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Identifier: 15835284

GI number: 15835284

Start: 798340

End: 799521

Strand: Direct

Name: Not Available

Synonym: TC0669

Alternate gene names: 15835284

Gene position: 798340-799521 (Clockwise)

Preceding gene: 15835283

Following gene: 15835285

Centisome position: 74.41

GC content: 40.27

Gene sequence:

>1182_bases
ATGAAGAGAAATCCCAATTTCACATCTTTAACACAGAATTACTTGTTTTCAGATTTACGCAATCGAATTGCTCAGTTTCA
TTCAGAAAATCCCCAGCATCAAGTAATCAATTTATCTATTGGAGATACCACTCAACCTTTGGATACTAGTGTCGCAGAAG
CTTTTTCCCAGGCTATTGCACGCTTTAGTTCTCCATCAACTTATTGTGGATATGGACCGGATTTTGGATTGCCTTCCCTA
AGACAAAAATTATCTGAAAAGCTTTATCATGGCTGTGTTAATGCAGAAGAAATCTTCATTTCTGATGGAGCAAAAGTCGA
TCTTTTTCGCTTACTGTCTTTTTTCGGCCCGAATCAAATAGTTGCTGTTCAGGATCCCTCTTATCCCGCTTATATCGATA
TTGCTCGCTTAACAGGTGCAAAAGAGATTGTTTCTCTCCCTTGCTTACAAGAGAATGATTTTCTCCCTGTATTTCCGGAA
AACACCCACATTGACATTCTATGTCTATGCTCCCCGAATAATCCAACGGGAACGGCTTTAAACAAGAATCAACTGCGGGC
GATTGTACGCTATGCAATAGAGCATAATATTCTTATTTTGTTCGATGCTGCTTACAGTGCTTTTATTTCGGCCCCTTCTC
TTCCTAAAAGCATCTTTGAAATCCCTGATGCACGGTTCTGCGCCATAGAAATCAATTCTTTCTCTAAATCACTCGGATTT
GCTGGCATTCGATTAGGCTGGACAGTCATTCCTAAAGAGTTGACTTACGAAGATGGACAGCCCATTATCCGTGATTGGAA
ACGTTTTCTATCAACAACTTTTAATGGTGCTTCCATCCCAGCACAAGAAGCTGCGACTGCTGGACTCTCTACTCTTTCTA
AACTTGAAGCAGTCCATTATTACAAAGAAAATAGCCATTTGCTGAAAACCTCTCTATTGAAAGCCGGATTTCAAGTATTC
GGCGGAGAACATGCCCCCTATTTATGGGTCAAACCTACGATAGAAACTGTTCCTTATAGAGATCTTTTTGACTTTTTCTT
ACAAGAATACCATATCGCAATTACACCTGGGATTGGGTTTGGTCTTTGTGGTTCTGGGTTTGTTCGCTTTTCCTCTCTTG
GAAAGCGAGAAGACGTATTAGTAGCCTGTGAACGTTTACAAATGACTCCTGCTCTACAATAA

Upstream 100 bases:

>100_bases
GCTTTTTCTCTAAAAATTACTCTGGACAGATGAGAGCCCCCTCTTTATATTACCGTCCACTATTTTGACTCCTTCGCGTT
TCATGCGATGTAGATGGTTT

Downstream 100 bases:

>100_bases
ATAGGAGTTCTATGCTTTTGCGAAAAATTTGCAGCTATCTTTTTTGTAGTTCCTTAGCCTGCTCCTTTATTTCCGTGATC
GCAGTTTCCTTTCGTGCGGA

Product: L,L-diaminopimelate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKRNPNFTSLTQNYLFSDLRNRIAQFHSENPQHQVINLSIGDTTQPLDTSVAEAFSQAIARFSSPSTYCGYGPDFGLPSL
RQKLSEKLYHGCVNAEEIFISDGAKVDLFRLLSFFGPNQIVAVQDPSYPAYIDIARLTGAKEIVSLPCLQENDFLPVFPE
NTHIDILCLCSPNNPTGTALNKNQLRAIVRYAIEHNILILFDAAYSAFISAPSLPKSIFEIPDARFCAIEINSFSKSLGF
AGIRLGWTVIPKELTYEDGQPIIRDWKRFLSTTFNGASIPAQEAATAGLSTLSKLEAVHYYKENSHLLKTSLLKAGFQVF
GGEHAPYLWVKPTIETVPYRDLFDFFLQEYHIAITPGIGFGLCGSGFVRFSSLGKREDVLVACERLQMTPALQ

Sequences:

>Translated_393_residues
MKRNPNFTSLTQNYLFSDLRNRIAQFHSENPQHQVINLSIGDTTQPLDTSVAEAFSQAIARFSSPSTYCGYGPDFGLPSL
RQKLSEKLYHGCVNAEEIFISDGAKVDLFRLLSFFGPNQIVAVQDPSYPAYIDIARLTGAKEIVSLPCLQENDFLPVFPE
NTHIDILCLCSPNNPTGTALNKNQLRAIVRYAIEHNILILFDAAYSAFISAPSLPKSIFEIPDARFCAIEINSFSKSLGF
AGIRLGWTVIPKELTYEDGQPIIRDWKRFLSTTFNGASIPAQEAATAGLSTLSKLEAVHYYKENSHLLKTSLLKAGFQVF
GGEHAPYLWVKPTIETVPYRDLFDFFLQEYHIAITPGIGFGLCGSGFVRFSSLGKREDVLVACERLQMTPALQ
>Mature_393_residues
MKRNPNFTSLTQNYLFSDLRNRIAQFHSENPQHQVINLSIGDTTQPLDTSVAEAFSQAIARFSSPSTYCGYGPDFGLPSL
RQKLSEKLYHGCVNAEEIFISDGAKVDLFRLLSFFGPNQIVAVQDPSYPAYIDIARLTGAKEIVSLPCLQENDFLPVFPE
NTHIDILCLCSPNNPTGTALNKNQLRAIVRYAIEHNILILFDAAYSAFISAPSLPKSIFEIPDARFCAIEINSFSKSLGF
AGIRLGWTVIPKELTYEDGQPIIRDWKRFLSTTFNGASIPAQEAATAGLSTLSKLEAVHYYKENSHLLKTSLLKAGFQVF
GGEHAPYLWVKPTIETVPYRDLFDFFLQEYHIAITPGIGFGLCGSGFVRFSSLGKREDVLVACERLQMTPALQ

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788722, Length=372, Percent_Identity=27.1505376344086, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786816, Length=383, Percent_Identity=25.3263707571802, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1788627, Length=379, Percent_Identity=23.2189973614776, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPAT_CHLMU (Q9PK04)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_297043.1
- ProteinModelPortal:   Q9PK04
- SMR:   Q9PK04
- GeneID:   1246030
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0669
- TIGR:   TC_0669
- HOGENOM:   HBG645860
- OMA:   ENTHIDI
- ProtClustDB:   PRK07590
- BioCyc:   CMUR243161:TC_0669-MONOMER
- HAMAP:   MF_01642
- InterPro:   IPR004839
- InterPro:   IPR019942
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR03542

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.83

Molecular weight: Translated: 43724; Mature: 43724

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: BINDING 41-41 BINDING 71-71 BINDING 74-74 BINDING 105-105 BINDING 128-128 BINDING 174-174 BINDING 174-174 BINDING 202-202 BINDING 205-205 BINDING 233-233 BINDING 235-235 BINDING 244-244 BINDING 275-275 BINDING 369-369

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNPNFTSLTQNYLFSDLRNRIAQFHSENPQHQVINLSIGDTTQPLDTSVAEAFSQAIA
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
RFSSPSTYCGYGPDFGLPSLRQKLSEKLYHGCVNAEEIFISDGAKVDLFRLLSFFGPNQI
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCEE
VAVQDPSYPAYIDIARLTGAKEIVSLPCLQENDFLPVFPENTHIDILCLCSPNNPTGTAL
EEEECCCCCCEEEEHHHCCCHHHHCCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCC
NKNQLRAIVRYAIEHNILILFDAAYSAFISAPSLPKSIFEIPDARFCAIEINSFSKSLGF
CHHHHHHHHHHHHHCCEEEEEECHHHHHHCCCCCCHHHHHCCCCEEEEEEECCHHHHCCC
AGIRLGWTVIPKELTYEDGQPIIRDWKRFLSTTFNGASIPAQEAATAGLSTLSKLEAVHY
CEEEECEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YKENSHLLKTSLLKAGFQVFGGEHAPYLWVKPTIETVPYRDLFDFFLQEYHIAITPGIGF
HHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHCEEEEECCCCC
GLCGSGFVRFSSLGKREDVLVACERLQMTPALQ
CCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKRNPNFTSLTQNYLFSDLRNRIAQFHSENPQHQVINLSIGDTTQPLDTSVAEAFSQAIA
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHH
RFSSPSTYCGYGPDFGLPSLRQKLSEKLYHGCVNAEEIFISDGAKVDLFRLLSFFGPNQI
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCEE
VAVQDPSYPAYIDIARLTGAKEIVSLPCLQENDFLPVFPENTHIDILCLCSPNNPTGTAL
EEEECCCCCCEEEEHHHCCCHHHHCCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCCCC
NKNQLRAIVRYAIEHNILILFDAAYSAFISAPSLPKSIFEIPDARFCAIEINSFSKSLGF
CHHHHHHHHHHHHHCCEEEEEECHHHHHHCCCCCCHHHHHCCCCEEEEEEECCHHHHCCC
AGIRLGWTVIPKELTYEDGQPIIRDWKRFLSTTFNGASIPAQEAATAGLSTLSKLEAVHY
CEEEECEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YKENSHLLKTSLLKAGFQVFGGEHAPYLWVKPTIETVPYRDLFDFFLQEYHIAITPGIGF
HHCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHCEEEEECCCCC
GLCGSGFVRFSSLGKREDVLVACERLQMTPALQ
CCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935