Click here to switch to the map view.

The map label for this gene is hrcA

Identifier: 15835288

GI number: 15835288

Start: 803696

End: 804874

Strand: Direct

Name: hrcA

Synonym: TC0673

Alternate gene names: 15835288

Gene position: 803696-804874 (Clockwise)

Preceding gene: 15835287

Following gene: 15835289

Centisome position: 74.91

GC content: 38.93

Gene sequence:

>1179_bases
ATGGAAAATAGAACAGAAATGTCCCAATTGCGAGCATCGAAAAAAGATTCTAAGATTTCGCATGTCCTACTCATGGCCAT
TAAGCTTTATTTGGAAAGCGGTCAGCCCGTAGGATCGAAACTTCTTAAAGAAACTTATTGTTCCGATCTAAGTTCGGCAA
CGATACGGAATTACTTTGCTCAACTGGAAACAGACGGTTTTTTACGAAAAAACCATATCTCTGGAGGAAGAATTCCTACA
GATCTGGCTTTCCGCTACTATGCAGATCATTGTTCTCCTGTTCTTGAACAAGAAGAAATCTCAATCATTCAACAAAAACT
GAAAGAGCTTCCAGAATACAGCAAAAATATTGTGAAAGATCTACAGAAAGCTTCGGAAATCCTTTCTGAGATTTTACAAC
TACCTGTTTGTTTCTCCTCTCCTCGTTTTGAAAGCGATTCTGTAACCAATATTCAACTAGTGTCTATAGATGACCTACGA
GTCGTTTTTGTACTCTCAACAGAGTTTGGGCAACTTTTCACGGATGTTCTTTGGCTCCCAGAACAACTTCCCGAAAACTC
TTTGAAAAGAATCGAAAGCTTTCTACAAAATTATTTACGAAAGCATCCCTCCAGTGTCCCTCTTTCTCAAAAAGAGGAAG
ATTTAGGTATGACCCTATATAACGAAGTTGTAGTCCGATACCTCACTCGTTATTGCCATTTCAGTGAAGAAGATCTTTAC
CAAACAGGACTATCTAGATTACTCAAATACGAGGTCTTTAAAGATCCTGAAACACTCGCTCAGGGGCTTTCTTTCTTTGA
AAACCGTAAACACATGTGTCAGCTTTTAAATTCTCATTTACATAAAAAAGCTCCCACTACGTTTATTGGCCGAGAACTCT
CTGATATTGTTGGGAATGCAGACCCTTCATGTGCAGTAATTACCGTGCCTTACTACATGGACCGCACTCCTTTGGGAGCA
TTCGGTGTACTAGGTCCTATGAACCTCCCTTATCAACAGGTGTTTGGCACACTTTCTTTATTCACAGAACGACTAAAAAC
GATTTTAACTCAAAGTTTTTACAAATTTAAATTATCTTTCAGGAGACCTTGTCCGACCGACCCTAGATGTTCACAAAAAC
CAGCAGAGTTGACTCGACGTTCTTCTATAAAATTATTACCAGCTAAGGAATTAACATGA

Upstream 100 bases:

>100_bases
AGAAAAATCCCTCCTATTCGAGAGTAAACTAGCACTCTTTGCTCGCGAGCGCTAAAATTCTTGACCAGAGGCTCCGGTTT
TCCTATAATGACACCGACTT

Downstream 100 bases:

>100_bases
CAGAAACCCCCAATACCTCGTCAGAAGAAATTCAGACTAGCGAGCCTTCGTCTGATAACGAACTCCAAACGCTTCAACAA
GAGAACGCTAATTTAAAAGC

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MENRTEMSQLRASKKDSKISHVLLMAIKLYLESGQPVGSKLLKETYCSDLSSATIRNYFAQLETDGFLRKNHISGGRIPT
DLAFRYYADHCSPVLEQEEISIIQQKLKELPEYSKNIVKDLQKASEILSEILQLPVCFSSPRFESDSVTNIQLVSIDDLR
VVFVLSTEFGQLFTDVLWLPEQLPENSLKRIESFLQNYLRKHPSSVPLSQKEEDLGMTLYNEVVVRYLTRYCHFSEEDLY
QTGLSRLLKYEVFKDPETLAQGLSFFENRKHMCQLLNSHLHKKAPTTFIGRELSDIVGNADPSCAVITVPYYMDRTPLGA
FGVLGPMNLPYQQVFGTLSLFTERLKTILTQSFYKFKLSFRRPCPTDPRCSQKPAELTRRSSIKLLPAKELT

Sequences:

>Translated_392_residues
MENRTEMSQLRASKKDSKISHVLLMAIKLYLESGQPVGSKLLKETYCSDLSSATIRNYFAQLETDGFLRKNHISGGRIPT
DLAFRYYADHCSPVLEQEEISIIQQKLKELPEYSKNIVKDLQKASEILSEILQLPVCFSSPRFESDSVTNIQLVSIDDLR
VVFVLSTEFGQLFTDVLWLPEQLPENSLKRIESFLQNYLRKHPSSVPLSQKEEDLGMTLYNEVVVRYLTRYCHFSEEDLY
QTGLSRLLKYEVFKDPETLAQGLSFFENRKHMCQLLNSHLHKKAPTTFIGRELSDIVGNADPSCAVITVPYYMDRTPLGA
FGVLGPMNLPYQQVFGTLSLFTERLKTILTQSFYKFKLSFRRPCPTDPRCSQKPAELTRRSSIKLLPAKELT
>Mature_392_residues
MENRTEMSQLRASKKDSKISHVLLMAIKLYLESGQPVGSKLLKETYCSDLSSATIRNYFAQLETDGFLRKNHISGGRIPT
DLAFRYYADHCSPVLEQEEISIIQQKLKELPEYSKNIVKDLQKASEILSEILQLPVCFSSPRFESDSVTNIQLVSIDDLR
VVFVLSTEFGQLFTDVLWLPEQLPENSLKRIESFLQNYLRKHPSSVPLSQKEEDLGMTLYNEVVVRYLTRYCHFSEEDLY
QTGLSRLLKYEVFKDPETLAQGLSFFENRKHMCQLLNSHLHKKAPTTFIGRELSDIVGNADPSCAVITVPYYMDRTPLGA
FGVLGPMNLPYQQVFGTLSLFTERLKTILTQSFYKFKLSFRRPCPTDPRCSQKPAELTRRSSIKLLPAKELT

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_CHLMU (P54306)

Other databases:

- EMBL:   U52216
- EMBL:   AE002160
- PIR:   F81676
- RefSeq:   NP_297047.1
- GeneID:   1246034
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0673
- TIGR:   TC_0673
- HOGENOM:   HBG414062
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   CMUR243161:TC_0673-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 44965; Mature: 44965

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENRTEMSQLRASKKDSKISHVLLMAIKLYLESGQPVGSKLLKETYCSDLSSATIRNYFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLETDGFLRKNHISGGRIPTDLAFRYYADHCSPVLEQEEISIIQQKLKELPEYSKNIVKD
HHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQKASEILSEILQLPVCFSSPRFESDSVTNIQLVSIDDLRVVFVLSTEFGQLFTDVLWLP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCEEEEEEECCHHHHHHHHHHHCH
EQLPENSLKRIESFLQNYLRKHPSSVPLSQKEEDLGMTLYNEVVVRYLTRYCHFSEEDLY
HHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
QTGLSRLLKYEVFKDPETLAQGLSFFENRKHMCQLLNSHLHKKAPTTFIGRELSDIVGNA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DPSCAVITVPYYMDRTPLGAFGVLGPMNLPYQQVFGTLSLFTERLKTILTQSFYKFKLSF
CCCEEEEEECCEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RRPCPTDPRCSQKPAELTRRSSIKLLPAKELT
CCCCCCCCCCCCCHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure
MENRTEMSQLRASKKDSKISHVLLMAIKLYLESGQPVGSKLLKETYCSDLSSATIRNYFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLETDGFLRKNHISGGRIPTDLAFRYYADHCSPVLEQEEISIIQQKLKELPEYSKNIVKD
HHCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQKASEILSEILQLPVCFSSPRFESDSVTNIQLVSIDDLRVVFVLSTEFGQLFTDVLWLP
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCEEEEEEECCHHHHHHHHHHHCH
EQLPENSLKRIESFLQNYLRKHPSSVPLSQKEEDLGMTLYNEVVVRYLTRYCHFSEEDLY
HHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCHHHHH
QTGLSRLLKYEVFKDPETLAQGLSFFENRKHMCQLLNSHLHKKAPTTFIGRELSDIVGNA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DPSCAVITVPYYMDRTPLGAFGVLGPMNLPYQQVFGTLSLFTERLKTILTQSFYKFKLSF
CCCEEEEEECCEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RRPCPTDPRCSQKPAELTRRSSIKLLPAKELT
CCCCCCCCCCCCCHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8955323; 10684935