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Identifier: 15835189

GI number: 15835189

Start: 682767

End: 683495

Strand: Direct

Name: Not Available

Synonym: TC0572

Alternate gene names: 15835189

Gene position: 682767-683495 (Clockwise)

Preceding gene: 15835188

Following gene: 15835190

Centisome position: 63.63

GC content: 42.25

Gene sequence:

>729_bases
ATGCTGTCCGCCTACTACAATGACCCTTTTCTATCCGATTTTTGTTTAGGGAAGATCCCTTTACGTTTAGCATCTCGGAA
GTCTCCTTTAGCCGTTCTACAAGCCCATGAATGCCTAAGAAGACTCCAAACATTTTTCCCTAGGTTATGGGGGCAGGTTA
TCACAGAAACAACACAAGGTGATCTTGACCAACACACCCCCTTACATTCCGTAGAAAACACCGGTTTTTTTACAGATGAT
ATCGATTTTCTTGTTCAATCTGGGAAATGTGATCTTGCCATACATTCTGCTAAAGATCTTCCAGAAAAACCAAAGGCAAG
GGTCATTGCCATTACAGCAAGTATAGATCCTCGAGATATCTTGGTATTTCAAGAAAAATATCTATTGCAGCCTTTCCCAT
CCCGATTACGCATCGGGTGCTCTTCTGATCGCAGAAGAGCACTTATCTCTTCTCTATACCCCTCTGCTGTTATCACAGAT
ATTCGCGGAACCATCCAAACTCGATTGGCACTCTTGGATCAGCAAAAATTTGATGCTATTGTGATGGCTAATGCAGCTGT
TTCTCGACTGGGATTACGCCTTCCTTGCACAGTAGTCCTGCCCCCCCCATACCATCCTTTTCAAGGACGTTTAGCAATCA
CATCCTGCCACCATATAGCAAGTTGGGAGAAATTATTCTTAACCTGTAAAATAACAGAAAATATAAACCTGCTCCATTTT
TTCTCATAA

Upstream 100 bases:

>100_bases
ATGGGATTTAAGGGTATCGTCATGCCCTCTGGGCAAATAAAAGGCTTACCTAAAGAATATTTGGATCAAATTGATATTAT
TGGAGTAAAAACAATTAAAG

Downstream 100 bases:

>100_bases
AAATGAAAAACGCGTTTCATCCCCCCCTCCCTTCGCATATAAAAAAACTTCAAAACAAAACTCCCCCAAGCTAGACTCTT
TCCCTAAGTTTCTATTTTAT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MLSAYYNDPFLSDFCLGKIPLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTDD
IDFLVQSGKCDLAIHSAKDLPEKPKARVIAITASIDPRDILVFQEKYLLQPFPSRLRIGCSSDRRRALISSLYPSAVITD
IRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCTVVLPPPYHPFQGRLAITSCHHIASWEKLFLTCKITENINLLHF
FS

Sequences:

>Translated_242_residues
MLSAYYNDPFLSDFCLGKIPLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTDD
IDFLVQSGKCDLAIHSAKDLPEKPKARVIAITASIDPRDILVFQEKYLLQPFPSRLRIGCSSDRRRALISSLYPSAVITD
IRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCTVVLPPPYHPFQGRLAITSCHHIASWEKLFLTCKITENINLLHF
FS
>Mature_242_residues
MLSAYYNDPFLSDFCLGKIPLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQGDLDQHTPLHSVENTGFFTDD
IDFLVQSGKCDLAIHSAKDLPEKPKARVIAITASIDPRDILVFQEKYLLQPFPSRLRIGCSSDRRRALISSLYPSAVITD
IRGTIQTRLALLDQQKFDAIVMANAAVSRLGLRLPCTVVLPPPYHPFQGRLAITSCHHIASWEKLFLTCKITENINLLHF
FS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI66933009, Length=202, Percent_Identity=32.6732673267327, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI20149500, Length=202, Percent_Identity=32.6732673267327, Blast_Score=101, Evalue=6e-22,
Organism=Escherichia coli, GI48994974, Length=196, Percent_Identity=35.2040816326531, Blast_Score=114, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319996, Length=189, Percent_Identity=35.978835978836, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20130425, Length=203, Percent_Identity=35.9605911330049, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_CHLMU (Q9PK95)

Other databases:

- EMBL:   AE002160
- PIR:   E81688
- RefSeq:   NP_296948.1
- ProteinModelPortal:   Q9PK95
- SMR:   Q9PK95
- GeneID:   1245931
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0572
- TIGR:   TC_0572
- HOGENOM:   HBG414030
- OMA:   GQILDIR
- ProtClustDB:   PRK01066
- BioCyc:   CMUR243161:TC_0572-MONOMER
- BRENDA:   2.5.1.61
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022417
- PANTHER:   PTHR11557
- PRINTS:   PR00151

Pfam domain/function: PF01379 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 27316; Mature: 27316

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSAYYNDPFLSDFCLGKIPLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQG
CCCCCCCCCCHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DLDQHTPLHSVENTGFFTDDIDFLVQSGKCDLAIHSAKDLPEKPKARVIAITASIDPRDI
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCEE
LVFQEKYLLQPFPSRLRIGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAI
EEEEHHHHCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEE
VMANAAVSRLGLRLPCTVVLPPPYHPFQGRLAITSCHHIASWEKLFLTCKITENINLLHF
EEEHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEHHHHHHCCEEEEEEEEEECCCCEEEE
FS
EC
>Mature Secondary Structure
MLSAYYNDPFLSDFCLGKIPLRLASRKSPLAVLQAHECLRRLQTFFPRLWGQVITETTQG
CCCCCCCCCCHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DLDQHTPLHSVENTGFFTDDIDFLVQSGKCDLAIHSAKDLPEKPKARVIAITASIDPRDI
CCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCEE
LVFQEKYLLQPFPSRLRIGCSSDRRRALISSLYPSAVITDIRGTIQTRLALLDQQKFDAI
EEEEHHHHCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEE
VMANAAVSRLGLRLPCTVVLPPPYHPFQGRLAITSCHHIASWEKLFLTCKITENINLLHF
EEEHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEHHHHHHCCEEEEEEEEEECCCCEEEE
FS
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935