Definition Chlamydia muridarum Nigg, complete genome.
Accession NC_002620
Length 1,072,950

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The map label for this gene is gyrB

Identifier: 15835080

GI number: 15835080

Start: 561250

End: 563664

Strand: Reverse

Name: gyrB

Synonym: TC0462

Alternate gene names: 15835080

Gene position: 563664-561250 (Counterclockwise)

Preceding gene: 15835081

Following gene: 15835079

Centisome position: 52.53

GC content: 41.41

Gene sequence:

>2415_bases
ATGGACGCACAAGAAAAGAAATACGATGCATCAGCCATTACCGTTTTAGAAGGATTACAAGCCGTTCGTGAGCGTCCTGG
AATGTATATTGGGGACACAGGCGTTACTGGATTGCACCATCTGGTTTACGAAGTTGTTGATAACAGCATCGACGAGGCTA
TGGCGGGGTTTTGTACCGAGGTTGTTGTTCGTATATTGGAAGATGGAGGCATCTCTGTCTCGGATAATGGTAGAGGGATC
CCTGTTCAAATTCATGAAAAAGAATCCGCCAAGCAAGGTCGAGAGATTTCTGCTTTAGAAGTCGTCCTTACTGTATTGCA
TGCCGGAGGGAAGTTTGACAAAGACAGCTACAAAGTTTCCGGAGGGTTGCACGGGGTTGGGGTGTCATGCGTTAATGCTT
TATCTGAAAAATTTATTGCTAACGTATTTAAGGATGGGCAAGCGTATAGCATGGAGTTTTCAAAAGGGGCTCCACTAACA
GCTCTACAAGTATTGGGATCTACGGATAAACGAGGGACTGAGATTCTTTTTTATCCCGACCCAACTGTATTCTCTACATG
CGTTTTTGATCGCGCGATTCTAATGAAGCGTTTGCGAGAGTTGGCATTTTTAAATCGTGGAATAACGATTATTTTTGAAG
ATGATCGTGATGCAGGTTTTGATAAAGTCACCTTCTTTTACGAGGGGGGAATTCAATCTTTCGTCAGCTATTTAAATCAG
AACAAAGAAAGTCTTTTCCCGACCCCCATTTATATTCAGGGATCAAAACGTGGAGATGATGGGGATATAGAGTTTGAAGC
TGCTTTGCAGTGGAATTCAGGCTATTCTGAACTCATTTATTCTTATGCGAACAATATTCCTACTCGGCAAGGGGGGACTC
ATTTAACAGGATTTTCTACAGCTTTGACAAGAGCCGTTAACTCCTATATTAAGTCTCACAACTTAGCTAAAAGCGATAAA
TTGTCTCTGACTGGAGAAGATATTCGAGAGGGGTTGGTAGCGATTGTTTCAGTCAAAGTTCCAAATCCTCAGTTCGAAGG
ACAAACAAAGCAGAAGTTAGGAAATAGCGACGTAGGCTCTGTAGCTCAGCAAATTAGTGGCGAAGTATTAACAACATTTT
TCGAGGAAAATCCTCAAATAGCCAAAACTATTGTAGACAAAGTCTTTGTTGCTGCCCAAGCAAGAGAAGCTGCTAAAAGA
GCTAGGGAGTTGACTATCCGAAAAAGTGCTTTGGATAGCGCCCGTTTACCAGGAAAGTTAGTGGATTGTTTAGAAAAAGA
TCCTGAAAAATGTGAAATGTACATCGTAGAGGGAGACTCTGCAGGGGGGTCAGCTAAGCAAGGAAGAGACCGACGATTCC
AGGCTATTCTGCCTATTCGGGGTAAAATTTTAAACGTAGAAAAAGCTCGTCTACAGAAAATTTTTCAGAACCAAGAAATC
GGAAGTATTATAGCTGCCCTAGGCTGCGGTATTGGAACGGATAATTTTAACCTGAGTAAATTGCGTTATAAACGTGTCAT
TATCATGACAGATGCTGACGTTGATGGCTCTCATATCCGAACCTTATTATTGACGTTCTTCTATAGACATATGTCAGCAT
TGATAGAGAACGGATGTGTTTATATCGCTCAGCCTCCATTATATCGGGTAAGTAAGAAGAAAGATTTCCGCTATATCCTC
TCTGAAAAAGAGATGGATGGCTATCTTTTAAATTTAGGAACACGAGAAAGCCGAGTGGTTTTCGATGATACGGCAAGAGA
ACTAGAGGGAACAGCTTTAGAATCGTTTGTTAACCTTATTTTGGAAGTGGAAAGCTTTATTATTGCTCTAGAGAAGAGAG
CGATTCCATTTTCTGAGTTTTTAGATATGTTCCGTGATGGGGCGTACCCCTTATATTATTACCCTCCAGAAAGTGGAAAA
CAGGGAGGAAATTATCTTTATTCGAATGAAGAAAAAGAGGCAGCAGTTGCCGCTAATGAAGAAGCTGCGGCAAGAATCAT
AGAGTTATATAAGGCTTCAGCCTTTGAGGAGATTCAGCATAATTTGAATGAGTACGGCTATGATATTCGCCACTATCTTC
ATCCAAAAGGGACGGGAATCACGGTTTCTACAGAAGATTCCAAAACTCCTAATTACACTTGTTATACTTTGAAAGAAGTT
ATAGATTACTTGAAGGGCCTTGGACGAAAGGGAATTGAGATTCAGCGATATAAGGGACTTGGAGAGATGAATGCTGACCA
GCTGTGGGATACCACAATGAATCCTGAACAAAGAACGCTTGTTCGCGTCTCTTTGAAAGATGCTGTGGAGGCGGATCATA
TCTTTACAATGTTAATGGGAGAAGAAGTCCCTCCGCGACGTGAATTTATTGAAAGCCATGCGCTATCCATTCGGATGAGT
AATTTAGATATTTAG

Upstream 100 bases:

>100_bases
CTGTACTAAAACAAAGCTCCCAAAAAGAGTTAATATCCCAAATTCATTCAGCTGTTCCCGGTGCCAAAATTAAAGAGATA
CGCTTTTTATTAGGATAATT

Downstream 100 bases:

>100_bases
GAGACAGAATCGCCATGCTAAATAAAGAAGAAATCATCGTCCCTAAAAATCTTGAAGAGGAGATGAAGGAGAGCTACCTT
CGCTACTCTATGTCTGTAAT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 804; Mature: 804

Protein sequence:

>804_residues
MDAQEKKYDASAITVLEGLQAVRERPGMYIGDTGVTGLHHLVYEVVDNSIDEAMAGFCTEVVVRILEDGGISVSDNGRGI
PVQIHEKESAKQGREISALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKFIANVFKDGQAYSMEFSKGAPLT
ALQVLGSTDKRGTEILFYPDPTVFSTCVFDRAILMKRLRELAFLNRGITIIFEDDRDAGFDKVTFFYEGGIQSFVSYLNQ
NKESLFPTPIYIQGSKRGDDGDIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFSTALTRAVNSYIKSHNLAKSDK
LSLTGEDIREGLVAIVSVKVPNPQFEGQTKQKLGNSDVGSVAQQISGEVLTTFFEENPQIAKTIVDKVFVAAQAREAAKR
ARELTIRKSALDSARLPGKLVDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI
GSIIAALGCGIGTDNFNLSKLRYKRVIIMTDADVDGSHIRTLLLTFFYRHMSALIENGCVYIAQPPLYRVSKKKDFRYIL
SEKEMDGYLLNLGTRESRVVFDDTARELEGTALESFVNLILEVESFIIALEKRAIPFSEFLDMFRDGAYPLYYYPPESGK
QGGNYLYSNEEKEAAVAANEEAAARIIELYKASAFEEIQHNLNEYGYDIRHYLHPKGTGITVSTEDSKTPNYTCYTLKEV
IDYLKGLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLVRVSLKDAVEADHIFTMLMGEEVPPRREFIESHALSIRMS
NLDI

Sequences:

>Translated_804_residues
MDAQEKKYDASAITVLEGLQAVRERPGMYIGDTGVTGLHHLVYEVVDNSIDEAMAGFCTEVVVRILEDGGISVSDNGRGI
PVQIHEKESAKQGREISALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKFIANVFKDGQAYSMEFSKGAPLT
ALQVLGSTDKRGTEILFYPDPTVFSTCVFDRAILMKRLRELAFLNRGITIIFEDDRDAGFDKVTFFYEGGIQSFVSYLNQ
NKESLFPTPIYIQGSKRGDDGDIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFSTALTRAVNSYIKSHNLAKSDK
LSLTGEDIREGLVAIVSVKVPNPQFEGQTKQKLGNSDVGSVAQQISGEVLTTFFEENPQIAKTIVDKVFVAAQAREAAKR
ARELTIRKSALDSARLPGKLVDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI
GSIIAALGCGIGTDNFNLSKLRYKRVIIMTDADVDGSHIRTLLLTFFYRHMSALIENGCVYIAQPPLYRVSKKKDFRYIL
SEKEMDGYLLNLGTRESRVVFDDTARELEGTALESFVNLILEVESFIIALEKRAIPFSEFLDMFRDGAYPLYYYPPESGK
QGGNYLYSNEEKEAAVAANEEAAARIIELYKASAFEEIQHNLNEYGYDIRHYLHPKGTGITVSTEDSKTPNYTCYTLKEV
IDYLKGLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLVRVSLKDAVEADHIFTMLMGEEVPPRREFIESHALSIRMS
NLDI
>Mature_804_residues
MDAQEKKYDASAITVLEGLQAVRERPGMYIGDTGVTGLHHLVYEVVDNSIDEAMAGFCTEVVVRILEDGGISVSDNGRGI
PVQIHEKESAKQGREISALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKFIANVFKDGQAYSMEFSKGAPLT
ALQVLGSTDKRGTEILFYPDPTVFSTCVFDRAILMKRLRELAFLNRGITIIFEDDRDAGFDKVTFFYEGGIQSFVSYLNQ
NKESLFPTPIYIQGSKRGDDGDIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFSTALTRAVNSYIKSHNLAKSDK
LSLTGEDIREGLVAIVSVKVPNPQFEGQTKQKLGNSDVGSVAQQISGEVLTTFFEENPQIAKTIVDKVFVAAQAREAAKR
ARELTIRKSALDSARLPGKLVDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI
GSIIAALGCGIGTDNFNLSKLRYKRVIIMTDADVDGSHIRTLLLTFFYRHMSALIENGCVYIAQPPLYRVSKKKDFRYIL
SEKEMDGYLLNLGTRESRVVFDDTARELEGTALESFVNLILEVESFIIALEKRAIPFSEFLDMFRDGAYPLYYYPPESGK
QGGNYLYSNEEKEAAVAANEEAAARIIELYKASAFEEIQHNLNEYGYDIRHYLHPKGTGITVSTEDSKTPNYTCYTLKEV
IDYLKGLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLVRVSLKDAVEADHIFTMLMGEEVPPRREFIESHALSIRMS
NLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain

Homologues:

Organism=Homo sapiens, GI19913408, Length=568, Percent_Identity=25.7042253521127, Blast_Score=140, Evalue=7e-33,
Organism=Homo sapiens, GI19913406, Length=558, Percent_Identity=25.8064516129032, Blast_Score=135, Evalue=1e-31,
Organism=Escherichia coli, GI48994957, Length=608, Percent_Identity=54.2763157894737, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=576, Percent_Identity=39.2361111111111, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI212645845, Length=522, Percent_Identity=26.0536398467433, Blast_Score=135, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17535065, Length=576, Percent_Identity=25.8680555555556, Blast_Score=133, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI212645657, Length=192, Percent_Identity=28.125, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=616, Percent_Identity=25.6493506493506, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17136538, Length=544, Percent_Identity=23.8970588235294, Blast_Score=130, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GYRB_CHLMU (Q9PKK3)

Other databases:

- EMBL:   AE002160
- PIR:   A81701
- RefSeq:   NP_296839.1
- ProteinModelPortal:   Q9PKK3
- GeneID:   1245817
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0462
- TIGR:   TC_0462
- HOGENOM:   HBG304889
- OMA:   DCSSRDP
- PhylomeDB:   Q9PKK3
- ProtClustDB:   PRK14939
- BioCyc:   CMUR243161:TC_0462-MONOMER
- BRENDA:   5.99.1.3
- GO:   GO:0005694
- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- Gene3D:   G3DSA:3.40.50.670
- PRINTS:   PR00418
- SMART:   SM00387
- SMART:   SM00433
- TIGRFAMs:   TIGR01059

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold; SSF56719 Topo_IIA_cen

EC number: =5.99.1.3

Molecular weight: Translated: 89585; Mature: 89585

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MDAQEKKYDASAITVLEGLQAVRERPGMYIGDTGVTGLHHLVYEVVDNSIDEAMAGFCTE
CCCCHHHCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHH
VVVRILEDGGISVSDNGRGIPVQIHEKESAKQGREISALEVVLTVLHAGGKFDKDSYKVS
HHHHHHHCCCEEECCCCCCCCEEEECCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEC
GGLHGVGVSCVNALSEKFIANVFKDGQAYSMEFSKGAPLTALQVLGSTDKRGTEILFYPD
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCEEEECCC
PTVFSTCVFDRAILMKRLRELAFLNRGITIIFEDDRDAGFDKVTFFYEGGIQSFVSYLNQ
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHCC
NKESLFPTPIYIQGSKRGDDGDIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFST
CCCCCCCCCEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCEECHHHH
ALTRAVNSYIKSHNLAKSDKLSLTGEDIREGLVAIVSVKVPNPQFEGQTKQKLGNSDVGS
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEEEECCCCCCCCCHHHHCCCCHHHH
VAQQISGEVLTTFFEENPQIAKTIVDKVFVAAQAREAAKRARELTIRKSALDSARLPGKL
HHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI
HHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCCHH
GSIIAALGCGIGTDNFNLSKLRYKRVIIMTDADVDGSHIRTLLLTFFYRHMSALIENGCV
HHHHHHHHCCCCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
YIAQPPLYRVSKKKDFRYILSEKEMDGYLLNLGTRESRVVFDDTARELEGTALESFVNLI
EEECCCCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHH
LEVESFIIALEKRAIPFSEFLDMFRDGAYPLYYYPPESGKQGGNYLYSNEEKEAAVAANE
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCH
EAAARIIELYKASAFEEIQHNLNEYGYDIRHYLHPKGTGITVSTEDSKTPNYTCYTLKEV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCCCCCEEEHHHHHH
IDYLKGLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLVRVSLKDAVEADHIFTMLMG
HHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCCCCHHEEEEEEHHHHHHHHHHHHHHHC
EEVPPRREFIESHALSIRMSNLDI
CCCCCHHHHHHHHHHEEEECCCCC
>Mature Secondary Structure
MDAQEKKYDASAITVLEGLQAVRERPGMYIGDTGVTGLHHLVYEVVDNSIDEAMAGFCTE
CCCCHHHCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHCHHHHHHHHHHHH
VVVRILEDGGISVSDNGRGIPVQIHEKESAKQGREISALEVVLTVLHAGGKFDKDSYKVS
HHHHHHHCCCEEECCCCCCCCEEEECCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEC
GGLHGVGVSCVNALSEKFIANVFKDGQAYSMEFSKGAPLTALQVLGSTDKRGTEILFYPD
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCEEEECCC
PTVFSTCVFDRAILMKRLRELAFLNRGITIIFEDDRDAGFDKVTFFYEGGIQSFVSYLNQ
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCHHHHHHHHCC
NKESLFPTPIYIQGSKRGDDGDIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFST
CCCCCCCCCEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCEECHHHH
ALTRAVNSYIKSHNLAKSDKLSLTGEDIREGLVAIVSVKVPNPQFEGQTKQKLGNSDVGS
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEEEECCCCCCCCCHHHHCCCCHHHH
VAQQISGEVLTTFFEENPQIAKTIVDKVFVAAQAREAAKRARELTIRKSALDSARLPGKL
HHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEI
HHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHHHHHCCCHH
GSIIAALGCGIGTDNFNLSKLRYKRVIIMTDADVDGSHIRTLLLTFFYRHMSALIENGCV
HHHHHHHHCCCCCCCCCHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCE
YIAQPPLYRVSKKKDFRYILSEKEMDGYLLNLGTRESRVVFDDTARELEGTALESFVNLI
EEECCCCCCCCCCCCHHHHHCCCCCCCEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHH
LEVESFIIALEKRAIPFSEFLDMFRDGAYPLYYYPPESGKQGGNYLYSNEEKEAAVAANE
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCH
EAAARIIELYKASAFEEIQHNLNEYGYDIRHYLHPKGTGITVSTEDSKTPNYTCYTLKEV
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCCCCCEEEHHHHHH
IDYLKGLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLVRVSLKDAVEADHIFTMLMG
HHHHHHCCCCCCEEEEECCCCCCCHHHHCCCCCCCCHHEEEEEEHHHHHHHHHHHHHHHC
EEVPPRREFIESHALSIRMSNLDI
CCCCCHHHHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935