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The map label for this gene is mutY

Identifier: 15835002

GI number: 15835002

Start: 444322

End: 445437

Strand: Direct

Name: mutY

Synonym: TC0383

Alternate gene names: 15835002

Gene position: 444322-445437 (Clockwise)

Preceding gene: 15835000

Following gene: 15835003

Centisome position: 41.41

GC content: 39.87

Gene sequence:

>1116_bases
ATGATAAGAACAGCTTTTTCCCAAGATAATGACCGTTTTCCTCTGGAAGCGTTTCGTTTATGGTTTCTTGAATGTAAAAG
ATCTTTCCCATGGAGGGAATCTCCTACTCCTTATCGTGTTTGGGTTTCTGAAGTTATGCTTCAACAAACTCGAGCAGAGG
TTGTGGTTCCCTATTTTTTAAGATGGATGGAGCGATTCCCTTCTATACAAGATCTTGCTCATGCCGAGGAAAGTGAAGTT
GTACGTCTTTGGGAAGGGTTGGGTTACTATTCTCGGGCGCGGAATCTTTTATCTGGAGCGCGTGTAATTACAGAGCTTTT
TCAAGGCGAGATTCCACAGGATCCTTTGCTTCTTAACTCTATTAAAGGGATAGGTCCTTATACTGCAAATGCTATCTTAG
CGTTTGCATTTAAGCAAAAAAAGGCTGCTGTTGACGGCAATGTTTTGCGCGTAATGAGCCGTTTATTTGCAATAAATCAA
TCCATTGATCGTATTAAGACACGACAAGAGATCACGGAATTGTGTGAAACCTTGCTTCCGGATTATGAGCCTGAGGTTAT
TGCAGAGGCTTTTATTGAACTAGGTGCAAGGATTTGCAATCGGAAGCCTGTTTGTGAACAGTGCCCATTACGCTCTTTTT
GCAAAGCGTATCAAGAAGGGACTGTGTTGCAATACCCAGTTAAAAACTCTCGTTCTGCAATCACACCTCTTTTTCGCGCT
GTAGTGATTATTGTATCTAAGGATAGGGTCCTTATGACAAAAAGAGAAGACCATGAGATTATGGCAGGATTATATGAATT
TCCTTACTATCAGCTTTCTCAAGAAGATTGTTGTGATGTTGAGAAAATAACCGATCTGGTTCGTCAAGATTTTGGAGACT
CTATTCGCTTTGTTGGAGGCCTTCCCTCCCAGAAACAGATTTTTACTCGTTATCGCGTTTCTCTATTCCCTTATATTTTT
CATATTAAAACTCTCTCTTCAGAACAAAATAGTTATACATTAGTAGAACTGAAAAATCTTCCAAGTTCCTCAGGACATCG
TAGAATTAAAGAGGATTTTTTGTCAGAGTACTGTAAATTTCCTGAAAAGATGGCCGGTTATTCTGGGGATCAATAA

Upstream 100 bases:

>100_bases
GAGAAAACAAGCAAGCCTTGTCTGGCGATCTGCTATACCAATAAACTCTTGCATAATCCTTTACCAATAAGTATGTTGGT
ACAATTTTACGCAAATTTCT

Downstream 100 bases:

>100_bases
AACAAAAAGAGTCTATTAAAACCTCGTAAGGTTTCTATATGAATGTTGCTGATCTTTTGCATGTTTTGAATGAATTATTA
TATCCTGAATTGTTTAATGA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MIRTAFSQDNDRFPLEAFRLWFLECKRSFPWRESPTPYRVWVSEVMLQQTRAEVVVPYFLRWMERFPSIQDLAHAEESEV
VRLWEGLGYYSRARNLLSGARVITELFQGEIPQDPLLLNSIKGIGPYTANAILAFAFKQKKAAVDGNVLRVMSRLFAINQ
SIDRIKTRQEITELCETLLPDYEPEVIAEAFIELGARICNRKPVCEQCPLRSFCKAYQEGTVLQYPVKNSRSAITPLFRA
VVIIVSKDRVLMTKREDHEIMAGLYEFPYYQLSQEDCCDVEKITDLVRQDFGDSIRFVGGLPSQKQIFTRYRVSLFPYIF
HIKTLSSEQNSYTLVELKNLPSSSGHRRIKEDFLSEYCKFPEKMAGYSGDQ

Sequences:

>Translated_371_residues
MIRTAFSQDNDRFPLEAFRLWFLECKRSFPWRESPTPYRVWVSEVMLQQTRAEVVVPYFLRWMERFPSIQDLAHAEESEV
VRLWEGLGYYSRARNLLSGARVITELFQGEIPQDPLLLNSIKGIGPYTANAILAFAFKQKKAAVDGNVLRVMSRLFAINQ
SIDRIKTRQEITELCETLLPDYEPEVIAEAFIELGARICNRKPVCEQCPLRSFCKAYQEGTVLQYPVKNSRSAITPLFRA
VVIIVSKDRVLMTKREDHEIMAGLYEFPYYQLSQEDCCDVEKITDLVRQDFGDSIRFVGGLPSQKQIFTRYRVSLFPYIF
HIKTLSSEQNSYTLVELKNLPSSSGHRRIKEDFLSEYCKFPEKMAGYSGDQ
>Mature_371_residues
MIRTAFSQDNDRFPLEAFRLWFLECKRSFPWRESPTPYRVWVSEVMLQQTRAEVVVPYFLRWMERFPSIQDLAHAEESEV
VRLWEGLGYYSRARNLLSGARVITELFQGEIPQDPLLLNSIKGIGPYTANAILAFAFKQKKAAVDGNVLRVMSRLFAINQ
SIDRIKTRQEITELCETLLPDYEPEVIAEAFIELGARICNRKPVCEQCPLRSFCKAYQEGTVLQYPVKNSRSAITPLFRA
VVIIVSKDRVLMTKREDHEIMAGLYEFPYYQLSQEDCCDVEKITDLVRQDFGDSIRFVGGLPSQKQIFTRYRVSLFPYIF
HIKTLSSEQNSYTLVELKNLPSSSGHRRIKEDFLSEYCKFPEKMAGYSGDQ

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=303, Percent_Identity=33.6633663366337, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI6912520, Length=303, Percent_Identity=33.6633663366337, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI115298654, Length=303, Percent_Identity=33.6633663366337, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI115298652, Length=303, Percent_Identity=33.6633663366337, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI190358497, Length=303, Percent_Identity=33.6633663366337, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI115298648, Length=303, Percent_Identity=33.6633663366337, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1789331, Length=305, Percent_Identity=32.7868852459016, Blast_Score=184, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 43047; Mature: 43047

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRTAFSQDNDRFPLEAFRLWFLECKRSFPWRESPTPYRVWVSEVMLQQTRAEVVVPYFL
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RWMERFPSIQDLAHAEESEVVRLWEGLGYYSRARNLLSGARVITELFQGEIPQDPLLLNS
HHHHHCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
IKGIGPYTANAILAFAFKQKKAAVDGNVLRVMSRLFAINQSIDRIKTRQEITELCETLLP
HCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DYEPEVIAEAFIELGARICNRKPVCEQCPLRSFCKAYQEGTVLQYPVKNSRSAITPLFRA
CCCHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
VVIIVSKDRVLMTKREDHEIMAGLYEFPYYQLSQEDCCDVEKITDLVRQDFGDSIRFVGG
HHHHCCCCEEEEECCCHHHHHHHHHHCCCHHCCCHHCCCHHHHHHHHHHHCCCCCHHHCC
LPSQKQIFTRYRVSLFPYIFHIKTLSSEQNSYTLVELKNLPSSSGHRRIKEDFLSEYCKF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
PEKMAGYSGDQ
HHHHCCCCCCC
>Mature Secondary Structure
MIRTAFSQDNDRFPLEAFRLWFLECKRSFPWRESPTPYRVWVSEVMLQQTRAEVVVPYFL
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RWMERFPSIQDLAHAEESEVVRLWEGLGYYSRARNLLSGARVITELFQGEIPQDPLLLNS
HHHHHCCCHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
IKGIGPYTANAILAFAFKQKKAAVDGNVLRVMSRLFAINQSIDRIKTRQEITELCETLLP
HCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DYEPEVIAEAFIELGARICNRKPVCEQCPLRSFCKAYQEGTVLQYPVKNSRSAITPLFRA
CCCHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
VVIIVSKDRVLMTKREDHEIMAGLYEFPYYQLSQEDCCDVEKITDLVRQDFGDSIRFVGG
HHHHCCCCEEEEECCCHHHHHHHHHHCCCHHCCCHHCCCHHHHHHHHHHHCCCCCHHHCC
LPSQKQIFTRYRVSLFPYIFHIKTLSSEQNSYTLVELKNLPSSSGHRRIKEDFLSEYCKF
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
PEKMAGYSGDQ
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]