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Identifier: 15835240

GI number: 15835240

Start: 749387

End: 750301

Strand: Direct

Name: Not Available

Synonym: TC0625

Alternate gene names: 15835240

Gene position: 749387-750301 (Clockwise)

Preceding gene: 15835239

Following gene: 15835241

Centisome position: 69.84

GC content: 42.19

Gene sequence:

>915_bases
ATGAGTTATCGAGGTCTAACTATTCTAGGTTGTTCAAGCCAACAACCAACTCGACATCGTAATCATGGGGCATATTTGCT
TCGCTGGAACGGTGAAGGTCTTTTATTTGATCCAGGAGAAGGAACCCAGCGACAATTCATTTATGCCAACATTGCCCCCA
CGGTAGTTTCTCGCATTTTTATCAGTCATTTTCATGGGGACCACTGTCTGGGTCTGGGATCCATGCTCATGCGCCTAAAC
CTAGATAAGGTTTCTCATCCAATACATTGCTACTATCCTGCTTCAGGAAAAAAATATTTTGATAGACTTCGCTATAGCAC
AATTTATCACGAAACGATCAAAGTTGTAGAGCATCCGATCAGCAGCGAAGGAATCGTGGAAGATTTCGGCAATTTTCGAA
TAGAAGCTCGCCAACTTGACCATCTTGTTGATACCTTAGGCTGGCGAATTACCGAGCCTGACACCACTAAATTTATCTCT
GAAAAAATTAAAGCAGCTGGCCTAAAAGGGCCAATTATGCAAGAACTCATTAACAAAGGGATAATAAAAGTTAATAACAA
TATCATCCGTTTAGAAGACGTCAGCTACACGCGTAAGGGAGACAGCATTGCGGTCGTTGCAGACTCCCTTCCTTGCCAAG
CTATTGTGGATTTAGCAAAAAATGCTCGTATCTTGTTATGCGAAAGCACCTATTTGGAAGAACACGCCCATCTCGCTAAA
AATCATTATCATATGACTGCAAAACAAGCTGCAGAACAAGCAAAACGTGCAGAGGCTCAACAACTAATTCTAACCCATTT
CTCTGCGCGGTATAATACAACTGAGCAGTTCGTCCAAGAAGCGGGAGAAATCTTCCCTAATGTATTTGCAGCGGAAGAAT
TTTGCAGCTACGAGTTTCCTAAAAACGCGAATTAA

Upstream 100 bases:

>100_bases
TCTCGCTTCCCTGTCCTGTCTTTTTTCAAGAAAGGGAAATGGCTTTGCTGGGCATAATAATTTCACCTTTTAGAAATCTC
TTCCTTAAAGAGGACATTGC

Downstream 100 bases:

>100_bases
CGCATATACTACAGAAACAACCCAAAAGCTTTCCTAGCTTGTGTGAATATAGTAGGTCTGGAATGATCGCATCCTTTTAT
GCATTTTTAGATTATCTAAA

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSYRGLTILGCSSQQPTRHRNHGAYLLRWNGEGLLFDPGEGTQRQFIYANIAPTVVSRIFISHFHGDHCLGLGSMLMRLN
LDKVSHPIHCYYPASGKKYFDRLRYSTIYHETIKVVEHPISSEGIVEDFGNFRIEARQLDHLVDTLGWRITEPDTTKFIS
EKIKAAGLKGPIMQELINKGIIKVNNNIIRLEDVSYTRKGDSIAVVADSLPCQAIVDLAKNARILLCESTYLEEHAHLAK
NHYHMTAKQAAEQAKRAEAQQLILTHFSARYNTTEQFVQEAGEIFPNVFAAEEFCSYEFPKNAN

Sequences:

>Translated_304_residues
MSYRGLTILGCSSQQPTRHRNHGAYLLRWNGEGLLFDPGEGTQRQFIYANIAPTVVSRIFISHFHGDHCLGLGSMLMRLN
LDKVSHPIHCYYPASGKKYFDRLRYSTIYHETIKVVEHPISSEGIVEDFGNFRIEARQLDHLVDTLGWRITEPDTTKFIS
EKIKAAGLKGPIMQELINKGIIKVNNNIIRLEDVSYTRKGDSIAVVADSLPCQAIVDLAKNARILLCESTYLEEHAHLAK
NHYHMTAKQAAEQAKRAEAQQLILTHFSARYNTTEQFVQEAGEIFPNVFAAEEFCSYEFPKNAN
>Mature_303_residues
SYRGLTILGCSSQQPTRHRNHGAYLLRWNGEGLLFDPGEGTQRQFIYANIAPTVVSRIFISHFHGDHCLGLGSMLMRLNL
DKVSHPIHCYYPASGKKYFDRLRYSTIYHETIKVVEHPISSEGIVEDFGNFRIEARQLDHLVDTLGWRITEPDTTKFISE
KIKAAGLKGPIMQELINKGIIKVNNNIIRLEDVSYTRKGDSIAVVADSLPCQAIVDLAKNARILLCESTYLEEHAHLAKN
HYHMTAKQAAEQAKRAEAQQLILTHFSARYNTTEQFVQEAGEIFPNVFAAEEFCSYEFPKNAN

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=319, Percent_Identity=28.2131661442006, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI260166619, Length=309, Percent_Identity=26.537216828479, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI145553959, Length=309, Percent_Identity=26.537216828479, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI260166622, Length=309, Percent_Identity=26.537216828479, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87082078, Length=304, Percent_Identity=32.5657894736842, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_CHLMU (Q9PK48)

Other databases:

- EMBL:   AE002160
- PIR:   G81681
- RefSeq:   NP_296999.1
- ProteinModelPortal:   Q9PK48
- SMR:   Q9PK48
- GeneID:   1245985
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0625
- TIGR:   TC_0625
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- PhylomeDB:   Q9PK48
- ProtClustDB:   PRK00055
- BioCyc:   CMUR243161:TC_0625-MONOMER
- BRENDA:   3.1.26.11
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34483; Mature: 34351

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYRGLTILGCSSQQPTRHRNHGAYLLRWNGEGLLFDPGEGTQRQFIYANIAPTVVSRIF
CCCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEEEEECHHHHHHHHHH
ISHFHGDHCLGLGSMLMRLNLDKVSHPIHCYYPASGKKYFDRLRYSTIYHETIKVVEHPI
HHHCCCCHHHHHHHHHHHHCHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
SSEGIVEDFGNFRIEARQLDHLVDTLGWRITEPDTTKFISEKIKAAGLKGPIMQELINKG
CCCCHHHHHCCCEEHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHCC
IIKVNNNIIRLEDVSYTRKGDSIAVVADSLPCQAIVDLAKNARILLCESTYLEEHAHLAK
EEEECCCEEEEECCCEECCCCEEEEEECCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHH
NHYHMTAKQAAEQAKRAEAQQLILTHFSARYNTTEQFVQEAGEIFPNVFAAEEFCSYEFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCC
KNAN
CCCC
>Mature Secondary Structure 
SYRGLTILGCSSQQPTRHRNHGAYLLRWNGEGLLFDPGEGTQRQFIYANIAPTVVSRIF
CCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEEEEECHHHHHHHHHH
ISHFHGDHCLGLGSMLMRLNLDKVSHPIHCYYPASGKKYFDRLRYSTIYHETIKVVEHPI
HHHCCCCHHHHHHHHHHHHCHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
SSEGIVEDFGNFRIEARQLDHLVDTLGWRITEPDTTKFISEKIKAAGLKGPIMQELINKG
CCCCHHHHHCCCEEHHHHHHHHHHHHCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHCC
IIKVNNNIIRLEDVSYTRKGDSIAVVADSLPCQAIVDLAKNARILLCESTYLEEHAHLAK
EEEECCCEEEEECCCEECCCCEEEEEECCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHH
NHYHMTAKQAAEQAKRAEAQQLILTHFSARYNTTEQFVQEAGEIFPNVFAAEEFCSYEFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCC
KNAN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935