TAAAGCTTTTGGCTTAAGCAAAGTTCTCCAAGATCAGACTTTTGCTAGCTTAACGGCTTTGGATGCTAAAGTGCGGCAGC
GTTCTTTCTGCTTAGAAAGACATCTTCTGTTGTCGATATTGTTGTTCCCTATCGTAAACTTCAATGTTCGATATAAATAT
AGTCAGCATCCAACAATGTCTATTCAGGATATTTTTGATTATATTAAAAACTTTTTAACAGAATTTTTTGCCGACTCTTT
TACCAGCTGCTCAAAGAAAAACTTTATTTTGACAACTTTACTTTTACAGATGCAGTATAGGCTGACCCCTCTAGCTCCAT
TAAAAAAAGAAAGAAATTCGTTCTTCAATAAAAAGCTTTTACGCCATACCTACTTTCTTGAAGCTCTTTACTTGTTAGAA
ATCCGCAGTCAGGTATTTCCAAAAGTAAAAGCTCCGTATGAGGAGTGGCTCAACCAGTATGAACGAATTTCGGAGTAA

Upstream 100 bases:

>100_bases
AATTTTTCTGTTATAGGAAGAGCCTTGTCGGAGAGGAGTCTAAAACCTCTCTTATTCAAGGCCAAAATTCCCCAGACTTT
TTAACTTCTAATGTCATATA

Downstream 100 bases:

>100_bases
TCATTCCTAGTTAAAATTAGGAAAATTCTTCTCCCCACGGATTTATAGTTAGTTGTTATGTTTCCCCAGAAAATCACGCT
TTGGTTATACCCTTTAGGAC

Product: poly(A) polymerase family protein

Products: NA

Alternate protein names: PAP; Plasmid copy number protein [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MMACNQELLSPRGLDLLSKNSHSNLTPTIFYPSDHNIDLQSFSPHALSVVRTLKKAGYEAYIVGGCIRDLLLKTEPKDFD
VSTSAKPEEVKALFKNCILVGKRFRLAHIRFPNQIIEVSTFRSGSNEEDSLITKDNLWGSAEEDVLRRDFTINGLFYDPS
SEVIIDYTGGVEDLKNRYLRTIGDPFLRFKQDPVRMLRLLKILSRYAFTVDPKTLEALRESRHELIKSSQPRVFEELIKV
LSSGESTIFFQLASEYRILEILFPYMSKAFGLSKVLQDQTFASLTALDAKVRQRSFCLERHLLLSILLFPIVNFNVRYKY
SQHPTMSIQDIFDYIKNFLTEFFADSFTSCSKKNFILTTLLLQMQYRLTPLAPLKKERNSFFNKKLLRHTYFLEALYLLE
IRSQVFPKVKAPYEEWLNQYERISE

Sequences:

>Translated_425_residues
MMACNQELLSPRGLDLLSKNSHSNLTPTIFYPSDHNIDLQSFSPHALSVVRTLKKAGYEAYIVGGCIRDLLLKTEPKDFD
VSTSAKPEEVKALFKNCILVGKRFRLAHIRFPNQIIEVSTFRSGSNEEDSLITKDNLWGSAEEDVLRRDFTINGLFYDPS
SEVIIDYTGGVEDLKNRYLRTIGDPFLRFKQDPVRMLRLLKILSRYAFTVDPKTLEALRESRHELIKSSQPRVFEELIKV
LSSGESTIFFQLASEYRILEILFPYMSKAFGLSKVLQDQTFASLTALDAKVRQRSFCLERHLLLSILLFPIVNFNVRYKY
SQHPTMSIQDIFDYIKNFLTEFFADSFTSCSKKNFILTTLLLQMQYRLTPLAPLKKERNSFFNKKLLRHTYFLEALYLLE
IRSQVFPKVKAPYEEWLNQYERISE
>Mature_425_residues
MMACNQELLSPRGLDLLSKNSHSNLTPTIFYPSDHNIDLQSFSPHALSVVRTLKKAGYEAYIVGGCIRDLLLKTEPKDFD
VSTSAKPEEVKALFKNCILVGKRFRLAHIRFPNQIIEVSTFRSGSNEEDSLITKDNLWGSAEEDVLRRDFTINGLFYDPS
SEVIIDYTGGVEDLKNRYLRTIGDPFLRFKQDPVRMLRLLKILSRYAFTVDPKTLEALRESRHELIKSSQPRVFEELIKV
LSSGESTIFFQLASEYRILEILFPYMSKAFGLSKVLQDQTFASLTALDAKVRQRSFCLERHLLLSILLFPIVNFNVRYKY
SQHPTMSIQDIFDYIKNFLTEFFADSFTSCSKKNFILTTLLLQMQYRLTPLAPLKKERNSFFNKKLLRHTYFLEALYLLE
IRSQVFPKVKAPYEEWLNQYERISE

Specific function: Polymerase that creates the 3' poly(A) tail found in some mRNA's. Seems to be involved in plasmid copy number control [H]

COG id: COG0617

COG function: function code J; tRNA nucleotidyltransferase/poly(A) polymerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family [H]

Homologues:

Organism=Homo sapiens, GI155030240, Length=213, Percent_Identity=30.9859154929577, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI87081691, Length=396, Percent_Identity=34.3434343434343, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1789436, Length=219, Percent_Identity=32.4200913242009, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71995920, Length=218, Percent_Identity=28.4403669724771, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321016, Length=229, Percent_Identity=29.2576419213974, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281360112, Length=222, Percent_Identity=29.7297297297297, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357337, Length=222, Percent_Identity=29.7297297297297, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002646
- InterPro:   IPR010206 [H]

Pfam domain/function: PF01743 PolyA_pol [H]

EC number: =2.7.7.19 [H]

Molecular weight: Translated: 49426; Mature: 49426

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMACNQELLSPRGLDLLSKNSHSNLTPTIFYPSDHNIDLQSFSPHALSVVRTLKKAGYEA
CCCCCHHHCCCCCCHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEE
YIVGGCIRDLLLKTEPKDFDVSTSAKPEEVKALFKNCILVGKRFRLAHIRFPNQIIEVST
EEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHEEEEE
FRSGSNEEDSLITKDNLWGSAEEDVLRRDFTINGLFYDPSSEVIIDYTGGVEDLKNRYLR
CCCCCCCCCCEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCEEEEECCCHHHHHHHHHH
TIGDPFLRFKQDPVRMLRLLKILSRYAFTVDPKTLEALRESRHELIKSSQPRVFEELIKV
HHCCHHHHHCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSSGESTIFFQLASEYRILEILFPYMSKAFGLSKVLQDQTFASLTALDAKVRQRSFCLER
HHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLLLSILLFPIVNFNVRYKYSQHPTMSIQDIFDYIKNFLTEFFADSFTSCSKKNFILTTL
HHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLQMQYRLTPLAPLKKERNSFFNKKLLRHTYFLEALYLLEIRSQVFPKVKAPYEEWLNQY
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ERISE
HHCCC
>Mature Secondary Structure
MMACNQELLSPRGLDLLSKNSHSNLTPTIFYPSDHNIDLQSFSPHALSVVRTLKKAGYEA
CCCCCHHHCCCCCCHHHCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCEE
YIVGGCIRDLLLKTEPKDFDVSTSAKPEEVKALFKNCILVGKRFRLAHIRFPNQIIEVST
EEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHEEEEE
FRSGSNEEDSLITKDNLWGSAEEDVLRRDFTINGLFYDPSSEVIIDYTGGVEDLKNRYLR
CCCCCCCCCCEEECCCCCCCCHHHHHHHCCEEEEEEECCCCCEEEEECCCHHHHHHHHHH
TIGDPFLRFKQDPVRMLRLLKILSRYAFTVDPKTLEALRESRHELIKSSQPRVFEELIKV
HHCCHHHHHCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LSSGESTIFFQLASEYRILEILFPYMSKAFGLSKVLQDQTFASLTALDAKVRQRSFCLER
HHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLLLSILLFPIVNFNVRYKYSQHPTMSIQDIFDYIKNFLTEFFADSFTSCSKKNFILTTL
HHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LLQMQYRLTPLAPLKKERNSFFNKKLLRHTYFLEALYLLEIRSQVFPKVKAPYEEWLNQY
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ERISE
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]