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The map label for this gene is pepF

Identifier: 15835007

GI number: 15835007

Start: 449311

End: 451137

Strand: Reverse

Name: pepF

Synonym: TC0388

Alternate gene names: 15835007

Gene position: 451137-449311 (Counterclockwise)

Preceding gene: 15835015

Following gene: 15835006

Centisome position: 42.05

GC content: 38.97

Gene sequence:

>1827_bases
ATGACGACTGATACAACTTCTCAAACAGTTTTACGCTCTAGAAAAGATGTTCCTTCTTCTGATTGTTGGGATACCAAAAG
TTTATATGCAAGCCGTGAAGCATGGAAAAAAGATTTGGAAAATTTATGTGGTAAAGAAGCTCCATTTTGGCCACATCTCA
ACGAAAAGCAATTCCATATAGAACAGCCATCCTCTCTTTATAAGTTACTTACCGAAGTCTTTTCTATTGAAAGAACCTTG
GAAAAACTCTATGTCTACGCCCATCTCACTCACGATGAGGATATATCCAACCAAGAGGCTACAGCAGACCTTAAGTCTAT
CACCTATCTACTTACGTCATTTTCAGAAGAAATCTCTTGGATTCAACCGGCCCTCATTGCTCTTCCTCAAAAAATTTCTG
AAGAGCTACTTACTTCTCCCGAACTCCAAACATACCATTTCTACCTAAAAAAAATATTTCGTTTAGCTCCTCACACAGGC
ACTTCTCGAGAAGAAAAAATTTTAGCATCTTCTTCTCCTGCATTAGAAGTAGCCTACAAAACGTTTTCAAGCTTGACTGA
TTCTGAAATTCCGTTTGGAGAAGCTGTGGATTCCGAAGGAAAATCCCATCCTCTTTCCCATGCTTTGTCTTCTCTTTATA
TGCAGTCCCCGGATCGAGAATTACGAAAAAGCGCTTATCAAAAACAATGCCAACGTTACCATGGGTATCGCCTATCTCTT
GCAAACTTACTGAACGGAAAAATTCAAGCACATTTGTTCAACGCAAAGGCCCATAATTATAAATCTTGTTTAGAAGCTGC
TCTATTTCAAAACAATATTAGCACTTCGGTCGTCACGACACTCATTGAGACAGTCAAGCAACATACACATCTGATAACTA
AATATTTTCAGTTAAAACAAAAAGCTCTGGGACTACCAGATTTCCATTTTTACGATGTCTATGCTCCGATAGCAGCTAGC
GAATTTGCTCGCCACTACTCTTACGAAGAAGCCGTCTCTCTAATTTGTGATAGCTTAACCCCTTTAGGAGATAACTACGT
GGAAGCTTTACGCAAAGGTCTCACCTCTGAAGGATGGGTAGATAAGTACGAAAACCAAAATAAACGCTCTGGCGCTTATT
CTTCTGGATGTTATGACAGCAAGCCTTACATACTCTTAAATTACACTGGAACTCTTTATGATGTGTCTGTGGTTGCTCAC
GAAGGCGGTCATAGCATGCACTCATTTTTGAGTCACAAACACCAGCAATACCATGAAGCACAATACCCCATTTTTTTGGC
CGAAATCGCTTCAACATTAAATGAAACTCTTTTGATGGAATTTTTGCTGAAAAATGCTCCGTCTAAGGAAGAGAAAATTG
CCATTCTTTCCCGGTCTTTAGACACCATCTTTGCAACTCTGTTCCGACAGACTTTGTTTGCAGATTTTGAGTTAGAAGCT
CATTCTGCAGCTGAACAAGGAATCCCTTTAACAGAAGAATTTTTCTCCCAAAGCTATAAGAAGCTACAGCATATCTTCTA
TGGCGATTGTGTAACATTTGACGAACTTAGCTCCATTGAATGGGCTCGTATTCCTCATTTTTACTACAATTTCTATGTCT
ATCAATATGCTACAGGAATCATTGCTTCTCTATGTTTTTCCGAAAAAATTCTTTCTAAAGAAGCTGGGGCTCAAGAGGCC
TATCTTACATTTTTACAGAGTGGAGGGTCAGATTTCCCTATCGAAATTTTGAAAAAATCTGGCTTAGATATGACTTCATC
GGCTCCTATGCTCAAAGCATTTTCCTATATTGAACGGAAGTTAGACGAACTTACTAACCTACTATAA

Upstream 100 bases:

>100_bases
CTGCTCCTTTTTATCGAAAGCTGGATAAAATCCCCCTCCTTCCTCTTGAAAGGAGGATTTATGATTTTCTCTGGCTCCCA
ATTTCTTCTAGGAGATCTTC

Downstream 100 bases:

>100_bases
AACTTTAAAATAGCAGTTGAGGTGCTCAACTGCTAAACCTATTGCAAAAAAGCTAAAGCTTTGTTATCGTTCCCCCTCTG
AACGTTCTGTCGTTCAAATC

Product: oligoendopeptidase F

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MTTDTTSQTVLRSRKDVPSSDCWDTKSLYASREAWKKDLENLCGKEAPFWPHLNEKQFHIEQPSSLYKLLTEVFSIERTL
EKLYVYAHLTHDEDISNQEATADLKSITYLLTSFSEEISWIQPALIALPQKISEELLTSPELQTYHFYLKKIFRLAPHTG
TSREEKILASSSPALEVAYKTFSSLTDSEIPFGEAVDSEGKSHPLSHALSSLYMQSPDRELRKSAYQKQCQRYHGYRLSL
ANLLNGKIQAHLFNAKAHNYKSCLEAALFQNNISTSVVTTLIETVKQHTHLITKYFQLKQKALGLPDFHFYDVYAPIAAS
EFARHYSYEEAVSLICDSLTPLGDNYVEALRKGLTSEGWVDKYENQNKRSGAYSSGCYDSKPYILLNYTGTLYDVSVVAH
EGGHSMHSFLSHKHQQYHEAQYPIFLAEIASTLNETLLMEFLLKNAPSKEEKIAILSRSLDTIFATLFRQTLFADFELEA
HSAAEQGIPLTEEFFSQSYKKLQHIFYGDCVTFDELSSIEWARIPHFYYNFYVYQYATGIIASLCFSEKILSKEAGAQEA
YLTFLQSGGSDFPIEILKKSGLDMTSSAPMLKAFSYIERKLDELTNLL

Sequences:

>Translated_608_residues
MTTDTTSQTVLRSRKDVPSSDCWDTKSLYASREAWKKDLENLCGKEAPFWPHLNEKQFHIEQPSSLYKLLTEVFSIERTL
EKLYVYAHLTHDEDISNQEATADLKSITYLLTSFSEEISWIQPALIALPQKISEELLTSPELQTYHFYLKKIFRLAPHTG
TSREEKILASSSPALEVAYKTFSSLTDSEIPFGEAVDSEGKSHPLSHALSSLYMQSPDRELRKSAYQKQCQRYHGYRLSL
ANLLNGKIQAHLFNAKAHNYKSCLEAALFQNNISTSVVTTLIETVKQHTHLITKYFQLKQKALGLPDFHFYDVYAPIAAS
EFARHYSYEEAVSLICDSLTPLGDNYVEALRKGLTSEGWVDKYENQNKRSGAYSSGCYDSKPYILLNYTGTLYDVSVVAH
EGGHSMHSFLSHKHQQYHEAQYPIFLAEIASTLNETLLMEFLLKNAPSKEEKIAILSRSLDTIFATLFRQTLFADFELEA
HSAAEQGIPLTEEFFSQSYKKLQHIFYGDCVTFDELSSIEWARIPHFYYNFYVYQYATGIIASLCFSEKILSKEAGAQEA
YLTFLQSGGSDFPIEILKKSGLDMTSSAPMLKAFSYIERKLDELTNLL
>Mature_607_residues
TTDTTSQTVLRSRKDVPSSDCWDTKSLYASREAWKKDLENLCGKEAPFWPHLNEKQFHIEQPSSLYKLLTEVFSIERTLE
KLYVYAHLTHDEDISNQEATADLKSITYLLTSFSEEISWIQPALIALPQKISEELLTSPELQTYHFYLKKIFRLAPHTGT
SREEKILASSSPALEVAYKTFSSLTDSEIPFGEAVDSEGKSHPLSHALSSLYMQSPDRELRKSAYQKQCQRYHGYRLSLA
NLLNGKIQAHLFNAKAHNYKSCLEAALFQNNISTSVVTTLIETVKQHTHLITKYFQLKQKALGLPDFHFYDVYAPIAASE
FARHYSYEEAVSLICDSLTPLGDNYVEALRKGLTSEGWVDKYENQNKRSGAYSSGCYDSKPYILLNYTGTLYDVSVVAHE
GGHSMHSFLSHKHQQYHEAQYPIFLAEIASTLNETLLMEFLLKNAPSKEEKIAILSRSLDTIFATLFRQTLFADFELEAH
SAAEQGIPLTEEFFSQSYKKLQHIFYGDCVTFDELSSIEWARIPHFYYNFYVYQYATGIIASLCFSEKILSKEAGAQEAY
LTFLQSGGSDFPIEILKKSGLDMTSSAPMLKAFSYIERKLDELTNLL

Specific function: Has oligopeptidase activity and degrades a variety of small bioactive peptides, including bradykinin, neurotensin, and peptide fragments of substance P and adrenocorticotropin. Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)

COG id: COG1164

COG function: function code E; Oligoendopeptidase F

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567
- InterPro:   IPR004438
- InterPro:   IPR013647 [H]

Pfam domain/function: PF01432 Peptidase_M3; PF08439 Peptidase_M3_N [H]

EC number: NA

Molecular weight: Translated: 69290; Mature: 69159

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDTTSQTVLRSRKDVPSSDCWDTKSLYASREAWKKDLENLCGKEAPFWPHLNEKQFHI
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEC
EQPSSLYKLLTEVFSIERTLEKLYVYAHLTHDEDISNQEATADLKSITYLLTSFSEEISW
CCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IQPALIALPQKISEELLTSPELQTYHFYLKKIFRLAPHTGTSREEKILASSSPALEVAYK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHH
TFSSLTDSEIPFGEAVDSEGKSHPLSHALSSLYMQSPDRELRKSAYQKQCQRYHGYRLSL
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHH
ANLLNGKIQAHLFNAKAHNYKSCLEAALFQNNISTSVVTTLIETVKQHTHLITKYFQLKQ
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALGLPDFHFYDVYAPIAASEFARHYSYEEAVSLICDSLTPLGDNYVEALRKGLTSEGWV
HHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCH
DKYENQNKRSGAYSSGCYDSKPYILLNYTGTLYDVSVVAHEGGHSMHSFLSHKHQQYHEA
HHHCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEECCCHHHHHHHHHHHHHHHHC
QYPIFLAEIASTLNETLLMEFLLKNAPSKEEKIAILSRSLDTIFATLFRQTLFADFELEA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
HSAAEQGIPLTEEFFSQSYKKLQHIFYGDCVTFDELSSIEWARIPHFYYNFYVYQYATGI
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCHHHHHHHHHHHHHHH
IASLCFSEKILSKEAGAQEAYLTFLQSGGSDFPIEILKKSGLDMTSSAPMLKAFSYIERK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
LDELTNLL
HHHHHCCC
>Mature Secondary Structure 
TTDTTSQTVLRSRKDVPSSDCWDTKSLYASREAWKKDLENLCGKEAPFWPHLNEKQFHI
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEC
EQPSSLYKLLTEVFSIERTLEKLYVYAHLTHDEDISNQEATADLKSITYLLTSFSEEISW
CCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IQPALIALPQKISEELLTSPELQTYHFYLKKIFRLAPHTGTSREEKILASSSPALEVAYK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHHHHH
TFSSLTDSEIPFGEAVDSEGKSHPLSHALSSLYMQSPDRELRKSAYQKQCQRYHGYRLSL
HHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHH
ANLLNGKIQAHLFNAKAHNYKSCLEAALFQNNISTSVVTTLIETVKQHTHLITKYFQLKQ
HHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALGLPDFHFYDVYAPIAASEFARHYSYEEAVSLICDSLTPLGDNYVEALRKGLTSEGWV
HHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCH
DKYENQNKRSGAYSSGCYDSKPYILLNYTGTLYDVSVVAHEGGHSMHSFLSHKHQQYHEA
HHHCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEEECCCHHHHHHHHHHHHHHHHC
QYPIFLAEIASTLNETLLMEFLLKNAPSKEEKIAILSRSLDTIFATLFRQTLFADFELEA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
HSAAEQGIPLTEEFFSQSYKKLQHIFYGDCVTFDELSSIEWARIPHFYYNFYVYQYATGI
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHCCHHHHHHHHHHHHHHH
IASLCFSEKILSKEAGAQEAYLTFLQSGGSDFPIEILKKSGLDMTSSAPMLKAFSYIERK
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
LDELTNLL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757883; 12354221 [H]