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Identifier: 15835185

GI number: 15835185

Start: 678237

End: 680018

Strand: Reverse

Name: Not Available

Synonym: TC0568

Alternate gene names: 15835185

Gene position: 680018-678237 (Counterclockwise)

Preceding gene: 15835186

Following gene: 15835184

Centisome position: 63.38

GC content: 40.18

Gene sequence:

>1782_bases
ATGGAAATTCCAAAAAAGAAAATTGAGGAAATGTTTGATCCTCAAACTGCCAAAAATATTTTATCTTGGTTGCAGGATAA
TGCATGTGATAACACCTTGATTTTAGATTTACTGGATAAGGACCCTGAAAAATTAAAAGAACGGTTCGGAGATATTTTAA
CTTTTGGGACAGCCGGATTGCGCAGTCTTATGGGAGTGGGCACAAATCGGTTAAATGTGTTTACCGTCCGCAGAGCCACG
CAAAGTTTAGCTCAGGTACTAAAGCAACGATATCCTGATGAGGATATCAGTGTTGTGGTTGGATATGATACACGACACCA
TTCTTTAGAGTTTGGACAAGAGACAGCGAAAGTTTTGGCCGGGAATGGTATTCTTACTTACTTGTTTCAGGTGCCTGAGC
CCTTAGCGCTTGTTTCTTATTCAGTTCGAGAATTTCAAGCTAAAGCTGGAGTTATGATCACAGCATCACATAATCCTCCT
GCTTACAACGGCTACAAAGTATACATGTCGACAGGAGGGCAGGTTTTGCCCCCAATGGATCAGGAAATCGTGAAAGAATT
TCAAATGATTGATCAAGTATTGTCAGTGGATACTTTAGATCACCCTTGTATTCGTTTGATTCAAGAGGAAATAGAAGCTG
ATTACGAGAAAGCCTTACATCAACTGCAGTTATGTAGGGAAGACAATCGTCAGCACGGTTCTTTACTACGGATGAGTTAC
TCTCCATTACACGGCACTGGAGTGTCAATGGTCCCAAGGATTTTGAAAGACTGGGGATTCTCTTCGGTCTGTTTAGTTGA
AAAGCAGATGATTCCTGATGGGGATTTCCCTACTATAGTTCTTCCTAATCCTGAAGATCCGGAAGCGTTGGTTCTGGGTA
TTCAGCAGATGCTAGATCAGAAGGATGATTTGTTCATTGCAACAGATCCTGATGCAGACAGGATAGGCATTGTTTCTTTG
GAAAAAGATGGTCCTTATCGGTTTAATGGTAACCAGATAGCATGTTTGTTAGCAGCTCATATTCTCAGTAGAGAATCTCA
AAAAGCTCCTTTAGGGGTTGAAGATAAGGTAGTCAAAAGCATTGTAACAACAGAACTTTTGACGGCCATTACTGAGTCGT
ATGGAGGTAGTGTTGTTAATGTTGGAGCTGGATTTAAATATATAGGCGAGAAAATAGAATTATGGCGGTCTGGTATGGAA
CGCTTTATTTTCGGAGCCGAGGAGTCTTATGGGTATTTGTATGGTTCTCATGTAGAAGATAAAGATGCAATGATATCTGC
AGCTCTCATTGCTGAAACAGCTTTACAGCAGAAACTGCGCGGATATACGTTGCGAGATGCTTTGTTAGAACTGTATGAGA
TCCATGGATATTATGCTAATTTAACAGAGTCTATTGATCTCCCTGTGGATCAACCTAATCAAAAGCAGGAGTTATTAGAG
CGTTGGGAGACTCAGGATCCTCTTTATATGTCTTTACCTGGTCGCAAACTGGTTGCCTTTGAAAATTATAAAACTGGAGA
AGGGTGTGATCTAGTTACAGGAATTACATACAAATTAGCCTTACCCAAAATGTCGATGCTTTGTTTCTACTATGAAGGAT
CGGGTAGAGTGATTGTGCGTCCCTCCGGAACAGAGCCAAAAATAAAGTTATACTTTGAATTAAAACACCATTTTTCAGAA
TTTTCTAAAGAGCGTACGGTTCGAGAATCTCGAGAGAAAGAAAGTTTTGAGGCGTTAGAGAATTTTGTTAAAGAAACAAA
AATGCGTCTTTTTCGTACCTAG

Upstream 100 bases:

>100_bases
TACAAAAACGGGGTGCTAACGTATAGTCCTGTTTGTCTACTCTTGCTTAGTATTTGTCAGAGTTGGGATGAGTGTTTTGC
ACTGATCGAAAGGGTGTTCT

Downstream 100 bases:

>100_bases
AATCTACAAATAAAACGGAGAGCTCTTGACAGTGAATATTTTATTGGTGTTCTATAGGGATTCGTCTGTTTAGCTTGCTA
GCAGAATAAGCTGGATAGTG

Product: phosphoglucomutase/phosphomannomutase, putative

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MEIPKKKIEEMFDPQTAKNILSWLQDNACDNTLILDLLDKDPEKLKERFGDILTFGTAGLRSLMGVGTNRLNVFTVRRAT
QSLAQVLKQRYPDEDISVVVGYDTRHHSLEFGQETAKVLAGNGILTYLFQVPEPLALVSYSVREFQAKAGVMITASHNPP
AYNGYKVYMSTGGQVLPPMDQEIVKEFQMIDQVLSVDTLDHPCIRLIQEEIEADYEKALHQLQLCREDNRQHGSLLRMSY
SPLHGTGVSMVPRILKDWGFSSVCLVEKQMIPDGDFPTIVLPNPEDPEALVLGIQQMLDQKDDLFIATDPDADRIGIVSL
EKDGPYRFNGNQIACLLAAHILSRESQKAPLGVEDKVVKSIVTTELLTAITESYGGSVVNVGAGFKYIGEKIELWRSGME
RFIFGAEESYGYLYGSHVEDKDAMISAALIAETALQQKLRGYTLRDALLELYEIHGYYANLTESIDLPVDQPNQKQELLE
RWETQDPLYMSLPGRKLVAFENYKTGEGCDLVTGITYKLALPKMSMLCFYYEGSGRVIVRPSGTEPKIKLYFELKHHFSE
FSKERTVRESREKESFEALENFVKETKMRLFRT

Sequences:

>Translated_593_residues
MEIPKKKIEEMFDPQTAKNILSWLQDNACDNTLILDLLDKDPEKLKERFGDILTFGTAGLRSLMGVGTNRLNVFTVRRAT
QSLAQVLKQRYPDEDISVVVGYDTRHHSLEFGQETAKVLAGNGILTYLFQVPEPLALVSYSVREFQAKAGVMITASHNPP
AYNGYKVYMSTGGQVLPPMDQEIVKEFQMIDQVLSVDTLDHPCIRLIQEEIEADYEKALHQLQLCREDNRQHGSLLRMSY
SPLHGTGVSMVPRILKDWGFSSVCLVEKQMIPDGDFPTIVLPNPEDPEALVLGIQQMLDQKDDLFIATDPDADRIGIVSL
EKDGPYRFNGNQIACLLAAHILSRESQKAPLGVEDKVVKSIVTTELLTAITESYGGSVVNVGAGFKYIGEKIELWRSGME
RFIFGAEESYGYLYGSHVEDKDAMISAALIAETALQQKLRGYTLRDALLELYEIHGYYANLTESIDLPVDQPNQKQELLE
RWETQDPLYMSLPGRKLVAFENYKTGEGCDLVTGITYKLALPKMSMLCFYYEGSGRVIVRPSGTEPKIKLYFELKHHFSE
FSKERTVRESREKESFEALENFVKETKMRLFRT
>Mature_593_residues
MEIPKKKIEEMFDPQTAKNILSWLQDNACDNTLILDLLDKDPEKLKERFGDILTFGTAGLRSLMGVGTNRLNVFTVRRAT
QSLAQVLKQRYPDEDISVVVGYDTRHHSLEFGQETAKVLAGNGILTYLFQVPEPLALVSYSVREFQAKAGVMITASHNPP
AYNGYKVYMSTGGQVLPPMDQEIVKEFQMIDQVLSVDTLDHPCIRLIQEEIEADYEKALHQLQLCREDNRQHGSLLRMSY
SPLHGTGVSMVPRILKDWGFSSVCLVEKQMIPDGDFPTIVLPNPEDPEALVLGIQQMLDQKDDLFIATDPDADRIGIVSL
EKDGPYRFNGNQIACLLAAHILSRESQKAPLGVEDKVVKSIVTTELLTAITESYGGSVVNVGAGFKYIGEKIELWRSGME
RFIFGAEESYGYLYGSHVEDKDAMISAALIAETALQQKLRGYTLRDALLELYEIHGYYANLTESIDLPVDQPNQKQELLE
RWETQDPLYMSLPGRKLVAFENYKTGEGCDLVTGITYKLALPKMSMLCFYYEGSGRVIVRPSGTEPKIKLYFELKHHFSE
FSKERTVRESREKESFEALENFVKETKMRLFRT

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=611, Percent_Identity=33.2242225859247, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI63055049, Length=580, Percent_Identity=29.8275862068966, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1789566, Length=278, Percent_Identity=26.978417266187, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71993870, Length=566, Percent_Identity=32.5088339222615, Blast_Score=235, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI71993878, Length=320, Percent_Identity=34.375, Blast_Score=167, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6323934, Length=568, Percent_Identity=29.2253521126761, Blast_Score=198, Evalue=2e-51,
Organism=Drosophila melanogaster, GI20129809, Length=573, Percent_Identity=30.5410122164049, Blast_Score=239, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24651977, Length=497, Percent_Identity=30.5835010060362, Blast_Score=222, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24653722, Length=567, Percent_Identity=28.5714285714286, Blast_Score=199, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 67063; Mature: 67063

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIPKKKIEEMFDPQTAKNILSWLQDNACDNTLILDLLDKDPEKLKERFGDILTFGTAGL
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
RSLMGVGTNRLNVFTVRRATQSLAQVLKQRYPDEDISVVVGYDTRHHSLEFGQETAKVLA
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHC
GNGILTYLFQVPEPLALVSYSVREFQAKAGVMITASHNPPAYNGYKVYMSTGGQVLPPMD
CCCCEEHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCCCCCCC
QEIVKEFQMIDQVLSVDTLDHPCIRLIQEEIEADYEKALHQLQLCREDNRQHGSLLRMSY
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
SPLHGTGVSMVPRILKDWGFSSVCLVEKQMIPDGDFPTIVLPNPEDPEALVLGIQQMLDQ
CCCCCCCHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCC
KDDLFIATDPDADRIGIVSLEKDGPYRFNGNQIACLLAAHILSRESQKAPLGVEDKVVKS
CCCEEEEECCCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
IVTTELLTAITESYGGSVVNVGAGFKYIGEKIELWRSGMERFIFGAEESYGYLYGSHVED
HHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCCC
KDAMISAALIAETALQQKLRGYTLRDALLELYEIHGYYANLTESIDLPVDQPNQKQELLE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
RWETQDPLYMSLPGRKLVAFENYKTGEGCDLVTGITYKLALPKMSMLCFYYEGSGRVIVR
HHCCCCCEEEECCCCEEEEEECCCCCCCCCEEECCEEEEECCCEEEEEEEEECCCEEEEE
PSGTEPKIKLYFELKHHFSEFSKERTVRESREKESFEALENFVKETKMRLFRT
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEIPKKKIEEMFDPQTAKNILSWLQDNACDNTLILDLLDKDPEKLKERFGDILTFGTAGL
CCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
RSLMGVGTNRLNVFTVRRATQSLAQVLKQRYPDEDISVVVGYDTRHHSLEFGQETAKVLA
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHC
GNGILTYLFQVPEPLALVSYSVREFQAKAGVMITASHNPPAYNGYKVYMSTGGQVLPPMD
CCCCEEHHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCCCCCCC
QEIVKEFQMIDQVLSVDTLDHPCIRLIQEEIEADYEKALHQLQLCREDNRQHGSLLRMSY
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
SPLHGTGVSMVPRILKDWGFSSVCLVEKQMIPDGDFPTIVLPNPEDPEALVLGIQQMLDQ
CCCCCCCHHHHHHHHHHCCCCCEEEEHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHCC
KDDLFIATDPDADRIGIVSLEKDGPYRFNGNQIACLLAAHILSRESQKAPLGVEDKVVKS
CCCEEEEECCCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
IVTTELLTAITESYGGSVVNVGAGFKYIGEKIELWRSGMERFIFGAEESYGYLYGSHVED
HHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCCC
KDAMISAALIAETALQQKLRGYTLRDALLELYEIHGYYANLTESIDLPVDQPNQKQELLE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
RWETQDPLYMSLPGRKLVAFENYKTGEGCDLVTGITYKLALPKMSMLCFYYEGSGRVIVR
HHCCCCCEEEECCCCEEEEEECCCCCCCCCEEECCEEEEECCCEEEEEEEEECCCEEEEE
PSGTEPKIKLYFELKHHFSEFSKERTVRESREKESFEALENFVKETKMRLFRT
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]