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The map label for this gene is groEL

Identifier: 15835005

GI number: 15835005

Start: 447159

End: 448793

Strand: Reverse

Name: groEL

Synonym: TC0386

Alternate gene names: 15835005

Gene position: 448793-447159 (Counterclockwise)

Preceding gene: 15835006

Following gene: 15835004

Centisome position: 41.83

GC content: 40.98

Gene sequence:

>1635_bases
ATGGTCGCTAAAAATATTAAATATAACGAAGAAGCCAGAAAAAAAATTCAAAAAGGAGTTAAGACTCTAGCTGAGGCTGT
AAAAGTCACTCTGGGGCCTAAAGGAAGACATGTTGTCATAGACAAAAGCTTTGGTTCTCCTCAAGTAACCAAAGACGGAG
TTACTGTTGCAAAAGAAGTTGAGCTCGCCGATAAGCATGAAAATATGGGCGCTCAAATGGTTAAAGAAGTCGCTAGTAAA
ACTGCTGACAAAGCTGGGGATGGAACCACAACAGCCACTGTTCTTGCCGAAGCTATCTATACAGAAGGGTTACGTAATGT
AACAGCTGGAGCAAACCCAATGGACCTCAAAAGAGGTATCGATAAAGCTGTTAAAGTCGTTGTAGATCAAATTAAAAAAA
TTAGCAAACCCGTTCAACATCACAAAGAAATTGCTCAAGTAGCCACTATTTCTGCAAACAATGATGCAGAAATTGGTAAT
CTTATTGCAGAAGCAATGGAAAAAGTTGGTAAAAACGGATCTATTACTGTTGAAGAAGCCAAAGGATTCGAAACAGTCTT
AGATGTCGTTGAGGGAATGAATTTCAATAGAGGATATCTCTCTAGCTATTTTGCAACGAATCCAGAAACTCAAGAATGTG
TATTAGAAGACGCTCTTGTTTTGATTTACGACAAAAAAATATCTGGAATTAAAGATTTCCTCCCTGTTTTACAACAAGTT
GCGGAATCAGGCCGTCCTCTTCTTATTATAGCAGAAGACATCGAGGGAGAAGCTTTGGCGACATTGGTTGTTAACCGAAT
TCGCGGAGGATTCAGAGTTTGTGCTGTTAAAGCTCCTGGGTTTGGAGATAGAAGAAAAGCTATGCTGGAAGACATCGCTA
TTTTAACTGGCGGTCAGCTTATCAGCGAAGAATTGGGTATGAAATTAGAAAATGCTAGCTTAGCAATGCTTGGTAAAGCT
AAGAAAGTTATCGTTTCTAAAGAAGACACGACTATTGTTGAAGGAATGGGCGAAAAAGAAGCTTTGGACGCTCGTTGCGA
AAGCATTAAAAAACAAATTGAAGACAGCACTTCCGATTACGACAAGGAAAAACTCCAAGAACGTCTTGCTAAACTTTCTG
GCGGCGTAGCGGTCATCCGCGTTGGAGCAGCAACAGAAATCGAAATGAAAGAGAAAAAGGATCGTGTAGACGATGCTCAA
CATGCCACAATCGCTGCTGTTGAAGAAGGAATTCTTCCTGGCGGTGGAACAGCATTAATTCGTTGCATTCCAACTCTTGA
AGCTTTCTTGCCTATGTTGACAAATGAAGATGAGCGAATTGGAGCCCGTATTGTTTTGAAAGCTCTCTCTGCTCCTTTGA
AACAAATTGCAGCAAATGCAGGAAAAGAAGGTGCTATTATCTTCCAACAAGTAATGTCCCGTTCTGCAAATGAAGGATAC
GATGCTCTACGTGATGCCTATACAGACATGATAGAAGCTGGTATCTTGGATCCTGCTAAGGTTACTCGTTCCGCTTTGGA
AAGTGCAGCATCTGTAGCTGGTCTACTATTGACAACAGAAGCTCTCATTGCAGAAATTCCAGAAGAAAAACCTGCTGCAG
CTCCAGCAATGCCTGGTGCAGGAATGGATTATTAA

Upstream 100 bases:

>100_bases
CTGTCGAAGGTGAAGAATATGTCATCGTTCAAATGAGCGAAGTTATAGCAGTCCTGCAATAAAAACTAAGAGAGTGAAGT
AAGATTTAAGGAGCGCATCG

Downstream 100 bases:

>100_bases
TCCCCTAAAAGGATTACAATCTTATTCGAGCCTCGTTTCCAATAAGGAACGGGGCTTTTTTCATTTCCTAATATTTCCTT
ATTCCTCTATCGTAAACATC

Product: chaperonin GroEL

Products: NA

Alternate protein names: 57 kDa chlamydial hypersensitivity antigen; GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MVAKNIKYNEEARKKIQKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEVELADKHENMGAQMVKEVASK
TADKAGDGTTTATVLAEAIYTEGLRNVTAGANPMDLKRGIDKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGN
LIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFATNPETQECVLEDALVLIYDKKISGIKDFLPVLQQV
AESGRPLLIIAEDIEGEALATLVVNRIRGGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLISEELGMKLENASLAMLGKA
KKVIVSKEDTTIVEGMGEKEALDARCESIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQ
HATIAAVEEGILPGGGTALIRCIPTLEAFLPMLTNEDERIGARIVLKALSAPLKQIAANAGKEGAIIFQQVMSRSANEGY
DALRDAYTDMIEAGILDPAKVTRSALESAASVAGLLLTTEALIAEIPEEKPAAAPAMPGAGMDY

Sequences:

>Translated_544_residues
MVAKNIKYNEEARKKIQKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEVELADKHENMGAQMVKEVASK
TADKAGDGTTTATVLAEAIYTEGLRNVTAGANPMDLKRGIDKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGN
LIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFATNPETQECVLEDALVLIYDKKISGIKDFLPVLQQV
AESGRPLLIIAEDIEGEALATLVVNRIRGGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLISEELGMKLENASLAMLGKA
KKVIVSKEDTTIVEGMGEKEALDARCESIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQ
HATIAAVEEGILPGGGTALIRCIPTLEAFLPMLTNEDERIGARIVLKALSAPLKQIAANAGKEGAIIFQQVMSRSANEGY
DALRDAYTDMIEAGILDPAKVTRSALESAASVAGLLLTTEALIAEIPEEKPAAAPAMPGAGMDY
>Mature_544_residues
MVAKNIKYNEEARKKIQKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEVELADKHENMGAQMVKEVASK
TADKAGDGTTTATVLAEAIYTEGLRNVTAGANPMDLKRGIDKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGN
LIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFATNPETQECVLEDALVLIYDKKISGIKDFLPVLQQV
AESGRPLLIIAEDIEGEALATLVVNRIRGGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLISEELGMKLENASLAMLGKA
KKVIVSKEDTTIVEGMGEKEALDARCESIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQ
HATIAAVEEGILPGGGTALIRCIPTLEAFLPMLTNEDERIGARIVLKALSAPLKQIAANAGKEGAIIFQQVMSRSANEGY
DALRDAYTDMIEAGILDPAKVTRSALESAASVAGLLLTTEALIAEIPEEKPAAAPAMPGAGMDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. This protein is implicated in the pathogenesis of chlamydial disease. Inflammation elicited by the 57 kDa antigen may damage tis

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=51.7958412098299, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=51.7958412098299, Blast_Score=543, Evalue=1e-154,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=61.6541353383459, Blast_Score=652, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=50.5660377358491, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=51.8867924528302, Blast_Score=208, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.9923954372624, Blast_Score=549, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=52.0833333333333, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=52.0833333333333, Blast_Score=550, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=529, Percent_Identity=49.7164461247637, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=529, Percent_Identity=49.7164461247637, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=529, Percent_Identity=49.7164461247637, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=545, Percent_Identity=43.4862385321101, Blast_Score=459, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24584129, Length=527, Percent_Identity=37.1916508538899, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI19921262, Length=527, Percent_Identity=37.1916508538899, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58107; Mature: 58107

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAKNIKYNEEARKKIQKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHH
ELADKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYTEGLRNVTAGANPMDLKRGI
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGNLIAEAMEKVGKNGSITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHH
KGFETVLDVVEGMNFNRGYLSSYFATNPETQECVLEDALVLIYDKKISGIKDFLPVLQQV
CCHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHCCEEEEECCHHCCHHHHHHHHHHH
AESGRPLLIIAEDIEGEALATLVVNRIRGGFRVCAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEELGMKLENASLAMLGKAKKVIVSKEDTTIVEGMGEKEALDARCESIKKQIEDSTSDY
HHHHHCCEECCCCHHHHCCCHHEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
DKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALI
CHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHH
RCIPTLEAFLPMLTNEDERIGARIVLKALSAPLKQIAANAGKEGAIIFQQVMSRSANEGY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCH
DALRDAYTDMIEAGILDPAKVTRSALESAASVAGLLLTTEALIAEIPEEKPAAAPAMPGA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GMDY
CCCC
>Mature Secondary Structure
MVAKNIKYNEEARKKIQKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHH
ELADKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYTEGLRNVTAGANPMDLKRGI
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DKAVKVVVDQIKKISKPVQHHKEIAQVATISANNDAEIGNLIAEAMEKVGKNGSITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHH
KGFETVLDVVEGMNFNRGYLSSYFATNPETQECVLEDALVLIYDKKISGIKDFLPVLQQV
CCHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHCCEEEEECCHHCCHHHHHHHHHHH
AESGRPLLIIAEDIEGEALATLVVNRIRGGFRVCAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEELGMKLENASLAMLGKAKKVIVSKEDTTIVEGMGEKEALDARCESIKKQIEDSTSDY
HHHHHCCEECCCCHHHHCCCHHEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
DKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALI
CHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHH
RCIPTLEAFLPMLTNEDERIGARIVLKALSAPLKQIAANAGKEGAIIFQQVMSRSANEGY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCH
DALRDAYTDMIEAGILDPAKVTRSALESAASVAGLLLTTEALIAEIPEEKPAAAPAMPGA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
GMDY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2571668; 12682364 [H]