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The map label for this gene is pgd

Identifier: 15834953

GI number: 15834953

Start: 394308

End: 395747

Strand: Direct

Name: pgd

Synonym: TC0333

Alternate gene names: 15834953

Gene position: 394308-395747 (Clockwise)

Preceding gene: 15834952

Following gene: 15834958

Centisome position: 36.75

GC content: 43.19

Gene sequence:

>1440_bases
GTGGCTCCAGCAGATATTGGGTTGATTGGTTTGGCCGTAATGGGCAAAAACCTTGTGTTGAATATGATTGATCACGGTTT
TGCTGTCTCTGTCTATAACCGCAGTCCAGAGAAAACGGAAGAGTTCTTGAAGGAGCATGGAGAGAATATATCTCTTCAAG
GGTTTACTGCCATCGAAGAGTTCGTTCAATCTTTGAAACGTCCTCGGAAGATTATGATTATGATTAAGGCGGGAGCTCCT
GTTGATGAAATGATTTCCTCGCTACTTCCCTTTTTAGAAGAGGGGGATATTCTCATTGATGGGGGGAATAGCTATTATCT
GGATTCTGAGCGTCGCTACATTGATCTCAAAAAGAAAGGGATTTTATTTGTCGGCATGGGGGTCTCTGGAGGAGAAGAAG
GGGCTCGTAAAGGACCTTCTATTATGCCCGGAGGGAATATTGAAGCTTGGCCTGTTATCGCTCCTATTTTTCAATCAATA
GCTGCTCAGGTTGATGGACAGCCTTGTTGCTCTTGGATTGGTACAGGAGGAGCGGGTCATTTTGTTAAAGCCGTTCATAA
TGGTATAGAATATGGGGATATTCAGTTAATCTGTGAAACCTATGAGATTCTTAAATCTCGGCTTGATTTGTCTCTTGAAC
AGATAGGAAACATCTTCTTTGAGTGGAATCAAACGGATTTAAATAGCTATCTTATGGGAGCTTCAGCAGCTGTTTTAACA
GCAAAAGATGAGAATGGAGTTGCTGTGGCTTCGACTATTTTGGATGTAGCTGGGCAGAAAGGTACTGGGCGTTGGGTTGC
GGAAGATGCGATTAAGGCAGGTGTTCCTATGTCGCTTATCATAGAGTCTGTTTTAGCTCGTTATCTCTCGGCTTGGAAGG
AGGTGCGTAGACAAGCTGCTCGAGAATTCCCTGTAGCTTCTCTTCTTTATCAACCTTCGCAAGAGGCCTCGGTCTTGATC
GAAGATGCAAGAGAAGCTCTTTACGCAGCAAAGATTATTAGTTATGCCCAAGGCTTCATGCTATTAAAGCAGATCTCTGA
AGAAAGGAATTGGGATCTTAATTTAGGAGAGCTTGCTTTGATATGGCGCGGCGGATGTATTATCCAAAGTGCTTTCTTGG
ATAAAATTCACCAAGGGTTTGAGAGTTGCCCGGATGCACACTCTTTGATGTTACAAGATTATTTCAAAAACGTTTTGTTG
AACTCAGAAACTGGTTTTCGCCGAGCTATTTTACATGCTGTTGGAGCTGGTGTAGCAATTCCTTGTTTAGCTTCTGCCTT
AGCTTTTTACGATGGGTATCGGACGGAAAACTCTCCATTATTCTTAGTTCAAGGATTAAGAGATTATTTTGGGGCTCATG
GTTATGAGCGGCAAGATCGTCCTCGCGGGGAGTTTTATCATACGGATTGGTTAGGAAGCAAAAACGCTTCCCGGATGTAA

Upstream 100 bases:

>100_bases
GAGTGTCCTAGATGGGACATATCTCTGTTTTGATCGGTATATTCTTCTCTCTCAAGGGAAAAAGAAAAAACAAGTTATAG
ATCTTAATTAGGAGGTGGCA

Downstream 100 bases:

>100_bases
AAAGATAAAGCCCGGCAAAAGTATTTGCCGGGCTTTTTTATGGAAGAATTTTTGAGAAAACTTGCCCTTATTCCATCTTA
AGGACTTCAACAAATGCTGT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MAPADIGLIGLAVMGKNLVLNMIDHGFAVSVYNRSPEKTEEFLKEHGENISLQGFTAIEEFVQSLKRPRKIMIMIKAGAP
VDEMISSLLPFLEEGDILIDGGNSYYLDSERRYIDLKKKGILFVGMGVSGGEEGARKGPSIMPGGNIEAWPVIAPIFQSI
AAQVDGQPCCSWIGTGGAGHFVKAVHNGIEYGDIQLICETYEILKSRLDLSLEQIGNIFFEWNQTDLNSYLMGASAAVLT
AKDENGVAVASTILDVAGQKGTGRWVAEDAIKAGVPMSLIIESVLARYLSAWKEVRRQAAREFPVASLLYQPSQEASVLI
EDAREALYAAKIISYAQGFMLLKQISEERNWDLNLGELALIWRGGCIIQSAFLDKIHQGFESCPDAHSLMLQDYFKNVLL
NSETGFRRAILHAVGAGVAIPCLASALAFYDGYRTENSPLFLVQGLRDYFGAHGYERQDRPRGEFYHTDWLGSKNASRM

Sequences:

>Translated_479_residues
MAPADIGLIGLAVMGKNLVLNMIDHGFAVSVYNRSPEKTEEFLKEHGENISLQGFTAIEEFVQSLKRPRKIMIMIKAGAP
VDEMISSLLPFLEEGDILIDGGNSYYLDSERRYIDLKKKGILFVGMGVSGGEEGARKGPSIMPGGNIEAWPVIAPIFQSI
AAQVDGQPCCSWIGTGGAGHFVKAVHNGIEYGDIQLICETYEILKSRLDLSLEQIGNIFFEWNQTDLNSYLMGASAAVLT
AKDENGVAVASTILDVAGQKGTGRWVAEDAIKAGVPMSLIIESVLARYLSAWKEVRRQAAREFPVASLLYQPSQEASVLI
EDAREALYAAKIISYAQGFMLLKQISEERNWDLNLGELALIWRGGCIIQSAFLDKIHQGFESCPDAHSLMLQDYFKNVLL
NSETGFRRAILHAVGAGVAIPCLASALAFYDGYRTENSPLFLVQGLRDYFGAHGYERQDRPRGEFYHTDWLGSKNASRM
>Mature_478_residues
APADIGLIGLAVMGKNLVLNMIDHGFAVSVYNRSPEKTEEFLKEHGENISLQGFTAIEEFVQSLKRPRKIMIMIKAGAPV
DEMISSLLPFLEEGDILIDGGNSYYLDSERRYIDLKKKGILFVGMGVSGGEEGARKGPSIMPGGNIEAWPVIAPIFQSIA
AQVDGQPCCSWIGTGGAGHFVKAVHNGIEYGDIQLICETYEILKSRLDLSLEQIGNIFFEWNQTDLNSYLMGASAAVLTA
KDENGVAVASTILDVAGQKGTGRWVAEDAIKAGVPMSLIIESVLARYLSAWKEVRRQAAREFPVASLLYQPSQEASVLIE
DAREALYAAKIISYAQGFMLLKQISEERNWDLNLGELALIWRGGCIIQSAFLDKIHQGFESCPDAHSLMLQDYFKNVLLN
SETGFRRAILHAVGAGVAIPCLASALAFYDGYRTENSPLFLVQGLRDYFGAHGYERQDRPRGEFYHTDWLGSKNASRM

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI40068518, Length=473, Percent_Identity=52.8541226215645, Blast_Score=495, Evalue=1e-140,
Organism=Escherichia coli, GI1788341, Length=474, Percent_Identity=48.5232067510549, Blast_Score=461, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17542558, Length=476, Percent_Identity=50, Blast_Score=496, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6321695, Length=477, Percent_Identity=48.2180293501048, Blast_Score=482, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6321977, Length=475, Percent_Identity=49.2631578947368, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24639279, Length=475, Percent_Identity=50.7368421052632, Blast_Score=468, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 6PGD_CHLMU (Q9PKX7)

Other databases:

- EMBL:   AE002160
- PIR:   A81714
- RefSeq:   NP_296712.1
- ProteinModelPortal:   Q9PKX7
- SMR:   Q9PKX7
- GeneID:   1246377
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0333
- TIGR:   TC_0333
- HOGENOM:   HBG286913
- OMA:   SHYKEER
- PhylomeDB:   Q9PKX7
- ProtClustDB:   PRK09287
- BioCyc:   CMUR243161:TC_0333-MONOMER
- BRENDA:   1.1.1.44
- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183
- Gene3D:   G3DSA:1.20.5.320
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PIRSF:   PIRSF000109
- PRINTS:   PR00076
- TIGRFAMs:   TIGR00873

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2; SSF48179 6DGDH_C_like

EC number: =1.1.1.44

Molecular weight: Translated: 52690; Mature: 52559

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00461 6PGD

Important sites: ACT_SITE 183-183 ACT_SITE 190-190 BINDING 103-103 BINDING 103-103 BINDING 191-191 BINDING 260-260 BINDING 287-287 BINDING 447-447 BINDING 453-453

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPADIGLIGLAVMGKNLVLNMIDHGFAVSVYNRSPEKTEEFLKEHGENISLQGFTAIEE
CCCCHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCEECCHHHHHH
FVQSLKRPRKIMIMIKAGAPVDEMISSLLPFLEEGDILIDGGNSYYLDSERRYIDLKKKG
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCEEEEECCC
ILFVGMGVSGGEEGARKGPSIMPGGNIEAWPVIAPIFQSIAAQVDGQPCCSWIGTGGAGH
EEEEECCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHH
FVKAVHNGIEYGDIQLICETYEILKSRLDLSLEQIGNIFFEWNQTDLNSYLMGASAAVLT
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEECCHHHHHHHHCCCEEEEE
AKDENGVAVASTILDVAGQKGTGRWVAEDAIKAGVPMSLIIESVLARYLSAWKEVRRQAA
ECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
REFPVASLLYQPSQEASVLIEDAREALYAAKIISYAQGFMLLKQISEERNWDLNLGELAL
HHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
IWRGGCIIQSAFLDKIHQGFESCPDAHSLMLQDYFKNVLLNSETGFRRAILHAVGAGVAI
EEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHH
PCLASALAFYDGYRTENSPLFLVQGLRDYFGAHGYERQDRPRGEFYHTDWLGSKNASRM
HHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCC
>Mature Secondary Structure 
APADIGLIGLAVMGKNLVLNMIDHGFAVSVYNRSPEKTEEFLKEHGENISLQGFTAIEE
CCCHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCEECCHHHHHH
FVQSLKRPRKIMIMIKAGAPVDEMISSLLPFLEEGDILIDGGNSYYLDSERRYIDLKKKG
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCCEEEEECCC
ILFVGMGVSGGEEGARKGPSIMPGGNIEAWPVIAPIFQSIAAQVDGQPCCSWIGTGGAGH
EEEEECCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHH
FVKAVHNGIEYGDIQLICETYEILKSRLDLSLEQIGNIFFEWNQTDLNSYLMGASAAVLT
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEECCHHHHHHHHCCCEEEEE
AKDENGVAVASTILDVAGQKGTGRWVAEDAIKAGVPMSLIIESVLARYLSAWKEVRRQAA
ECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
REFPVASLLYQPSQEASVLIEDAREALYAAKIISYAQGFMLLKQISEERNWDLNLGELAL
HHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
IWRGGCIIQSAFLDKIHQGFESCPDAHSLMLQDYFKNVLLNSETGFRRAILHAVGAGVAI
EEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHH
PCLASALAFYDGYRTENSPLFLVQGLRDYFGAHGYERQDRPRGEFYHTDWLGSKNASRM
HHHHHHHHHHCCCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935