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The map label for this gene is lspA

Identifier: 15835303

GI number: 15835303

Start: 819655

End: 820158

Strand: Direct

Name: lspA

Synonym: TC0688

Alternate gene names: 15835303

Gene position: 819655-820158 (Clockwise)

Preceding gene: 15835302

Following gene: 15835304

Centisome position: 76.39

GC content: 40.87

Gene sequence:

>504_bases
ATGACGACCCGCTCTCTATCGACCTTCCTCACCTCTTTTCTCCTAGTCTCTCTTGATTGGGTCTCAAAACTAGTTGTGTT
ACTAAAGAGCTGTCAGCTCTCCCCCCACTCCCCTGCTTTACTTTATAGCTATGTGTGGGGACATTTCTCTTTTCTCATTG
TGCCCTCTTTCAATGAGGGAGCGGCCTTTGGCCTATTTGCTCAATACAAAATACCCCTGCTCATTTTCAGAGTTTTCGTT
ATCTTATGTCTTTTTTTATTCTTAGGAATTAAATTTAGATCTTTACATATTAGAACGCGAATCGCTTTAACCCTAATTCT
TGCAGGAGCTCTGGGTAACGTTGGAGACATCTTATTTCATGGTAAGGTGGTCGATTTCCTCTCTATTAACTACTATTCTT
GGAGTTTCCCCTCCTTCAATTTAGCAGATGCTTTCATCTCCCTTGGCACTCTCCTCCTTGTCGGGCATCTGTATTTCAGC
AAAGAAGATAAAAAATATTTTTAA

Upstream 100 bases:

>100_bases
AAATTCCATTAGCAAGATTAATGGCAATTCCTTACGCTACAATGACTGTAAAATCACAAGAAAAATTCGAAAAAGGCCTT
CTTTCCGGAAACTAGTTACA

Downstream 100 bases:

>100_bases
TAAAAATTGTTCTCTAAAAGATCCTCTACCAAACAAAAAAGAAAAAGAGGATAATATAGGGCAATTTTCAGAAGAAAATG
ATTTAAATTACATATTTTAT

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MTTRSLSTFLTSFLLVSLDWVSKLVVLLKSCQLSPHSPALLYSYVWGHFSFLIVPSFNEGAAFGLFAQYKIPLLIFRVFV
ILCLFLFLGIKFRSLHIRTRIALTLILAGALGNVGDILFHGKVVDFLSINYYSWSFPSFNLADAFISLGTLLLVGHLYFS
KEDKKYF

Sequences:

>Translated_167_residues
MTTRSLSTFLTSFLLVSLDWVSKLVVLLKSCQLSPHSPALLYSYVWGHFSFLIVPSFNEGAAFGLFAQYKIPLLIFRVFV
ILCLFLFLGIKFRSLHIRTRIALTLILAGALGNVGDILFHGKVVDFLSINYYSWSFPSFNLADAFISLGTLLLVGHLYFS
KEDKKYF
>Mature_166_residues
TTRSLSTFLTSFLLVSLDWVSKLVVLLKSCQLSPHSPALLYSYVWGHFSFLIVPSFNEGAAFGLFAQYKIPLLIFRVFVI
LCLFLFLGIKFRSLHIRTRIALTLILAGALGNVGDILFHGKVVDFLSINYYSWSFPSFNLADAFISLGTLLLVGHLYFSK
EDKKYF

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_CHLMU (Q9PJY8)

Other databases:

- EMBL:   AE002160
- PIR:   B81676
- RefSeq:   NP_297062.1
- GeneID:   1246049
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0688
- TIGR:   TC_0688
- HOGENOM:   HBG724422
- OMA:   GLFAQYK
- ProtClustDB:   PRK00376
- BioCyc:   CMUR243161:TC_0688-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 18918; Mature: 18786

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 116-116 ACT_SITE 143-143

Signals:

None

Transmembrane regions:

HASH(0xb9ff6d0)-; HASH(0xce497f4)-; HASH(0xd2540b0)-; HASH(0xd358fa4)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRSLSTFLTSFLLVSLDWVSKLVVLLKSCQLSPHSPALLYSYVWGHFSFLIVPSFNEG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCEEEEEEECCCCC
AAFGLFAQYKIPLLIFRVFVILCLFLFLGIKFRSLHIRTRIALTLILAGALGNVGDILFH
CEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
GKVVDFLSINYYSWSFPSFNLADAFISLGTLLLVGHLYFSKEDKKYF
CCEEHHEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure 
TTRSLSTFLTSFLLVSLDWVSKLVVLLKSCQLSPHSPALLYSYVWGHFSFLIVPSFNEG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCEEEEEEECCCCC
AAFGLFAQYKIPLLIFRVFVILCLFLFLGIKFRSLHIRTRIALTLILAGALGNVGDILFH
CEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
GKVVDFLSINYYSWSFPSFNLADAFISLGTLLLVGHLYFSKEDKKYF
CCEEHHEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10684935