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Identifier: 15835296

GI number: 15835296

Start: 813673

End: 814902

Strand: Reverse

Name: Not Available

Synonym: TC0681

Alternate gene names: 15835296

Gene position: 814902-813673 (Counterclockwise)

Preceding gene: 15835297

Following gene: 15835295

Centisome position: 75.95

GC content: 41.87

Gene sequence:

>1230_bases
ATGAAATTATGGATGAAAATCTTTATAGGCCTAATCATCGGAGTTGTTTCTGGCTTGGTTCTAGAAGACAAAGCAGTTTT
TGTTAAGCCTTTTGGGGATATATTTTTAAATCTACTGAGCATGGTGGTGTATCCTTTAGTTTTTTGCTCTATGGTTCTAG
GAATTGCTTCGATTAGTGATATGAAAAAATTGGGGCGTATAGGCTTGAGAAGCCTAGGATTGTATTTAGGGACCACTGCT
GTTGCGATTGGCATCGGCTTGGCCTTTGCTCTTTTCTTTTGCCCGGGGAGGGGATGCGATCTTCAGGGATTTAATGGGAT
AGATTTTTCTGCTGGTCAACCTAGTGAGATCAATTTTTTAACTGCATTTGCACAGGTTTTCCCTTCCAACCCCATGCGTT
CTTTTGTTGAAGGAAATATTTTGCAAATCATTATATTCGCTTTATTTACAGGAATTGCCCTGCGTTTGGCAGGAGAGGTA
GCTCGTCCTGTAGAACAGGTGATCCACGGATGTAACGAAATTATGTTACGAATGGTCAATATGATCATGTCTTTTGCTCC
TTATGGGGTAGCAGCAAGTATGGCCTGGATATCTGGAAATCATGGGTTAACCGTTTTACTTCAATTAGGGAAGTTCCTTG
TCGTCTATTATATCGCCTGTATTTGTCATGCCGTGTTGGTGTTTGGTGGTTTAGTTCGGTTGGGATGTAGACGTTCGTTC
AGCGGCTTTTTGTCGTCGATGATGGACGCGATTTCTTGTGCTGTATCTACTGCAAGTAGTTCTGCAACACTACCTGTTAC
CATGCGTTGTGTTTCAAAAAATCTTGGTGTTTCTTCTGAAATATCGGGATTTGTGCTTCCTTTAGGAGCAACTGTAAATA
TGAATGGTACAGCGATTTTTCAAGGGATGGCCGCAGTGTTTATCGCTCAGGCATATAATTGCCCTCTTTCTTTAACAAGT
TTGCTTCTTTTAGTTGTGACAGCAACATTTTCTGCTGTAGGCAGTGCAGGGGTTCCTGGAGGAGGAATGATTACGCTAGG
TTCTGTTCTAGCCTCTGTAGGACTACCTATCCAAGGGATTGCAGTTTTAGCTGGTATTGATCGCTTACGAGATATTATCG
GTACTCCTATGAACATTTTAGGAGATTCTGTTGTTGCGTTATATGTCGCTAATGGAGAAGGAGAGTTGGCTTCTCCAGAA
GAAGAGGAAGCTCTTCCTCAAAATGGTTAG

Upstream 100 bases:

>100_bases
GAGAAGTCCGTATGCGGTTTTCTTGTGTGTGTAATGAAGAACGAATGGTAGCCATGTTGGATGCAATAGAAGCCATCCAG
AAGAATAAGAAGGTGACTAC

Downstream 100 bases:

>100_bases
AAGACGTTTTTAACGAAGAGAGAAAACTCTCTTCGTTTTCTTTTTAAGATTCCCTGAATTCTTTTCTGTAGCTTCAAAAA
GTGTTTAGTGTAACATGAGA

Product: sodium:dicarboxylate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKLWMKIFIGLIIGVVSGLVLEDKAVFVKPFGDIFLNLLSMVVYPLVFCSMVLGIASISDMKKLGRIGLRSLGLYLGTTA
VAIGIGLAFALFFCPGRGCDLQGFNGIDFSAGQPSEINFLTAFAQVFPSNPMRSFVEGNILQIIIFALFTGIALRLAGEV
ARPVEQVIHGCNEIMLRMVNMIMSFAPYGVAASMAWISGNHGLTVLLQLGKFLVVYYIACICHAVLVFGGLVRLGCRRSF
SGFLSSMMDAISCAVSTASSSATLPVTMRCVSKNLGVSSEISGFVLPLGATVNMNGTAIFQGMAAVFIAQAYNCPLSLTS
LLLLVVTATFSAVGSAGVPGGGMITLGSVLASVGLPIQGIAVLAGIDRLRDIIGTPMNILGDSVVALYVANGEGELASPE
EEEALPQNG

Sequences:

>Translated_409_residues
MKLWMKIFIGLIIGVVSGLVLEDKAVFVKPFGDIFLNLLSMVVYPLVFCSMVLGIASISDMKKLGRIGLRSLGLYLGTTA
VAIGIGLAFALFFCPGRGCDLQGFNGIDFSAGQPSEINFLTAFAQVFPSNPMRSFVEGNILQIIIFALFTGIALRLAGEV
ARPVEQVIHGCNEIMLRMVNMIMSFAPYGVAASMAWISGNHGLTVLLQLGKFLVVYYIACICHAVLVFGGLVRLGCRRSF
SGFLSSMMDAISCAVSTASSSATLPVTMRCVSKNLGVSSEISGFVLPLGATVNMNGTAIFQGMAAVFIAQAYNCPLSLTS
LLLLVVTATFSAVGSAGVPGGGMITLGSVLASVGLPIQGIAVLAGIDRLRDIIGTPMNILGDSVVALYVANGEGELASPE
EEEALPQNG
>Mature_409_residues
MKLWMKIFIGLIIGVVSGLVLEDKAVFVKPFGDIFLNLLSMVVYPLVFCSMVLGIASISDMKKLGRIGLRSLGLYLGTTA
VAIGIGLAFALFFCPGRGCDLQGFNGIDFSAGQPSEINFLTAFAQVFPSNPMRSFVEGNILQIIIFALFTGIALRLAGEV
ARPVEQVIHGCNEIMLRMVNMIMSFAPYGVAASMAWISGNHGLTVLLQLGKFLVVYYIACICHAVLVFGGLVRLGCRRSF
SGFLSSMMDAISCAVSTASSSATLPVTMRCVSKNLGVSSEISGFVLPLGATVNMNGTAIFQGMAAVFIAQAYNCPLSLTS
LLLLVVTATFSAVGSAGVPGGGMITLGSVLASVGLPIQGIAVLAGIDRLRDIIGTPMNILGDSVVALYVANGEGELASPE
EEEALPQNG

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=423, Percent_Identity=32.8605200945626, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI5032093, Length=422, Percent_Identity=35.3080568720379, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI169790839, Length=418, Percent_Identity=29.4258373205742, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI40254478, Length=437, Percent_Identity=29.5194508009153, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI223468566, Length=281, Percent_Identity=37.3665480427046, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=37.1323529411765, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI4827012, Length=274, Percent_Identity=36.4963503649635, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI66773030, Length=431, Percent_Identity=27.3781902552204, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI194239697, Length=264, Percent_Identity=32.5757575757576, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI301601644, Length=192, Percent_Identity=42.1875, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI262359914, Length=351, Percent_Identity=27.9202279202279, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI1790514, Length=390, Percent_Identity=34.1025641025641, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1789947, Length=408, Percent_Identity=31.6176470588235, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1788024, Length=414, Percent_Identity=27.0531400966184, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1789473, Length=217, Percent_Identity=29.4930875576037, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17537407, Length=419, Percent_Identity=30.0715990453461, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71983106, Length=418, Percent_Identity=27.511961722488, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71983099, Length=418, Percent_Identity=27.511961722488, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI193206654, Length=437, Percent_Identity=27.0022883295195, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI193206505, Length=437, Percent_Identity=29.5194508009153, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71996953, Length=435, Percent_Identity=27.3563218390805, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17541374, Length=395, Percent_Identity=29.873417721519, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24583025, Length=436, Percent_Identity=25.6880733944954, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI17137668, Length=436, Percent_Identity=25.6880733944954, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24583023, Length=436, Percent_Identity=25.6880733944954, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI281360481, Length=456, Percent_Identity=27.6315789473684, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI281360483, Length=456, Percent_Identity=27.6315789473684, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17137666, Length=456, Percent_Identity=27.6315789473684, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 42849; Mature: 42849

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCHHHHCCCEEEEEEECCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHCCCHHHHCCCEEEEEEECCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]