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The map label for this gene is pgi

Identifier: 15835272

GI number: 15835272

Start: 784460

End: 786034

Strand: Reverse

Name: pgi

Synonym: TC0657

Alternate gene names: 15835272

Gene position: 786034-784460 (Counterclockwise)

Preceding gene: 15835273

Following gene: 15835271

Centisome position: 73.26

GC content: 41.78

Gene sequence:

>1575_bases
ATGGGTAAAAGTTTCTTAGATTGTGAGTCATTAATTGCTTTGCAAGAGATAGCTACGAATCCAGTTGATTTGACTTTACC
AGGAACTTTGTCCCAAGATCGGATACAGCAGTATGCTTTGTCTGCGGAAGGGTTTACTTATAGTTATGCTACGGAGCGCG
TGGATGATCGTAGCCTTAATGCTTTAAGAATGCTTGCCGAGGAAAGGGAGCTAATAAAGCAGATGGAGAGTATGCAACAA
GGCGCTGTCATGAATTATATAGAGGGGTTTCAGAGCGAGTCCCGTTCTGTGTTACATACAGCAACGAGAGCTTGGGTTCG
AGACCATGATCTTAAGGATGAGGCGGCATCTATAGCCAATCATTCTGAACGAGAGGCTCATCGTCTTGCAGAGTTTTTGT
ATGCAGCCCGTTCTAAATTTTCTACGCTTGTGCAGATAGGTATTGGCGGATCAGAATTGGGCCCTAAAGCTATGTATTTT
GCTATGCAGGGGATTTGTCCATCTGATAAACGTATCTTTTTTGTTTCCAATATTGATCCAGATAATGCTGCAGAGGTCTT
AAAAGAAGTAGATCTCAAGCAAACCCTAATTGTTGTCGTGTCTAAATCAGGGACAACTTTAGAACCTTCAGTGAATGAGG
AATTATTTAAGCGAGCTTATCAAGACAAAGGATTGTCTGTAGCAGATCATTTTGTAGCGGTAACTGCTGAGGGTAGTCCC
ATGGATGATAAAACCCATTATTTGGAAGTTTTCCATCTTTGGGATAGTGTTGGTGGAAGGTTCTCGGCTACCTCTATGGT
GGGAGGGGTTGTACTTGGGTTTGCTTTTGGCTACGAAGTCTTTTTTGAGTTCTTGCAGGGAGCAGCTTCTATGGATGCTC
ATGCATTGACTCCAATTATGGAAAAGAATTTGCCTCTTTTATCTGCTATGCTCGGTATTTGGAACCGCAATGTATTAAAA
TATCCCACGACAGCTGTGATCCCCTATGCAACAGGATTGAAATATTTTACTGCGCATTTACAACAGTGCGGAATGGAATC
CAATGGGAAAAGCATTTCTAGACAAGGGAAAGAGGTGCATTTTGCGACATCTCCTATTATTTGGGGAGACGTTGGGACTA
ATTGTCAGCATTCCTTTTTCCAGAGTCTTCATCAAGGAACAGATATTGTTCCTGTGGAATTTATTGGATTTCTACAGAAT
CAACGAGGTATTGACTGTGTATTATCGGGGAGCTCTTCTTCTCAGAAGTTGTTTGCTAATCTTGTTGCACAATCGCTAGC
TTTAGCTCAGGGGAGAGACAACGATAATCCTAACAAACGATTTAAAGGGAATAGACCCTCTTCGATATTGGTTGCGCAGC
AACTCTCTCCTCGTATTGCTGGAGGATTACTGGCATTTTATGAGCATAAGTTTGCTTTTCAAGGTTTTTGTTGGGGAATC
AATTCCTTCGATCAGGAGGGAGTTTCATTAGGGAAAGAATTAGCCACTCAAATTATAGGCTTGATGTCTGGGGCTGCTCC
GATAGAATTTCCTGAGGCAAGAGAATTGTTAAGACTTTTTAATGTTTTGCAATGA

Upstream 100 bases:

>100_bases
GAAATATGTTCTGTCCTGAAAAAATGAAATCGTGAAAGATCAAAAAAGATAGTAAACAGAAAAGTCTCTCGTATCAAATT
TCCTTAAAAGGAGAATCATA

Downstream 100 bases:

>100_bases
TGTTTTAAGTAGGGCTTCCTATTTGTTCTGCAGAATTTTTATTTTAAATATGTTATAATGGGAGCCTTCTTCTTTTTTGA
AAGTGTTTAAGGTGCCCGTA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MGKSFLDCESLIALQEIATNPVDLTLPGTLSQDRIQQYALSAEGFTYSYATERVDDRSLNALRMLAEERELIKQMESMQQ
GAVMNYIEGFQSESRSVLHTATRAWVRDHDLKDEAASIANHSEREAHRLAEFLYAARSKFSTLVQIGIGGSELGPKAMYF
AMQGICPSDKRIFFVSNIDPDNAAEVLKEVDLKQTLIVVVSKSGTTLEPSVNEELFKRAYQDKGLSVADHFVAVTAEGSP
MDDKTHYLEVFHLWDSVGGRFSATSMVGGVVLGFAFGYEVFFEFLQGAASMDAHALTPIMEKNLPLLSAMLGIWNRNVLK
YPTTAVIPYATGLKYFTAHLQQCGMESNGKSISRQGKEVHFATSPIIWGDVGTNCQHSFFQSLHQGTDIVPVEFIGFLQN
QRGIDCVLSGSSSSQKLFANLVAQSLALAQGRDNDNPNKRFKGNRPSSILVAQQLSPRIAGGLLAFYEHKFAFQGFCWGI
NSFDQEGVSLGKELATQIIGLMSGAAPIEFPEARELLRLFNVLQ

Sequences:

>Translated_524_residues
MGKSFLDCESLIALQEIATNPVDLTLPGTLSQDRIQQYALSAEGFTYSYATERVDDRSLNALRMLAEERELIKQMESMQQ
GAVMNYIEGFQSESRSVLHTATRAWVRDHDLKDEAASIANHSEREAHRLAEFLYAARSKFSTLVQIGIGGSELGPKAMYF
AMQGICPSDKRIFFVSNIDPDNAAEVLKEVDLKQTLIVVVSKSGTTLEPSVNEELFKRAYQDKGLSVADHFVAVTAEGSP
MDDKTHYLEVFHLWDSVGGRFSATSMVGGVVLGFAFGYEVFFEFLQGAASMDAHALTPIMEKNLPLLSAMLGIWNRNVLK
YPTTAVIPYATGLKYFTAHLQQCGMESNGKSISRQGKEVHFATSPIIWGDVGTNCQHSFFQSLHQGTDIVPVEFIGFLQN
QRGIDCVLSGSSSSQKLFANLVAQSLALAQGRDNDNPNKRFKGNRPSSILVAQQLSPRIAGGLLAFYEHKFAFQGFCWGI
NSFDQEGVSLGKELATQIIGLMSGAAPIEFPEARELLRLFNVLQ
>Mature_523_residues
GKSFLDCESLIALQEIATNPVDLTLPGTLSQDRIQQYALSAEGFTYSYATERVDDRSLNALRMLAEERELIKQMESMQQG
AVMNYIEGFQSESRSVLHTATRAWVRDHDLKDEAASIANHSEREAHRLAEFLYAARSKFSTLVQIGIGGSELGPKAMYFA
MQGICPSDKRIFFVSNIDPDNAAEVLKEVDLKQTLIVVVSKSGTTLEPSVNEELFKRAYQDKGLSVADHFVAVTAEGSPM
DDKTHYLEVFHLWDSVGGRFSATSMVGGVVLGFAFGYEVFFEFLQGAASMDAHALTPIMEKNLPLLSAMLGIWNRNVLKY
PTTAVIPYATGLKYFTAHLQQCGMESNGKSISRQGKEVHFATSPIIWGDVGTNCQHSFFQSLHQGTDIVPVEFIGFLQNQ
RGIDCVLSGSSSSQKLFANLVAQSLALAQGRDNDNPNKRFKGNRPSSILVAQQLSPRIAGGLLAFYEHKFAFQGFCWGIN
SFDQEGVSLGKELATQIIGLMSGAAPIEFPEARELLRLFNVLQ

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=515, Percent_Identity=34.1747572815534, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI296080693, Length=506, Percent_Identity=33.399209486166, Blast_Score=253, Evalue=5e-67,
Organism=Escherichia coli, GI1790457, Length=524, Percent_Identity=34.9236641221374, Blast_Score=269, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI71996708, Length=493, Percent_Identity=34.0770791075051, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71996703, Length=493, Percent_Identity=34.0770791075051, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319673, Length=484, Percent_Identity=35.5371900826446, Blast_Score=249, Evalue=6e-67,
Organism=Drosophila melanogaster, GI24651916, Length=484, Percent_Identity=37.603305785124, Blast_Score=283, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24651914, Length=484, Percent_Identity=37.603305785124, Blast_Score=283, Evalue=3e-76,
Organism=Drosophila melanogaster, GI17737445, Length=484, Percent_Identity=37.603305785124, Blast_Score=283, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_CHLMU (Q9PK16)

Other databases:

- EMBL:   AE002160
- PIR:   E81678
- RefSeq:   NP_297031.1
- ProteinModelPortal:   Q9PK16
- GeneID:   1246018
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0657
- TIGR:   TC_0657
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK14095
- BioCyc:   CMUR243161:TC_0657-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 57776; Mature: 57645

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 346-346 ACT_SITE 377-377 ACT_SITE 492-492

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKSFLDCESLIALQEIATNPVDLTLPGTLSQDRIQQYALSAEGFTYSYATERVDDRSLN
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEHHHHCCCHHHHH
ALRMLAEERELIKQMESMQQGAVMNYIEGFQSESRSVLHTATRAWVRDHDLKDEAASIAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
HSEREAHRLAEFLYAARSKFSTLVQIGIGGSELGPKAMYFAMQGICPSDKRIFFVSNIDP
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
DNAAEVLKEVDLKQTLIVVVSKSGTTLEPSVNEELFKRAYQDKGLSVADHFVAVTAEGSP
CHHHHHHHHHCCCEEEEEEEECCCCEECCCCCHHHHHHHHHCCCCCEECEEEEEEECCCC
MDDKTHYLEVFHLWDSVGGRFSATSMVGGVVLGFAFGYEVFFEFLQGAASMDAHALTPIM
CCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EKNLPLLSAMLGIWNRNVLKYPTTAVIPYATGLKYFTAHLQQCGMESNGKSISRQGKEVH
HCCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEE
FATSPIIWGDVGTNCQHSFFQSLHQGTDIVPVEFIGFLQNQRGIDCVLSGSSSSQKLFAN
EEECCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
LVAQSLALAQGRDNDNPNKRFKGNRPSSILVAQQLSPRIAGGLLAFYEHKFAFQGFCWGI
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHEEECC
NSFDQEGVSLGKELATQIIGLMSGAAPIEFPEARELLRLFNVLQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKSFLDCESLIALQEIATNPVDLTLPGTLSQDRIQQYALSAEGFTYSYATERVDDRSLN
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCCCEEEHHHHCCCHHHHH
ALRMLAEERELIKQMESMQQGAVMNYIEGFQSESRSVLHTATRAWVRDHDLKDEAASIAN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
HSEREAHRLAEFLYAARSKFSTLVQIGIGGSELGPKAMYFAMQGICPSDKRIFFVSNIDP
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCC
DNAAEVLKEVDLKQTLIVVVSKSGTTLEPSVNEELFKRAYQDKGLSVADHFVAVTAEGSP
CHHHHHHHHHCCCEEEEEEEECCCCEECCCCCHHHHHHHHHCCCCCEECEEEEEEECCCC
MDDKTHYLEVFHLWDSVGGRFSATSMVGGVVLGFAFGYEVFFEFLQGAASMDAHALTPIM
CCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
EKNLPLLSAMLGIWNRNVLKYPTTAVIPYATGLKYFTAHLQQCGMESNGKSISRQGKEVH
HCCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEE
FATSPIIWGDVGTNCQHSFFQSLHQGTDIVPVEFIGFLQNQRGIDCVLSGSSSSQKLFAN
EEECCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
LVAQSLALAQGRDNDNPNKRFKGNRPSSILVAQQLSPRIAGGLLAFYEHKFAFQGFCWGI
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHEEECC
NSFDQEGVSLGKELATQIIGLMSGAAPIEFPEARELLRLFNVLQ
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935