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Identifier: 15835268

GI number: 15835268

Start: 780341

End: 781792

Strand: Direct

Name: Not Available

Synonym: TC0653

Alternate gene names: 15835268

Gene position: 780341-781792 (Clockwise)

Preceding gene: 15835267

Following gene: 15835269

Centisome position: 72.73

GC content: 40.77

Gene sequence:

>1452_bases
ATGTTCTTGAAAAAACGCTCCTCTTCAGGAATTTTAGGGACATTGTCTCTTACTGGAGTTGTGATCAGCTCCATGGTTGG
AGGGGGGATTTTCAGTCTTCCTCAGAATATGGCAGCCTCTGCAAGCGCAGGGGCTATTATCATTGCCTGGCTTCTCTCCG
GAATAGGAATATTTTTTATCGCAAATACCTTTAAAACTCTTTCCCTTGTTCGTCCTGACTTAAAGGCCGGTATCTATACC
TATAGTAGAGAAGGATTTGGCCCCTACGTAGGATTTACAATAGCATGGGGATACTGGCTTTGCCAAATTTTTGGAAATGT
CGGCTATGCCGTAATTACCATGGATGCCCTAAACTATTTCTTTCCCCCCTATTTCGAAGGAGGAAATACTCTCCCTGCTA
TTCTATTAGGATCTATCCTTATTTGGGTATTCAATTCCATCGTCTTACGAGGCATCCGTCAAGCTGCTTTTATGAATGTG
ATTGGTGTAATTTTTACTCTAATTCCTCTACTTATTTTCATTCTCATTACAGCTCTATTTTTCAAATTCTCAATATTTAA
AACCGATTTTTGGGGAACTGCTCCCCAACACCATCTGGGATCTATCGGCTCTCAGCTTAAAAGCACCATGTTAGTCACCC
TCTGGGCCTTTATCGGAATTGAAGGCGCCGTAGTCATGTCTGGAAGAGCCTCAAATCCCTCTTCTGTCGGGAAAGCTACG
ATCCTAGGGTTTTCCGGATGCTTACTCATTTATGTCCTTCTTTCTTTACTTCCTTTTGGATCTCTATCCCAATATCAACT
TGCTAAGATTGCTGACCCCTCCACTGCTGGGGTACTGAAATTTCTAGTTGGGAAATGGGGAGAAGTCCTTATGAATACAG
GACTTTTAATTGCTGTTTTAACAAGCTGGTTATCCTGGACTATTCTTACTGCTGAAATTCCTTACGCAGCAGCAAAAAAT
GGCACTTTCCCAGAATGCTTTGCAATTGAAAATGCTAAACACTCACCTGCATTCTCTTTATTCATTACAAGCGGCTTGAT
GCAAATTACCATGCTGTTAGTGTATTTTTCCTCTAATGCTTGGCATACCATGTTAGAAATCACCAGTGTTATGGTTCTTC
CGGCTTACTTAACTAGCTCTCTTTTCCTTGTTAAGCTCAGCTTAAGTAAAAAATATCCTAAACAGGCACCCATCAAGGCC
CGCGTTGCAATATTCACGGGAATATTAGGGACGCTATATTCTCTATGGCTAATCTATGCTGGAGGATTACAGCACCTATT
TATGGTCGCTGTTCTCCTTGCTTTAGGAATTCCGTTCTACATAGACTCGGGAATAAGACATGATCAAGAAAAGACATTCT
TGAACCGTAAGGAAGTCATGAAAATGACTACCTTAGCTCTTATAGCTTTGCTTGCTGTATTTTTATTCTCTGCAAATAAA
ATTCATTTATAA

Upstream 100 bases:

>100_bases
TCAATATCAAAAAGAAATTCGGATTTTGCTTAACAGCTCTTGGCTTCTTAAATTTTGAAAATGCAGATCCAGTTGTTATC
CAATAAGCAAGGGGGATTTT

Downstream 100 bases:

>100_bases
CCAGAGAGTTAAGCACTTGCTATTCACGCTACTCACTCTTGCATAAAAAAGAACTGATTCTCATTCAGGGGAATCAGTTC
TTTCTATTCTTTAAAAGCTT

Product: amino acid permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MFLKKRSSSGILGTLSLTGVVISSMVGGGIFSLPQNMAASASAGAIIIAWLLSGIGIFFIANTFKTLSLVRPDLKAGIYT
YSREGFGPYVGFTIAWGYWLCQIFGNVGYAVITMDALNYFFPPYFEGGNTLPAILLGSILIWVFNSIVLRGIRQAAFMNV
IGVIFTLIPLLIFILITALFFKFSIFKTDFWGTAPQHHLGSIGSQLKSTMLVTLWAFIGIEGAVVMSGRASNPSSVGKAT
ILGFSGCLLIYVLLSLLPFGSLSQYQLAKIADPSTAGVLKFLVGKWGEVLMNTGLLIAVLTSWLSWTILTAEIPYAAAKN
GTFPECFAIENAKHSPAFSLFITSGLMQITMLLVYFSSNAWHTMLEITSVMVLPAYLTSSLFLVKLSLSKKYPKQAPIKA
RVAIFTGILGTLYSLWLIYAGGLQHLFMVAVLLALGIPFYIDSGIRHDQEKTFLNRKEVMKMTTLALIALLAVFLFSANK
IHL

Sequences:

>Translated_483_residues
MFLKKRSSSGILGTLSLTGVVISSMVGGGIFSLPQNMAASASAGAIIIAWLLSGIGIFFIANTFKTLSLVRPDLKAGIYT
YSREGFGPYVGFTIAWGYWLCQIFGNVGYAVITMDALNYFFPPYFEGGNTLPAILLGSILIWVFNSIVLRGIRQAAFMNV
IGVIFTLIPLLIFILITALFFKFSIFKTDFWGTAPQHHLGSIGSQLKSTMLVTLWAFIGIEGAVVMSGRASNPSSVGKAT
ILGFSGCLLIYVLLSLLPFGSLSQYQLAKIADPSTAGVLKFLVGKWGEVLMNTGLLIAVLTSWLSWTILTAEIPYAAAKN
GTFPECFAIENAKHSPAFSLFITSGLMQITMLLVYFSSNAWHTMLEITSVMVLPAYLTSSLFLVKLSLSKKYPKQAPIKA
RVAIFTGILGTLYSLWLIYAGGLQHLFMVAVLLALGIPFYIDSGIRHDQEKTFLNRKEVMKMTTLALIALLAVFLFSANK
IHL
>Mature_483_residues
MFLKKRSSSGILGTLSLTGVVISSMVGGGIFSLPQNMAASASAGAIIIAWLLSGIGIFFIANTFKTLSLVRPDLKAGIYT
YSREGFGPYVGFTIAWGYWLCQIFGNVGYAVITMDALNYFFPPYFEGGNTLPAILLGSILIWVFNSIVLRGIRQAAFMNV
IGVIFTLIPLLIFILITALFFKFSIFKTDFWGTAPQHHLGSIGSQLKSTMLVTLWAFIGIEGAVVMSGRASNPSSVGKAT
ILGFSGCLLIYVLLSLLPFGSLSQYQLAKIADPSTAGVLKFLVGKWGEVLMNTGLLIAVLTSWLSWTILTAEIPYAAAKN
GTFPECFAIENAKHSPAFSLFITSGLMQITMLLVYFSSNAWHTMLEITSVMVLPAYLTSSLFLVKLSLSKKYPKQAPIKA
RVAIFTGILGTLYSLWLIYAGGLQHLFMVAVLLALGIPFYIDSGIRHDQEKTFLNRKEVMKMTTLALIALLAVFLFSANK
IHL

Specific function: Catalyzes the exchange of L-arginine for agmatine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Escherichia coli, GI1787890, Length=454, Percent_Identity=40.9691629955947, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI2367353, Length=463, Percent_Identity=27.2138228941685, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1790575, Length=355, Percent_Identity=27.0422535211268, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786908, Length=444, Percent_Identity=24.3243243243243, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AAXC_CHLMU (Q9PK20)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_297027.1
- GeneID:   1246014
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0653
- TIGR:   TC_0653
- HOGENOM:   HBG586921
- OMA:   IANTFKI
- PhylomeDB:   Q9PK20
- ProtClustDB:   CLSK871339
- BioCyc:   CMUR243161:TC_0653-MONOMER
- GO:   GO:0009405
- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060
- TIGRFAMs:   TIGR00905

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 52591; Mature: 52591

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb6d06b0)-; HASH(0xd4f57cc)-; HASH(0xcaaf740)-; HASH(0xc296f00)-; HASH(0xca3a1d4)-; HASH(0xba01218)-; HASH(0xd2b0dac)-; HASH(0x403d1604)-; HASH(0xc99e1f4)-; HASH(0xcaa4f10)-; HASH(0xcdb7a20)-; HASH(0xc37ce50)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLKKRSSSGILGTLSLTGVVISSMVGGGIFSLPQNMAASASAGAIIIAWLLSGIGIFFI
CCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHH
ANTFKTLSLVRPDLKAGIYTYSREGFGPYVGFTIAWGYWLCQIFGNVGYAVITMDALNYF
HHHHHHHHHHCCHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHC
FPPYFEGGNTLPAILLGSILIWVFNSIVLRGIRQAAFMNVIGVIFTLIPLLIFILITALF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKFSIFKTDFWGTAPQHHLGSIGSQLKSTMLVTLWAFIGIEGAVVMSGRASNPSSVGKAT
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHCCHH
ILGFSGCLLIYVLLSLLPFGSLSQYQLAKIADPSTAGVLKFLVGKWGEVLMNTGLLIAVL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
TSWLSWTILTAEIPYAAAKNGTFPECFAIENAKHSPAFSLFITSGLMQITMLLVYFSSNA
HHHHHHHHEEEECCCHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
WHTMLEITSVMVLPAYLTSSLFLVKLSLSKKYPKQAPIKARVAIFTGILGTLYSLWLIYA
HHHHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GGLQHLFMVAVLLALGIPFYIDSGIRHDQEKTFLNRKEVMKMTTLALIALLAVFLFSANK
CCHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IHL
CCH
>Mature Secondary Structure
MFLKKRSSSGILGTLSLTGVVISSMVGGGIFSLPQNMAASASAGAIIIAWLLSGIGIFFI
CCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHH
ANTFKTLSLVRPDLKAGIYTYSREGFGPYVGFTIAWGYWLCQIFGNVGYAVITMDALNYF
HHHHHHHHHHCCHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHC
FPPYFEGGNTLPAILLGSILIWVFNSIVLRGIRQAAFMNVIGVIFTLIPLLIFILITALF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKFSIFKTDFWGTAPQHHLGSIGSQLKSTMLVTLWAFIGIEGAVVMSGRASNPSSVGKAT
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHCCHH
ILGFSGCLLIYVLLSLLPFGSLSQYQLAKIADPSTAGVLKFLVGKWGEVLMNTGLLIAVL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
TSWLSWTILTAEIPYAAAKNGTFPECFAIENAKHSPAFSLFITSGLMQITMLLVYFSSNA
HHHHHHHHEEEECCCHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
WHTMLEITSVMVLPAYLTSSLFLVKLSLSKKYPKQAPIKARVAIFTGILGTLYSLWLIYA
HHHHHHHHHHHHHHHHHHHHHHEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GGLQHLFMVAVLLALGIPFYIDSGIRHDQEKTFLNRKEVMKMTTLALIALLAVFLFSANK
CCHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IHL
CCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10684935